Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.006 0.107 -9999.0 0.0 -0.45 35.0 35.0 IHH 0.018 0.034 0.112 7.0 -0.115 35.0 42.0 SHH Np/Cholesterol/GAS1 0.01 0.043 0.09 53.0 -0.115 50.0 103.0 LRPAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.01 0.042 0.115 50.0 -0.089 53.0 103.0 SMO/beta Arrestin2 0.012 0.072 -9999.0 0.0 -0.284 26.0 26.0 SMO 0.0 0.065 -9999.0 0.0 -0.288 27.0 27.0 AKT1 0.004 0.076 -9999.0 0.0 -0.399 16.0 16.0 ARRB2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.025 0.124 42.0 -9999.0 0.0 42.0 ADRBK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.0 0.064 -9999.0 0.0 -0.285 27.0 27.0 STIL 0.004 0.087 0.171 101.0 -0.224 29.0 130.0 DHH N/PTCH2 0.029 0.02 -9999.0 0.0 -0.157 2.0 2.0 DHH N/PTCH1 0.017 0.065 -9999.0 0.0 -0.25 34.0 34.0 PIK3CA 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.018 0.124 19.0 -9999.0 0.0 19.0 PTHLH -0.023 0.167 -9999.0 0.0 -0.719 35.0 35.0 determination of left/right symmetry 0.0 0.064 -9999.0 0.0 -0.285 27.0 27.0 PIK3R1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.023 0.165 -9999.0 0.0 -0.712 35.0 35.0 IHH N/Hhip -0.005 0.079 0.122 1.0 -0.179 106.0 107.0 DHH N/Hhip 0.002 0.07 0.106 15.0 -0.156 105.0 120.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.0 0.064 -9999.0 0.0 -0.285 27.0 27.0 pancreas development 0.017 0.009 0.124 1.0 -9999.0 0.0 1.0 HHAT 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.037 0.038 0.124 107.0 -9999.0 0.0 107.0 somite specification 0.0 0.064 -9999.0 0.0 -0.285 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.005 0.059 -9999.0 0.0 -0.236 29.0 29.0 SHH Np/Cholesterol/PTCH2 0.002 0.037 -9999.0 0.0 -0.12 53.0 53.0 SHH Np/Cholesterol/Megalin -0.003 0.05 0.086 16.0 -0.122 92.0 108.0 SHH -0.009 0.008 0.051 4.0 -9999.0 0.0 4.0 catabolic process 0.004 0.068 -9999.0 0.0 -0.281 34.0 34.0 SMO/Vitamin D3 -0.004 0.071 0.243 6.0 -0.271 27.0 33.0 SHH Np/Cholesterol/Hhip -0.012 0.055 -9999.0 0.0 -0.126 119.0 119.0 LRP2 0.022 0.018 0.124 18.0 -9999.0 0.0 18.0 receptor-mediated endocytosis -0.016 0.074 0.195 2.0 -0.275 32.0 34.0 SHH Np/Cholesterol/BOC 0.007 0.04 0.086 32.0 -0.118 52.0 84.0 SHH Np/Cholesterol/CDO 0.004 0.036 0.086 3.0 -0.117 51.0 54.0 mesenchymal cell differentiation 0.012 0.055 0.125 119.0 -9999.0 0.0 119.0 mol:Vitamin D3 0.022 0.092 0.184 108.0 -0.237 29.0 137.0 IHH N/PTCH2 0.026 0.024 -9999.0 0.0 -0.216 2.0 2.0 CDON 0.022 0.012 0.124 8.0 -9999.0 0.0 8.0 IHH N/PTCH1 0.012 0.071 -9999.0 0.0 -0.282 34.0 34.0 Megalin/LRPAP1 0.014 0.058 0.106 18.0 -0.156 66.0 84.0 PTCH2 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.033 -9999.0 0.0 -0.114 52.0 52.0 PTCH1 0.004 0.068 -9999.0 0.0 -0.281 34.0 34.0 HHIP 0.017 0.009 0.124 1.0 -9999.0 0.0 1.0