E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.016 0.072 -9999.0 0.0 -0.351 24.0 24.0 KLHL20 -0.011 0.035 -9999.0 0.0 -0.219 7.0 7.0 CYFIP2 0.008 0.026 -9999.0 0.0 -0.324 4.0 4.0 Rac1/GDP 0.037 0.046 -9999.0 0.0 -0.209 8.0 8.0 ENAH 0.015 0.073 -9999.0 0.0 -0.351 24.0 24.0 AP1M1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.005 0.044 -9999.0 0.0 -0.374 9.0 9.0 RAP1A 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.024 -9999.0 0.0 -0.227 1.0 1.0 ABI1/Sra1/Nap1 -0.007 0.024 -9999.0 0.0 -0.143 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.011 0.04 -9999.0 0.0 -0.175 21.0 21.0 RAPGEF1 0.028 0.065 -9999.0 0.0 -0.301 24.0 24.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.069 -9999.0 0.0 -0.367 24.0 24.0 CRK 0.023 0.069 -9999.0 0.0 -0.328 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.01 0.042 -9999.0 0.0 -0.185 35.0 35.0 alphaE/beta7 Integrin -0.004 0.032 -9999.0 0.0 -0.252 11.0 11.0 IQGAP1 0.006 0.039 -9999.0 0.0 -0.374 7.0 7.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.002 0.021 -9999.0 0.0 -0.181 9.0 9.0 DLG1 0.016 0.073 -9999.0 0.0 -0.351 24.0 24.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.004 0.017 -9999.0 0.0 -0.158 1.0 1.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.001 0.011 -9999.0 0.0 -0.171 3.0 3.0 PI3K -0.005 0.021 -9999.0 0.0 -0.2 1.0 1.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.012 0.052 -9999.0 0.0 -0.232 35.0 35.0 TIAM1 0.009 0.013 -9999.0 0.0 -0.324 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.007 0.032 -9999.0 0.0 -0.163 10.0 10.0 AKT1 -0.003 0.012 -9999.0 0.0 -0.115 1.0 1.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.008 0.077 -9999.0 0.0 -0.339 34.0 34.0 RhoA/GDP 0.037 0.046 -9999.0 0.0 -0.286 1.0 1.0 actin cytoskeleton organization -0.008 0.026 -9999.0 0.0 -0.16 7.0 7.0 CDC42/GDP 0.037 0.046 -9999.0 0.0 -0.286 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.039 -9999.0 0.0 -0.177 24.0 24.0 ITGB7 0.005 0.042 -9999.0 0.0 -0.374 8.0 8.0 RAC1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.008 0.034 -9999.0 0.0 -0.175 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.033 -9999.0 0.0 -0.149 34.0 34.0 mol:GDP 0.034 0.052 -9999.0 0.0 -0.238 8.0 8.0 CDC42/GTP/IQGAP1 -0.002 0.021 -9999.0 0.0 -0.209 7.0 7.0 JUP 0.009 0.021 -9999.0 0.0 -0.374 2.0 2.0 p120 catenin/RhoA/GDP -0.008 0.036 -9999.0 0.0 -0.289 1.0 1.0 RAC1/GTP/IQGAP1 -0.002 0.021 -9999.0 0.0 -0.209 7.0 7.0 PIP5K1C/AP1M1 -0.0 0.008 -9999.0 0.0 -0.213 1.0 1.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.047 -9999.0 0.0 -0.152 45.0 45.0 NME1 0.009 0.021 -9999.0 0.0 -0.374 2.0 2.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.016 0.072 -9999.0 0.0 -0.351 24.0 24.0 regulation of cell-cell adhesion -0.005 0.021 -9999.0 0.0 -0.201 1.0 1.0 WASF2 -0.004 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.007 0.027 -9999.0 0.0 -0.259 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.01 0.038 -9999.0 0.0 -0.31 1.0 1.0 CCND1 0.016 0.057 -9999.0 0.0 -0.186 45.0 45.0 VAV2 0.025 0.071 -9999.0 0.0 -0.334 24.0 24.0 RAP1/GDP -0.006 0.032 -9999.0 0.0 -0.276 1.0 1.0 adherens junction assembly 0.018 0.071 -9999.0 0.0 -0.341 24.0 24.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.009 0.013 -9999.0 0.0 -0.324 1.0 1.0 regulation of heterotypic cell-cell adhesion -0.009 0.035 -9999.0 0.0 -0.292 1.0 1.0 E-cadherin/beta catenin -0.011 0.051 -9999.0 0.0 -0.261 24.0 24.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.016 0.073 -9999.0 0.0 -0.352 24.0 24.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.017 0.055 -9999.0 0.0 -0.339 8.0 8.0 E-cadherin/beta catenin/alpha catenin -0.009 0.039 -9999.0 0.0 -0.178 34.0 34.0 ITGAE 0.008 0.026 -9999.0 0.0 -0.374 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.07 -9999.0 0.0 -0.374 24.0 24.0