E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.004 0.075 -9999.0 0.0 -0.325 33.0 33.0 KLHL20 0.014 0.046 0.152 8.0 -0.178 7.0 15.0 CYFIP2 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.004 0.052 0.23 5.0 -0.207 21.0 26.0 ENAH -0.004 0.075 -9999.0 0.0 -0.324 33.0 33.0 AP1M1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.021 0.009 0.124 4.0 -9999.0 0.0 4.0 RAP1A 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.03 -9999.0 0.0 -0.127 10.0 10.0 ABI1/Sra1/Nap1 -0.008 0.02 -9999.0 0.0 -0.121 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.037 -9999.0 0.0 -0.122 24.0 24.0 RAPGEF1 -0.007 0.071 0.164 22.0 -0.298 29.0 51.0 CTNND1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.003 0.079 -9999.0 0.0 -0.331 34.0 34.0 CRK -0.008 0.069 -9999.0 0.0 -0.314 30.0 30.0 E-cadherin/gamma catenin/alpha catenin 0.036 0.034 -9999.0 0.0 -0.132 24.0 24.0 alphaE/beta7 Integrin 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.022 0.01 0.124 6.0 -9999.0 0.0 6.0 NCKAP1 0.021 0.001 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.074 -9999.0 0.0 -0.327 32.0 32.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.02 0.018 -9999.0 0.0 -0.1 19.0 19.0 MLLT4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.024 0.022 -9999.0 0.0 -0.126 15.0 15.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.025 0.036 -9999.0 0.0 -0.156 24.0 24.0 TIAM1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.043 0.033 -9999.0 0.0 -0.114 24.0 24.0 AKT1 -0.012 0.028 0.079 41.0 -9999.0 0.0 41.0 PIK3R1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.022 0.013 0.124 9.0 -9999.0 0.0 9.0 RhoA/GDP 0.008 0.061 0.225 8.0 -0.207 24.0 32.0 actin cytoskeleton organization 0.015 0.042 0.137 28.0 -0.132 7.0 35.0 CDC42/GDP 0.009 0.06 0.23 7.0 -0.203 24.0 31.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.032 -9999.0 0.0 -0.155 24.0 24.0 ITGB7 0.022 0.012 0.124 8.0 -9999.0 0.0 8.0 RAC1 0.018 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.046 0.036 -9999.0 0.0 -0.122 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.029 -9999.0 0.0 -0.11 24.0 24.0 mol:GDP -0.002 0.066 0.232 8.0 -0.233 24.0 32.0 CDC42/GTP/IQGAP1 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.006 0.124 2.0 -9999.0 0.0 2.0 p120 catenin/RhoA/GDP 0.014 0.061 0.223 5.0 -0.212 24.0 29.0 RAC1/GTP/IQGAP1 0.024 0.012 0.096 5.0 -9999.0 0.0 5.0 PIP5K1C/AP1M1 0.03 0.01 -9999.0 0.0 -0.157 1.0 1.0 RHOA 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.036 0.118 36.0 -0.097 2.0 38.0 NME1 0.021 0.006 0.124 2.0 -9999.0 0.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.003 0.075 -9999.0 0.0 -0.328 32.0 32.0 regulation of cell-cell adhesion -0.018 0.021 -9999.0 0.0 -0.114 12.0 12.0 WASF2 0.002 0.02 0.056 21.0 -0.075 3.0 24.0 Rap1/GTP 0.013 0.044 0.157 27.0 -9999.0 0.0 27.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.038 -9999.0 0.0 -0.117 24.0 24.0 CCND1 0.018 0.04 0.133 34.0 -0.117 2.0 36.0 VAV2 0.005 0.105 -9999.0 0.0 -0.568 10.0 10.0 RAP1/GDP 0.014 0.051 0.173 22.0 -0.168 11.0 33.0 adherens junction assembly -0.003 0.073 -9999.0 0.0 -0.319 32.0 32.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.036 0.174 7.0 -0.115 24.0 31.0 E-cadherin/beta catenin -0.0 0.046 -9999.0 0.0 -0.23 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.003 0.074 -9999.0 0.0 -0.328 31.0 31.0 PIK3CA 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.003 0.049 -9999.0 0.0 -0.268 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.036 0.035 -9999.0 0.0 -0.133 24.0 24.0 ITGAE 0.021 0.007 0.124 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.08 -9999.0 0.0 -0.337 34.0 34.0