Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	64.0	2964.0	46.0	-1.135	0.029	1000.0	-1000.0	-0.151	-1000.0
Ephrin A  reverse signaling	61.0	429.0	7.0	-0.203	0.015	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by the Hedgehog family	46.0	2393.0	52.0	-0.267	0.163	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	40.0	3138.0	78.0	-0.462	0.149	1000.0	-1000.0	-0.065	-1000.0
Signaling events regulated by Ret tyrosine kinase	29.0	2419.0	82.0	-0.191	0.031	1000.0	-1000.0	-0.066	-1000.0
Glypican 1 network	27.0	1307.0	48.0	-0.174	0.031	1000.0	-1000.0	-0.036	-1000.0
Reelin signaling pathway	21.0	1220.0	56.0	-0.151	0.062	1000.0	-1000.0	-0.054	-1000.0
S1P5 pathway	20.0	349.0	17.0	-0.171	0.083	1000.0	-1000.0	-0.02	-1000.0
Effects of Botulinum toxin	20.0	531.0	26.0	-0.158	0.024	1000.0	-1000.0	-0.018	-1000.0
p75(NTR)-mediated signaling	18.0	2258.0	125.0	-0.227	0.065	1000.0	-1000.0	-0.074	-1000.0
Aurora B signaling	16.0	1090.0	67.0	-0.279	0.034	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	15.0	62.0	4.0	0.001	0.001	1000.0	-1000.0	-0.005	-1000.0
Nongenotropic Androgen signaling	15.0	787.0	52.0	-0.119	0.032	1000.0	-1000.0	-0.042	-1000.0
Visual signal transduction: Cones	14.0	542.0	38.0	-0.081	0.041	1000.0	-1000.0	-0.017	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	14.0	798.0	54.0	-0.14	0.034	1000.0	-1000.0	-0.067	-1000.0
S1P4 pathway	14.0	364.0	25.0	-0.171	0.037	1000.0	-1000.0	-0.032	-1000.0
BMP receptor signaling	13.0	1124.0	81.0	-0.211	0.044	1000.0	-1000.0	-0.068	-1000.0
Nectin adhesion pathway	13.0	850.0	63.0	-0.112	0.045	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	13.0	663.0	48.0	-0.113	0.042	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	13.0	677.0	51.0	-0.144	0.222	1000.0	-1000.0	-0.055	-1000.0
Wnt signaling	13.0	93.0	7.0	-0.076	0.022	1000.0	-1000.0	-0.024	-1000.0
Coregulation of Androgen receptor activity	12.0	973.0	76.0	-0.382	0.048	1000.0	-1000.0	-0.026	-1000.0
Syndecan-1-mediated signaling events	12.0	423.0	34.0	-0.168	0.027	1000.0	-1000.0	-0.047	-1000.0
Syndecan-2-mediated signaling events	12.0	857.0	69.0	-0.222	0.042	1000.0	-1000.0	-0.042	-1000.0
Integrins in angiogenesis	12.0	1018.0	84.0	-0.361	0.054	1000.0	-1000.0	-0.054	-1000.0
Fc-epsilon receptor I signaling in mast cells	11.0	1145.0	97.0	-0.066	0.034	1000.0	-1000.0	-0.063	-1000.0
Visual signal transduction: Rods	11.0	593.0	52.0	-0.102	0.025	1000.0	-1000.0	-0.039	-1000.0
LPA4-mediated signaling events	10.0	121.0	12.0	-0.07	0.007	1000.0	-1000.0	-0.031	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	617.0	61.0	-0.144	0.065	1000.0	-1000.0	-0.049	-1000.0
Aurora C signaling	10.0	76.0	7.0	-0.052	0.016	1000.0	-1000.0	-0.017	-1000.0
IL4-mediated signaling events	10.0	969.0	91.0	-0.627	0.371	1000.0	-1000.0	-0.161	-1000.0
TCGA08_retinoblastoma	10.0	81.0	8.0	-0.058	0.025	1000.0	-1000.0	-0.006	-1000.0
IGF1 pathway	10.0	577.0	57.0	-0.029	0.046	1000.0	-1000.0	-0.046	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1218.0	120.0	-0.192	0.061	1000.0	-1000.0	-0.052	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	257.0	28.0	-0.171	0.043	1000.0	-1000.0	-0.026	-1000.0
Osteopontin-mediated events	9.0	359.0	38.0	-0.202	0.034	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	9.0	244.0	26.0	-0.076	0.025	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PTP1B	9.0	745.0	76.0	-0.22	0.041	1000.0	-1000.0	-0.05	-1000.0
amb2 Integrin signaling	9.0	742.0	82.0	-0.121	0.038	1000.0	-1000.0	-0.048	-1000.0
Glucocorticoid receptor regulatory network	9.0	1061.0	114.0	-0.383	0.176	1000.0	-1000.0	-0.065	-1000.0
EPHB forward signaling	9.0	789.0	85.0	-0.114	0.094	1000.0	-1000.0	-0.07	-1000.0
IL1-mediated signaling events	8.0	509.0	62.0	-0.162	0.041	1000.0	-1000.0	-0.054	-1000.0
Endothelins	8.0	842.0	96.0	-0.244	0.079	1000.0	-1000.0	-0.072	-1000.0
TCGA08_p53	8.0	56.0	7.0	-0.044	0.027	1000.0	-1000.0	-0.01	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	819.0	93.0	-0.134	0.063	1000.0	-1000.0	-0.056	-1000.0
LPA receptor mediated events	8.0	903.0	102.0	-0.193	0.042	1000.0	-1000.0	-0.084	-1000.0
ErbB4 signaling events	7.0	545.0	69.0	-0.1	0.095	1000.0	-1000.0	-0.056	-1000.0
HIF-1-alpha transcription factor network	7.0	575.0	76.0	-0.225	0.033	1000.0	-1000.0	-0.148	-1000.0
PLK1 signaling events	7.0	618.0	85.0	-0.117	0.042	1000.0	-1000.0	-0.05	-1000.0
BCR signaling pathway	7.0	721.0	99.0	-0.062	0.038	1000.0	-1000.0	-0.061	-1000.0
S1P3 pathway	7.0	298.0	42.0	-0.102	0.042	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling events	7.0	39.0	5.0	0.015	0.035	1000.0	-1000.0	-0.003	-1000.0
Regulation of Androgen receptor activity	7.0	539.0	70.0	-0.429	0.034	1000.0	-1000.0	-0.065	-1000.0
Arf6 signaling events	6.0	428.0	62.0	-0.102	0.051	1000.0	-1000.0	-0.045	-1000.0
Aurora A signaling	6.0	400.0	60.0	-0.119	0.052	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	253.0	37.0	-0.123	0.059	1000.0	-1000.0	-0.039	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	215.0	31.0	-0.155	0.024	1000.0	-1000.0	-0.056	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	414.0	68.0	-0.279	0.031	1000.0	-1000.0	-0.108	-1000.0
Plasma membrane estrogen receptor signaling	6.0	556.0	86.0	-0.108	0.048	1000.0	-1000.0	-0.058	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	221.0	33.0	-0.189	0.058	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	340.0	65.0	-0.403	0.059	1000.0	-1000.0	-0.052	-1000.0
Ceramide signaling pathway	5.0	437.0	76.0	-0.052	0.062	1000.0	-1000.0	-0.041	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	263.0	52.0	-0.049	0.045	1000.0	-1000.0	-0.056	-1000.0
S1P1 pathway	5.0	189.0	36.0	-0.077	0.024	1000.0	-1000.0	-0.049	-1000.0
Syndecan-3-mediated signaling events	5.0	203.0	35.0	-0.222	0.065	1000.0	-1000.0	-0.033	-1000.0
Regulation of p38-alpha and p38-beta	5.0	291.0	54.0	-0.174	0.053	1000.0	-1000.0	-0.057	-1000.0
Syndecan-4-mediated signaling events	5.0	360.0	67.0	-0.168	0.035	1000.0	-1000.0	-0.057	-1000.0
FOXM1 transcription factor network	5.0	281.0	51.0	-0.112	0.03	1000.0	-1000.0	-0.17	-1000.0
Caspase cascade in apoptosis	4.0	306.0	74.0	-0.065	0.054	1000.0	-1000.0	-0.04	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	0.003	-1000.0	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	4.0	220.0	53.0	-0.018	0.063	1000.0	-1000.0	-0.041	-1000.0
Retinoic acid receptors-mediated signaling	4.0	242.0	58.0	-0.05	0.045	1000.0	-1000.0	-0.045	-1000.0
TCGA08_rtk_signaling	4.0	108.0	26.0	-0.057	0.094	1000.0	-1000.0	-0.028	-1000.0
EGFR-dependent Endothelin signaling events	4.0	104.0	21.0	-0.046	0.035	1000.0	-1000.0	-0.045	-1000.0
IL23-mediated signaling events	4.0	247.0	60.0	-0.304	0.024	1000.0	-1000.0	-0.118	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	410.0	88.0	-0.075	0.042	1000.0	-1000.0	-0.083	-1000.0
ErbB2/ErbB3 signaling events	3.0	205.0	65.0	-0.051	0.04	1000.0	-1000.0	-0.059	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	442.0	136.0	-0.191	0.071	1000.0	-1000.0	-0.059	-1000.0
Canonical NF-kappaB pathway	3.0	123.0	39.0	-0.052	0.05	1000.0	-1000.0	-0.048	-1000.0
IL12-mediated signaling events	3.0	345.0	87.0	-0.054	0.024	1000.0	-1000.0	-0.109	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.02	0.052	1000.0	-1000.0	-0.048	-1000.0
Thromboxane A2 receptor signaling	3.0	327.0	105.0	-0.102	0.038	1000.0	-1000.0	-0.06	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	265.0	85.0	-0.006	0.053	1000.0	-1000.0	-0.053	-1000.0
EPO signaling pathway	3.0	213.0	55.0	-0.025	0.04	1000.0	-1000.0	-0.055	-1000.0
IFN-gamma pathway	3.0	215.0	68.0	-0.058	0.033	1000.0	-1000.0	-0.067	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	269.0	68.0	-0.118	0.06	1000.0	-1000.0	-0.036	-1000.0
TRAIL signaling pathway	3.0	167.0	48.0	-0.0	0.056	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	3.0	185.0	49.0	-0.052	0.058	1000.0	-1000.0	-0.045	-1000.0
FAS signaling pathway (CD95)	3.0	155.0	47.0	-0.019	0.047	1000.0	-1000.0	-0.061	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	48.0	15.0	-0.023	0.024	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by PI3K	3.0	228.0	58.0	-0.042	0.085	1000.0	-1000.0	-0.059	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	133.0	44.0	-0.085	0.025	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	163.0	45.0	-0.052	0.06	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	3.0	231.0	75.0	-0.349	0.043	1000.0	-1000.0	-0.087	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	264.0	74.0	-0.094	0.055	1000.0	-1000.0	-0.072	-1000.0
PDGFR-beta signaling pathway	3.0	387.0	97.0	-0.188	0.06	1000.0	-1000.0	-0.061	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	55.0	17.0	0.0	0.042	1000.0	-1000.0	-0.039	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	84.0	34.0	-0.018	0.045	1000.0	-1000.0	-0.038	-1000.0
Cellular roles of Anthrax toxin	2.0	88.0	39.0	-0.052	0.032	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	2.0	76.0	32.0	-0.118	0.047	1000.0	-1000.0	-0.038	-1000.0
PDGFR-alpha signaling pathway	2.0	92.0	44.0	-0.017	0.051	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	2.0	89.0	40.0	-0.058	0.046	1000.0	-1000.0	-0.025	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	168.0	83.0	-0.118	0.047	1000.0	-1000.0	-0.05	-1000.0
FoxO family signaling	2.0	152.0	64.0	-0.118	0.084	1000.0	-1000.0	-0.065	-1000.0
IL27-mediated signaling events	2.0	150.0	51.0	-0.055	0.025	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	201.0	76.0	-0.062	0.053	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by STAT5	2.0	48.0	22.0	-0.009	0.045	1000.0	-1000.0	-0.063	-1000.0
Class I PI3K signaling events	2.0	197.0	73.0	-0.141	0.044	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PRL	2.0	78.0	34.0	-0.046	0.055	1000.0	-1000.0	-0.052	-1000.0
p38 MAPK signaling pathway	2.0	124.0	44.0	-0.058	0.045	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	1.0	100.0	57.0	-0.121	0.067	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	1.0	63.0	43.0	-0.068	0.069	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by HDAC Class I	1.0	133.0	104.0	-0.052	0.06	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	171.0	125.0	0.0	0.064	1000.0	-1000.0	-0.066	-1000.0
Arf6 trafficking events	1.0	90.0	71.0	-0.096	0.044	1000.0	-1000.0	-0.036	-1000.0
Regulation of Telomerase	1.0	194.0	102.0	-0.051	0.074	1000.0	-1000.0	-0.065	-1000.0
Insulin Pathway	1.0	129.0	74.0	-0.038	0.062	1000.0	-1000.0	-0.053	-1000.0
VEGFR1 specific signals	1.0	72.0	56.0	-0.032	0.046	1000.0	-1000.0	-0.056	-1000.0
E-cadherin signaling in keratinocytes	1.0	82.0	43.0	-0.041	0.057	1000.0	-1000.0	-0.041	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	0.006	0.041	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class II	0.0	22.0	75.0	-0.028	0.063	1000.0	-1000.0	-0.028	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.009	0.057	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.024	0.036	1000.0	-1000.0	0.001	-1000.0
Arf6 downstream pathway	0.0	15.0	43.0	-0.039	0.044	1000.0	-1000.0	-0.032	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	19.0	36.0	-0.049	0.05	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	0.0	18.0	31.0	0.0	0.031	1000.0	-1000.0	-0.024	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.0	0.054	1000.0	-1000.0	-0.038	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.012	0.032	1000.0	-1000.0	-0.012	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.024	0.025	1000.0	-1000.0	-0.002	-1000.0
Arf1 pathway	0.0	30.0	54.0	-0.001	0.032	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.065	1000.0	-1000.0	-0.003	-1000.0
Total	1003	57083	7203	-16.1726967858	-993.19106655	131000	-131000	-6.59355460793	-131000