Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.107 0.059 -9999.0 0.0 -0.128 455.0 455.0 epithelial cell differentiation 0.029 0.042 -9999.0 0.0 -0.193 18.0 18.0 CYFIP2 0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.008 0.071 -9999.0 0.0 -0.264 20.0 20.0 EGFR -0.141 0.207 -9999.0 0.0 -0.413 194.0 194.0 EPHA2 0.007 0.067 -9999.0 0.0 -0.413 13.0 13.0 MYO6 0.018 0.037 -9999.0 0.0 -0.181 18.0 18.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.02 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.027 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.009 0.059 -9999.0 0.0 -0.413 10.0 10.0 mol:PI-4-5-P2 0.017 0.036 -9999.0 0.0 -0.179 17.0 17.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.037 -9999.0 0.0 -0.179 18.0 18.0 EGF 0.015 0.026 -9999.0 0.0 -0.413 2.0 2.0 NCKAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.024 0.045 -9999.0 0.0 -0.322 3.0 3.0 cortical microtubule organization 0.029 0.042 -9999.0 0.0 -0.193 18.0 18.0 GO:0000145 0.012 0.034 -9999.0 0.0 -0.171 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.043 -9999.0 0.0 -0.194 18.0 18.0 MLLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.068 -9999.0 0.0 -0.352 15.0 15.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.022 0.085 -9999.0 0.0 -0.262 38.0 38.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.078 -9999.0 0.0 -0.222 39.0 39.0 PVRL2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.033 0.099 -9999.0 0.0 -0.193 140.0 140.0 ARF6/GTP 0.028 0.08 -9999.0 0.0 -0.24 38.0 38.0 CDH1 0.011 0.052 -9999.0 0.0 -0.413 8.0 8.0 EGFR/EGFR/EGF/EGF -0.05 0.106 -9999.0 0.0 -0.18 207.0 207.0 RhoA/GDP 0.03 0.039 -9999.0 0.0 -0.18 18.0 18.0 actin cytoskeleton organization 0.019 0.035 -9999.0 0.0 -0.167 18.0 18.0 IGF-1R heterotetramer 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.037 -9999.0 0.0 -0.413 4.0 4.0 DIAPH1 -0.129 0.202 -9999.0 0.0 -0.359 225.0 225.0 Wnt receptor signaling pathway -0.029 0.042 0.193 18.0 -9999.0 0.0 18.0 RHOA 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.068 -9999.0 0.0 -0.351 15.0 15.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.019 0.036 -9999.0 0.0 -0.171 18.0 18.0 EFNA1 -0.002 0.09 -9999.0 0.0 -0.413 24.0 24.0 LPP 0.003 0.069 -9999.0 0.0 -0.191 55.0 55.0 Ephrin A1/EPHA2 0.012 0.071 -9999.0 0.0 -0.205 47.0 47.0 SEC6/SEC8 -0.005 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.018 0.037 -9999.0 0.0 -0.181 18.0 18.0 HGF/MET 0.022 0.052 -9999.0 0.0 -0.194 27.0 27.0 HGF 0.015 0.026 -9999.0 0.0 -0.413 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.107 0.059 -9999.0 0.0 -0.129 455.0 455.0 actin cable formation -0.006 0.07 -9999.0 0.0 -0.231 25.0 25.0 KIAA1543 0.007 0.034 -9999.0 0.0 -0.176 18.0 18.0 KIFC3 0.018 0.037 -9999.0 0.0 -0.181 18.0 18.0 NCK1 0.008 0.061 -9999.0 0.0 -0.413 11.0 11.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.002 0.072 -9999.0 0.0 -0.204 54.0 54.0 NCK1/GIT1 0.019 0.044 -9999.0 0.0 -0.285 11.0 11.0 mol:GDP 0.029 0.042 -9999.0 0.0 -0.193 18.0 18.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.018 0.037 -9999.0 0.0 -0.181 18.0 18.0 PIP5K1C 0.018 0.037 -9999.0 0.0 -0.181 17.0 17.0 LIMA1 -0.352 0.15 -9999.0 0.0 -0.413 453.0 453.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.069 -9999.0 0.0 -0.308 15.0 15.0 adherens junction assembly 0.015 0.037 -9999.0 0.0 -0.172 11.0 11.0 IGF-1R heterotetramer/IGF1 0.025 0.044 -9999.0 0.0 -0.191 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.009 0.059 -9999.0 0.0 -0.413 10.0 10.0 PLEKHA7 0.007 0.036 -9999.0 0.0 -0.184 18.0 18.0 mol:GTP 0.021 0.084 -9999.0 0.0 -0.26 38.0 38.0 establishment of epithelial cell apical/basal polarity 0.026 0.034 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.107 0.059 -9999.0 0.0 -0.128 455.0 455.0 regulation of cell-cell adhesion 0.019 0.035 -9999.0 0.0 -0.167 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.107 0.059 -9999.0 0.0 -0.129 455.0 455.0