Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.026 -9999.0 0.0 -0.118 23.0 23.0 epithelial cell differentiation 0.063 0.028 -9999.0 0.0 -0.049 24.0 24.0 CYFIP2 0.019 0.017 -9999.0 0.0 0.0 223.0 223.0 ENAH -0.062 0.059 0.384 5.0 -9999.0 0.0 5.0 EGFR 0.012 0.016 -9999.0 0.0 0.0 329.0 329.0 EPHA2 0.031 0.008 -9999.0 0.0 0.0 28.0 28.0 MYO6 -0.042 0.035 0.159 12.0 -9999.0 0.0 12.0 CTNNB1 0.032 0.006 -9999.0 0.0 0.0 15.0 15.0 ABI1/Sra1/Nap1 0.021 0.042 -9999.0 0.0 -0.046 76.0 76.0 AQP5 -0.026 0.05 -9999.0 0.0 -0.334 8.0 8.0 CTNND1 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 mol:PI-4-5-P2 -0.041 0.03 0.156 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.035 0.156 13.0 -9999.0 0.0 13.0 EGF 0.033 0.004 -9999.0 0.0 0.0 8.0 8.0 NCKAP1 0.033 0.003 -9999.0 0.0 0.0 3.0 3.0 AQP3 -0.047 0.089 -9999.0 0.0 -0.337 40.0 40.0 cortical microtubule organization 0.063 0.028 -9999.0 0.0 -0.049 24.0 24.0 GO:0000145 -0.039 0.028 0.137 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.069 0.03 -9999.0 0.0 -0.049 24.0 24.0 MLLT4 0.03 0.009 -9999.0 0.0 0.0 45.0 45.0 ARF6/GDP -0.073 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.031 0.008 -9999.0 0.0 0.0 31.0 31.0 Ephrin A1/EPHA2/NCK1/GIT1 0.072 0.034 -9999.0 0.0 -0.053 15.0 15.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.019 0.025 0.143 2.0 -0.202 2.0 4.0 PVRL2 0.031 0.009 -9999.0 0.0 0.0 37.0 37.0 ZYX -0.026 0.031 0.156 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.074 0.046 -9999.0 0.0 -0.059 34.0 34.0 CDH1 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 EGFR/EGFR/EGF/EGF 0.018 0.034 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.064 0.031 -9999.0 0.0 -0.057 24.0 24.0 actin cytoskeleton organization -0.033 0.033 0.136 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.033 0.005 -9999.0 0.0 0.0 11.0 11.0 GIT1 0.033 0.004 -9999.0 0.0 0.0 8.0 8.0 IGF1R 0.033 0.005 -9999.0 0.0 0.0 11.0 11.0 IGF1 0.032 0.005 -9999.0 0.0 0.0 12.0 12.0 DIAPH1 -0.239 0.268 -9999.0 0.0 -0.48 265.0 265.0 Wnt receptor signaling pathway -0.063 0.028 0.049 24.0 -9999.0 0.0 24.0 RHOA 0.032 0.006 -9999.0 0.0 0.0 19.0 19.0 RhoA/GTP -0.072 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.005 -9999.0 0.0 0.0 10.0 10.0 VCL -0.034 0.034 0.137 8.0 -9999.0 0.0 8.0 EFNA1 0.031 0.009 -9999.0 0.0 0.0 36.0 36.0 LPP -0.047 0.03 0.138 7.0 -9999.0 0.0 7.0 Ephrin A1/EPHA2 0.047 0.042 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.059 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.041 0.036 0.158 13.0 -9999.0 0.0 13.0 HGF/MET 0.029 0.038 -9999.0 0.0 -9999.0 0.0 0.0 HGF 0.019 0.016 -9999.0 0.0 0.0 213.0 213.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.026 -9999.0 0.0 -0.119 23.0 23.0 actin cable formation -0.051 0.081 0.355 10.0 -0.248 7.0 17.0 KIAA1543 -0.034 0.028 0.138 13.0 -9999.0 0.0 13.0 KIFC3 -0.044 0.031 0.159 10.0 -9999.0 0.0 10.0 NCK1 0.031 0.008 -9999.0 0.0 0.0 28.0 28.0 EXOC3 0.032 0.006 -9999.0 0.0 0.0 18.0 18.0 ACTN1 -0.041 0.033 0.159 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.046 0.014 -9999.0 0.0 -0.016 10.0 10.0 mol:GDP 0.063 0.028 -9999.0 0.0 -0.049 24.0 24.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.044 0.034 0.159 12.0 -9999.0 0.0 12.0 PIP5K1C -0.041 0.031 0.157 8.0 -9999.0 0.0 8.0 LIMA1 0.005 0.012 -9999.0 0.0 0.0 437.0 437.0 ABI1 0.024 0.015 -9999.0 0.0 0.0 138.0 138.0 ROCK1 -0.059 0.074 0.397 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.033 0.048 0.256 3.0 -0.225 7.0 10.0 IGF-1R heterotetramer/IGF1 0.051 0.039 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.017 -9999.0 0.0 0.0 222.0 222.0 PLEKHA7 -0.039 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.07 0.033 -9999.0 0.0 -0.052 15.0 15.0 establishment of epithelial cell apical/basal polarity -0.055 0.055 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.01 0.026 -9999.0 0.0 -0.118 23.0 23.0 regulation of cell-cell adhesion -0.033 0.033 0.136 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.026 -9999.0 0.0 -0.119 23.0 23.0