Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.061 0.108 0.239 172.0 -9999.0 0.0 172.0 KIRREL -0.022 0.098 -9999.0 0.0 -0.378 47.0 47.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.062 0.108 -9999.0 0.0 -0.239 172.0 172.0 PLCG1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.041 0.074 -9999.0 0.0 -0.213 37.0 37.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.026 0.087 -9999.0 0.0 -0.19 135.0 135.0 FYN -0.03 0.077 -9999.0 0.0 -0.157 172.0 172.0 mol:Ca2+ -0.041 0.073 -9999.0 0.0 -0.326 10.0 10.0 mol:DAG -0.041 0.073 -9999.0 0.0 -0.327 10.0 10.0 NPHS2 -0.007 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.041 0.073 -9999.0 0.0 -0.327 10.0 10.0 regulation of endocytosis -0.036 0.064 -9999.0 0.0 -0.289 10.0 10.0 Nephrin/NEPH1/podocin/Cholesterol -0.043 0.077 -9999.0 0.0 -0.168 172.0 172.0 establishment of cell polarity -0.061 0.108 -9999.0 0.0 -0.239 172.0 172.0 Nephrin/NEPH1/podocin/NCK1-2 -0.036 0.064 -9999.0 0.0 -0.284 11.0 11.0 Nephrin/NEPH1/beta Arrestin2 -0.022 0.073 -9999.0 0.0 -0.292 10.0 10.0 NPHS1 -0.063 0.135 -9999.0 0.0 -0.33 135.0 135.0 Nephrin/NEPH1/podocin -0.04 0.072 -9999.0 0.0 -0.158 162.0 162.0 TJP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.009 0.015 -9999.0 0.0 -0.374 1.0 1.0 NCK2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.041 0.074 -9999.0 0.0 -0.329 10.0 10.0 CD2AP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.041 0.074 -9999.0 0.0 -0.213 37.0 37.0 GRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.026 0.077 -9999.0 0.0 -0.195 51.0 51.0 cytoskeleton organization -0.028 0.1 -9999.0 0.0 -0.214 135.0 135.0 Nephrin/NEPH1 -0.041 0.073 -9999.0 0.0 -0.16 172.0 172.0 Nephrin/NEPH1/ZO-1 -0.045 0.081 -9999.0 0.0 -0.177 172.0 172.0