Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.038 -9999.0 0.0 -0.151 26.0 26.0 epithelial cell differentiation 0.038 0.032 -9999.0 0.0 -0.113 24.0 24.0 CYFIP2 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.023 0.042 0.278 6.0 -9999.0 0.0 6.0 EGFR 0.053 0.054 0.124 235.0 -9999.0 0.0 235.0 EPHA2 0.02 0.013 0.124 8.0 -9999.0 0.0 8.0 MYO6 -0.017 0.034 0.17 15.0 -9999.0 0.0 15.0 CTNNB1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.036 0.019 -9999.0 0.0 -0.133 3.0 3.0 AQP5 -0.076 0.149 0.214 1.0 -0.366 134.0 135.0 CTNND1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.017 0.032 0.168 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.034 0.168 14.0 -0.201 2.0 16.0 EGF 0.024 0.019 0.124 22.0 -9999.0 0.0 22.0 NCKAP1 0.021 0.001 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.063 0.135 -9999.0 0.0 -0.365 107.0 107.0 cortical microtubule organization 0.038 0.032 -9999.0 0.0 -0.113 24.0 24.0 GO:0000145 -0.017 0.03 0.158 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.043 0.033 -9999.0 0.0 -0.114 24.0 24.0 MLLT4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.03 0.017 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.02 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.008 0.026 0.164 3.0 -0.246 4.0 7.0 PVRL2 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.015 0.028 0.169 7.0 -9999.0 0.0 7.0 ARF6/GTP 0.051 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.022 0.013 0.124 9.0 -9999.0 0.0 9.0 EGFR/EGFR/EGF/EGF 0.038 0.04 -9999.0 0.0 -0.107 19.0 19.0 RhoA/GDP 0.039 0.031 -9999.0 0.0 -0.11 24.0 24.0 actin cytoskeleton organization -0.016 0.032 0.157 14.0 -9999.0 0.0 14.0 IGF-1R heterotetramer 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.021 0.005 0.124 1.0 -9999.0 0.0 1.0 DIAPH1 -0.013 0.155 -9999.0 0.0 -0.463 63.0 63.0 Wnt receptor signaling pathway -0.038 0.032 0.113 24.0 -9999.0 0.0 24.0 RHOA 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.017 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.032 0.158 14.0 -9999.0 0.0 14.0 EFNA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.019 0.03 0.162 12.0 -9999.0 0.0 12.0 Ephrin A1/EPHA2 0.03 0.031 -9999.0 0.0 -0.105 23.0 23.0 SEC6/SEC8 -0.022 0.02 -9999.0 0.0 -0.113 14.0 14.0 MGAT3 -0.017 0.034 0.17 14.0 -0.203 2.0 16.0 HGF/MET -0.026 0.074 -9999.0 0.0 -0.119 236.0 236.0 HGF 0.018 0.013 0.124 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.037 -9999.0 0.0 -0.152 26.0 26.0 actin cable formation -0.011 0.059 0.217 15.0 -0.245 4.0 19.0 KIAA1543 -0.017 0.029 0.16 11.0 -9999.0 0.0 11.0 KIFC3 -0.019 0.03 0.169 10.0 -9999.0 0.0 10.0 NCK1 0.021 0.005 0.124 1.0 -9999.0 0.0 1.0 EXOC3 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.017 0.032 0.17 13.0 -9999.0 0.0 13.0 NCK1/GIT1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.038 0.032 -9999.0 0.0 -0.113 24.0 24.0 EXOC4 0.017 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.033 0.17 14.0 -9999.0 0.0 14.0 PIP5K1C -0.017 0.032 0.17 13.0 -9999.0 0.0 13.0 LIMA1 0.05 0.048 0.124 192.0 -9999.0 0.0 192.0 ABI1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.022 0.047 0.297 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.006 0.044 0.246 9.0 -0.249 3.0 12.0 IGF-1R heterotetramer/IGF1 0.031 0.034 -9999.0 0.0 -0.113 31.0 31.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.026 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.009 0.011 0.124 1.0 -9999.0 0.0 1.0 PLEKHA7 -0.018 0.031 0.17 11.0 -9999.0 0.0 11.0 mol:GTP 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.016 0.094 0.176 150.0 -9999.0 0.0 150.0 cortical actin cytoskeleton stabilization 0.016 0.038 -9999.0 0.0 -0.151 26.0 26.0 regulation of cell-cell adhesion -0.016 0.032 0.157 14.0 -9999.0 0.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.037 -9999.0 0.0 -0.152 26.0 26.0