Clinical feature	Statistical test	Significant genes	Associated with	               	Associated with	
DAYS_TO_DEATH_OR_LAST_FUP	Cox regression test	N=3	 	N=NA	 	N=NA
YEARS_TO_BIRTH	Spearman correlation test	N=30	older	N=11	younger	N=19
PATHOLOGIC_STAGE	Kruskal-Wallis test	N=30	 	 	 	 
PATHOLOGY_T_STAGE	Spearman correlation test	N=30	higher stage	N=23	lower stage	N=7
PATHOLOGY_N_STAGE	Spearman correlation test	N=30	higher stage	N=23	lower stage	N=7
PATHOLOGY_M_STAGE	Wilcoxon test	N=0	 	 	 	 
GENDER	Wilcoxon test	N=2	male	N=2	female	N=0
RADIATION_THERAPY	Wilcoxon test	N=30	yes	N=30	no	N=0
KARNOFSKY_PERFORMANCE_SCORE	Spearman correlation test	N=30	higher score	N=25	lower score	N=5
HISTOLOGICAL_TYPE	Wilcoxon test	N=30	esophagus squamous cell carcinoma	N=30	esophagus adenocarcinoma, nos	N=0
NUMBER_PACK_YEARS_SMOKED	Spearman correlation test	N=30	higher number_pack_years_smoked	N=10	lower number_pack_years_smoked	N=20
RESIDUAL_TUMOR	Kruskal-Wallis test	N=0	 	 	 	 
NUMBER_OF_LYMPH_NODES	Spearman correlation test	N=0	 	 	 	 
RACE	Kruskal-Wallis test	N=30	 	 	 	 
ETHNICITY	Wilcoxon test	N=0