Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	56.0	226.0	4.0	-0.03	0.037	1000.0	-1000.0	0.021	-1000.0
Aurora B signaling	30.0	2073.0	67.0	-0.066	0.11	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	28.0	199.0	7.0	-0.02	0.023	1000.0	-1000.0	-0.011	-1000.0
TCGA08_retinoblastoma	26.0	214.0	8.0	-0.071	0.08	1000.0	-1000.0	-0.002	-1000.0
Aurora C signaling	21.0	153.0	7.0	-0.056	0.063	1000.0	-1000.0	-0.006	-1000.0
Ceramide signaling pathway	19.0	1512.0	76.0	-0.136	0.048	1000.0	-1000.0	-0.026	-1000.0
Effects of Botulinum toxin	17.0	457.0	26.0	-0.014	0.025	1000.0	-1000.0	-0.01	-1000.0
Arf6 signaling events	15.0	985.0	62.0	-0.007	0.091	1000.0	-1000.0	-0.025	-1000.0
EPO signaling pathway	15.0	829.0	55.0	-0.004	0.043	1000.0	-1000.0	-0.031	-1000.0
LPA4-mediated signaling events	14.0	172.0	12.0	-0.017	0.005	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by the Hedgehog family	14.0	776.0	52.0	-0.016	0.055	1000.0	-1000.0	-0.024	-1000.0
a4b1 and a4b7 Integrin signaling	14.0	73.0	5.0	0.013	0.041	1000.0	-1000.0	0.022	-1000.0
Retinoic acid receptors-mediated signaling	13.0	798.0	58.0	-0.223	0.048	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by STAT5	13.0	297.0	22.0	-0.036	0.052	1000.0	-1000.0	-0.033	-1000.0
Rapid glucocorticoid signaling	13.0	262.0	20.0	-0.007	0.031	1000.0	-1000.0	-0.011	-1000.0
Syndecan-1-mediated signaling events	12.0	441.0	34.0	-0.043	0.033	1000.0	-1000.0	-0.022	-1000.0
JNK signaling in the CD4+ TCR pathway	12.0	211.0	17.0	-0.327	0.046	1000.0	-1000.0	-0.022	-1000.0
PLK1 signaling events	12.0	1023.0	85.0	-0.056	0.065	1000.0	-1000.0	-0.021	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	973.0	82.0	-0.073	0.032	1000.0	-1000.0	-0.036	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	11.0	945.0	83.0	-0.162	0.155	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	10.0	75.0	7.0	-0.017	0.029	1000.0	-1000.0	-0.012	-1000.0
TCGA08_rtk_signaling	10.0	267.0	26.0	-0.045	0.132	1000.0	-1000.0	-0.004	-1000.0
LPA receptor mediated events	10.0	1055.0	102.0	-0.043	0.039	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	10.0	220.0	21.0	-0.012	0.038	1000.0	-1000.0	-0.028	-1000.0
Syndecan-4-mediated signaling events	10.0	688.0	67.0	-0.045	0.04	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	10.0	357.0	33.0	-0.056	0.049	1000.0	-1000.0	-0.025	-1000.0
S1P4 pathway	10.0	268.0	25.0	-0.0	0.048	1000.0	-1000.0	-0.014	-1000.0
Alternative NF-kappaB pathway	10.0	142.0	13.0	0.0	0.044	1000.0	-1000.0	0.0	-1000.0
amb2 Integrin signaling	9.0	780.0	82.0	-0.043	0.071	1000.0	-1000.0	-0.018	-1000.0
Caspase cascade in apoptosis	8.0	609.0	74.0	-0.062	0.065	1000.0	-1000.0	-0.029	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	693.0	85.0	-0.051	0.108	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	8.0	563.0	63.0	-0.019	0.06	1000.0	-1000.0	-0.032	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	331.0	37.0	-0.034	0.061	1000.0	-1000.0	-0.02	-1000.0
FAS signaling pathway (CD95)	8.0	402.0	47.0	-0.168	0.037	1000.0	-1000.0	-0.029	-1000.0
Arf6 trafficking events	8.0	582.0	71.0	-0.043	0.045	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	7.0	752.0	105.0	-0.066	0.034	1000.0	-1000.0	-0.047	-1000.0
HIF-1-alpha transcription factor network	7.0	575.0	76.0	-0.076	0.126	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by PI3K	7.0	420.0	58.0	-0.22	0.037	1000.0	-1000.0	-0.042	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	232.0	31.0	-0.03	0.026	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	7.0	482.0	68.0	-0.062	0.052	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PRL	7.0	247.0	34.0	-0.025	0.045	1000.0	-1000.0	-0.027	-1000.0
Aurora A signaling	6.0	401.0	60.0	-0.056	0.07	1000.0	-1000.0	-0.022	-1000.0
BMP receptor signaling	6.0	524.0	81.0	-0.027	0.049	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	6.0	728.0	114.0	-0.175	0.108	1000.0	-1000.0	-0.051	-1000.0
Canonical Wnt signaling pathway	6.0	329.0	51.0	-0.013	0.113	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling in keratinocytes	6.0	275.0	43.0	-0.019	0.074	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	518.0	78.0	-0.023	0.061	1000.0	-1000.0	-0.049	-1000.0
BARD1 signaling events	5.0	331.0	57.0	-0.061	0.076	1000.0	-1000.0	-0.046	-1000.0
Cellular roles of Anthrax toxin	5.0	199.0	39.0	-0.023	0.037	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	5.0	452.0	76.0	-0.038	0.075	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	5.0	236.0	43.0	-0.038	0.039	1000.0	-1000.0	-0.031	-1000.0
Glypican 1 network	5.0	276.0	48.0	-0.03	0.051	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	508.0	97.0	-0.119	0.095	1000.0	-1000.0	-0.04	-1000.0
Insulin-mediated glucose transport	5.0	177.0	32.0	-0.056	0.051	1000.0	-1000.0	-0.021	-1000.0
mTOR signaling pathway	5.0	312.0	53.0	-0.022	0.055	1000.0	-1000.0	-0.034	-1000.0
Reelin signaling pathway	5.0	300.0	56.0	-0.069	0.044	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	5.0	312.0	62.0	-0.054	0.074	1000.0	-1000.0	-0.041	-1000.0
Endothelins	5.0	564.0	96.0	-0.121	0.044	1000.0	-1000.0	-0.044	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	521.0	93.0	-0.336	0.381	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	5.0	446.0	85.0	-0.049	0.071	1000.0	-1000.0	-0.041	-1000.0
Regulation of p38-alpha and p38-beta	5.0	285.0	54.0	-0.008	0.046	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	708.0	125.0	-0.043	0.097	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	398.0	76.0	-0.037	0.069	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	5.0	495.0	99.0	-0.046	0.08	1000.0	-1000.0	-0.04	-1000.0
IL23-mediated signaling events	5.0	312.0	60.0	-0.183	0.058	1000.0	-1000.0	-0.119	-1000.0
Plasma membrane estrogen receptor signaling	5.0	436.0	86.0	-0.035	0.047	1000.0	-1000.0	-0.041	-1000.0
PDGFR-beta signaling pathway	5.0	519.0	97.0	-0.04	0.083	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	5.0	266.0	52.0	-0.035	0.075	1000.0	-1000.0	-0.037	-1000.0
p38 MAPK signaling pathway	5.0	225.0	44.0	-0.0	0.05	1000.0	-1000.0	-0.015	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	97.0	17.0	-0.067	0.044	1000.0	-1000.0	-0.019	-1000.0
IL12-mediated signaling events	4.0	409.0	87.0	-0.067	0.063	1000.0	-1000.0	-0.076	-1000.0
Visual signal transduction: Cones	4.0	176.0	38.0	-0.021	0.056	1000.0	-1000.0	-0.02	-1000.0
Osteopontin-mediated events	4.0	186.0	38.0	-0.063	0.067	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	4.0	311.0	69.0	-0.027	0.045	1000.0	-1000.0	-0.025	-1000.0
p75(NTR)-mediated signaling	4.0	558.0	125.0	-0.045	0.075	1000.0	-1000.0	-0.045	-1000.0
IFN-gamma pathway	4.0	303.0	68.0	-0.125	0.049	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	331.0	68.0	-0.025	0.048	1000.0	-1000.0	-0.021	-1000.0
HIF-2-alpha transcription factor network	4.0	194.0	43.0	-0.043	0.048	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	4.0	207.0	48.0	-0.022	0.05	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	4.0	162.0	36.0	-0.02	0.042	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	4.0	336.0	84.0	-0.053	0.069	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	4.0	253.0	52.0	-0.028	0.051	1000.0	-1000.0	-0.021	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	4.0	123.0	27.0	-0.027	0.056	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events	4.0	348.0	73.0	-0.025	0.053	1000.0	-1000.0	-0.031	-1000.0
S1P3 pathway	4.0	176.0	42.0	-0.0	0.041	1000.0	-1000.0	-0.021	-1000.0
FOXM1 transcription factor network	4.0	210.0	51.0	-0.016	0.073	1000.0	-1000.0	-0.16	-1000.0
Arf1 pathway	4.0	264.0	54.0	-0.084	0.047	1000.0	-1000.0	-0.012	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	88.0	28.0	-0.021	0.035	1000.0	-1000.0	-0.02	-1000.0
PDGFR-alpha signaling pathway	3.0	149.0	44.0	-0.021	0.054	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	3.0	153.0	48.0	-0.049	0.071	1000.0	-1000.0	-0.02	-1000.0
S1P5 pathway	3.0	64.0	17.0	-0.028	0.029	1000.0	-1000.0	-0.001	-1000.0
ceramide signaling pathway	3.0	161.0	49.0	-0.015	0.048	1000.0	-1000.0	-0.027	-1000.0
FoxO family signaling	3.0	242.0	64.0	-0.075	0.047	1000.0	-1000.0	-0.071	-1000.0
Atypical NF-kappaB pathway	3.0	112.0	31.0	-0.025	0.036	1000.0	-1000.0	-0.022	-1000.0
Syndecan-3-mediated signaling events	3.0	125.0	35.0	0.0	0.063	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	132.0	44.0	-0.025	0.064	1000.0	-1000.0	-0.017	-1000.0
IL6-mediated signaling events	3.0	244.0	75.0	-0.001	0.112	1000.0	-1000.0	-0.066	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	229.0	74.0	-0.104	0.061	1000.0	-1000.0	-0.04	-1000.0
Insulin Pathway	3.0	288.0	74.0	-0.062	0.067	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	3.0	192.0	56.0	-0.037	0.05	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	2.0	139.0	65.0	-0.041	0.038	1000.0	-1000.0	-0.05	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	398.0	136.0	-0.195	0.079	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	2.0	218.0	76.0	-0.02	0.053	1000.0	-1000.0	-0.018	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	48.0	23.0	-0.019	0.048	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class II	2.0	183.0	75.0	-0.026	0.07	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	2.0	7.0	3.0	-0.021	-1000.0	1000.0	-1000.0	-0.02	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	134.0	54.0	-0.037	0.037	1000.0	-1000.0	-0.032	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	156.0	65.0	-0.001	0.065	1000.0	-1000.0	-0.036	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	173.0	61.0	-0.0	0.063	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	2.0	189.0	91.0	-0.279	0.082	1000.0	-1000.0	-0.153	-1000.0
Signaling events mediated by HDAC Class III	2.0	97.0	40.0	-0.035	0.036	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	116.0	52.0	-0.012	0.069	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	2.0	237.0	104.0	-0.049	0.057	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	100.0	36.0	-0.03	0.041	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	126.0	45.0	-0.062	0.051	1000.0	-1000.0	-0.043	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	340.0	120.0	-0.035	0.068	1000.0	-1000.0	-0.04	-1000.0
Canonical NF-kappaB pathway	1.0	73.0	39.0	-0.025	0.054	1000.0	-1000.0	-0.016	-1000.0
ErbB4 signaling events	1.0	103.0	69.0	-0.024	0.039	1000.0	-1000.0	-0.025	-1000.0
Noncanonical Wnt signaling pathway	1.0	42.0	26.0	-0.015	0.041	1000.0	-1000.0	-0.023	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	80.0	46.0	-0.065	0.037	1000.0	-1000.0	-0.101	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.024	0.026	1000.0	-1000.0	-0.022	-1000.0
IL27-mediated signaling events	1.0	66.0	51.0	-0.011	0.044	1000.0	-1000.0	-0.047	-1000.0
Wnt signaling	1.0	8.0	7.0	0.011	0.025	1000.0	-1000.0	-0.008	-1000.0
Regulation of Telomerase	1.0	137.0	102.0	-0.025	0.067	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	1.0	74.0	57.0	-0.047	0.071	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	164.0	88.0	-0.032	0.039	1000.0	-1000.0	-0.058	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	0.025	0.05	1000.0	-1000.0	0.021	-1000.0
Regulation of Androgen receptor activity	1.0	130.0	70.0	-0.047	0.04	1000.0	-1000.0	-0.031	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	31.0	34.0	-0.034	0.066	1000.0	-1000.0	-0.033	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.003	0.051	1000.0	-1000.0	-0.023	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.025	0.026	1000.0	-1000.0	-0.022	-1000.0
Total	847	43832	7203	-6.64841661046	-992.307384223	131000	-131000	-4.13519513944	-131000