E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.05 -9999.0 0.0 -0.295 12.0 12.0 KLHL20 0.027 0.071 0.173 33.0 -0.186 17.0 50.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.005 0.042 0.167 10.0 -0.161 8.0 18.0 ENAH 0.005 0.054 -9999.0 0.0 -0.295 14.0 14.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.108 21.0 -0.118 6.0 27.0 ABI1/Sra1/Nap1 -0.011 0.024 -9999.0 0.0 -0.123 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.034 -9999.0 0.0 -0.056 10.0 10.0 RAPGEF1 -0.001 0.059 0.163 33.0 -0.275 10.0 43.0 CTNND1 0.03 0.015 -9999.0 0.0 -0.07 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.055 -9999.0 0.0 -0.296 13.0 13.0 CRK 0.006 0.06 0.172 25.0 -0.286 12.0 37.0 E-cadherin/gamma catenin/alpha catenin 0.057 0.03 -9999.0 0.0 -0.058 20.0 20.0 alphaE/beta7 Integrin 0.046 0.011 -9999.0 0.0 -0.054 2.0 2.0 IQGAP1 0.008 0.043 -9999.0 0.0 -0.07 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.019 -9999.0 0.0 -0.024 44.0 44.0 DLG1 0.006 0.054 -9999.0 0.0 -0.294 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.018 -9999.0 0.0 -0.093 10.0 10.0 MLLT4 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.017 -9999.0 0.0 -0.024 26.0 26.0 PI3K -0.036 0.022 -9999.0 0.0 -0.115 10.0 10.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.043 0.022 -9999.0 0.0 -0.062 19.0 19.0 TIAM1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.066 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.016 0.037 0.144 8.0 -0.098 1.0 9.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.07 8.0 8.0 RhoA/GDP 0.01 0.061 0.174 28.0 -0.165 15.0 43.0 actin cytoskeleton organization 0.023 0.056 0.142 34.0 -0.137 17.0 51.0 CDC42/GDP 0.01 0.059 0.174 24.0 -0.163 15.0 39.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -9999.0 0.0 -0.103 20.0 20.0 ITGB7 0.032 0.008 -9999.0 0.0 -0.07 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.037 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.022 -9999.0 0.0 -0.043 9.0 9.0 mol:GDP -0.002 0.063 0.172 29.0 -0.178 15.0 44.0 CDC42/GTP/IQGAP1 0.022 0.037 -9999.0 0.0 -0.043 119.0 119.0 JUP 0.029 0.018 -9999.0 0.0 -0.07 16.0 16.0 p120 catenin/RhoA/GDP 0.024 0.064 0.185 27.0 -0.171 15.0 42.0 RAC1/GTP/IQGAP1 0.015 0.033 -9999.0 0.0 -0.043 89.0 89.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.041 0.107 30.0 -0.093 17.0 47.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 2.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.006 0.053 -9999.0 0.0 -0.294 14.0 14.0 regulation of cell-cell adhesion -0.03 0.017 0.043 2.0 -0.099 11.0 13.0 WASF2 -0.006 0.013 -9999.0 0.0 -0.066 17.0 17.0 Rap1/GTP -0.022 0.045 0.143 30.0 -0.134 3.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.083 0.043 -9999.0 0.0 -0.081 5.0 5.0 CCND1 0.016 0.048 0.125 29.0 -0.113 17.0 46.0 VAV2 0.01 0.12 -9999.0 0.0 -0.548 17.0 17.0 RAP1/GDP -0.011 0.052 0.162 32.0 -0.179 1.0 33.0 adherens junction assembly 0.006 0.052 -9999.0 0.0 -0.286 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.189 3.0 -0.084 5.0 8.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.153 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 2.0 2.0 SRC 0.006 0.052 -9999.0 0.0 -0.294 13.0 13.0 PIK3CA 0.028 0.019 -9999.0 0.0 -0.07 17.0 17.0 Rac1/GTP -0.009 0.06 -9999.0 0.0 -0.279 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.059 0.025 -9999.0 0.0 -0.052 9.0 9.0 ITGAE 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.056 -9999.0 0.0 -0.301 13.0 13.0