Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.002 0.076 0.165 110.0 -0.136 2.0 112.0 KIRREL 0.018 0.036 0.124 42.0 -0.037 102.0 144.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.002 0.076 0.137 2.0 -0.165 110.0 112.0 PLCG1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.017 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.018 0.068 0.174 1.0 -0.124 110.0 111.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.016 0.066 -9999.0 0.0 -0.176 86.0 86.0 FYN -0.026 0.051 0.144 17.0 -0.124 108.0 125.0 mol:Ca2+ 0.016 0.066 0.169 2.0 -0.123 108.0 110.0 mol:DAG 0.017 0.067 0.172 2.0 -0.123 108.0 110.0 NPHS2 0.006 0.022 -9999.0 0.0 -0.039 110.0 110.0 mol:IP3 0.017 0.067 0.172 2.0 -0.123 108.0 110.0 regulation of endocytosis 0.011 0.062 -9999.0 0.0 -0.119 110.0 110.0 Nephrin/NEPH1/podocin/Cholesterol 0.009 0.061 0.161 2.0 -0.119 110.0 112.0 establishment of cell polarity -0.002 0.076 0.136 2.0 -0.165 110.0 112.0 Nephrin/NEPH1/podocin/NCK1-2 0.027 0.069 0.179 2.0 -0.115 109.0 111.0 Nephrin/NEPH1/beta Arrestin2 0.012 0.063 -9999.0 0.0 -0.12 110.0 110.0 NPHS1 0.015 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin 0.008 0.062 -9999.0 0.0 -0.124 110.0 110.0 TJP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.005 0.124 1.0 -9999.0 0.0 1.0 NCK2 0.021 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.017 0.067 0.175 2.0 -0.124 108.0 110.0 CD2AP 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.018 0.067 0.175 2.0 -0.124 106.0 108.0 GRB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.024 0.048 0.142 18.0 -0.112 108.0 126.0 cytoskeleton organization -0.034 0.076 0.202 11.0 -0.206 84.0 95.0 Nephrin/NEPH1 0.004 0.052 0.088 29.0 -0.107 110.0 139.0 Nephrin/NEPH1/ZO-1 0.011 0.066 0.133 1.0 -0.13 110.0 111.0