E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.0 0.06 -9999.0 0.0 -0.277 6.0 6.0 KLHL20 0.022 0.07 0.158 13.0 -0.17 5.0 18.0 CYFIP2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.001 0.05 0.169 7.0 -9999.0 0.0 7.0 ENAH 0.001 0.055 -9999.0 0.0 -0.279 5.0 5.0 AP1M1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.01 -9999.0 0.0 -0.058 1.0 1.0 RAP1A 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.025 0.041 0.112 10.0 -9999.0 0.0 10.0 ABI1/Sra1/Nap1 -0.014 0.023 -9999.0 0.0 -0.122 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.061 0.022 -9999.0 0.0 -0.027 5.0 5.0 RAPGEF1 0.001 0.066 0.16 11.0 -0.254 4.0 15.0 CTNND1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.011 0.063 -9999.0 0.0 -0.279 6.0 6.0 CRK 0.0 0.068 0.165 9.0 -0.268 5.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.049 0.015 -9999.0 0.0 -0.043 1.0 1.0 alphaE/beta7 Integrin 0.037 0.007 -9999.0 0.0 0.0 5.0 5.0 IQGAP1 0.026 0.004 -9999.0 0.0 0.0 3.0 3.0 NCKAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.024 -9999.0 0.0 -0.02 15.0 15.0 DLG1 -0.001 0.06 -9999.0 0.0 -0.277 6.0 6.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.017 -9999.0 0.0 -0.087 2.0 2.0 MLLT4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.045 0.019 -9999.0 0.0 -0.02 10.0 10.0 PI3K -0.037 0.022 -9999.0 0.0 -0.114 1.0 1.0 ARF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.037 0.008 -9999.0 0.0 0.0 7.0 7.0 TIAM1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.056 0.022 -9999.0 0.0 -0.026 6.0 6.0 AKT1 -0.016 0.037 0.126 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.002 0.068 0.163 10.0 -9999.0 0.0 10.0 actin cytoskeleton organization 0.02 0.057 0.133 14.0 -0.126 5.0 19.0 CDC42/GDP -0.004 0.066 0.161 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.022 -9999.0 0.0 -0.099 6.0 6.0 ITGB7 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.061 0.023 -9999.0 0.0 -0.028 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.042 0.015 -9999.0 0.0 -0.019 5.0 5.0 mol:GDP -0.0 0.069 0.221 2.0 -9999.0 0.0 2.0 CDC42/GTP/IQGAP1 0.034 0.007 -9999.0 0.0 0.0 6.0 6.0 JUP 0.026 0.007 -9999.0 0.0 -0.058 1.0 1.0 p120 catenin/RhoA/GDP -0.001 0.072 0.168 12.0 -9999.0 0.0 12.0 RAC1/GTP/IQGAP1 0.023 0.017 -9999.0 0.0 0.0 50.0 50.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 0.0 8.0 8.0 RHOA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.041 0.099 14.0 -0.083 5.0 19.0 NME1 0.025 0.007 -9999.0 0.0 -0.058 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.001 0.054 -9999.0 0.0 -0.276 5.0 5.0 regulation of cell-cell adhesion -0.03 0.018 0.047 1.0 -0.1 1.0 2.0 WASF2 0.003 0.03 0.064 12.0 -0.07 5.0 17.0 Rap1/GTP -0.02 0.051 0.15 10.0 -9999.0 0.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.069 0.028 -9999.0 0.0 -0.049 1.0 1.0 CCND1 0.017 0.048 0.114 14.0 -0.1 5.0 19.0 VAV2 0.004 0.129 -9999.0 0.0 -0.59 5.0 5.0 RAP1/GDP -0.011 0.055 0.159 10.0 -9999.0 0.0 10.0 adherens junction assembly 0.001 0.053 -9999.0 0.0 -0.269 5.0 5.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.046 0.024 0.177 1.0 -9999.0 0.0 1.0 E-cadherin/beta catenin 0.0 0.02 -9999.0 0.0 -0.12 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.0 0.055 -9999.0 0.0 -0.276 5.0 5.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.052 -9999.0 0.0 -0.256 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.049 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.026 0.004 -9999.0 0.0 0.0 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.011 0.064 -9999.0 0.0 -0.284 6.0 6.0