Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.033 0.074 -9999.0 0.0 -0.318 22.0 22.0 IHH 0.024 0.023 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.002 0.074 -9999.0 0.0 -0.211 58.0 58.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.073 0.21 58.0 -9999.0 0.0 58.0 SMO/beta Arrestin2 0.045 0.047 -9999.0 0.0 -0.268 7.0 7.0 SMO 0.038 0.048 -9999.0 0.0 -0.284 7.0 7.0 AKT1 0.029 0.055 -9999.0 0.0 -0.269 11.0 11.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.038 0.048 -9999.0 0.0 -0.281 7.0 7.0 STIL 0.004 0.084 -9999.0 0.0 -0.184 75.0 75.0 DHH N/PTCH2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.025 0.053 -9999.0 0.0 -0.217 22.0 22.0 PIK3CA -0.003 0.091 -9999.0 0.0 -0.413 25.0 25.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.033 0.076 -9999.0 0.0 -0.329 22.0 22.0 determination of left/right symmetry 0.038 0.048 -9999.0 0.0 -0.281 7.0 7.0 PIK3R1 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.033 0.075 -9999.0 0.0 -0.328 22.0 22.0 IHH N/Hhip 0.016 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.038 0.048 -9999.0 0.0 -0.281 7.0 7.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.009 0.065 -9999.0 0.0 -0.279 25.0 25.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.134 -9999.0 0.0 -0.413 58.0 58.0 somite specification 0.038 0.048 -9999.0 0.0 -0.281 7.0 7.0 SHH Np/Cholesterol/PTCH1 0.035 0.048 -9999.0 0.0 -0.298 7.0 7.0 SHH Np/Cholesterol/PTCH2 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.023 0.01 -9999.0 0.0 -0.211 1.0 1.0 SHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.03 0.061 -9999.0 0.0 -0.247 22.0 22.0 SMO/Vitamin D3 0.042 0.047 -9999.0 0.0 -0.275 7.0 7.0 SHH Np/Cholesterol/Hhip 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.016 0.019 -9999.0 0.0 -0.413 1.0 1.0 receptor-mediated endocytosis 0.042 0.044 -9999.0 0.0 -0.254 7.0 7.0 SHH Np/Cholesterol/BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.037 0.049 -9999.0 0.0 -0.298 7.0 7.0 IHH N/PTCH2 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.038 0.063 -9999.0 0.0 -0.248 22.0 22.0 Megalin/LRPAP1 0.025 0.014 -9999.0 0.0 -0.285 1.0 1.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.03 0.061 -9999.0 0.0 -0.247 22.0 22.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0