Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.064 -9999.0 0.0 -0.214 26.0 26.0 epithelial cell differentiation -0.007 0.031 -9999.0 0.0 -0.162 10.0 10.0 CYFIP2 0.008 0.026 -9999.0 0.0 -0.324 4.0 4.0 ENAH 0.044 0.033 -9999.0 0.0 -0.181 1.0 1.0 EGFR -0.207 0.191 -9999.0 0.0 -0.374 377.0 377.0 EPHA2 0.005 0.042 -9999.0 0.0 -0.374 8.0 8.0 MYO6 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.001 0.013 -9999.0 0.0 -0.169 4.0 4.0 AQP5 -0.086 0.145 -9999.0 0.0 -0.349 152.0 152.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.038 -9999.0 0.0 -0.266 2.0 2.0 EGF -0.003 0.07 -9999.0 0.0 -0.372 23.0 23.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.072 0.141 -9999.0 0.0 -0.355 129.0 129.0 cortical microtubule organization -0.007 0.031 -9999.0 0.0 -0.162 10.0 10.0 GO:0000145 0.021 0.033 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.032 -9999.0 0.0 -0.163 10.0 10.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.006 0.025 -9999.0 0.0 -0.242 1.0 1.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.002 0.02 -9999.0 0.0 -0.175 9.0 9.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.028 0.038 -9999.0 0.0 -0.203 1.0 1.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.016 0.048 -9999.0 0.0 -0.297 1.0 1.0 ARF6/GTP -0.002 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.008 0.077 -9999.0 0.0 -0.339 34.0 34.0 EGFR/EGFR/EGF/EGF -0.091 0.081 -9999.0 0.0 -0.299 31.0 31.0 RhoA/GDP -0.007 0.028 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.026 0.036 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.009 0.015 -9999.0 0.0 -0.374 1.0 1.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.015 -9999.0 0.0 -0.374 1.0 1.0 IGF1 0.005 0.039 -9999.0 0.0 -0.33 9.0 9.0 DIAPH1 -0.003 0.042 -9999.0 0.0 -0.54 4.0 4.0 Wnt receptor signaling pathway 0.007 0.031 0.162 10.0 -9999.0 0.0 10.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.006 0.025 -9999.0 0.0 -0.242 1.0 1.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.026 0.037 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.026 0.039 -9999.0 0.0 -0.281 1.0 1.0 Ephrin A1/EPHA2 -0.008 0.031 -9999.0 0.0 -0.282 1.0 1.0 SEC6/SEC8 -0.005 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.021 0.038 -9999.0 0.0 -0.27 2.0 2.0 HGF/MET -0.059 0.073 -9999.0 0.0 -0.274 30.0 30.0 HGF -0.0 0.059 -9999.0 0.0 -0.345 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.064 -9999.0 0.0 -0.216 26.0 26.0 actin cable formation 0.055 0.034 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.018 0.051 -9999.0 0.0 -0.279 11.0 11.0 KIFC3 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.009 0.015 -9999.0 0.0 -0.374 1.0 1.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 -0.0 0.01 -9999.0 0.0 -0.252 1.0 1.0 mol:GDP -0.007 0.031 -9999.0 0.0 -0.162 10.0 10.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.103 0.175 -9999.0 0.0 -0.374 196.0 196.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.022 -9999.0 0.0 -0.213 1.0 1.0 adherens junction assembly 0.007 0.083 -9999.0 0.0 -0.299 11.0 11.0 IGF-1R heterotetramer/IGF1 -0.008 0.032 -9999.0 0.0 -0.269 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.134 0.166 -9999.0 0.0 -0.325 287.0 287.0 PLEKHA7 0.02 0.042 -9999.0 0.0 -0.297 2.0 2.0 mol:GTP -0.002 0.02 -9999.0 0.0 -0.174 9.0 9.0 establishment of epithelial cell apical/basal polarity 0.042 0.032 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.016 0.064 -9999.0 0.0 -0.214 26.0 26.0 regulation of cell-cell adhesion 0.026 0.036 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.064 -9999.0 0.0 -0.216 26.0 26.0