Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.027 0.161 8.0 -0.092 14.0 22.0 IHH 0.038 0.022 0.126 8.0 -0.052 1.0 9.0 SHH Np/Cholesterol/GAS1 0.013 0.02 -9999.0 0.0 -0.044 36.0 36.0 LRPAP1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.013 0.02 0.044 36.0 -9999.0 0.0 36.0 SMO/beta Arrestin2 0.067 0.057 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 AKT1 0.004 0.081 -9999.0 0.0 -0.369 15.0 15.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 STIL 0.024 0.086 0.17 127.0 -9999.0 0.0 127.0 DHH N/PTCH2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.015 -9999.0 0.0 -0.071 1.0 1.0 PIK3CA 0.028 0.019 -9999.0 0.0 -0.07 17.0 17.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.016 0.026 0.157 7.0 -9999.0 0.0 7.0 determination of left/right symmetry 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.016 0.025 0.156 7.0 -9999.0 0.0 7.0 IHH N/Hhip 0.025 0.013 0.073 15.0 -9999.0 0.0 15.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.023 -9999.0 0.0 -0.054 16.0 16.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.032 -9999.0 0.0 -0.07 55.0 55.0 somite specification 0.013 0.019 0.137 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.014 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 SHH Np/Cholesterol/Megalin 0.018 0.014 -9999.0 0.0 -0.034 5.0 5.0 SHH -0.015 0.011 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.021 0.018 -9999.0 0.0 -0.083 1.0 1.0 SMO/Vitamin D3 0.015 0.032 0.181 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/Hhip -0.011 0.007 0.0 165.0 -9999.0 0.0 165.0 LRP2 0.032 0.005 -9999.0 0.0 -0.07 1.0 1.0 receptor-mediated endocytosis 0.012 0.027 0.154 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/BOC -0.011 0.007 0.0 165.0 -9999.0 0.0 165.0 SHH Np/Cholesterol/CDO 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 mesenchymal cell differentiation 0.011 0.007 -9999.0 0.0 0.0 165.0 165.0 mol:Vitamin D3 0.064 0.083 0.191 146.0 -9999.0 0.0 146.0 IHH N/PTCH2 0.049 0.016 0.106 8.0 -0.037 1.0 9.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.022 -9999.0 0.0 -0.07 13.0 13.0 Megalin/LRPAP1 0.048 0.007 -9999.0 0.0 -0.054 1.0 1.0 PTCH2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.021 0.018 -9999.0 0.0 -0.084 1.0 1.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0