Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.007 0.131 -9999.0 0.0 -0.402 53.0 53.0 IHH 0.008 0.034 -9999.0 0.0 -0.236 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.05 0.09 -9999.0 0.0 -0.194 171.0 171.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.049 0.089 0.193 171.0 -9999.0 0.0 171.0 SMO/beta Arrestin2 0.002 0.088 -9999.0 0.0 -0.341 11.0 11.0 SMO -0.004 0.093 -9999.0 0.0 -0.291 38.0 38.0 AKT1 0.015 0.048 -9999.0 0.0 -0.232 2.0 2.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.094 -9999.0 0.0 -0.374 43.0 43.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.092 -9999.0 0.0 -0.287 38.0 38.0 STIL 0.005 0.09 -9999.0 0.0 -0.286 28.0 28.0 DHH N/PTCH2 -0.008 0.043 -9999.0 0.0 -0.248 21.0 21.0 DHH N/PTCH1 0.009 0.086 -9999.0 0.0 -0.252 47.0 47.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.001 0.064 -9999.0 0.0 -0.374 19.0 19.0 PTHLH -0.006 0.195 -9999.0 0.0 -0.785 36.0 36.0 determination of left/right symmetry -0.004 0.092 -9999.0 0.0 -0.287 38.0 38.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.006 0.193 -9999.0 0.0 -0.776 36.0 36.0 IHH N/Hhip -0.029 0.1 -9999.0 0.0 -0.248 114.0 114.0 DHH N/Hhip -0.043 0.091 -9999.0 0.0 -0.225 129.0 129.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.092 -9999.0 0.0 -0.287 38.0 38.0 pancreas development -0.047 0.126 -9999.0 0.0 -0.324 114.0 114.0 HHAT 0.009 0.013 -9999.0 0.0 -0.324 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.057 0.146 -9999.0 0.0 -0.374 116.0 116.0 somite specification -0.004 0.092 -9999.0 0.0 -0.287 38.0 38.0 SHH Np/Cholesterol/PTCH1 0.002 0.09 -9999.0 0.0 -0.3 25.0 25.0 SHH Np/Cholesterol/PTCH2 -0.018 0.051 -9999.0 0.0 -0.156 78.0 78.0 SHH Np/Cholesterol/Megalin -0.038 0.074 -9999.0 0.0 -0.169 151.0 151.0 SHH -0.01 0.075 -9999.0 0.0 -0.217 77.0 77.0 catabolic process 0.011 0.092 -9999.0 0.0 -0.292 48.0 48.0 SMO/Vitamin D3 -0.011 0.099 -9999.0 0.0 -0.323 21.0 21.0 SHH Np/Cholesterol/Hhip -0.044 0.078 -9999.0 0.0 -0.169 174.0 174.0 LRP2 -0.034 0.116 -9999.0 0.0 -0.335 86.0 86.0 receptor-mediated endocytosis -0.051 0.089 -9999.0 0.0 -0.318 35.0 35.0 SHH Np/Cholesterol/BOC -0.029 0.065 -9999.0 0.0 -0.167 118.0 118.0 SHH Np/Cholesterol/CDO -0.02 0.056 -9999.0 0.0 -0.165 82.0 82.0 mesenchymal cell differentiation 0.044 0.078 0.168 174.0 -9999.0 0.0 174.0 mol:Vitamin D3 0.004 0.091 -9999.0 0.0 -0.292 27.0 27.0 IHH N/PTCH2 0.014 0.023 -9999.0 0.0 -0.245 3.0 3.0 CDON 0.005 0.044 -9999.0 0.0 -0.374 9.0 9.0 IHH N/PTCH1 0.011 0.092 -9999.0 0.0 -0.293 48.0 48.0 Megalin/LRPAP1 -0.028 0.074 -9999.0 0.0 -0.221 86.0 86.0 PTCH2 0.009 0.018 -9999.0 0.0 -0.324 2.0 2.0 SHH Np/Cholesterol -0.018 0.051 -9999.0 0.0 -0.161 77.0 77.0 PTCH1 0.011 0.092 -9999.0 0.0 -0.293 48.0 48.0 HHIP -0.047 0.126 -9999.0 0.0 -0.325 114.0 114.0