Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.155 0.201 -9999.0 0.0 -0.424 51.0 51.0 IHH -0.213 0.259 -9999.0 0.0 -0.502 80.0 80.0 SHH Np/Cholesterol/GAS1 -0.067 0.131 -9999.0 0.0 -0.256 57.0 57.0 LRPAP1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.067 0.13 0.255 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 -0.181 0.225 -9999.0 0.0 -0.445 64.0 64.0 SMO -0.193 0.229 -9999.0 0.0 -0.442 76.0 76.0 AKT1 -0.083 0.153 -9999.0 0.0 -0.534 12.0 12.0 ARRB2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.084 -9999.0 0.0 -0.45 6.0 6.0 ADRBK1 0.024 0.019 0.269 1.0 -9999.0 0.0 1.0 heart looping -0.19 0.226 -9999.0 0.0 -0.436 76.0 76.0 STIL -0.19 0.197 -9999.0 0.0 -0.421 64.0 64.0 DHH N/PTCH2 0.03 0.041 -9999.0 0.0 -0.282 3.0 3.0 DHH N/PTCH1 -0.125 0.174 -9999.0 0.0 -0.353 48.0 48.0 PIK3CA 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.222 0.281 -9999.0 0.0 -0.626 49.0 49.0 determination of left/right symmetry -0.19 0.226 -9999.0 0.0 -0.436 76.0 76.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.22 0.278 -9999.0 0.0 -0.62 49.0 49.0 IHH N/Hhip -0.267 0.228 -9999.0 0.0 -0.411 122.0 122.0 DHH N/Hhip -0.124 0.177 -9999.0 0.0 -0.322 81.0 81.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.19 0.226 -9999.0 0.0 -0.436 76.0 76.0 pancreas development -0.188 0.233 -9999.0 0.0 -0.45 81.0 81.0 HHAT 0.013 0.069 -9999.0 0.0 -0.45 4.0 4.0 PI3K 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.101 -9999.0 0.0 -0.442 9.0 9.0 somite specification -0.19 0.226 -9999.0 0.0 -0.436 76.0 76.0 SHH Np/Cholesterol/PTCH1 -0.17 0.211 -9999.0 0.0 -0.424 64.0 64.0 SHH Np/Cholesterol/PTCH2 -0.059 0.129 -9999.0 0.0 -0.257 51.0 51.0 SHH Np/Cholesterol/Megalin -0.062 0.125 -9999.0 0.0 -0.249 54.0 54.0 SHH -0.082 0.153 -9999.0 0.0 -0.333 48.0 48.0 catabolic process -0.149 0.188 -9999.0 0.0 -0.343 79.0 79.0 SMO/Vitamin D3 -0.191 0.235 -9999.0 0.0 -0.473 64.0 64.0 SHH Np/Cholesterol/Hhip -0.164 0.181 -9999.0 0.0 -0.317 98.0 98.0 LRP2 0.008 0.071 -9999.0 0.0 -0.373 6.0 6.0 receptor-mediated endocytosis -0.192 0.227 -9999.0 0.0 -0.459 65.0 65.0 SHH Np/Cholesterol/BOC -0.062 0.132 -9999.0 0.0 -0.263 51.0 51.0 SHH Np/Cholesterol/CDO -0.058 0.129 0.174 1.0 -0.258 51.0 52.0 mesenchymal cell differentiation 0.163 0.18 0.315 98.0 -9999.0 0.0 98.0 mol:Vitamin D3 -0.171 0.212 -9999.0 0.0 -0.425 64.0 64.0 IHH N/PTCH2 -0.121 0.171 -9999.0 0.0 -0.308 80.0 80.0 CDON 0.016 0.063 0.269 1.0 -0.45 3.0 4.0 IHH N/PTCH1 -0.147 0.193 -9999.0 0.0 -0.346 79.0 79.0 Megalin/LRPAP1 0.022 0.054 -9999.0 0.0 -0.261 6.0 6.0 PTCH2 0.018 0.054 -9999.0 0.0 -0.399 3.0 3.0 SHH Np/Cholesterol -0.06 0.12 -9999.0 0.0 -0.254 49.0 49.0 PTCH1 -0.149 0.188 -9999.0 0.0 -0.344 79.0 79.0 HHIP -0.189 0.233 -9999.0 0.0 -0.45 81.0 81.0