Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.21 0.29 -9999.0 0.0 -0.593 54.0 54.0 IHH -0.244 0.285 -9999.0 0.0 -0.564 80.0 80.0 SHH Np/Cholesterol/GAS1 -0.094 0.137 -9999.0 0.0 -0.587 3.0 3.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.093 0.136 0.582 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.204 0.26 -9999.0 0.0 -0.542 51.0 51.0 SMO -0.221 0.273 -9999.0 0.0 -0.574 52.0 52.0 AKT1 -0.079 0.122 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.09 -9999.0 0.0 -0.496 6.0 6.0 ADRBK1 0.008 0.058 -9999.0 0.0 -0.783 1.0 1.0 heart looping -0.218 0.269 -9999.0 0.0 -0.565 52.0 52.0 STIL -0.251 0.266 -9999.0 0.0 -0.642 37.0 37.0 DHH N/PTCH2 -0.008 0.067 -9999.0 0.0 -0.513 3.0 3.0 DHH N/PTCH1 -0.152 0.208 -9999.0 0.0 -0.535 7.0 7.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.348 0.447 -9999.0 0.0 -0.902 65.0 65.0 determination of left/right symmetry -0.218 0.269 -9999.0 0.0 -0.565 52.0 52.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.343 0.441 -9999.0 0.0 -0.889 65.0 65.0 IHH N/Hhip -0.308 0.251 -9999.0 0.0 -0.486 108.0 108.0 DHH N/Hhip -0.163 0.174 -9999.0 0.0 -0.348 86.0 86.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.218 0.269 -9999.0 0.0 -0.565 52.0 52.0 pancreas development -0.225 0.252 -9999.0 0.0 -0.495 86.0 86.0 HHAT 0.001 0.074 -9999.0 0.0 -0.496 4.0 4.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.118 -9999.0 0.0 -0.528 9.0 9.0 somite specification -0.218 0.269 -9999.0 0.0 -0.565 52.0 52.0 SHH Np/Cholesterol/PTCH1 -0.204 0.255 -9999.0 0.0 -0.566 44.0 44.0 SHH Np/Cholesterol/PTCH2 -0.086 0.137 -9999.0 0.0 -0.558 4.0 4.0 SHH Np/Cholesterol/Megalin -0.095 0.142 -9999.0 0.0 -0.484 8.0 8.0 SHH -0.092 0.177 -9999.0 0.0 -0.359 55.0 55.0 catabolic process -0.178 0.232 -9999.0 0.0 -0.49 50.0 50.0 SMO/Vitamin D3 -0.225 0.277 -9999.0 0.0 -0.609 45.0 45.0 SHH Np/Cholesterol/Hhip -0.202 0.191 -9999.0 0.0 -0.52 34.0 34.0 LRP2 -0.015 0.141 -9999.0 0.0 -0.783 6.0 6.0 receptor-mediated endocytosis -0.244 0.239 -9999.0 0.0 -0.588 45.0 45.0 SHH Np/Cholesterol/BOC -0.088 0.136 -9999.0 0.0 -0.601 3.0 3.0 SHH Np/Cholesterol/CDO -0.09 0.136 -9999.0 0.0 -0.51 5.0 5.0 mesenchymal cell differentiation 0.2 0.19 0.516 34.0 -9999.0 0.0 34.0 mol:Vitamin D3 -0.203 0.257 -9999.0 0.0 -0.568 44.0 44.0 IHH N/PTCH2 -0.144 0.193 -9999.0 0.0 -0.384 50.0 50.0 CDON -0.006 0.101 -9999.0 0.0 -0.544 6.0 6.0 IHH N/PTCH1 -0.18 0.234 -9999.0 0.0 -0.495 50.0 50.0 Megalin/LRPAP1 -0.019 0.106 -9999.0 0.0 -0.596 6.0 6.0 PTCH2 0.001 0.09 -9999.0 0.0 -0.687 3.0 3.0 SHH Np/Cholesterol -0.082 0.129 -9999.0 0.0 -0.527 2.0 2.0 PTCH1 -0.179 0.233 -9999.0 0.0 -0.491 50.0 50.0 HHIP -0.226 0.253 -9999.0 0.0 -0.496 86.0 86.0