Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.018 0.058 1.0 -0.116 3.0 4.0 KIRREL 0.035 0.011 0.084 1.0 -0.039 5.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.018 0.116 3.0 -0.058 1.0 4.0 PLCG1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.068 0.046 0.176 7.0 -9999.0 0.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.019 -9999.0 0.0 -0.118 4.0 4.0 FYN -0.01 0.044 0.163 28.0 -9999.0 0.0 28.0 mol:Ca2+ 0.074 0.036 0.171 19.0 -9999.0 0.0 19.0 mol:DAG 0.075 0.037 0.174 19.0 -9999.0 0.0 19.0 NPHS2 0.035 0.01 0.084 1.0 -0.03 4.0 5.0 mol:IP3 0.075 0.037 0.174 19.0 -9999.0 0.0 19.0 regulation of endocytosis 0.056 0.029 0.134 1.0 -0.061 2.0 3.0 Nephrin/NEPH1/podocin/Cholesterol 0.062 0.029 0.156 19.0 -0.045 1.0 20.0 establishment of cell polarity 0.049 0.018 0.116 3.0 -0.058 1.0 4.0 Nephrin/NEPH1/podocin/NCK1-2 0.09 0.039 0.204 2.0 -9999.0 0.0 2.0 Nephrin/NEPH1/beta Arrestin2 0.058 0.03 0.14 1.0 -0.061 2.0 3.0 NPHS1 0.034 0.011 0.076 6.0 -9999.0 0.0 6.0 Nephrin/NEPH1/podocin 0.059 0.024 0.17 3.0 -0.056 4.0 7.0 TJP1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.016 -9999.0 0.0 -0.07 11.0 11.0 NCK2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.077 0.038 0.177 19.0 -9999.0 0.0 19.0 CD2AP 0.022 0.03 -9999.0 0.0 -0.07 48.0 48.0 Nephrin/NEPH1/podocin/GRB2 0.078 0.035 0.178 16.0 -9999.0 0.0 16.0 GRB2 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.013 0.051 0.172 30.0 -9999.0 0.0 30.0 cytoskeleton organization -0.007 0.034 0.182 11.0 -0.147 3.0 14.0 Nephrin/NEPH1 0.041 0.016 0.097 3.0 -0.03 5.0 8.0 Nephrin/NEPH1/ZO-1 0.062 0.024 -9999.0 0.0 -0.045 5.0 5.0