Clinical Features Time to Death YEARS_TO_BIRTH PATHOLOGIC_STAGE PATHOLOGY_T_STAGE PATHOLOGY_N_STAGE PATHOLOGY_M_STAGE GENDER RADIATION_THERAPY HISTOLOGICAL_TYPE NUMBER_PACK_YEARS_SMOKED YEAR_OF_TOBACCO_SMOKING_ONSET NUMBER_OF_LYMPH_NODES RACE ETHNICITY nMutated (%) nWild-Type logrank test_P logrank test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Wilcoxon-test_P Wilcoxon-test_Q Wilcoxon-test_P Wilcoxon-test_Q Wilcoxon-test_P Wilcoxon-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 364 (71%) 147 0.0069577 0.287 0.53016 1 0.50248 1 0.01866 0.476 0.62655 1 1 1 0.91273 1 0.32827 1 0.0072799 0.287 0.11378 0.87 0.72327 1 0.60295 1 0.32846 1 0.068483 0.791 CDKN2A 112 (22%) 399 0.9963 1 0.11204 0.87 0.16826 0.907 0.81169 1 0.39811 1 1 1 0.90422 1 0.54836 1 0.25364 0.961 0.64789 1 0.40206 1 0.22414 0.933 0.49529 1 0.47363 1 NSD1 62 (12%) 449 0.037946 0.6 0.091159 0.851 0.16243 0.907 0.40381 1 0.03355 0.6 0.14063 0.907 0.17079 0.907 1 1 0.42679 1 0.11504 0.87 0.40144 1 0.00012362 0.0358 0.76467 1 0.2064 0.933 CASP8 54 (11%) 457 0.063221 0.773 7.616e-09 6.61e-06 0.72549 1 0.46333 1 0.082419 0.836 1 1 0.00052251 0.113 0.085413 0.842 0.65008 1 0.062919 0.773 0.019856 0.479 0.023168 0.503 0.43524 1 0.33973 1 MLL2 81 (16%) 430 0.12533 0.876 0.28948 0.986 0.35522 1 0.21535 0.933 0.76936 1 1 1 1 1 0.78917 1 0.47735 1 0.44913 1 0.86643 1 0.94488 1 0.113 0.87 0.40057 1 TGFBR2 24 (5%) 487 0.86173 1 0.10871 0.87 0.94904 1 0.70479 1 0.70424 1 1 1 1 1 0.48416 1 1 1 0.386 1 0.23014 0.933 0.48965 1 0.8458 1 1 1 HLA-B 24 (5%) 487 0.96278 1 0.19694 0.933 0.7509 1 0.37064 1 0.03017 0.6 1 1 0.10371 0.87 0.16745 0.907 0.41511 1 0.22501 0.933 0.12887 0.876 0.28689 0.986 0.60437 1 0.61439 1 FBXW7 33 (6%) 478 0.31809 1 0.006675 0.287 0.7479 1 0.41962 1 0.32375 1 1 1 0.10669 0.87 0.32647 1 1 1 0.32317 1 0.96733 1 0.17017 0.907 1 1 0.65958 1 NOTCH1 90 (18%) 421 0.1001 0.87 0.0087753 0.293 0.35385 1 0.29566 0.991 0.67388 1 0.17188 0.907 0.089352 0.851 0.020413 0.479 1 1 0.055091 0.736 0.18524 0.907 0.35972 1 0.93328 1 0.18755 0.909 FAT1 112 (22%) 399 0.38875 1 2.3148e-07 1e-04 0.35352 1 0.02276 0.503 0.20744 0.933 0.22917 0.933 0.0036546 0.227 0.71867 1 0.76586 1 0.079919 0.83 0.0087062 0.293 0.35971 1 0.58702 1 0.45032 1 JUB 34 (7%) 477 0.024467 0.518 0.0025437 0.184 0.65069 1 0.60614 1 0.22419 0.933 1 1 0.69483 1 0.84656 1 1 1 0.2144 0.933 0.0029003 0.194 0.47036 1 0.27522 0.983 0.67433 1 ZNF750 21 (4%) 490 0.97439 1 0.1348 0.893 0.20998 0.933 0.5589 1 0.22721 0.933 1 1 0.21747 0.933 0.47285 1 0.37254 1 0.76466 1 0.5408 1 0.034752 0.6 0.17772 0.907 0.61763 1 NFE2L2 27 (5%) 484 0.28337 0.986 0.0018259 0.158 0.72616 1 0.73036 1 0.66725 1 1 1 0.11826 0.87 0.089952 0.851 1 1 0.49689 1 0.37691 1 0.51003 1 0.41713 1 0.34557 1 HLA-A 22 (4%) 489 0.75486 1 0.075819 0.812 0.88392 1 0.073709 0.8 0.41602 1 1 1 1 1 0.13024 0.876 1 1 0.43949 1 0.011723 0.377 0.55857 1 0.67041 1 0.61439 1 EPHA2 24 (5%) 487 0.29314 0.991 0.084586 0.842 0.87442 1 0.65344 1 0.51841 1 1 1 0.48363 1 0.16745 0.907 1 1 0.047793 0.703 0.18389 0.907 0.93348 1 0.58679 1 1 1 RAC1 15 (3%) 496 0.48498 1 0.0011667 0.113 0.21582 0.933 0.18037 0.907 0.35857 1 1 1 0.006534 0.287 1 1 1 1 0.708 1 0.0043391 0.235 0.17859 0.907 0.20782 0.933 1 1 HRAS 31 (6%) 480 0.24743 0.961 0.39682 1 0.409 1 0.65005 1 0.14125 0.907 1 1 0.061418 0.773 0.21971 0.933 0.4997 1 0.73349 1 0.46371 1 0.080106 0.83 0.38786 1 0.39519 1 EP300 38 (7%) 473 0.24669 0.961 0.54064 1 0.98832 1 0.50362 1 0.38803 1 1 1 0.56894 1 0.70498 1 0.57888 1 0.11452 0.87 0.91055 1 0.69537 1 0.82375 1 1 1 OR6C65 16 (3%) 495 0.24301 0.961 0.98487 1 0.52793 1 0.93736 1 0.87376 1 1 1 0.25654 0.961 0.27819 0.985 1 1 0.57986 1 0.44302 1 0.9169 1 0.5732 1 1 1 PIK3CA 94 (18%) 417 0.82846 1 0.87923 1 0.28961 0.986 0.32397 1 0.10423 0.87 1 1 0.054483 0.736 0.8989 1 0.75284 1 0.8032 1 0.7974 1 0.5084 1 0.090939 0.851 0.59535 1 PTEN 14 (3%) 497 0.205 0.933 0.3196 1 0.93541 1 0.28964 0.986 0.49097 1 1 1 1 1 0.77884 1 1 1 0.42611 1 0.14996 0.907 0.49637 1 0.56266 1 1 1 RASA1 18 (4%) 493 0.50687 1 0.34724 1 0.11754 0.87 0.37648 1 0.7333 1 0.036458 0.6 0.42278 1 0.30578 1 1 1 0.16164 0.907 0.8534 1 0.36058 1 0.61974 1 1 1 MAPK1 9 (2%) 502 0.16079 0.907 0.94994 1 0.86857 1 0.41236 1 0.65017 1 1 1 0.70809 1 0.72551 1 1 1 NA NA 0.4602 1 0.86501 1 0.23884 0.961 1 1 NUDT11 9 (2%) 502 0.25405 0.961 0.35101 1 0.57959 1 0.75822 1 0.64911 1 1 1 0.12183 0.876 0.096108 0.851 1 1 0.58438 1 0.29533 0.991 0.50427 1 1 1 0.38856 1 KDM6A 17 (3%) 494 0.26014 0.961 0.053405 0.736 0.39917 1 0.25772 0.961 0.8039 1 1 1 1 1 0.78392 1 1 1 0.14611 0.907 0.17907 0.907 0.87554 1 0.4906 1 1 1 RB1 17 (3%) 494 0.071958 0.791 0.35312 1 0.15413 0.907 0.22589 0.933 0.57955 1 1 1 0.001043 0.113 0.79552 1 1 1 0.68647 1 0.28135 0.985 0.2008 0.933 0.24546 0.961 0.58579 1 KEAP1 22 (4%) 489 0.7648 1 0.096011 0.851 0.1509 0.907 0.0078199 0.293 0.36988 1 1 1 0.14412 0.907 0.015903 0.454 0.10538 0.87 0.094343 0.851 0.30199 1 0.87126 1 0.68998 1 0.61439 1 KRT17 6 (1%) 505 0.2098 0.933 0.64253 1 0.25917 0.961 0.18607 0.907 0.050729 0.722 NA NA 0.35091 1 0.61358 1 1 1 0.90069 1 0.94489 1 0.12162 0.876 0.53589 1 1 1 RHOA 10 (2%) 501 0.51161 1 0.38999 1 1 1 0.38564 1 0.03671 0.6 1 1 0.47036 1 0.50535 1 0.1995 0.933 0.69597 1 0.57249 1 0.34323 1 0.69146 1 1 1 PTPN14 16 (3%) 495 0.15385 0.907 0.828 1 0.04094 0.623 0.85236 1 0.2489 0.961 0.036458 0.6 0.77525 1 0.59117 1 1 1 0.73833 1 0.5925 1 0.41214 1 0.061869 0.773 0.58579 1 KRTAP5-5 4 (1%) 507 0.73014 1 0.42523 1 0.064919 0.783 0.19163 0.919 1 1 1 1 0.29566 0.991 1 1 1 1 0.58391 1 0.26717 0.97 0.80396 1 1 1 1 1 ZNF623 12 (2%) 499 0.3107 1 0.64332 1 1 1 0.78749 1 0.7944 1 1 1 0.74227 1 0.75438 1 1 1 0.80347 1 0.57811 1 0.2425 0.961 0.49944 1 1 1 TIGD4 7 (1%) 504 0.32003 1 0.17539 0.907 0.25312 0.961 0.77581 1 0.17073 0.907 1 1 0.68037 1 0.6621 1 1 1 0.50057 1 0.40343 1 0.16688 0.907 0.58911 1 1 1 NAP1L2 7 (1%) 504 0.93238 1 0.25889 0.961 0.77985 1 1 1 0.77339 1 1 1 0.39418 1 1 1 0.14158 0.907 0.24943 0.961 0.42346 1 0.8869 1 1 1 0.0023437 0.184 CUL3 16 (3%) 495 0.92391 1 0.3773 1 0.24046 0.961 0.15997 0.907 0.94817 1 1 1 0.25654 0.961 0.78392 1 1 1 0.77579 1 0.33559 1 0.28455 0.986 0.0366 0.6 1 1 CREBBP 34 (7%) 477 0.5073 1 0.016754 0.454 0.75336 1 0.72989 1 0.88706 1 1 1 0.54847 1 1 1 0.53679 1 0.71481 1 0.035126 0.6 0.68851 1 0.10355 0.87 1 1 VEZF1 8 (2%) 503 0.52955 1 0.94407 1 0.0129 0.386 0.01666 0.454 0.065959 0.784 1 1 1 1 0.05347 0.736 0.16067 0.907 0.70699 1 0.55823 1 0.18903 0.912 1 1 0.3539 1 MLL4 19 (4%) 492 0.31187 1 0.00086603 0.113 0.19408 0.926 0.92261 1 0.086439 0.843 1 1 0.18428 0.907 0.4507 1 1 1 0.64216 1 0.050249 0.722 0.14411 0.907 0.44124 1 0.61439 1 IRS4 17 (3%) 494 0.73334 1 0.93127 1 0.69816 1 0.78633 1 0.3887 1 1 1 0.26348 0.961 0.55641 1 1 1 0.80232 1 0.91068 1 0.14399 0.907 0.75788 1 0.18427 0.907 HUWE1 46 (9%) 465 0.41703 1 0.41879 1 0.84238 1 0.61897 1 0.49221 1 1 1 0.035155 0.6 0.86259 1 1 1 0.2613 0.961 0.58093 1 0.52025 1 0.03961 0.614 0.27512 0.983 THSD7A 32 (6%) 479 0.67626 1 0.70446 1 0.95111 1 0.21514 0.933 0.90174 1 1 1 0.41007 1 0.3096 1 0.51149 1 0.0046624 0.238 0.52083 1 0.069027 0.791 0.5504 1 0.67433 1 C3ORF59 10 (2%) 501 0.94726 1 0.39059 1 0.9543 1 0.75726 1 0.35894 1 1 1 0.73397 1 0.27119 0.981 1 1 0.64984 1 0.72745 1 0.53878 1 1 1 1 1 DYSF 20 (4%) 491 0.73318 1 0.061384 0.773 0.96046 1 0.6584 1 0.094179 0.851 1 1 0.79819 1 1 1 1 1 0.026507 0.548 0.10736 0.87 0.071759 0.791 0.82344 1 0.61439 1 ZNF233 9 (2%) 502 0.31422 1 0.2807 0.985 0.39191 1 0.46784 1 0.22793 0.933 NA NA 1 1 1 1 1 1 0.070248 0.791 0.11578 0.87 0.0084084 0.293 0.68441 1 1 1 KIAA1267 11 (2%) 500 0.45849 1 0.26295 0.961 0.47365 1 0.21976 0.933 0.88911 1 1 1 0.49832 1 0.75438 1 1 1 0.88442 1 0.46889 1 0.48908 1 0.69575 1 0.10971 0.87 ASXL1 16 (3%) 495 0.28779 0.986 0.83674 1 0.51702 1 0.17498 0.907 0.12417 0.876 1 1 0.77525 1 0.0055714 0.269 1 1 0.94898 1 0.78195 1 0.83551 1 0.77209 1 1 1 SMAD4 13 (3%) 498 0.60164 1 0.3044 1 0.77052 1 1 1 0.61783 1 1 1 1 1 0.5263 1 1 1 0.40241 1 0.17069 0.907 0.90166 1 1 1 1 1 GAGE2A 4 (1%) 507 0.90415 1 0.30665 1 0.64226 1 0.79668 1 1 1 1 1 0.57831 1 0.27977 0.985 1 1 NA NA NA NA 0.75482 1 0.39658 1 1 1 EMG1 3 (1%) 508 0.66319 1 0.81202 1 0.81736 1 0.85049 1 0.11777 0.87 1 1 0.17887 0.907 0.27977 0.985 1 1 NA NA NA NA 0.57758 1 1 1 1 1 PIK3R1 8 (2%) 503 0.12901 0.876 0.93637 1 0.52094 1 0.79715 1 0.15567 0.907 1 1 0.68882 1 0.71916 1 1 1 0.91367 1 0.96224 1 0.16688 0.907 1 1 1 1 KRTAP5-7 5 (1%) 506 0.1693 0.907 0.49532 1 0.40452 1 0.7822 1 0.68913 1 1 1 0.12474 0.876 0.34803 1 1 1 0.95923 1 0.77152 1 0.3467 1 0.18394 0.907 1 1 SLC9A6 5 (1%) 506 0.012899 0.386 0.77779 1 0.32614 1 0.45578 1 0.12992 0.876 1 1 0.12474 0.876 0.6621 1 1 1 0.8488 1 NA NA 0.14995 0.907 1 1 1 1 ELF4 7 (1%) 504 0.37385 1 0.92179 1 0.01737 0.457 0.072019 0.791 0.21672 0.933 1 1 0.68037 1 0.021275 0.486 1 1 0.42325 1 0.87418 1 0.060461 0.773 1 1 1 1 CTCF 15 (3%) 496 0.035547 0.6 0.0010653 0.113 0.16135 0.907 1 1 0.4121 1 1 1 0.033776 0.6 0.77441 1 1 1 0.98065 1 0.038027 0.6 0.32561 1 0.34347 1 1 1 HNRNPL 11 (2%) 500 0.48041 1 0.10452 0.87 0.30169 1 0.31932 1 0.10396 0.87 1 1 0.1771 0.907 1 1 0.21325 0.933 0.2612 0.961 0.7919 1 0.21406 0.933 1 1 1 1 ZFP36L2 8 (2%) 503 0.13146 0.878 0.55177 1 0.76605 1 0.88072 1 0.30657 1 NA NA 0.45066 1 1 1 1 1 0.66096 1 0.20112 0.933 0.86797 1 1 1 0.3539 1 MYH9 21 (4%) 490 0.76469 1 0.81872 1 0.86213 1 0.38379 1 0.89274 1 1 1 0.21747 0.933 0.47345 1 0.37345 1 0.46778 1 0.36129 1 0.86217 1 0.43973 1 0.24421 0.961 NOTCH2 21 (4%) 490 0.54511 1 0.14704 0.907 0.33304 1 0.77968 1 0.69162 1 1 1 0.0039832 0.23 0.60887 1 1 1 0.12923 0.876 0.15795 0.907 0.51372 1 0.83056 1 0.61763 1 NCOR1 17 (3%) 494 0.8776 1 0.17765 0.907 0.75882 1 0.56867 1 0.68607 1 1 1 0.41549 1 0.39 1 1 1 0.79976 1 0.26149 0.961 0.34629 1 0.78783 1 0.22403 0.933 AK5 13 (3%) 498 0.00092273 0.113 0.32552 1 0.76847 1 0.38313 1 0.65735 1 1 1 0.35106 1 1 1 1 1 0.81569 1 0.54312 1 0.45598 1 0.49999 1 0.092705 0.851 SPTY2D1 10 (2%) 501 0.4707 1 0.019657 0.479 0.86705 1 0.6236 1 0.78614 1 1 1 0.73397 1 0.3286 1 1 1 0.042075 0.63 0.22109 0.933 0.22491 0.933 1 1 0.42143 1 PIWIL2 8 (2%) 503 0.55469 1 0.27503 0.983 0.56578 1 0.71126 1 1 1 1 1 1 1 0.699 1 1 1 0.082833 0.836 0.080353 0.83 0.55437 1 1 1 1 1