E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.025 0.029 -9999.0 0.0 -0.154 8.0 8.0 KLHL20 0.004 0.065 -9999.0 0.0 -0.131 95.0 95.0 CYFIP2 0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.033 0.027 -9999.0 0.0 -0.136 4.0 4.0 ENAH 0.016 0.053 -9999.0 0.0 -0.179 33.0 33.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 4.0 4.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.0 0.02 -9999.0 0.0 -0.125 4.0 4.0 ABI1/Sra1/Nap1 -0.015 0.032 -9999.0 0.0 -0.088 80.0 80.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.037 -9999.0 0.0 -0.231 9.0 9.0 RAPGEF1 0.027 0.026 -9999.0 0.0 -0.141 4.0 4.0 CTNND1 0.009 0.059 -9999.0 0.0 -0.413 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.024 0.03 -9999.0 0.0 -0.162 8.0 8.0 CRK 0.026 0.028 -9999.0 0.0 -0.146 8.0 8.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.064 -9999.0 0.0 -0.293 19.0 19.0 alphaE/beta7 Integrin 0.024 0.019 -9999.0 0.0 -0.285 2.0 2.0 IQGAP1 -0.086 0.184 -9999.0 0.0 -0.413 127.0 127.0 NCKAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.025 0.03 -9999.0 0.0 -0.155 9.0 9.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.025 -9999.0 0.0 -0.125 12.0 12.0 MLLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.008 0.031 -9999.0 0.0 -0.161 11.0 11.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.001 97.0 97.0 E-cadherin/gamma catenin 0.012 0.073 -9999.0 0.0 -0.35 19.0 19.0 TIAM1 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.032 0.043 -9999.0 0.0 -0.196 18.0 18.0 AKT1 0.016 0.028 -9999.0 0.0 -0.125 8.0 8.0 PIK3R1 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.01 0.053 -9999.0 0.0 -0.413 8.0 8.0 RhoA/GDP 0.034 0.025 -9999.0 0.0 -0.135 2.0 2.0 actin cytoskeleton organization 0.004 0.049 -9999.0 0.0 -0.098 95.0 95.0 CDC42/GDP 0.035 0.025 -9999.0 0.0 -0.135 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.043 -9999.0 0.0 -0.16 28.0 28.0 ITGB7 0.015 0.026 -9999.0 0.0 -0.413 2.0 2.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.046 -9999.0 0.0 -0.209 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.027 0.028 -9999.0 0.0 -0.199 8.0 8.0 mol:GDP 0.027 0.027 -9999.0 0.0 -0.147 4.0 4.0 CDC42/GTP/IQGAP1 -0.04 0.112 -9999.0 0.0 -0.239 127.0 127.0 JUP 0.004 0.074 -9999.0 0.0 -0.413 16.0 16.0 p120 catenin/RhoA/GDP 0.036 0.032 -9999.0 0.0 -0.141 9.0 9.0 RAC1/GTP/IQGAP1 -0.04 0.112 -9999.0 0.0 -0.239 127.0 127.0 PIP5K1C/AP1M1 0.012 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.013 0.074 -9999.0 0.0 -0.167 99.0 99.0 NME1 -0.0 0.0 -9999.0 0.0 -0.001 99.0 99.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.025 0.029 -9999.0 0.0 -0.154 8.0 8.0 regulation of cell-cell adhesion -0.003 0.016 -9999.0 0.0 -0.112 4.0 4.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.049 80.0 80.0 Rap1/GTP 0.025 0.026 -9999.0 0.0 -0.141 4.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.062 -9999.0 0.0 -0.251 20.0 20.0 CCND1 -0.017 0.091 -9999.0 0.0 -0.206 99.0 99.0 VAV2 0.031 0.03 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.028 0.026 -9999.0 0.0 -0.137 5.0 5.0 adherens junction assembly 0.025 0.028 -9999.0 0.0 -0.151 8.0 8.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.037 0.058 -9999.0 0.0 -0.237 20.0 20.0 E-cadherin/beta catenin 0.019 0.032 -9999.0 0.0 -0.164 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.001 99.0 99.0 SRC 0.025 0.029 -9999.0 0.0 -0.156 8.0 8.0 PIK3CA -0.003 0.091 -9999.0 0.0 -0.413 25.0 25.0 Rac1/GTP -0.038 0.078 -9999.0 0.0 -0.201 95.0 95.0 E-cadherin/beta catenin/alpha catenin 0.03 0.033 -9999.0 0.0 -0.236 8.0 8.0 ITGAE 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.024 0.03 -9999.0 0.0 -0.164 8.0 8.0