Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.019 0.026 0.151 10.0 -9999.0 0.0 10.0 IHH 0.039 0.018 0.115 19.0 -0.035 8.0 27.0 SHH Np/Cholesterol/GAS1 -0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.033 0.004 -9999.0 0.0 0.0 7.0 7.0 dorsoventral neural tube patterning 0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.077 0.066 0.248 10.0 -9999.0 0.0 10.0 SMO 0.005 0.017 0.128 3.0 -0.15 2.0 5.0 AKT1 -0.002 0.082 -9999.0 0.0 -0.35 19.0 19.0 ARRB2 0.032 0.005 -9999.0 0.0 0.0 13.0 13.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.033 0.004 -9999.0 0.0 0.0 7.0 7.0 heart looping 0.005 0.017 0.127 3.0 -0.149 2.0 5.0 STIL 0.033 0.097 0.165 170.0 -9999.0 0.0 170.0 DHH N/PTCH2 0.024 0.004 -9999.0 0.0 0.0 11.0 11.0 DHH N/PTCH1 0.012 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.031 0.009 -9999.0 0.0 0.0 41.0 41.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.007 0.02 0.146 8.0 -9999.0 0.0 8.0 determination of left/right symmetry 0.005 0.017 0.127 3.0 -0.149 2.0 5.0 PIK3R1 0.03 0.01 -9999.0 0.0 0.0 47.0 47.0 skeletal system development -0.007 0.02 0.146 8.0 -9999.0 0.0 8.0 IHH N/Hhip 0.026 0.009 0.073 19.0 -9999.0 0.0 19.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.005 0.017 0.127 3.0 -0.149 2.0 5.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 PI3K 0.041 0.019 -9999.0 0.0 -0.016 15.0 15.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.029 0.012 -9999.0 0.0 0.0 71.0 71.0 somite specification 0.005 0.017 0.127 3.0 -0.149 2.0 5.0 SHH Np/Cholesterol/PTCH1 -0.019 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 -0.02 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.02 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.019 0.016 0.0 219.0 -9999.0 0.0 219.0 catabolic process 0.015 0.011 0.088 2.0 -9999.0 0.0 2.0 SMO/Vitamin D3 -0.011 0.03 0.168 11.0 -9999.0 0.0 11.0 SHH Np/Cholesterol/Hhip -0.013 0.012 0.0 214.0 -9999.0 0.0 214.0 LRP2 0.033 0.003 -9999.0 0.0 0.0 4.0 4.0 receptor-mediated endocytosis -0.009 0.03 0.139 11.0 -9999.0 0.0 11.0 SHH Np/Cholesterol/BOC -0.013 0.012 0.0 214.0 -9999.0 0.0 214.0 SHH Np/Cholesterol/CDO -0.02 0.017 0.0 218.0 -9999.0 0.0 218.0 mesenchymal cell differentiation 0.013 0.011 -9999.0 0.0 0.0 214.0 214.0 mol:Vitamin D3 0.052 0.107 0.185 193.0 -9999.0 0.0 193.0 IHH N/PTCH2 0.051 0.012 0.104 12.0 -9999.0 0.0 12.0 CDON 0.033 0.004 -9999.0 0.0 0.0 9.0 9.0 IHH N/PTCH1 0.033 0.013 0.145 1.0 -9999.0 0.0 1.0 Megalin/LRPAP1 0.048 0.007 -9999.0 0.0 -0.016 1.0 1.0 PTCH2 0.033 0.005 -9999.0 0.0 0.0 11.0 11.0 SHH Np/Cholesterol 0.06 0.103 0.189 197.0 -9999.0 0.0 197.0 PTCH1 0.015 0.011 0.089 2.0 -9999.0 0.0 2.0 HHIP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0