Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.048 -9999.0 0.0 -0.126 17.0 17.0 epithelial cell differentiation 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.049 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.243 0.243 -9999.0 0.0 -0.475 80.0 80.0 EPHA2 0.005 0.055 -9999.0 0.0 -0.475 2.0 2.0 MYO6 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.005 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EGF 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.002 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.031 -9999.0 0.0 -0.242 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.028 0.02 -9999.0 0.0 -0.212 1.0 1.0 ARF6/GTP 0.03 0.029 -9999.0 0.0 -0.218 2.0 2.0 CDH1 0.011 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.104 0.1 -9999.0 0.0 -0.199 80.0 80.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 -0.005 0.043 -9999.0 0.0 -0.381 2.0 2.0 Wnt receptor signaling pathway -0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.002 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.003 0.023 -9999.0 0.0 -0.199 2.0 2.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.001 0.016 -9999.0 0.0 -0.199 1.0 1.0 HGF 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.048 -9999.0 0.0 -0.127 17.0 17.0 actin cable formation 0.062 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.042 0.153 -9999.0 0.0 -0.475 17.0 17.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.031 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.039 -9999.0 0.0 -0.475 1.0 1.0 PLEKHA7 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.026 0.031 -9999.0 0.0 -0.24 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.048 0.007 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.009 0.048 -9999.0 0.0 -0.126 17.0 17.0 regulation of cell-cell adhesion 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.048 -9999.0 0.0 -0.127 17.0 17.0