rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CAPN1(3), CAPN2(5), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(7), FADD(3), FAS(5), FASLG(1), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(2), TNFSF10(1), TP53(432), TRADD(1), TRAF2(2) 63750063 847 442 552 87 120 166 133 154 262 12 <1.00e-15 <1.00e-15 <3.42e-14 2 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(114), MDM2(3), MYC(6), PIK3CA(97), PIK3R1(9), POLR1A(9), POLR1B(3), POLR1C(2), RAC1(15), RB1(17), TBX2(4), TP53(432), TWIST1(1) 15458536 720 423 370 24 91 114 88 120 294 13 <1.00e-15 <1.00e-15 <3.42e-14 3 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(12), ATM(16), ATR(24), BAI1(8), BID(3), CASP3(2), CASP8(60), CASP9(1), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(1), CDKN2A(114), CHEK1(1), CHEK2(4), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(9), IGF1(1), IGFBP3(1), MDM2(3), MDM4(1), PERP(1), PMAIP1(2), PPM1D(7), PTEN(14), RCHY1(1), RFWD2(2), RRM2(1), RRM2B(1), SERPINB5(1), SERPINE1(7), SESN1(2), SESN2(4), SESN3(4), SFN(7), SIAH1(4), STEAP3(4), THBS1(8), TNFRSF10B(1), TP53(432), TSC2(7), ZMAT3(2) 49912643 822 419 531 66 100 106 120 133 348 15 <1.00e-15 <1.00e-15 <3.42e-14 4 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(1), BTK(8), CAD(5), CASP10(2), CASP3(2), CASP8(60), CSNK1A1(1), DAXX(6), DEDD(1), DEDD2(5), DIABLO(1), EGFR(19), EPHB2(3), FADD(3), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MET(4), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(1), PFN1(1), PFN2(1), PTPN13(12), RALBP1(3), RIPK1(2), ROCK1(19), TNFRSF6B(4), TP53(432), TPX2(5), TRAF2(2) 55608973 686 419 448 68 109 98 121 102 243 13 <1.00e-15 <1.00e-15 <3.42e-14 5 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(16), CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG2(4), CDC25A(3), CDK4(5), CDKN1B(2), CDKN2A(114), CDKN2C(1), CDKN2D(1), CREB3L1(4), CREB3L3(9), CREB3L4(2), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), GADD45A(1), GBA2(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MNAT1(1), MYC(6), MYT1(11), NACA(24), PCNA(1), POLA2(2), POLE(11), PRIM1(3), RB1(17), RBL1(12), RPA1(5), RPA2(1), TFDP1(2), TFDP2(1), TNXB(25), TP53(432), WEE1(2) 58898340 795 418 513 78 106 110 136 114 315 14 <1.00e-15 <1.00e-15 <3.42e-14 6 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(8), ATM(16), ATR(24), CCNA1(7), CCND1(3), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), CDKN2A(114), DHFR(2), GSK3B(3), HDAC1(1), RB1(17), SKP2(4), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), TP53(432) 22993891 654 398 374 32 85 68 93 99 296 13 <1.00e-15 <1.00e-15 <3.42e-14 7 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(16), ATR(24), BRCA1(12), CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CDC34(4), CDKN2D(1), CHEK1(1), CHEK2(4), EP300(38), GADD45A(1), MDM2(3), MYT1(11), PRKDC(28), RPS6KA1(10), TP53(432), WEE1(2), YWHAH(2), YWHAQ(3) 31973159 605 398 379 37 94 84 105 104 208 10 <1.00e-15 <1.00e-15 <3.42e-14 8 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(16), ATR(24), BRCA1(12), BRCA2(17), CHEK1(1), CHEK2(4), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(10), RAD51(1), RAD9A(2), TP53(432), TREX1(4) 33566948 558 393 339 36 80 83 92 96 197 10 <1.00e-15 <1.00e-15 <3.42e-14 9 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(3), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(4), MYEF2(8), NFATC3(5), NR2C2(1), PAPPA(13), SHC1(2), TP53(432), TRAF6(3), ZAK(5) 38482261 598 393 376 50 95 82 117 94 200 10 <1.00e-15 <1.00e-15 <3.42e-14 10 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(11), JAK2(5), LIN7A(4), NFKB1(5), NFKBIA(1), RB1(17), RELA(2), TNFRSF1A(2), TNFRSF1B(2), TP53(432), USH1C(3), WT1(3) 13883618 500 388 280 29 77 56 82 77 198 10 <1.00e-15 <1.00e-15 <3.42e-14 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(11), RB1(17), TP53(432), WEE1(2), YWHAH(2) 13377483 497 385 278 17 79 60 73 77 198 10 <1.00e-15 <1.00e-15 <3.42e-14 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(12), ATM(16), BCL2(1), CCND1(3), CCNE1(4), CDK4(5), GADD45A(1), MDM2(3), PCNA(1), RB1(17), TP53(432) 13812803 495 382 276 20 74 60 71 82 198 10 <1.00e-15 <1.00e-15 <3.42e-14 13 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(19), AKT1(2), ATM(16), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(1), GADD45A(1), HIC1(1), HIF1A(4), IGFBP3(1), MAPK8(4), MDM2(3), NFKBIB(1), NQO1(3), TP53(432) 15860408 494 375 275 30 81 56 79 79 189 10 <1.00e-15 <1.00e-15 <3.42e-14 14 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(6), DNAJC3(3), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2), TP53(432) 7499157 457 372 238 15 76 50 65 73 183 10 <1.00e-15 <1.00e-15 <3.42e-14 15 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(34), MAPK1(9), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), NTRK1(3), PIK3CA(97), PIK3R1(9), PLCG1(9), RPS6KA1(10), SHC1(2) 14446419 206 164 114 13 27 71 43 48 17 0 <1.00e-15 <1.00e-15 <3.42e-14 16 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(4), GH1(4), GHR(9), HRAS(34), IGF1(1), IGF1R(11), PIK3CA(97), PIK3R1(9), SHC1(2), SOD1(1), SOD2(1), SOD3(4) 10154707 179 147 94 12 20 68 37 43 11 0 5.96e-14 <1.00e-15 <3.42e-14 17 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(97), PIK3R1(9), PLCB1(22), PLCG1(9), PRKCA(7), VAV1(7) 9776480 153 137 91 15 10 62 27 40 14 0 3.55e-09 <1.00e-15 <3.42e-14 18 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(1), CD80(4), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3CA(97), PIK3R1(9), PTPN11(2) 9746141 134 123 72 8 3 61 13 40 17 0 3.65e-11 <1.00e-15 <3.42e-14 19 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(8), PXN(2), STAT1(8), TLN1(22), TP53(432) 20884789 529 391 310 32 82 73 82 88 194 10 <1.00e-15 1.22e-15 3.96e-14 20 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), CHUK(6), GH1(4), GHR(9), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3CA(97), PIK3R1(9), RELA(2), YWHAH(2) 10771408 143 128 81 10 8 65 17 38 15 0 6.99e-11 2.11e-15 6.50e-14 21 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(19), IGF1R(11), MYC(6), POLR2A(12), PRKCA(7), RB1(17), TEP1(15), TERF1(5), TERT(3), TNKS(7), TP53(432), XRCC5(4) 21550992 541 392 320 44 85 75 87 86 197 11 <1.00e-15 2.44e-15 7.16e-14 22 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), TP53(432), WT1(3) 5385023 449 366 228 13 72 49 68 72 178 10 <1.00e-15 2.66e-15 7.43e-14 23 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(37), DAXX(6), HRAS(34), PAX3(6), PML(1), RARA(5), RB1(17), SIRT1(3), SP100(8), TNFRSF1A(2), TNFRSF1B(2), TP53(432) 14523211 553 408 309 34 86 68 104 82 202 11 <1.00e-15 2.78e-15 7.43e-14 24 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(9), HLA-A(24), IL18(1), ITGB1(15), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LAT(3), MAP2K1(5), PAK1(3), PIK3CA(97), PIK3R1(9), PTK2B(4), PTPN6(3), RAC1(15), SYK(8), VAV1(7) 14166713 209 167 136 17 24 67 25 49 44 0 1.61e-12 3.11e-15 7.93e-14 25 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(3), CDK4(5), CDKN1B(2), CDKN2A(114), CFL1(2), E2F2(3), MDM2(3), PRB1(7), TP53(432) 6437253 572 377 293 18 77 54 76 81 271 13 <1.00e-15 3.22e-15 7.93e-14 26 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(16), ATR(24), CDC25C(4), CHEK1(1), CHEK2(4), TP53(432), YWHAH(2) 12188438 483 372 264 15 76 60 70 83 184 10 <1.00e-15 3.44e-15 8.06e-14 27 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(12), BAD(1), BAK1(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(3), BIRC3(2), BIRC5(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), CHUK(6), FADD(3), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(11), IRF1(7), IRF2(7), IRF3(1), IRF4(4), IRF5(3), IRF6(5), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), PLEKHG5(7), PRF1(5), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TP53(432), TRADD(1), TRAF2(2), TRAF3(6) 43864630 676 412 443 61 107 102 111 98 246 12 <1.00e-15 3.66e-15 8.06e-14 28 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(4), GADD45A(1), JUN(1), MAPK8(4), MDM2(3), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(10), RAD51(1), RBBP8(5), RELA(2), TP53(432) 22741707 509 381 289 30 78 64 85 82 190 10 <1.00e-15 3.66e-15 8.06e-14 29 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(34), KLK2(2), NTRK1(3), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), SHC1(2), SOS1(9) 11875897 174 145 89 13 16 67 39 42 10 0 3.23e-12 4.00e-15 8.49e-14 30 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), INSR(3), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(97), PIK3R1(9), PTPN11(2), RAF1(3), RASA1(18), SHC1(2), SLC2A4(3), SOS1(9), SRF(1) 19422638 208 169 121 10 18 67 48 46 28 1 <1.00e-15 4.22e-15 8.66e-14 31 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), IGF1(1), IGF1R(11), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(97), PIK3R1(9), PTPN11(2), RAF1(3), RASA1(18), SHC1(2), SOS1(9), SRF(1) 18890599 214 172 127 12 22 69 48 47 27 1 <1.00e-15 4.44e-15 8.82e-14 32 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), FADD(3), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(5), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(1), TP53(432), TRADD(1), TRAF2(2) 28611114 594 403 361 34 91 80 95 91 225 12 <1.00e-15 4.77e-15 9.19e-14 33 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), CDKN2A(114), CDKN2C(1), CDKN2D(1), RB1(17), RBL1(12), TFDP1(2) 12205423 176 161 116 19 8 16 18 17 114 3 4.80e-07 5.00e-15 9.33e-14 34 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(2), CASP8(60), CFL1(2), CFLAR(2) 2956254 67 61 55 6 5 13 8 8 31 2 8.78e-05 5.44e-15 9.86e-14 35 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), HRAS(34), IGF1R(11), IRS1(2), MAP2K1(5), MAPK1(9), PIK3CA(97), PIK3R1(9), RAF1(3), SHC1(2), SOS1(9), YWHAH(2) 14466351 186 148 94 12 26 69 38 41 12 0 6.99e-15 6.55e-15 1.15e-13 36 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(1), PIK3CA(97), PIK3R1(9), PLCG1(9), RAF1(3), SHC1(2), SOS1(9) 14548231 191 154 106 11 20 66 47 41 17 0 7.22e-15 7.88e-15 1.31e-13 37 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(4), CCND1(3), CCNE1(4), CCNE2(4), CDK4(5), CDKN1B(2), CDKN2A(114), E2F2(3), E2F4(3), PRB1(7) 6843887 156 147 96 14 5 13 18 19 98 3 1.18e-07 7.88e-15 1.31e-13 38 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(2), CASP9(1), CDC42(3), CHUK(6), ELK1(2), H2AFX(1), HRAS(34), MAP2K1(5), NFKB1(5), PIK3CA(97), PIK3R1(9), RAC1(15), RAF1(3), RALBP1(3), RALGDS(6), RELA(2), RHOA(10) 14545526 207 160 112 14 26 71 48 43 19 0 3.44e-15 8.33e-15 1.35e-13 39 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(3), CCNE1(4), CDK4(5), CDK6(1), CDKN1B(2), HRAS(34), MAPK1(9), NFKB1(5), NFKBIA(1), PAK1(3), PIK3CA(97), PIK3R1(9), RAC1(15), RAF1(3), RB1(17), RELA(2), TFDP1(2) 15427541 214 170 115 20 27 72 39 45 31 0 1.11e-12 9.21e-15 1.46e-13 40 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(13), PIK3CA(97), PIK3R1(9), RAC1(15), WASL(2) 10192211 150 130 82 15 13 64 21 40 12 0 5.24e-08 7.89e-13 1.21e-11 41 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(4), AKT3(6), ELK1(2), HRAS(34), MAP2K1(5), MAP2K2(6), NGFR(1), NTRK1(3), PIK3CA(97), PIK3CD(8), SHC1(2), SOS1(9) 12329643 179 146 94 19 24 64 38 45 8 0 1.31e-10 7.97e-12 1.20e-10 42 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), CDKN1B(2), ILK(4), ITGB1(15), MAPK1(9), PDK2(1), PDPK1(4), PIK3CA(97), PIK3R1(9), PTEN(14), PTK2(8), SHC1(2), SOS1(9) 14760612 179 147 109 16 19 67 23 41 29 0 1.11e-10 9.91e-12 1.45e-10 43 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(13), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3CA(97), PIK3R1(9), RELA(2), SYT1(9) 13688453 160 135 99 14 16 66 21 43 14 0 5.42e-10 9.04e-09 1.29e-07 44 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(6), HRAS(34), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), RASA1(18), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), THPO(1) 22846537 239 180 152 22 24 79 55 48 32 1 4.14e-13 9.56e-09 1.34e-07 45 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(5), FURIN(1), NOTCH1(99) 7155733 110 101 105 14 19 20 17 11 42 1 1.83e-05 3.27e-08 4.47e-07 46 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), MAPK1(9), PDK1(3), PIK3CA(97), PIK3CD(8), PTEN(14), PTK2B(4), RBL2(6), SHC1(2), SOS1(9) 15587139 170 142 102 17 22 65 22 44 17 0 2.16e-10 5.72e-08 7.67e-07 47 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(21), AKT1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(13), HRAS(34), MAPK1(9), MAPK14(2), PIK3CA(97), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAC1(15), RPS6KA1(10), RPS6KA5(5), SOS1(9) 22218433 260 197 160 28 44 86 57 51 22 0 5.25e-13 6.53e-08 8.56e-07 48 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(2), CASP3(2), CASP8(60), CASP9(1), GZMB(2), JUN(1), PRF1(5) 9834123 98 84 86 8 8 17 13 19 39 2 1.98e-05 1.04e-07 1.33e-06 49 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(11), INPPL1(8), PDK2(1), PDPK1(4), PIK3CA(97), PIK3R1(9), PTEN(14), RPS6KB1(4) 15044317 171 140 109 18 14 71 18 42 26 0 1.00e-09 1.89e-07 2.38e-06 50 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(13), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), RASA1(18), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3) 26591527 262 195 175 28 27 82 63 52 37 1 2.05e-12 2.25e-06 2.77e-05 51 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIK(2), BIRC2(3), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), DIABLO(1) 10232772 98 83 86 8 7 22 12 14 41 2 7.01e-06 7.76e-06 9.37e-05 52 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(21), ARHGEF1(8), F2(3), F2R(4), F2RL3(3), GNA12(1), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3CA(97), PIK3R1(9), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2B(4), ROCK1(19) 19736653 217 174 153 27 22 76 47 53 19 0 4.38e-10 1.37e-05 0.000163 53 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(1), BTK(8), CDKN2A(114), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(8), PDK1(3), PIK3CA(97), PPP1R13B(2), PTEN(14), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 27469217 352 257 231 45 22 87 53 65 121 4 6.20e-12 0.000171 0.00198 54 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(21), AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CSF2RB(7), IGF1(1), IGF1R(11), IL3(1), IL3RA(5), KIT(12), KITLG(1), PIK3CA(97), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), YWHAH(2) 16730228 189 153 127 29 16 76 29 47 21 0 2.78e-08 0.00122 0.0139 55 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(1), CHRNG(8), MUSK(8), PIK3CA(97), PIK3R1(9), PTK2(8), PTK2B(4), SRC(1), TERT(3), YWHAH(2) 12504672 144 132 83 22 9 62 20 39 14 0 4.55e-07 0.00139 0.0156 56 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(4), GHR(9), HRAS(34), INSR(3), IRS1(2), JAK2(5), MAP2K1(5), MAPK1(9), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(2), SLC2A4(3), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5) 25219882 233 179 141 25 31 82 58 45 17 0 4.01e-13 0.00164 0.0181 57 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NFKB1(5), PIK3CA(97), PIK3R1(9), RB1(17), RELA(2), SP1(3) 14792898 170 149 102 25 20 61 23 36 30 0 1.09e-05 0.00289 0.0312 58 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), HRAS(34), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3CA(97), PIK3R1(9), RAF1(3), SOS1(9), STAT1(8), STAT5A(3), STAT5B(5) 21468970 211 160 124 27 19 81 50 42 19 0 1.42e-09 0.00418 0.0444 59 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(6), JUN(1), KEAP1(24), MAPK1(9), MAPK14(2), MAPK8(4), NFE2L2(28), PRKCA(7) 6789875 82 73 65 12 16 16 26 15 9 0 0.000904 0.00430 0.0449 60 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(7), BIRC3(2), CASP8(60), FADD(3), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 6427884 81 70 69 12 8 14 13 11 33 2 0.000966 0.00465 0.0478 61 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(16), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND2(2), CCNE1(4), CCNE2(4), CDAN1(5), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(3), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CDKN2A(114), CHEK1(1), CHEK2(4), DTX4(5), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), EP300(38), ESPL1(9), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), HDAC8(1), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(2), RB1(17), RBL1(12), SKP2(4), SMAD4(14), TBC1D8(4), TFDP1(2), TGFB1(1), TP53(432), WEE1(2) 83761194 897 438 610 109 121 127 148 140 348 13 <1.00e-15 0.0103 0.104 62 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(4), PIK3CA(97), PIK3R1(9), PTEN(14), RPS6KB1(4), TSC1(3), TSC2(7) 21101179 192 156 130 23 11 75 30 42 34 0 1.90e-08 0.0239 0.238 63 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(11), HRAS(34), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(5), MAPK1(9), MAPK8(4), MET(4), PAK1(3), PIK3CA(97), PIK3R1(9), PTEN(14), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAF1(3), RAP1B(3), RASA1(18), SOS1(9), SRC(1), STAT3(6) 33604945 314 224 217 36 42 82 75 69 45 1 1.53e-12 0.0394 0.386 64 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), GHR(9), IRS1(2), MAPK1(9), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3CA(97), PIK3R1(9), PRKCA(7), PTEN(14), RPS6KB1(4) 21491871 205 165 136 27 15 79 30 45 36 0 7.03e-08 0.0616 0.593 65 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CUL1(11), FBXW7(34), RB1(17), TFDP1(2) 6275262 72 64 63 12 7 13 16 8 27 1 0.0422 0.0635 0.602 66 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(8), EGFR(19), ELK1(2), FOS(6), HRAS(34), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), RASA1(18), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3) 28544479 276 207 189 33 27 84 66 59 38 2 2.28e-11 0.0761 0.710 67 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(6), HRAS(34), JUN(1), MAP2K1(5), MAPK1(9), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RAF1(3), RELA(2) 11863866 103 92 69 15 22 18 43 11 9 0 0.000101 0.148 1.000 68 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(37), EP300(38), FYN(4), IL7(2), IL7R(6), JAK1(10), JAK3(6), LCK(5), NMI(6), PIK3CA(97), PIK3R1(9), PTK2B(4), STAT5A(3), STAT5B(5) 21310688 233 186 164 31 17 83 37 59 36 1 2.26e-10 0.150 1.000 69 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF1(2), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(14), HIF1A(4), HRAS(34), KDR(14), NOS3(4), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PXN(2), SHC1(2) 25890479 265 194 180 32 37 88 59 57 24 0 1.78e-11 0.192 1.000 70 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 387333 2 2 2 0 0 0 0 0 2 0 0.660 0.289 1.000 71 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(1), EGR1(4), HRAS(34), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), NGFR(1), RAF1(3) 6230019 68 60 37 12 22 9 27 5 5 0 0.00158 0.297 1.000 72 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2) 4654771 25 23 25 2 5 7 5 5 3 0 0.0271 0.363 1.000 73 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(97), PIK3CD(8), PIK3R1(9), SYT1(9), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 25721276 204 164 136 29 31 73 31 42 27 0 6.51e-10 0.420 1.000 74 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(21), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(6), MAPK1(9), PDGFRA(13), PIK3CA(97), PIK3R1(9), PLCB1(22), PRKCA(7), PTK2(8), RAC1(15), SRC(1) 20907390 222 180 145 32 29 78 43 50 22 0 2.81e-09 0.486 1.000 75 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), IL6(2), IL6R(6), IL6ST(5), JAK1(10), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT3(6) 18144822 113 98 89 12 21 16 45 19 12 0 8.82e-06 0.489 1.000 76 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(2), CXCL12(3), CXCR4(2), GNAI1(2), GNB1(3), HRAS(34), MAP2K1(5), MAPK1(9), NFKB1(5), PIK3C2G(11), PIK3CA(97), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PTK2B(4), PXN(2), RAF1(3), RELA(2) 21106112 220 168 127 30 31 69 49 49 22 0 1.21e-08 0.500 1.000 77 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(12), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP7(3), CASP8(60), CASP9(1), GZMB(2), PRF1(5), SCAP(8), SREBF1(5), SREBF2(5) 13878813 110 91 98 14 12 21 19 17 39 2 0.000107 0.536 1.000 78 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(6) 1385935 9 9 9 2 1 3 2 2 1 0 0.347 0.596 1.000 79 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(34), PTK2B(4), SHC1(2), SOS1(9), SRC(1) 6719376 51 45 27 8 13 6 24 6 2 0 0.0340 0.641 1.000 80 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(12), ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), GZMB(2), LMNA(1), LMNB1(2), LMNB2(8), PRF1(5) 14723171 116 93 104 14 12 23 18 21 40 2 5.86e-05 0.649 1.000 81 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(15), C5(10), C6(23), C7(12), C8A(8), C9(15) 9584407 83 70 82 13 11 22 24 14 12 0 0.00648 0.659 1.000 82 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(4) 1259018 6 6 6 2 1 3 2 0 0 0 0.649 0.692 1.000 83 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(4), CHEK1(1), NEK1(9), WEE1(2) 5234638 19 19 19 1 4 4 6 1 4 0 0.0923 0.727 1.000 84 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(5), APC(27), AXIN1(12), BTRC(1), CTNNB1(6), DLL1(5), DVL1(8), FZD1(6), GSK3B(3), NOTCH1(99), WNT1(2) 16455991 174 134 168 29 31 35 31 23 52 2 8.00e-05 0.735 1.000 85 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(2), RAB3A(2), RAB4A(1), RAB5A(3) 3216067 13 13 13 1 5 4 2 1 1 0 0.0409 0.737 1.000 86 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(6) 1540877 12 12 12 3 0 4 5 2 1 0 0.411 0.761 1.000 87 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(27), CDH1(5), CREBBP(37), EP300(38), MAP2K1(5), MAP3K7(8), SKIL(4), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26) 19554277 158 125 139 22 20 31 36 32 38 1 0.000179 0.762 1.000 88 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(3), UXS1(2) 2930825 10 10 10 0 0 1 5 3 1 0 0.131 0.779 1.000 89 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2) 1803977 7 7 6 2 0 1 0 3 3 0 0.747 0.790 1.000 90 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 550302 1 1 1 1 0 0 0 1 0 0 0.924 0.819 1.000 91 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(10), RDH5(1) 2972225 12 12 12 2 1 1 5 2 3 0 0.404 0.824 1.000 92 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 1699430 7 7 7 2 1 4 1 0 1 0 0.418 0.838 1.000 93 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), HRAS(34), IL2RA(2), IL2RB(3), IRS1(2), JAK1(10), JAK3(6), MAPK1(9), MYC(6), NMI(6), PIK3CA(97), PIK3R1(9), PTPN6(3), RAF1(3), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 27557882 243 179 149 31 30 88 53 49 23 0 3.94e-12 0.843 1.000 94 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(3), UGP2(2), UXS1(2) 3731305 12 12 12 0 0 1 7 3 1 0 0.0936 0.850 1.000 95 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(1), RXRA(4) 4408546 15 15 15 1 2 4 5 2 2 0 0.0366 0.854 1.000 96 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(37), EP300(38), ESR1(5), MAPK1(9), PELP1(2), SRC(1) 11235505 92 83 77 15 16 17 20 16 22 1 0.00219 0.890 1.000 97 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(4), SNCA(1), SNCAIP(4), UBE2L3(2), UBE2L6(2) 4900386 23 21 23 4 4 5 5 7 2 0 0.140 0.896 1.000 98 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), HRAS(34), ITGA1(4), ITGB1(15), MAP2K1(5), MAPK1(9), PLA2G4A(3), PLCB1(22), PRKCA(7), PTGS1(7), PTK2(8), RAF1(3), SRC(1), SYK(8), TBXAS1(5) 18579177 146 118 113 22 29 22 52 22 21 0 8.30e-05 0.921 1.000 99 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(5), PRKCA(7), TGM2(4) 3767281 19 19 19 4 2 6 5 3 3 0 0.104 0.925 1.000 100 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(2), GRIA2(16), JUND(1) 2848398 22 22 22 7 4 5 10 2 1 0 0.393 0.940 1.000 101 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1163469 1 1 1 0 0 0 0 1 0 0 0.757 0.950 1.000 102 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT2(2), FUT9(11), GCNT2(5), ST8SIA1(3) 4707553 24 23 23 5 3 6 13 2 0 0 0.153 0.957 1.000 103 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(10), DIAPH1(7), FYN(4), GSN(5), HRAS(34), ITGA1(4), ITGB1(15), MAP2K1(5), MAPK1(9), MYLK(8), PFN1(1), PIK3CA(97), PIK3R1(9), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SRC(1), TLN1(22) 28462554 265 193 172 37 37 78 60 62 28 0 1.17e-08 0.960 1.000 104 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(6), CHST13(7), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2) 7066234 43 39 43 7 11 7 11 8 6 0 0.0371 0.963 1.000 105 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(5), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2) 2309391 11 11 10 4 0 3 4 0 4 0 0.699 0.969 1.000 106 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(37), EP300(38), LPL(4), NCOA1(7), NCOA2(9), PPARG(1), RXRA(4) 14090413 100 86 92 15 11 22 24 22 20 1 0.00178 0.970 1.000 107 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2) 6648166 27 25 27 4 1 5 10 7 4 0 0.128 0.971 1.000 108 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 862651 1 1 1 1 0 0 1 0 0 0 0.944 0.972 1.000 109 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(4), AKT3(6), BRD4(10), CAP1(3), CBL(3), CDC42(3), CDKN2A(114), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), LNPEP(5), MAPK1(9), PARD3(14), PARD6A(1), PDK1(3), PIK3CA(97), PIK3CD(8), PIK3R1(9), PTEN(14), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SERPINB6(4), SFN(7), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 45409625 437 284 308 60 50 104 69 73 138 3 3.79e-14 0.974 1.000 110 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(13), GNB1(3), PRKACA(4), PRKAR1A(4) 5059800 45 38 44 8 15 6 14 6 4 0 0.0427 0.979 1.000 111 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(2), EPO(2), EPOR(1), FOS(6), HRAS(34), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(9), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5) 16354879 101 87 77 14 19 20 44 8 10 0 0.000246 0.982 1.000 112 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(4) 3907972 15 14 15 3 3 3 6 2 1 0 0.191 0.983 1.000 113 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(4), HRAS(34), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PIK3CA(97), PIK3R1(9), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(4), RAC1(15), RAF1(3), RASA1(18), RELA(2), SHC1(2), SOS1(9), SYT1(9), VAV1(7), ZAP70(4) 36479551 312 219 218 42 44 87 74 62 44 1 4.72e-11 0.986 1.000 114 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(5), CES1(6), ESD(3) 4610630 20 19 20 4 3 9 6 0 2 0 0.101 0.987 1.000 115 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(1), IL12B(3), IL18(1), IL2(2) 2272852 11 11 11 4 1 1 2 4 3 0 0.838 0.988 1.000 116 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), HRAS(34), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PAK2(8), PIK3CA(97), PIK3R1(9), PLA2G4A(3), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7) 32809920 293 210 201 42 43 84 70 63 32 1 2.23e-09 0.988 1.000 117 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4) 1302996 4 4 4 3 0 1 2 0 1 0 0.872 0.989 1.000 118 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(3), AASS(3), KARS(4) 3590576 13 13 13 3 1 2 2 3 5 0 0.441 0.990 1.000 119 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(3) 4066446 22 20 22 6 1 1 11 1 8 0 0.486 0.992 1.000 120 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2), TAT(2) 2001633 5 5 5 2 0 0 3 1 1 0 0.768 0.992 1.000 121 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(4), GAD1(4), GAD2(6), GGT1(4) 4389193 22 22 22 5 4 6 5 2 5 0 0.173 0.992 1.000 122 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(2) 1605413 7 7 7 3 1 2 3 1 0 0 0.692 0.994 1.000 123 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C6(23), C7(12), C8A(8), C9(15) 13364210 99 82 98 18 11 30 29 16 13 0 0.00534 0.997 1.000 124 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(6), FOSL1(3), FOSL2(10), IFNAR1(2), IFNAR2(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3) 8459745 41 38 41 8 6 9 10 7 9 0 0.226 0.997 1.000 125 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(1), SPCS1(2), SPCS3(1) 2326227 6 6 6 5 0 2 1 0 3 0 0.911 0.997 1.000 126 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4) 4292194 13 12 13 4 1 3 2 2 5 0 0.634 0.998 1.000 127 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SEC61A2(4), SRP54(2), SRP68(5), SRP72(1), SRPR(3) 5742620 18 17 18 3 3 8 5 1 1 0 0.168 0.998 1.000 128 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2) 2762619 18 14 18 6 1 8 5 2 2 0 0.389 0.999 1.000 129 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4) 6173621 34 32 34 9 5 7 12 6 4 0 0.286 0.999 1.000 130 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1) 3023870 14 14 13 5 0 4 3 4 3 0 0.703 0.999 1.000 131 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 3691094 12 10 12 3 0 4 3 3 2 0 0.472 0.999 1.000 132 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(5), CD3D(1), CD4(1), CD58(2), CD8A(3), IL3(1), IL6(2), KITLG(1) 4712361 17 16 17 5 2 2 2 4 7 0 0.535 0.999 1.000 133 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1) 3259670 9 9 9 3 2 5 1 1 0 0 0.406 0.999 1.000 134 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(2), HMGCL(1), OXCT1(1) 2574695 4 4 4 2 1 0 1 0 2 0 0.857 0.999 1.000 135 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(15), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MYOD1(2), YWHAH(2) 5871852 47 41 47 11 7 9 13 11 7 0 0.151 0.999 1.000 136 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(4), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(4) 4151822 19 18 18 5 4 5 5 1 4 0 0.308 0.999 1.000 137 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 4121663 14 14 14 4 2 3 4 4 1 0 0.547 0.999 1.000 138 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3) 7784242 33 32 33 6 7 9 8 3 6 0 0.0490 0.999 1.000 139 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(3), STX1A(5) 2478478 8 8 8 3 4 0 3 1 0 0 0.726 0.999 1.000 140 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(4), CDC34(4), CUL1(11), RB1(17), SKP2(4), TFDP1(2) 6487151 49 43 49 12 4 11 12 5 17 0 0.218 1.000 1.000 141 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(3), GLUD2(10) 3476172 16 16 16 6 4 1 4 3 4 0 0.749 1.000 1.000 142 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(6), CTH(3), MUT(5) 3737326 18 17 18 5 2 6 4 3 3 0 0.473 1.000 1.000 143 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(10), JAK2(5), STAT1(8) 6237387 33 29 32 9 2 9 8 5 9 0 0.257 1.000 1.000 144 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(2), TAT(2), TYR(8) 3584284 20 18 20 6 2 3 10 1 4 0 0.520 1.000 1.000 145 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(2), IDI1(1) 2437437 7 7 7 3 2 4 1 0 0 0 0.550 1.000 1.000 146 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(2) 3054940 16 15 16 6 2 3 6 2 3 0 0.686 1.000 1.000 147 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(8), EGFR(19), FOS(6), HRAS(34), JUN(1), MYC(6), NFKB1(5), PLCG1(9), PRKCA(7), RELA(2) 15673598 119 104 93 26 19 23 50 17 9 1 0.0149 1.000 1.000 148 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(4), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2) 6778760 25 22 25 5 4 8 10 1 2 0 0.137 1.000 1.000 149 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26), TGFBR3(5), TOB2(3) 8052696 53 48 44 12 7 12 8 13 13 0 0.116 1.000 1.000 150 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(5), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2) 4060506 18 18 17 6 1 4 8 2 3 0 0.600 1.000 1.000 151 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(3), CD3D(1), CD4(1) 2444270 5 5 5 3 0 0 1 3 1 0 0.904 1.000 1.000 152 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5051402 26 25 26 7 4 3 7 7 5 0 0.331 1.000 1.000 153 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5051402 26 25 26 7 4 3 7 7 5 0 0.331 1.000 1.000 154 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C6(23), C7(12), C8A(8), C9(15), MASP1(7), MASP2(5), MBL2(2) 16264792 113 90 111 21 13 32 29 23 16 0 0.00372 1.000 1.000 155 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(8), EGFR(19), HRAS(34), MAP2K1(5), MAPK1(9), PTPRB(22), RAF1(3), RASA1(18), SHC1(2), SOS1(9), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), SRC(1) 19011879 145 127 112 27 27 17 51 25 23 2 0.00744 1.000 1.000 156 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), FOS(6), HRAS(34), IL3(1), IL3RA(5), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5) 13480436 88 75 64 16 15 19 37 10 7 0 0.00447 1.000 1.000 157 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(6), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(3) 8163969 38 34 38 9 5 7 8 13 5 0 0.302 1.000 1.000 158 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 6045395 23 21 23 5 6 3 7 2 5 0 0.307 1.000 1.000 159 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(1), FARSB(8), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6), YARS2(4) 6628304 36 34 36 9 2 11 13 5 5 0 0.159 1.000 1.000 160 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1) 5951533 17 16 17 4 2 4 5 4 2 0 0.379 1.000 1.000 161 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(21), CAP1(3), CCNB1(2), CDC25C(4), GNAI1(2), GNAS(13), GNB1(3), HRAS(34), MAPK1(9), MYT1(11), PIN1(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10), SRC(1) 15682920 134 108 102 23 40 23 43 15 13 0 0.000158 1.000 1.000 162 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(6), SDHB(1), SDHC(1), UQCRC1(1) 5040611 16 16 15 4 1 4 6 4 1 0 0.399 1.000 1.000 163 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(3), HTR2C(4), PLCB1(22), TUB(3) 5443928 32 32 31 9 7 5 13 5 2 0 0.331 1.000 1.000 164 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BCL2(1), CASP8(60), FADD(3), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), TNFRSF1A(2), TRADD(1), TRAF2(2) 15689077 114 95 95 23 20 14 24 14 40 2 0.0146 1.000 1.000 165 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6) 10687545 47 41 47 8 11 11 12 6 7 0 0.0219 1.000 1.000 166 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(4) 5293186 18 18 18 5 1 2 3 6 6 0 0.542 1.000 1.000 167 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(5), ST6GALNAC2(2), ST8SIA1(3) 4308320 17 17 17 5 4 4 4 2 3 0 0.295 1.000 1.000 168 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(1), CREBBP(37), EP300(38), NCOA3(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RARA(5), RXRA(4) 15740639 114 99 106 23 18 28 22 19 26 1 0.00888 1.000 1.000 169 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(1), FOS(6), FYN(4), JUN(1), MAPK14(2), THBS1(8) 5649868 24 22 24 7 3 6 5 6 4 0 0.310 1.000 1.000 170 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NFS1(1), PHPT1(1), TPK1(3) 4877663 14 13 14 4 3 3 4 3 1 0 0.567 1.000 1.000 171 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(8), ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(24), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(1), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(4), CDC26(1), CDC27(9), CDC6(2), CDC7(1), CDK4(5), CDK6(1), CDKN1B(2), CDKN2A(114), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(4), CREBBP(37), CUL1(11), DBF4(3), E2F2(3), E2F3(3), EP300(38), ESPL1(9), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(17), RBL1(12), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMAD4(14), SMC1A(3), SMC1B(7), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), TP53(432), WEE1(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 103644718 998 442 709 135 127 154 174 168 361 14 <1.00e-15 1.000 1.000 172 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(6), CREBBP(37), DUSP1(2), EP300(38), IKBKB(11), IL1B(1), MAP2K3(5), MAP2K6(1), MAP3K7(8), MAPK11(3), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TGFBR2(26), TLR2(2) 22645337 158 131 140 29 22 32 35 28 40 1 0.00111 1.000 1.000 173 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(2), BLNK(4), ELK1(2), FOS(6), HRAS(34), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK1(9), MAPK8IP3(9), PAPPA(13), RAC1(15), RPS6KA1(10), RPS6KA3(4), SHC1(2), SOS1(9), SYK(8), VAV1(7), VAV2(4), VAV3(4) 24442044 163 126 125 26 45 23 50 21 24 0 5.62e-05 1.000 1.000 174 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(12), BAD(1), BAK1(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(6) 8339516 29 29 29 6 4 9 4 5 7 0 0.240 1.000 1.000 175 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C6(23), C7(12), C8A(8), C8B(9), C9(15), MASP1(7) 15876165 115 92 113 24 13 31 33 22 16 0 0.0145 1.000 1.000 176 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(10), COPS5(2), CREB1(1), EDN1(1), EP300(38), EPO(2), HIF1A(4), JUN(1), LDHA(1), NOS3(4), P4HB(1) 12947788 74 72 67 14 12 20 13 15 14 0 0.0167 1.000 1.000 177 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(3) 4614627 23 23 23 8 3 2 11 2 5 0 0.621 1.000 1.000 178 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(22), NRG2(5), NRG3(19), PRKCA(7) 6848799 58 52 58 15 4 10 22 12 10 0 0.333 1.000 1.000 179 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(3) 3169211 9 9 9 5 3 0 3 1 2 0 0.886 1.000 1.000 180 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(37), GZMA(2), GZMB(2), HMGB2(2), PRF1(5), SET(1) 8090593 51 44 50 12 9 8 14 10 9 1 0.145 1.000 1.000 181 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), IMPA2(2), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3) 8888555 39 37 39 9 9 10 10 3 7 0 0.0645 1.000 1.000 182 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1), PPT2(2) 6455846 26 23 26 7 2 3 9 8 4 0 0.433 1.000 1.000 183 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6) 6576401 22 21 22 5 6 6 2 5 3 0 0.290 1.000 1.000 184 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(11), PDXK(1), PSAT1(1) 3694776 13 11 13 6 1 2 2 6 2 0 0.850 1.000 1.000 185 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(2), IL6(2), LDLR(4), LPL(4) 4050270 14 14 13 5 2 4 6 1 1 0 0.567 1.000 1.000 186 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(11), WEE1(2), YWHAH(2) 10473104 43 37 43 8 7 10 10 8 8 0 0.169 1.000 1.000 187 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1) 6363842 18 16 18 5 1 3 7 5 2 0 0.569 1.000 1.000 188 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(6), CREBBP(37), EP300(38), FADD(3), HDAC3(4), IKBKB(11), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3) 17105714 117 106 109 23 16 24 29 22 25 1 0.00682 1.000 1.000 189 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3) 5296122 15 14 15 4 3 5 5 1 1 0 0.423 1.000 1.000 190 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(3), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), IL9(2) 4632206 20 20 20 9 4 3 7 3 3 0 0.751 1.000 1.000 191 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(1), FHL5(5), FSHB(2), FSHR(12), GNAS(13), XPO1(6) 7324088 60 51 59 13 14 11 19 13 3 0 0.127 1.000 1.000 192 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6) 10275904 47 41 47 9 3 9 18 6 11 0 0.0963 1.000 1.000 193 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), CDKN2A(114), FLOT1(2), FLOT2(3), GAB1(5), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PHF11(1), PIK3CA(97), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(14), PTEN(14), PTPRC(18), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SAG(1), SYK(8), TEC(2), VAV1(7) 41950991 411 273 289 69 36 104 54 77 136 4 2.87e-11 1.000 1.000 194 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(2), FOS(6), HRAS(34), IL2(2), IL2RA(2), IL2RB(3), JAK1(10), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 17754994 117 97 93 23 17 22 47 14 17 0 0.00247 1.000 1.000 195 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(3), OAT(1), PRODH(1) 4223754 7 7 7 3 0 1 1 3 2 0 0.754 1.000 1.000 196 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6) 9816929 38 33 38 8 1 8 14 10 5 0 0.213 1.000 1.000 197 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(5), ITPKB(5) 4623535 11 9 11 4 1 3 4 1 2 0 0.609 1.000 1.000 198 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(2), IRS2(6), JAK1(10), JAK3(6), MAP4K1(5), MAPK1(9), PDK1(3), PIK3CA(97), PIK3CD(8), PIK3R1(9), PPP1R13B(2), RAF1(3), SHC1(2), SOCS1(1), SOS1(9), SOS2(11), STAT6(5) 27924885 215 164 147 34 28 77 37 54 19 0 3.97e-08 1.000 1.000 199 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(3), MDH1(1), ME1(2), PC(14), PDHA1(4) 7071633 28 28 28 8 4 8 6 5 5 0 0.279 1.000 1.000 200 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDKN1B(2), CKS1B(3), CUL1(11), NEDD8(2), RB1(17), RBX1(3), SKP2(4), TFDP1(2), UBE2M(3) 6526682 51 47 51 14 3 12 10 7 19 0 0.291 1.000 1.000 201 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(2), CCL2(2), CCL4(1), CXCL12(3), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(9), PRKCA(7), PTK2B(4), SYT1(9) 10511573 55 49 55 13 8 10 19 14 4 0 0.0943 1.000 1.000 202 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GGT1(4), SHMT1(1), SHMT2(3) 4201908 11 11 11 5 5 1 2 1 2 0 0.722 1.000 1.000 203 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(34), MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1) 5729928 57 51 33 18 9 12 24 9 3 0 0.313 1.000 1.000 204 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(9), GLI2(16), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3) 12690994 71 62 70 16 12 18 24 8 9 0 0.0393 1.000 1.000 205 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(4), JAK1(10), JAK2(5), PLA2G2A(2), PTPRU(10), REG1A(14), STAT1(8) 8711534 56 49 55 14 9 16 14 7 10 0 0.0874 1.000 1.000 206 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(11), EPHB1(15), FYN(4), ITGA1(4), ITGB1(15), L1CAM(10), LYN(8), RAP1B(3), SELP(16) 12031630 90 63 88 19 13 17 24 18 18 0 0.0606 1.000 1.000 207 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(4), BMPR1B(4), BMPR2(6) 4770080 14 14 14 5 3 4 4 1 2 0 0.655 1.000 1.000 208 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(5), TAX1BP3(1), UBE2D2(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2S(1), UBE3A(6) 8030648 27 25 27 8 3 11 7 1 5 0 0.419 1.000 1.000 209 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(12), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), CFLAR(2), CHUK(6), FADD(3), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2) 25526258 152 116 140 24 20 33 29 19 49 2 4.34e-05 1.000 1.000 210 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(14) 6426979 16 16 16 9 3 4 5 0 4 0 0.956 1.000 1.000 211 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHB(1), LDHC(4), MPST(2) 5220421 18 16 18 6 4 1 10 2 1 0 0.635 1.000 1.000 212 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(27), AXIN1(12), CCND1(3), CD14(1), CTNNB1(6), DVL1(8), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(7), LEF1(5), LY96(2), NFKB1(5), PDPK1(4), PIK3CA(97), PIK3R1(9), RELA(2), TIRAP(1), TLR4(17), TOLLIP(2), WNT1(2) 23531102 228 170 165 42 23 85 39 50 30 1 2.81e-06 1.000 1.000 213 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(10), CREB1(1), CREB5(7), MAPK1(9), RAF1(3), SNX13(2), SRC(1), TERF2IP(1) 8478575 35 26 28 9 9 5 9 6 6 0 0.378 1.000 1.000 214 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(9), CD3D(1), GZMB(2), HLA-A(24), ICAM1(6), ITGAL(8), ITGB2(3), PRF1(5) 6666688 58 50 54 17 5 7 8 8 30 0 0.289 1.000 1.000 215 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), EPO(2), EPOR(1), GRIN1(4), HIF1A(4), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1) 9683106 34 34 34 9 5 11 6 7 5 0 0.175 1.000 1.000 216 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(1), OXCT2(1) 5482791 12 11 12 8 3 2 2 3 2 0 0.943 1.000 1.000 217 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8) 9637613 52 46 50 14 4 9 15 8 16 0 0.291 1.000 1.000 218 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(11), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MYOD1(2), NFATC1(7), NFATC2(15), PIK3CA(97), PIK3R1(9), PPP3CA(2), PPP3CB(1), SYT1(9), YWHAH(2) 26591144 221 168 160 43 22 81 37 59 22 0 9.39e-07 1.000 1.000 219 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(4), ST3GAL4(1) 5514832 16 15 16 7 4 2 6 2 2 0 0.779 1.000 1.000 220 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST7(1), CHSY1(3), DSE(2), UST(2), XYLT1(10), XYLT2(3) 10714043 56 50 56 12 14 5 18 11 8 0 0.0709 1.000 1.000 221 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4) 6732916 19 16 19 9 2 6 6 2 3 0 0.937 1.000 1.000 222 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3) 7727050 35 32 35 10 7 7 13 4 4 0 0.196 1.000 1.000 223 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(7), BIRC2(3), BIRC3(2), CASP3(2), CASP8(60), CFLAR(2), FADD(3), JUN(1), MAP2K4(2), MAP3K3(2), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR2C2(1), RALBP1(3), RIPK1(2), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 20867862 125 101 112 25 18 29 21 15 40 2 0.00215 1.000 1.000 224 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(13), GNB1(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7) 7329209 40 35 40 10 13 9 9 4 5 0 0.185 1.000 1.000 225 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(2), SRC(1) 7005394 24 23 24 8 5 8 5 2 4 0 0.412 1.000 1.000 226 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(4), TGFB3(1) 6301711 23 20 23 9 6 2 8 5 2 0 0.655 1.000 1.000 227 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1) 5585129 17 17 16 6 3 2 6 5 1 0 0.740 1.000 1.000 228 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(6), JAK1(10), JAK2(5), JAK3(6), PIAS3(4), PTPRU(10), REG1A(14), SRC(1), STAT3(6) 11581437 65 61 65 16 13 11 22 12 7 0 0.0828 1.000 1.000 229 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(2), DDX20(4), E2F4(3), ETS1(5), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), HRAS(34), JUN(1), NCOR2(22), RBL1(12), RBL2(6), SIN3A(7), SIN3B(11) 19836865 128 96 104 28 23 32 42 17 14 0 0.00300 1.000 1.000 230 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(4), HDAC5(3), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(3), SYT1(9), YWHAH(2) 15446548 69 60 68 15 5 20 22 16 6 0 0.0323 1.000 1.000 231 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(2), IL1B(1), MST1R(9) 4965226 14 14 14 9 1 5 7 0 1 0 0.882 1.000 1.000 232 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(13), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(19), ELK1(2), HRAS(34), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), PAK1(3), PRKCA(7), PTK2(8), PTK2B(4), RAC1(15), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9) 25489133 196 148 158 36 39 36 69 35 17 0 0.000171 1.000 1.000 233 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAPN2(5), CAPNS1(2), CAPNS2(2), EP300(38), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(7), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(9) 18606142 112 96 104 27 16 27 26 24 19 0 0.0201 1.000 1.000 234 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(14), GNA12(1), PRKACB(3), PRKACG(2), PRKAR2B(3) 7662733 23 22 23 8 3 8 6 3 3 0 0.609 1.000 1.000 235 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL12A(1), IL12B(3), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4) 7576239 35 33 35 11 7 8 10 6 4 0 0.424 1.000 1.000 236 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB5(7), CREBBP(37), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(11), PIK3CA(97), PIK3CD(8), PIK3R1(9), PTPN11(2), RPS6KA3(4), SHC1(2), SRC(1), TERF2IP(1), TH(3) 39241865 285 207 215 51 37 88 56 64 39 1 2.83e-07 1.000 1.000 237 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6) 11431730 49 45 49 12 10 13 11 8 7 0 0.0924 1.000 1.000 238 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(4), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(3) 5750455 13 13 13 8 1 3 4 4 1 0 0.935 1.000 1.000 239 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3) 8200744 36 33 36 11 7 7 14 4 4 0 0.241 1.000 1.000 240 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(10), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(10), REG1A(14), SOAT1(5) 10429753 56 52 56 15 11 10 18 9 8 0 0.208 1.000 1.000 241 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(19), ELK1(2), GNAS(13), GNB1(3), HRAS(34), IGF1R(11), ITGB1(15), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MKNK1(1), MKNK2(2), MYC(6), NGFR(1), PDGFRA(13), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(2), SOS1(9), SRC(1), STAT3(6) 25195800 183 136 149 32 49 31 65 21 17 0 8.51e-05 1.000 1.000 242 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(37), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), HRAS(34), IGF1(1), LIF(2), MAP2K1(5), MAPK1(9), MAPK14(2), MAPK8(4), MEF2C(15), MYH2(26), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKX2-5(1), NPPA(3), PIK3CA(97), PIK3R1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(4), SYT1(9) 38730617 346 228 253 66 46 106 87 65 41 1 3.02e-08 1.000 1.000 243 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(3), F2R(4), F3(2), F5(19), F7(2), FGA(12), FGB(4), FGG(6), PROC(2), PROS1(10), SERPINC1(4), TFPI(2) 12478498 73 57 73 19 6 23 21 13 10 0 0.158 1.000 1.000 244 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB5(7), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4) 21813257 102 84 94 22 21 26 23 15 17 0 0.0164 1.000 1.000 245 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(4), ACTN2(10), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(15), ITGB3(6), PTK2(8), PXN(2), RAC1(15), SPTAN1(23), SRC(1), TLN1(22) 21773866 121 95 113 24 23 21 42 22 13 0 0.00697 1.000 1.000 246 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(27), AXIN1(12), CREBBP(37), CTNNB1(6), DVL1(8), EP300(38), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(5), PITX2(2), TRRAP(22), WNT1(2) 25318669 171 123 162 33 29 38 37 33 32 2 0.000369 1.000 1.000 247 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MIOX(4), OCRL(3), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CA(97), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9) 34134254 270 198 204 48 37 82 60 61 30 0 2.10e-07 1.000 1.000 248 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9) 7035680 32 29 32 10 6 8 10 6 2 0 0.343 1.000 1.000 249 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(4), AFMID(5), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3) 10194513 53 46 53 16 7 14 18 8 5 1 0.385 1.000 1.000 250 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(1), CAMKK2(6), CREB1(1), SYT1(9) 8808971 36 36 36 11 4 8 13 8 3 0 0.497 1.000 1.000 251 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(4), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), LALBA(1), LCT(17), MGAM(29), PFKM(6), PFKP(5), PGM1(5), PGM3(1) 24759228 116 96 115 25 20 29 31 15 20 1 0.00492 1.000 1.000 252 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(2), EGF(8), EGFR(19), MET(4), PDGFRA(13), PRKCA(7), SH3GLB1(1), SH3GLB2(3), SH3KBP1(8), SRC(1) 14777379 69 65 69 20 9 13 23 12 11 1 0.239 1.000 1.000 253 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(19), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(22), RARA(5), RXRA(4), THRA(5), THRB(1) 13159977 77 65 77 22 13 11 23 15 14 1 0.254 1.000 1.000 254 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(3), LCT(17), MPI(4), PGM1(5), PYGL(9), PYGM(8), TPI1(4) 10161153 54 43 54 17 10 14 14 9 7 0 0.195 1.000 1.000 255 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(6), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(3) 8624495 38 36 38 12 5 13 9 6 5 0 0.396 1.000 1.000 256 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(1), ARRB2(1), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(4), CACNB2(6), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(3), CACNG6(5), CACNG7(5), CACNG8(7), CASP3(2), CD14(1), CDC25B(4), CDC42(3), CHUK(6), CRK(2), CRKL(3), DAXX(6), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(3), EGF(8), EGFR(19), ELK1(2), ELK4(3), FAS(5), FASLG(1), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FLNA(24), FLNB(9), FLNC(19), FOS(6), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(34), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAPT(9), MAX(1), MEF2C(15), MKNK1(1), MKNK2(2), MOS(7), MYC(6), NF1(14), NFATC2(15), NFATC4(3), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(13), PDGFRB(9), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(4), PTPRR(5), RAC1(15), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA1(18), RASA2(7), RASGRF1(17), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(2), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(2), TAOK1(5), TAOK2(11), TAOK3(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26), TNFRSF1A(2), TP53(432), TRAF2(2), TRAF6(3), ZAK(5) 217928756 1627 475 1349 368 313 292 402 243 364 13 <1.00e-15 1.000 1.000 257 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(27), APC2(6), AXIN1(12), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(3), CCND2(2), CER1(1), CHD8(18), CREBBP(37), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTBP1(2), CTBP2(2), CTNNB1(6), CUL1(11), CXXC4(3), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(8), DVL2(1), DVL3(9), EP300(38), FBXW11(3), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(5), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(4), MMP7(1), MYC(6), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKD1(8), NKD2(3), NLK(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PORCN(3), PPARD(3), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAC1(15), RAC2(3), RAC3(3), RBX1(3), RHOA(10), ROCK1(19), ROCK2(11), SENP2(3), SFRP1(2), SFRP4(11), SFRP5(1), SIAH1(4), SKP1(1), SMAD2(4), SMAD3(4), SMAD4(14), SOX17(2), TBL1X(6), TBL1XR1(4), TBL1Y(3), TCF7(2), TCF7L1(2), TCF7L2(1), TP53(432), VANGL1(1), VANGL2(6), WIF1(1), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3) 123358277 1157 462 915 208 196 194 277 189 289 12 <1.00e-15 1.000 1.000 258 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(1), BCAR1(3), BCL2(1), BIRC2(3), BIRC3(2), BRAF(10), CAPN2(5), CAV1(1), CCND1(3), CCND2(2), CDC42(3), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(8), EGFR(19), ELK1(2), ERBB2(12), FARP2(4), FIGF(1), FLNA(24), FLNB(9), FLNC(19), FLT1(17), FN1(18), FYN(4), GSK3B(3), HGF(11), HRAS(34), IBSP(4), IGF1(1), IGF1R(11), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), JUN(1), KDR(14), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), MAP2K1(5), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PDPK1(4), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTEN(14), PTK2(8), PXN(2), RAC1(15), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(50), RHOA(10), ROCK1(19), ROCK2(11), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SPP1(2), SRC(1), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TLN1(22), TLN2(12), TNC(12), TNN(21), TNR(21), TNXB(25), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2) 283126099 1662 440 1548 484 258 379 504 269 246 6 0.000177 1.000 1.000 259 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(4), ACTN2(10), ACTN4(6), APC(27), APC2(6), ARAF(3), ARHGEF1(8), ARHGEF12(11), ARHGEF4(5), ARHGEF6(7), ARHGEF7(2), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), BCAR1(3), BDKRB1(2), BDKRB2(3), BRAF(10), CD14(1), CDC42(3), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CRK(2), CRKL(3), CSK(1), CYFIP1(8), CYFIP2(8), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(8), EGFR(19), F2(3), F2R(4), FGD1(11), FGD3(5), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FN1(18), GIT1(5), GNA12(1), GNA13(2), GNG12(1), GSN(5), HRAS(34), IQGAP1(11), IQGAP2(7), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(6), MAP2K1(5), MAP2K2(6), MAPK1(9), MOS(7), MSN(3), MYH10(24), MYH14(7), MYH9(23), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), NCKAP1(8), NCKAP1L(7), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(13), PDGFRB(9), PFN1(1), PFN2(1), PFN4(1), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(4), PTK2(8), PXN(2), RAC1(15), RAC2(3), RAC3(3), RAF1(3), RDX(1), RHOA(10), ROCK1(19), ROCK2(11), RRAS(2), RRAS2(2), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(6), SSH2(7), SSH3(4), TIAM1(15), TIAM2(14), TMSB4Y(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), WAS(2), WASF1(3), WASF2(5), WASL(2) 210552739 1164 403 1050 356 207 263 326 199 167 2 0.00451 1.000 1.000 260 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY7(6), ADCY8(28), ADCY9(9), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), AGTR1(13), ATP2A1(9), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), ATP2B4(6), AVPR1A(9), AVPR1B(6), BDKRB1(2), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(3), CD38(5), CHRM2(5), CHRM3(9), CHRM5(4), CHRNA7(2), CYSLTR1(2), CYSLTR2(6), DRD1(2), EDNRA(2), EDNRB(7), EGFR(19), ERBB2(12), ERBB3(17), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(13), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), LHCGR(9), LTB4R2(2), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(13), PDGFRB(9), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(6), PTGFR(2), PTK2B(4), RYR1(34), RYR2(76), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(15), SPHK2(3), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), TNNC2(1), TRHR(5), TRPC1(10) 205214407 1225 398 1219 420 261 262 347 199 155 1 0.00415 1.000 1.000 261 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(6), ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(13), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(3), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CNR1(3), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(6), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHB(2), FSHR(12), GABBR1(4), GABBR2(6), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GABRB1(6), GABRB2(7), GABRB3(13), GABRD(2), GABRE(9), GABRG1(11), GABRG2(8), GABRG3(6), GABRP(5), GABRQ(9), GABRR1(4), GABRR2(3), GALR1(3), GALR2(4), GALR3(2), GH1(4), GH2(4), GHR(9), GHRHR(3), GHSR(3), GIPR(2), GLP1R(1), GLP2R(5), GLRA1(4), GLRA2(5), GLRA3(3), GLRB(4), GNRHR(2), GPR156(5), GPR35(2), GPR50(7), GPR63(6), GPR83(1), GRIA1(16), GRIA2(16), GRIA3(8), GRIA4(11), GRID1(20), GRID2(19), GRIK1(8), GRIK2(16), GRIK3(7), GRIK4(6), GRIK5(8), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM6(4), GRM7(20), GRM8(24), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LEP(1), LEPR(17), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(2), MAS1(2), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), MCHR1(2), MCHR2(4), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR2(4), NPFFR2(18), NPY1R(5), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), P2RY1(5), P2RY10(5), P2RY11(4), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), P2RY8(3), PARD3(14), PRL(3), PRLHR(5), PRLR(9), PRSS1(9), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(6), PTGER4(8), PTGFR(2), PTGIR(3), PTH2R(11), RXFP1(6), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), THRA(5), THRB(1), TRHR(5), TRPV1(6), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(5) 169154506 1232 395 1224 435 215 233 405 212 166 1 0.0232 1.000 1.000 262 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(8), ABLIM1(5), ABLIM2(5), ABLIM3(6), ARHGEF12(11), CDC42(3), CDK5(3), CFL1(2), CXCL12(3), CXCR4(2), DCC(27), DPYSL2(4), DPYSL5(6), EFNA1(2), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA2(27), EPHA3(18), EPHA4(11), EPHA5(25), EPHA6(17), EPHA7(24), EPHA8(6), EPHB1(15), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(7), FYN(4), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(34), ITGB1(15), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(6), LRRC4C(30), MAPK1(9), MET(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLXNA1(23), PLXNA2(17), PLXNA3(16), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PTK2(8), RAC1(15), RAC2(3), RAC3(3), RASA1(18), RGS3(10), RHOA(10), RHOD(1), ROBO1(12), ROBO2(16), ROBO3(5), ROCK1(19), ROCK2(11), SEMA3A(13), SEMA3C(8), SEMA3D(5), SEMA3E(10), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(1), SEMA4C(3), SEMA4D(9), SEMA4F(5), SEMA4G(8), SEMA5A(27), SEMA5B(14), SEMA6A(3), SEMA6B(6), SEMA6C(2), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(26), SLIT3(9), SRGAP1(10), SRGAP2(2), SRGAP3(7), UNC5A(6), UNC5B(9), UNC5C(20), UNC5D(18) 150155271 1001 377 948 273 165 193 311 159 168 5 2.77e-05 1.000 1.000 263 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(4), ACTG1(3), CHAD(5), COL11A1(67), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(8), DSG2(4), DSG3(2), DSG4(5), FN1(18), GJA1(2), GJA10(8), GJA3(2), GJA4(1), GJA5(6), GJA8(7), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(4), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(12), KRT15(2), KRT16(2), KRT17(6), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(3), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(8), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(5), KRT35(4), KRT36(5), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(4), KRT72(5), KRT73(4), KRT74(8), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(3), KRT8(1), KRT82(6), KRT83(6), KRT84(1), KRT85(6), KRT86(4), KRT9(3), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), LMNA(1), LMNB1(2), LMNB2(8), NES(13), RELN(50), SPP1(2), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VIM(4), VTN(2), VWF(19) 190208792 1052 367 1043 358 169 211 356 148 163 5 0.390 1.000 1.000 264 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(9), CD36(1), CD44(3), CD47(1), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DAG1(5), FN1(18), FNDC1(15), FNDC3A(11), FNDC4(4), FNDC5(1), GP5(4), GP6(1), GP9(2), HMMR(3), HSPG2(23), IBSP(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), RELN(50), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VTN(2), VWF(19) 171183674 942 354 937 317 150 199 303 143 143 4 0.371 1.000 1.000 265 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(6), ARRB1(1), ARRB2(1), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(15), CACNB1(4), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), ITPR1(15), ITPR2(25), ITPR3(10), KCNB1(3), KCNJ3(9), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(15), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 142816320 838 346 834 297 177 191 229 130 109 2 0.0383 1.000 1.000 266 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(6), ASH1L(20), CASK(4), CDC42(3), CDK4(5), CGN(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTTN(10), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(23), EXOC3(3), EXOC4(15), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(34), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(13), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(8), MYH1(22), MYH10(24), MYH11(11), MYH13(27), MYH14(7), MYH15(13), MYH2(26), MYH3(15), MYH4(18), MYH6(19), MYH7(16), MYH7B(6), MYH8(26), MYH9(23), MYL7(2), MYL9(4), NRAS(1), OCLN(1), PARD3(14), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP2R3A(12), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PTEN(14), RAB13(2), RHOA(10), RRAS(2), RRAS2(2), SPTAN1(23), SRC(1), SYMPK(7), TJAP1(4), TJP1(13), TJP2(5), TJP3(6), VAPA(1), YES1(2), ZAK(5) 147976834 875 346 836 262 143 191 278 136 125 2 0.00678 1.000 1.000 267 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(3), CCND2(2), CISH(1), CNTFR(1), CREBBP(37), CRLF2(3), CSF2RA(1), CSF2RB(7), CSF3R(3), EP300(38), EPO(2), EPOR(1), GH1(4), GH2(4), GHR(9), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL13RA2(4), IL19(5), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), IRF9(2), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(3), PIAS1(1), PIAS2(4), PIAS3(4), PIAS4(3), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIM1(3), PRL(3), PRLR(9), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(6), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(8), STAT2(4), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(12), TSLP(3), TYK2(8) 110827061 673 332 597 172 78 171 179 144 100 1 4.90e-05 1.000 1.000 268 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(3), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(7), CACNB3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(6), GJA1(2), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), GSTO1(2), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(1), IL6(2), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(3), PDE4B(7), PDE4D(6), PKIG(1), PLCB3(9), PLCD1(5), PLCG1(9), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RAMP3(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(25), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 131871121 738 329 735 253 141 178 209 115 93 2 0.0430 1.000 1.000 269 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(16), ACACB(18), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(3), FOXO1(4), G6PC(2), G6PC2(6), GCK(4), GSK3B(3), GYS1(6), GYS2(6), HRAS(34), IKBKB(11), INPP5D(8), INSR(3), IRS1(2), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(4), PDE3A(19), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(14), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(16), PYGB(6), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(3), TSC2(7) 122145112 696 328 599 185 130 171 177 125 93 0 1.83e-05 1.000 1.000 270 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(4), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(10), CAV1(1), CDC42(3), CDKN2A(114), CRK(2), CSE1L(3), DOCK1(15), EPHB2(3), FYN(4), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CA(97), PIK3CB(6), PKLR(3), PLCG1(9), PLCG2(9), PTEN(14), PTK2(8), RAF1(3), RHO(3), ROCK1(19), ROCK2(11), SHC1(2), SOS1(9), SOS2(11), SRC(1), TERF2IP(1), TLN1(22), TLN2(12), VASP(1), WAS(2), ZYX(2) 93237610 622 325 492 139 78 127 134 116 164 3 5.76e-07 1.000 1.000 271 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(4), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(1), CCL3(1), CCL4(1), CCL8(3), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(4), CNTFR(1), CRLF2(3), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(7), CSF3R(3), CX3CL1(4), CX3CR1(1), CXCL1(3), CXCL10(3), CXCL12(3), CXCL13(1), CXCL14(1), CXCL2(1), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(3), EDA2R(1), EDAR(2), EGF(8), EGFR(19), EPO(2), EPOR(1), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(14), GDF5(4), GH1(4), GH2(4), GHR(9), HGF(11), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(7), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(5), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), INHBA(3), INHBB(4), INHBC(3), INHBE(1), KDR(14), KIT(12), KITLG(1), LEP(1), LEPR(17), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(1), OSMR(3), PDGFB(1), PDGFC(3), PDGFRA(13), PDGFRB(9), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(3), PRLR(9), RELT(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(3), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(12), TSLP(3), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3) 135027413 691 312 678 225 109 132 212 124 113 1 0.154 1.000 1.000 272 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(9), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), BTC(3), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(2), CRK(2), CRKL(3), EGF(8), EGFR(19), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(17), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), HRAS(34), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(1), NRG2(5), NRG3(19), NRG4(2), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), RAF1(3), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SRC(1), STAT5A(3), STAT5B(5) 78503987 576 309 478 139 80 146 167 118 64 1 3.41e-05 1.000 1.000 273 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(4), CADM3(4), CD2(1), CD22(3), CD226(6), CD274(1), CD276(1), CD28(3), CD34(5), CD4(1), CD40(7), CD40LG(4), CD58(2), CD6(1), CD80(4), CD86(2), CD8A(3), CD8B(2), CDH1(5), CDH15(4), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(9), CNTN2(9), CNTNAP1(9), CNTNAP2(24), CTLA4(2), ESAM(4), F11R(1), GLG1(5), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(14), ITGA6(4), ITGA8(22), ITGA9(3), ITGAL(8), ITGAM(8), ITGAV(6), ITGB1(15), ITGB2(3), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(6), NCAM2(14), NEGR1(6), NEO1(4), NFASC(7), NLGN1(19), NLGN2(6), NLGN3(4), NRCAM(15), NRXN1(32), NRXN2(10), NRXN3(19), OCLN(1), PDCD1(1), PTPRC(18), PTPRF(16), PTPRM(21), PVR(3), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SELE(7), SELL(2), SELP(16), SELPLG(3), SIGLEC1(12), SPN(3), VCAM1(10), VCAN(32) 112497880 701 308 688 245 104 136 194 124 143 0 0.338 1.000 1.000 274 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(3), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FYN(4), GZMB(2), HLA-A(24), HLA-B(26), HLA-C(5), HLA-E(1), HLA-G(2), HRAS(34), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(8), ITGB2(3), KIR2DL3(1), KIR3DL1(3), KIR3DL2(9), KLRC1(1), KLRC2(1), KLRC3(3), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MICB(3), NCR1(6), NCR2(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NRAS(1), PAK1(3), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRF1(5), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC1(15), RAC2(3), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(7), VAV2(4), VAV3(4), ZAP70(4) 86545870 621 308 508 144 102 142 155 110 112 0 1.93e-07 1.000 1.000 275 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(4), ACTN2(10), ACTN4(6), ARHGAP5(10), BCAR1(3), CDC42(3), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), CXCL12(3), CXCR4(2), CYBB(3), ESAM(4), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), ITK(3), JAM2(2), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), NCF1(2), NCF2(6), NCF4(2), NOX1(6), NOX3(8), OCLN(1), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAC1(15), RAC2(3), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOA(10), RHOH(1), ROCK1(19), ROCK2(11), SIPA1(3), THY1(2), TXK(6), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCAM1(10), VCL(5) 94841235 608 307 530 175 90 151 147 126 93 1 0.00366 1.000 1.000 276 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(8), EGFR(19), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(13), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), HRAS(34), HTR2A(5), HTR2B(2), HTR2C(4), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(2), MAPK1(9), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), SRC(1), TJP1(13), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3) 100695419 621 305 584 176 120 132 190 107 71 1 0.000201 1.000 1.000 277 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2L1(2), CDC42(3), CDKN1B(2), CDKN2A(114), CREB1(1), CREB5(7), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARD3(14), PARD6A(1), PDK1(3), PIK3CA(97), PIK3CD(8), PPP1R13B(2), PREX1(14), PTEN(14), PTK2(8), PTPN1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SLC2A4(3), SOS1(9), SOS2(11), TSC1(3), TSC2(7), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 58960440 503 303 380 88 48 119 93 89 151 3 2.75e-11 1.000 1.000 278 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(3), CGA(1), EGFR(19), ELK1(2), FSHB(2), GNA11(4), GNAS(13), GNRHR(2), HRAS(34), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(4), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLD1(15), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11), SRC(1) 96741266 575 301 539 176 120 124 172 92 67 0 0.00394 1.000 1.000 279 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), AKAP1(9), AKAP10(5), AKAP11(9), AKAP12(14), AKAP2(14), AKAP3(8), AKAP4(11), AKAP5(5), AKAP6(26), AKAP7(5), AKAP8(3), AKAP9(32), ARHGEF1(8), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(1), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB5(2), GNG10(1), GNG12(1), GNG13(2), HRAS(34), ITPR1(15), KCNJ3(9), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PLCB3(9), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RHOA(10), RRAS(2), SLC9A1(4), USP5(5) 89029495 573 298 542 152 110 128 168 94 73 0 0.000194 1.000 1.000 280 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADK(1), ADSL(4), ADSS(4), ADSSL1(5), AK1(1), AK2(1), AK5(13), AK7(2), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), FHIT(1), GART(5), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NME4(2), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE10A(20), PDE11A(4), PDE1A(6), PDE1C(14), PDE2A(5), PDE3B(4), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PDE9A(3), PFAS(11), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), XDH(6) 124432263 606 298 603 197 109 128 184 98 87 0 0.157 1.000 1.000 281 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(4), CD8A(3), CD8B(2), CDC42(3), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(4), GRAP2(3), HRAS(34), ICOS(1), IFNG(2), IKBKB(11), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDCD1(1), PDK1(3), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCQ(8), PTPN6(3), PTPRC(18), RASGRP1(8), RHOA(10), SOS1(9), SOS2(11), TEC(2), VAV1(7), VAV2(4), VAV3(4), ZAP70(4) 77489119 518 297 428 126 71 127 141 102 77 0 0.000132 1.000 1.000 282 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(8), INPP5E(1), INPPL1(8), ITPK1(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), OCRL(3), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3C3(5), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PRKCA(7), PRKCG(14), PTEN(14), PTPMT1(2), SYNJ1(10), SYNJ2(8) 94766854 575 295 508 150 77 153 136 121 88 0 4.06e-05 1.000 1.000 283 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3L1(4), CREB3L2(3), CREB3L3(9), CREB3L4(2), CREBBP(37), CTNNB1(6), DCT(3), DVL1(8), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), EP300(38), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GSK3B(3), HRAS(34), KIT(12), KITLG(1), KRAS(1), LEF1(5), MAP2K1(5), MAP2K2(6), MAPK1(9), MC1R(3), MITF(5), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(2), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3) 83221082 552 295 509 148 122 100 163 93 72 2 2.10e-05 1.000 1.000 284 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(4), ACVR1B(5), ACVRL1(3), AKT1(2), AURKB(4), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(7), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MAP3K10(5), MOS(7), NEK1(9), NEK3(1), OCRL(3), PAK4(1), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CA(97), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9), PLK3(5), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(7), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KB1(4), STK11(6), TGFBR1(2), VRK1(1) 85935244 546 295 479 140 85 138 139 102 82 0 8.52e-05 1.000 1.000 285 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(2), CDC42(3), CDH1(5), CREBBP(37), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), EGFR(19), EP300(38), ERBB2(12), FARP2(4), FER(6), FGFR1(1), FYN(4), IGF1R(11), INSR(3), IQGAP1(11), LEF1(5), LMO7(7), MAP3K7(8), MAPK1(9), MET(4), MLLT4(13), NLK(1), PARD3(14), PTPN1(3), PTPN6(3), PTPRB(22), PTPRF(16), PTPRJ(7), PTPRM(21), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(4), RAC1(15), RAC2(3), RAC3(3), RHOA(10), SMAD2(4), SMAD3(4), SMAD4(14), SNAI2(1), SORBS1(7), SRC(1), SSX2IP(6), TCF7(2), TCF7L1(2), TCF7L2(1), TGFBR1(2), TGFBR2(26), TJP1(13), VCL(5), WAS(2), WASF1(3), WASF2(5), WASF3(6), WASL(2), YES1(2) 91194177 566 294 527 150 98 117 148 103 98 2 0.00274 1.000 1.000 286 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(4), AKT3(6), CASP8(60), CCL3(1), CCL4(1), CD14(1), CD40(7), CD80(4), CD86(2), CHUK(6), CXCL10(3), CXCL9(3), FADD(3), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IKBKB(11), IKBKE(5), IL12A(1), IL12B(3), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(1), IRF5(3), IRF7(3), JUN(1), LBP(7), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), RAC1(15), RELA(2), RIPK1(2), SPP1(2), STAT1(8), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(2), TLR3(1), TLR4(17), TLR5(3), TLR6(3), TLR7(8), TLR8(7), TLR9(4), TOLLIP(2), TRAF3(6), TRAF6(3) 68475350 510 291 420 119 73 137 117 92 89 2 4.42e-07 1.000 1.000 287 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(13), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(9), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(7), GPR6(3), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LHCGR(9), LTB4R(3), MAS1(2), MC1R(3), MC3R(2), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(6), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(3), P2RY1(5), P2RY10(5), P2RY11(4), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), RGR(3), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(5) 92761820 575 288 572 229 111 121 188 91 64 0 0.111 1.000 1.000 288 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(3), ACTN2(10), ACTN4(6), DES(3), DMD(57), MYBPC1(11), MYBPC2(8), MYBPC3(5), MYH3(15), MYH6(19), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(38), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(2), TNNT3(2), TPM1(2), TPM2(2), TPM4(1), TTN(371), VIM(4) 103976175 637 288 632 185 87 154 229 98 65 4 0.234 1.000 1.000 289 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(21), ADCY8(28), ARAF(3), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(37), EP300(38), GRIA1(16), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), HRAS(34), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP1CA(1), PPP1R12A(5), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8) 75679491 553 282 510 161 100 123 155 101 73 1 0.00140 1.000 1.000 290 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADK(1), ADSL(4), ADSS(4), AK1(1), AK2(1), AK5(13), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(5), GDA(7), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(11), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1) 97756080 496 268 493 153 86 104 159 72 75 0 0.0558 1.000 1.000 291 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(4), GAB2(4), HRAS(34), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(8), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MS4A2(4), NRAS(1), PDK1(3), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC1(15), RAC2(3), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(7), VAV2(4), VAV3(4) 54967058 429 265 328 98 71 108 112 83 54 1 1.16e-05 1.000 1.000 292 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(4), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(7), FCGR2B(1), FOS(6), GSK3B(3), HRAS(34), IKBKB(11), INPP5D(8), JUN(1), KRAS(1), LILRB3(4), LYN(8), MALT1(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG2(9), PPP3CA(2), PPP3CB(1), PTPN6(3), RAC1(15), RAC2(3), RAC3(3), RASGRP3(9), SYK(8), VAV1(7), VAV2(4), VAV3(4) 56854452 422 261 328 96 68 117 101 84 51 1 2.42e-06 1.000 1.000 293 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(1), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GNAZ(6), GRIA1(16), GRIA2(16), GRIA3(8), GRID2(19), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), HRAS(34), IGF1(1), IGF1R(11), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), RAF1(3), RYR1(34) 83781760 517 261 484 152 102 101 158 93 63 0 0.0137 1.000 1.000 294 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(4), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BMPR1B(4), BMPR2(6), CHRD(11), CREBBP(37), CUL1(11), DCN(4), E2F4(3), E2F5(6), EP300(38), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(9), MYC(6), NODAL(1), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), RBL1(12), RBL2(6), RBX1(3), RHOA(10), ROCK1(19), ROCK2(11), RPS6KB1(4), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD4(14), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(4), SMURF2(6), SP1(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26), THBS1(8), THBS2(10), THBS3(3), THBS4(7), ZFYVE16(10), ZFYVE9(8) 75510185 457 260 428 96 58 99 122 85 92 1 2.34e-06 1.000 1.000 295 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(4), AKT3(6), BAD(1), CASP9(1), CDC42(3), HRAS(34), KDR(14), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NOS3(4), NRAS(1), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PRKCG(14), PTGS2(3), PTK2(8), PXN(2), RAC1(15), RAC2(3), RAC3(3), RAF1(3), SHC2(5), SPHK2(3), SRC(1) 55001649 411 253 310 99 76 113 98 78 46 0 7.48e-06 1.000 1.000 296 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), AMY2B(8), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(6), GAA(3), GANC(6), GBA(2), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), IFIH1(7), LYZL1(1), MGAM(29), MOV10L1(5), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SI(59), SKIV2L2(4), SMARCA2(15), SMARCA5(2), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UXS1(2) 94222153 460 252 455 141 55 88 146 96 74 1 0.370 1.000 1.000 297 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(3), CAPN11(2), CAPN2(5), CAPN3(6), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(5), CAPNS1(2), CAV1(1), CDC42(3), CRK(2), CSK(1), DOCK1(15), FYN(4), GIT2(4), ILK(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(7), MAPK6(4), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(8), PXN(2), RAC1(15), RAC2(3), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(11), SDCCAG8(6), SEPP1(1), SHC1(2), SHC3(6), SORBS1(7), SOS1(9), SRC(1), TLN1(22), TNS1(9), VASP(1), VAV2(4), VAV3(4), VCL(5), ZYX(2) 102113936 490 246 478 157 84 104 144 79 79 0 0.0822 1.000 1.000 298 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(5), MIOX(4), OCRL(3), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PTEN(14), PTPMT1(2), SYNJ1(10), SYNJ2(8) 56661509 380 244 314 94 58 104 90 80 48 0 3.31e-05 1.000 1.000 299 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(15), ABCA10(11), ABCA12(20), ABCA13(41), ABCA2(17), ABCA3(10), ABCA4(14), ABCA5(6), ABCA6(10), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(19), ABCB11(8), ABCB4(13), ABCB5(10), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(6), ABCC10(9), ABCC11(9), ABCC12(10), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(8), ABCG8(13), CFTR(13), TAP1(6), TAP2(3) 90008118 429 244 426 145 66 88 129 70 76 0 0.153 1.000 1.000 300 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), CD36(1), CPT1B(4), CREBBP(37), DUSP1(2), EHHADH(5), EP300(38), FABP1(3), HSD17B4(5), JUN(1), LPL(4), MAPK1(9), ME1(2), MYC(6), NCOA1(7), NCOR1(20), NCOR2(22), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(8), PIK3CA(97), PIK3R1(9), PPARA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(3), RB1(17), RELA(2), RXRA(4), SP1(3), STAT5A(3), STAT5B(5) 48256399 350 237 268 68 36 115 67 65 66 1 1.70e-07 1.000 1.000 301 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(4), BAD(1), BCL2(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(3), CREBBP(37), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), EP300(38), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(8), GSK3A(2), GSK3B(3), HRAS(34), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(4), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB2(5), NFKBIB(1), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(18), RELA(2), RPL13A(2), SFN(7), SLA(1), SP1(3), SP3(3), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(7), VAV2(4), VAV3(4), XPO5(4) 69515933 382 236 350 111 52 73 119 73 64 1 0.0465 1.000 1.000 302 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(10), ARHGEF11(3), BTK(8), CDC42(3), CFL1(2), GDI1(5), GDI2(5), INPPL1(8), ITPR1(15), ITPR2(25), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CA(97), PIK3CD(8), PIK3CG(20), PIK3R1(9), PITX2(2), PPP1R13B(2), PTEN(14), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(11), SAG(1), WASF1(3), WASL(2) 53349120 362 233 299 101 46 118 72 77 48 1 0.00246 1.000 1.000 303 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(10), CPEB1(5), EGFR(19), ERBB2(12), ERBB4(22), ETS1(5), ETS2(7), ETV6(6), ETV7(4), FMN2(40), KRAS(1), MAP2K1(5), MAPK1(9), NOTCH1(99), NOTCH2(22), NOTCH3(22), NOTCH4(8), PIWIL1(9), PIWIL2(10), PIWIL3(8), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1) 39956701 355 232 340 83 58 67 93 51 85 1 0.00833 1.000 1.000 304 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(4), CREBBP(37), CTBP1(2), CTBP2(2), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(8), DVL2(1), DVL3(9), EP300(38), HDAC1(1), HDAC2(3), JAG1(9), JAG2(7), LFNG(2), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(22), NCSTN(2), NOTCH1(99), NOTCH2(22), NOTCH3(22), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(5), RBPJL(5), RFNG(3), SNW1(4) 53057562 372 230 359 106 67 79 80 45 99 2 0.0181 1.000 1.000 305 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(6), ELK1(2), FOS(6), HRAS(34), IKBKB(11), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAP4K5(1), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(7), MAPK6(4), MAPK7(6), MAPK8(4), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MKNK1(1), MKNK2(2), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAC1(15), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(3), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 72808443 393 225 350 106 74 79 128 58 54 0 0.0154 1.000 1.000 306 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), BCR(2), BLNK(4), BTK(8), CD19(4), CD22(3), CR2(7), CSK(1), DAG1(5), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), INPP5D(8), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), MAP4K1(5), MAPK1(9), NFATC1(7), NFATC2(15), NR0B2(1), PDK1(3), PIK3CA(97), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(18), RAF1(3), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7) 56344877 350 220 281 93 50 110 61 84 44 1 0.000621 1.000 1.000 307 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(7), BDKRB1(2), BDKRB2(3), C1QA(2), C1QC(1), C1R(3), C1S(6), C2(5), C3(15), C3AR1(5), C4BPA(6), C4BPB(2), C5(10), C5AR1(2), C6(23), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(2), CD59(1), CFB(4), CFH(18), CFI(4), CPB2(4), CR1(10), CR2(7), F10(3), F11(2), F12(2), F13A1(9), F13B(13), F2(3), F2R(4), F3(2), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), KNG1(4), MASP1(7), MASP2(5), MBL2(2), PLAT(4), PLG(13), PROC(2), PROS1(10), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(7), SERPING1(5), TFPI(2), THBD(2), VWF(19) 69004041 396 215 394 133 47 101 111 73 63 1 0.429 1.000 1.000 308 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(5), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(2), CHPF(7), CHST1(4), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST2(6), CHST4(4), CHST6(8), CHST7(1), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GANAB(4), GCNT1(1), GCNT3(1), GCNT4(4), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(10), XYLT1(10), XYLT2(3) 84248498 356 213 356 139 73 73 112 49 48 1 0.759 1.000 1.000 309 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(19), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), MAPK1(9), MAPK10(4), MAPK14(2), PHKA2(10), PIK3CA(97), PIK3CD(8), PIK3R1(9), PITX2(2), PTX3(4), RAF1(3), SRC(1) 40544403 299 207 230 63 40 98 58 67 36 0 3.10e-06 1.000 1.000 310 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(10), EZH1(5), EZH2(5), FBXO11(6), HCFC1(8), HSF4(1), JMJD4(1), JMJD6(2), KDM6A(17), MEN1(3), NSD1(72), OGT(4), PAXIP1(4), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(35), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), RBBP5(2), SATB1(6), SETD1A(10), SETD2(12), SETD7(4), SETD8(1), SETDB1(9), SETDB2(2), SETMAR(2), SMYD3(3), STK38(2), SUV39H1(4), SUV39H2(2), SUV420H1(6), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6) 90553709 344 206 337 86 44 59 91 54 90 6 0.0500 1.000 1.000 311 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(4), IGF1(1), MAPK1(9), PDPK1(4), PIK3CA(97), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), STK11(6), TSC1(3), TSC2(7), ULK1(7), ULK2(2), VEGFB(1), VEGFC(6) 40533791 294 206 223 56 44 94 55 60 41 0 1.04e-06 1.000 1.000 312 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCR(2), BLNK(4), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PI3(2), PIK3CA(97), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7) 40301686 273 202 205 56 43 84 50 59 36 1 5.86e-06 1.000 1.000 313 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(7), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), CFLAR(2), CHUK(6), CRADD(2), DAXX(6), FADD(3), GSN(5), LMNA(1), LMNB1(2), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(3), NFKB1(5), NFKBIA(1), NUMA1(19), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(8), RASA1(18), RB1(17), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 52881263 305 191 291 74 33 59 73 48 89 3 0.0113 1.000 1.000 314 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(18), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(1), CAMKK2(6), CD36(1), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(6), IKBKB(11), IRS1(2), IRS2(6), IRS4(16), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), MAPK10(4), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(5), PCK1(2), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(4), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(3), SOCS3(1), STAT3(6), STK11(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8) 63324449 305 191 305 97 52 60 86 52 54 1 0.117 1.000 1.000 315 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(1), ITGA9(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), MAP2K1(5), MAPK1(9), NR1I3(1), PAK1(3), PDE3A(19), PDE3B(4), PI3(2), PIK3C2G(11), PIK3CA(97), PIK3CD(8), PIK3R1(9), PSME1(1), RIPK3(1), SGCB(3), VASP(1) 36997639 251 183 182 57 28 87 44 57 35 0 0.000244 1.000 1.000 316 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(13), AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(2), GRPR(1), LHCGR(9), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), NMBR(3), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), TACR1(4), TACR2(4), TACR3(5), TRHR(5), TSHR(4) 39938492 270 182 270 99 47 65 83 41 34 0 0.0758 1.000 1.000 317 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(7), CPSF2(5), CPSF3(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(3), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(2), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(12), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(12), PTBP1(3), PTBP2(4), RBM17(1), RBM5(8), RNGTT(1), RNMT(5), RNPS1(3), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(5), SF3B2(3), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(6), SRPK1(1), SRPK2(10), SRRM1(4), SUPT5H(4), U2AF1(2), U2AF2(2), XRN2(8) 80690535 287 177 285 100 34 70 83 46 54 0 0.794 1.000 1.000 318 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(13), PIK3CA(97), PIK3R1(9), PLD1(15), PPP1R12B(4), RAC1(15), RALBP1(3), RPS6KB1(4), TRIO(20), VAV1(7), WASF1(3) 26619167 231 177 163 56 28 85 46 47 25 0 0.00258 1.000 1.000 319 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(4), CD1A(8), CD1B(2), CD1C(5), CD1D(5), CD1E(13), CD2(1), CD22(3), CD33(2), CD34(5), CD36(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD59(1), CD8A(3), CD8B(2), CD9(1), CR1(10), CR2(7), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(2), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL7(2), IL7R(6), IL9R(6), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(6), KIT(12), KITLG(1), MME(16), MS4A1(4), TFRC(8), THPO(1), TPO(12) 62169654 281 173 278 111 45 59 78 55 44 0 0.867 1.000 1.000 320 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(6), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(3), CHUK(6), CSK(1), CXCL1(3), EGFR(19), F11R(1), GIT1(5), IGSF5(4), IKBKB(11), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(7), PAK1(3), PLCG1(9), PLCG2(9), PTPN11(2), PTPRZ1(16), RAC1(15), RELA(2), SRC(1), TCIRG1(7), TJP1(13) 53542106 252 173 244 76 33 55 76 50 38 0 0.212 1.000 1.000 321 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), FBXW7(34), GRAP2(3), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), MAPK1(9), NCK1(5), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLCG1(9), PTPRC(18), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), SOS1(9), SOS2(11), VAV1(7), ZAP70(4) 42629122 232 172 216 69 36 38 70 33 54 1 0.333 1.000 1.000 322 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(4), CCKBR(3), CCR2(4), CCR3(5), CELSR1(24), CELSR2(27), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(3), GNRHR(2), GPR116(8), GPR132(4), GPR133(9), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR56(3), GPR61(3), GPR84(3), GRM1(28), GRPR(1), HRH4(3), LGR6(10), LPHN2(10), LPHN3(22), LTB4R2(2), NTSR1(3), OR2M4(7), P2RY11(4), P2RY13(2), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2) 50768765 275 169 274 105 51 60 81 45 38 0 0.331 1.000 1.000 323 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(27), AXIN1(12), CCND1(3), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(8), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(4), MAPK10(4), MAPK9(4), MYC(6), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), RAC1(15), RHOA(10), SFRP4(11), TCF7(2), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1) 45874703 267 167 253 88 46 56 86 53 25 1 0.161 1.000 1.000 324 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(72), OGDH(10), OGDHL(11), PIPOX(2), PLOD1(4), PLOD2(9), PLOD3(4), RDH11(2), RDH12(4), SETD1A(10), SETD7(4), SETDB1(9), SHMT1(1), SHMT2(3), SPCS1(2), SPCS3(1), SUV39H1(4), SUV39H2(2), TMLHE(2) 44207561 244 166 241 70 36 40 59 38 65 6 0.158 1.000 1.000 325 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(8), JAK1(10), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PIK3CA(97), PPP1R13B(2), RPS6KB1(4), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT6(5), TYK2(8) 28126746 213 166 152 45 19 77 45 55 17 0 0.000122 1.000 1.000 326 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), AMY2B(8), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(4), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), MGAM(29), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), SI(59), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UXS1(2) 43293602 244 166 241 82 30 46 77 49 41 1 0.579 1.000 1.000 327 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(5), CCND1(3), CREBBP(37), EP300(38), ERCC3(5), ESR1(5), GRIP1(12), GTF2A1(4), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), MEF2C(15), NCOR2(22), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(12), TBP(2) 35079349 227 164 219 60 24 46 63 45 48 1 0.0398 1.000 1.000 328 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(19), EPHB2(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), MAPK1(9), PI3(2), PIK3CB(6), PITX2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), RAF1(3), RGS20(4), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT3(6), TERF2IP(1) 44471249 231 163 223 75 41 48 64 51 27 0 0.231 1.000 1.000 329 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(16), GLI3(12), GSK3B(3), HHIP(5), IHH(2), LRP2(40), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), PTCH1(13), PTCH2(10), RAB23(2), SHH(2), SMO(3), STK36(6), SUFU(3), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3), ZIC2(6) 46433064 236 158 235 82 51 43 85 33 24 0 0.364 1.000 1.000 330 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 BCL2(1), CHUK(6), DAXX(6), EGF(8), EGFR(19), ETS1(5), ETS2(7), FOS(6), HOXA7(4), HRAS(34), IKBKB(11), JUN(1), MAP2K1(5), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 37610496 215 158 184 68 41 42 72 29 30 1 0.187 1.000 1.000 331 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(6), GNA15(4), GNB1(3), HRAS(34), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NCF1(2), NCF2(6), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(11), PLCB1(22), PPP3CA(2), PPP3CB(1), RAC1(15), RAF1(3), RELA(2), SYT1(9) 29145047 204 157 164 49 50 31 72 28 23 0 0.0123 1.000 1.000 332 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ANGPTL4(3), APOA5(2), AQP7(3), CD36(1), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(2), CYP4A11(12), CYP4A22(9), CYP7A1(6), CYP8B1(6), DBI(4), EHHADH(5), FABP1(3), FABP2(2), FABP3(1), FABP4(3), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(5), GK2(7), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(6), NR1H3(1), OLR1(1), PCK1(2), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(3), PPARG(1), RXRA(4), RXRB(3), RXRG(7), SCD(1), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1) 49890908 229 157 228 82 37 56 63 32 40 1 0.393 1.000 1.000 333 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UPB1(1), UPP1(3), UPP2(3), UPRT(2) 61670726 229 155 229 94 40 37 65 50 37 0 0.959 1.000 1.000 334 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(60), CFLAR(2), DAXX(6), FADD(3), FAF1(2), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(12), RB1(17), RIPK2(6), SPTAN1(23) 31141887 215 153 202 40 21 42 52 32 66 2 0.00210 1.000 1.000 335 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(14), KDR(14), NOS3(4), PDE2A(5), PDE3A(19), PDE3B(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKG1(7), PRKG2(2), RYR2(76), SLC7A1(4), SYT1(9) 30803422 206 151 206 74 32 54 57 36 26 1 0.499 1.000 1.000 336 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(7), CASP2(3), CASP3(2), CASP8(60), CRADD(2), FADD(3), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(17), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TRADD(1), TRAF2(2) 29693375 206 149 193 45 23 35 54 32 60 2 0.0153 1.000 1.000 337 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT2(2), ACMSD(6), AFMID(5), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), NFX1(2), OGDH(10), OGDHL(11), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), TDO2(4), TPH1(3), TPH2(6), WARS(2), WARS2(8) 46073837 203 148 203 64 30 44 62 33 34 0 0.278 1.000 1.000 338 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(13), GNAS(13), GNAT3(6), GNB1(3), GNB3(6), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(6), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(5), SCNN1G(5), TAS1R1(8), TAS1R2(5), TAS1R3(3), TAS2R1(4), TAS2R10(2), TAS2R13(1), TAS2R14(4), TAS2R16(4), TAS2R3(1), TAS2R38(3), TAS2R39(1), TAS2R40(5), TAS2R41(3), TAS2R42(1), TAS2R43(1), TAS2R46(6), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(5) 43464946 221 148 219 111 51 40 52 44 34 0 0.976 1.000 1.000 339 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(12), BAD(1), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(60), CASP9(1), CD40(7), CD40LG(4), CRADD(2), DAXX(6), FADD(3), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(1), NR3C1(6), NTRK1(3), PTPN13(12), RIPK1(2), TFG(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3) 33178003 188 147 176 37 22 44 37 29 54 2 0.000734 1.000 1.000 340 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), HRAS(34), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), RAC1(15), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7) 29146647 188 142 157 36 39 33 61 31 23 1 0.000464 1.000 1.000 341 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(5), DGAT1(1), DGAT2(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), GK(5), GK2(7), GLA(2), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 44612162 198 142 198 63 27 44 49 41 37 0 0.173 1.000 1.000 342 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(9), CALR(2), CANX(3), CD4(1), CD74(2), CD8A(3), CD8B(2), CIITA(13), CREB1(1), CTSS(4), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(6), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), KIR2DL3(1), KIR3DL1(3), KIR3DL2(9), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LGMN(4), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(3), TAP1(6), TAP2(3), TAPBP(4) 35423604 209 139 197 58 20 43 53 28 65 0 0.0919 1.000 1.000 343 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(2), ACMSD(6), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(3), WARS(2), WARS2(8) 41929402 187 138 187 63 26 40 60 31 29 1 0.452 1.000 1.000 344 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(4), GNA11(4), GNAI1(2), GNB1(3), HRAS(34), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(9), PRKCA(7), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), SYT1(9) 31664060 182 137 151 49 44 37 61 25 15 0 0.0218 1.000 1.000 345 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(6), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(6), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 44294154 183 137 183 75 30 48 44 28 33 0 0.734 1.000 1.000 346 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHFR(2), DHX58(2), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), FPGS(1), GCH1(1), GGH(2), IFIH1(7), MOV10L1(5), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SKIV2L2(4), SMARCA2(15), SMARCA5(2) 47925115 184 137 182 54 24 34 58 38 30 0 0.357 1.000 1.000 347 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 40034104 203 137 197 77 29 46 65 27 35 1 0.659 1.000 1.000 348 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 40034104 203 137 197 77 29 46 65 27 35 1 0.659 1.000 1.000 349 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), RRM1(2), RRM2(1), TXNRD1(6), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(3) 43710626 183 137 183 61 27 32 58 32 34 0 0.481 1.000 1.000 350 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(3), CARM1(5), CYP11B1(6), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7) 38284188 184 136 184 62 35 33 58 38 20 0 0.445 1.000 1.000 351 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(21), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(13), GNB1(3), HRAS(34), JUN(1), MAP2K1(5), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(9) 26633875 174 134 149 37 39 31 60 25 19 0 0.00156 1.000 1.000 352 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST3(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7) 43816385 197 134 197 84 27 38 65 38 28 1 0.942 1.000 1.000 353 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(3), CFL1(2), FLNA(24), FLNC(19), FSCN1(3), FSCN2(1), FSCN3(6), GDI1(5), GDI2(5), LIMK1(5), MYH2(26), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PFN1(1), PFN2(1), RHO(3), ROCK1(19), ROCK2(11), VASP(1), WASF1(3), WASL(2) 36527951 198 134 198 77 32 48 56 28 34 0 0.620 1.000 1.000 354 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(4), ACTN2(10), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(4), HRAS(34), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK8(4), PPP1R12B(4), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SOS1(9), SRC(1), TLN1(22), VCL(5), ZYX(2) 35990312 194 133 162 42 40 29 76 29 20 0 0.00647 1.000 1.000 355 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(3), CREB1(1), DAXX(6), ELK1(2), HRAS(34), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RAC1(15), RIPK1(2), RPS6KA5(5), SHC1(2), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 27898416 163 130 129 36 29 35 55 22 22 0 0.0133 1.000 1.000 356 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(3), EPHB2(3), GNAI1(2), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), MAPK1(9), PITX2(2), PTX3(4), RAC1(15), RHO(3), RYR1(34) 34818307 176 130 161 60 43 39 40 26 28 0 0.147 1.000 1.000 357 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(3), CAPN2(5), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(8), EGFR(19), HRAS(34), ITGA1(4), ITGB1(15), MAPK1(9), MYLK(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTK2(8), PXN(2), TLN1(22) 24919933 162 127 129 43 37 24 55 26 19 1 0.0696 1.000 1.000 358 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(27), ATF2(1), AXIN1(12), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(11), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), MAP3K7(8), MEF2C(15), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR2(26), TGFBR3(5), WNT1(2) 27848263 179 126 168 38 27 41 40 34 36 1 0.00348 1.000 1.000 359 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(35), B3GALT4(3), CDR1(6), DGKI(13), IL6ST(5), MRPL19(2), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL17(1), RPL18A(1), RPL22(2), RPL23(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(2), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(1), RPS10(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS23(1), RPS25(2), RPS27A(1), RPS28(1), RPS3(2), RPS5(1), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5) 39912118 175 126 175 75 20 40 65 23 27 0 0.960 1.000 1.000 360 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), ATP5L(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(2), NDUFA9(3), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(1), PPA1(1), SDHA(6), SDHB(1), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRC2(1), UQCRFS1(4) 42504142 165 125 164 45 18 35 54 32 26 0 0.119 1.000 1.000 361 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), GK(5), GLA(2), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 36655248 161 123 161 54 22 31 41 31 36 0 0.335 1.000 1.000 362 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), CARM1(5), COMT(1), DBH(8), DCT(3), DDC(7), ECH1(2), ESCO1(4), ESCO2(3), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PNMT(1), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SH3GLB1(1), TAT(2), TH(3), TPO(12), TYR(8), TYRP1(4) 45290323 162 123 161 52 27 40 46 22 27 0 0.215 1.000 1.000 363 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(5), CFL1(2), GNAS(13), GNB1(3), HRAS(34), LIMK1(5), MAP2K1(5), MAPK1(9), NOX1(6), PIK3C2G(11), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2(8), RAF1(3), ROCK2(11) 19177872 148 122 115 32 32 24 59 15 18 0 0.0331 1.000 1.000 364 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), F10(3), F11(2), F12(2), F2(3), F2R(4), F5(19), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), PROC(2), PROS1(10), SERPINC1(4), SERPING1(5) 33810396 169 122 168 54 16 51 47 30 25 0 0.567 1.000 1.000 365 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(3), ETNK1(1), ETNK2(3), GNPAT(5), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(1) 49892679 183 121 183 55 19 39 52 29 44 0 0.212 1.000 1.000 366 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(4), AKT3(6), ANKRD6(4), APC(27), AXIN1(12), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(8), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(33), MVP(4), NKD1(8), NKD2(3), PIN1(1), PTPRA(2), SENP2(3), SFRP1(2), TSHB(2), WIF1(1) 30830754 160 121 159 54 24 38 41 31 25 1 0.400 1.000 1.000 367 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(4), CDC26(1), CDC27(9), CUL1(11), CUL2(3), CUL3(16), FBXW11(3), FBXW7(34), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(4), SMURF2(6), TCEB1(2), UBA1(3), UBE2D2(1), UBE2D4(1), WWP1(7), WWP2(7) 30529062 147 119 137 41 19 31 36 28 32 1 0.363 1.000 1.000 368 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(3), ALOX12B(4), ALOX15B(6), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP4A11(12), CYP4A22(9), CYP4F2(6), CYP4F3(2), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 29663622 148 118 148 55 20 31 46 23 27 1 0.463 1.000 1.000 369 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(5), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(6), PLCG1(9), PLCG2(9), PPAP2A(1), PPAP2B(1) 38034000 156 117 156 51 21 26 47 26 36 0 0.335 1.000 1.000 370 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37207275 150 116 150 56 23 38 37 24 28 0 0.576 1.000 1.000 371 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37207275 150 116 150 56 23 38 37 24 28 0 0.576 1.000 1.000 372 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(18), AR(6), ESR1(5), ESR2(1), ESRRA(4), HNF4A(6), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(3), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(7), NR2F1(3), NR2F2(8), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(4), PGR(3), PPARA(2), PPARD(3), PPARG(1), RARA(5), RARB(6), RARG(13), ROR1(9), RORA(3), RORC(3), RXRA(4), RXRB(3), RXRG(7), THRA(5), THRB(1), VDR(2) 32048108 166 116 164 51 30 27 55 25 28 1 0.256 1.000 1.000 373 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(16), ACACB(18), ACAT2(2), ACOT12(3), ACSS1(6), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 35606563 145 115 145 53 31 26 39 27 22 0 0.703 1.000 1.000 374 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(4), GCNT2(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(5), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1) 37034758 153 115 151 59 30 37 49 18 19 0 0.421 1.000 1.000 375 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(4), AKT3(6), ARHGEF11(3), BCL2(1), CDC42(3), DLG4(3), GNA13(2), LPA(17), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PI3(2), PIK3CB(6), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RDX(1), ROCK1(19), ROCK2(11), SERPINA4(7), SRF(1), TBXA2R(1) 37471753 160 114 159 59 12 42 50 26 30 0 0.759 1.000 1.000 376 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(14), BAIAP2(2), CASP1(2), CASP3(2), CASP7(3), CASP8(60), GAPDH(2), INSR(3), ITCH(7), MAGI1(13), MAGI2(20), RERE(7), WWP1(7), WWP2(7) 18286658 149 113 137 38 16 33 30 24 44 2 0.0731 1.000 1.000 377 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(5), ACAT2(2), ACOX1(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(12), CYP4A22(9), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5) 37283483 145 112 145 50 16 34 40 31 24 0 0.503 1.000 1.000 378 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), HRAS(34), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(9), PRKCA(7), PTK2B(4), RAC1(15), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9) 21715007 147 112 109 30 40 22 53 19 13 0 0.00394 1.000 1.000 379 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(9), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PIK3CB(6), PITX2(2), PLD1(15), PLD2(1), PLD3(2), VN1R1(2) 34128794 136 112 136 52 15 42 31 24 24 0 0.544 1.000 1.000 380 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(16), EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(5), EEF2K(5), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G3(8), EIF5(3), EIF5A(5), EIF5B(6), ETF1(2), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1) 33415084 149 110 148 42 17 32 49 27 24 0 0.319 1.000 1.000 381 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(2), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4) 32322727 149 109 149 56 25 40 38 23 23 0 0.441 1.000 1.000 382 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(6), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(29), PFKL(6), PFKM(6), PFKP(5), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2) 29369150 143 109 142 34 26 32 42 20 22 1 0.00873 1.000 1.000 383 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(9), GABBR1(4), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM7(20), GRM8(24) 15942015 144 107 142 44 31 29 39 30 15 0 0.0567 1.000 1.000 384 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(4), EPRS(5), FARS2(5), FARSA(1), FARSB(8), HARS(1), HARS2(2), IARS(11), IARS2(2), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), TARS(6), TARS2(4), VARS(5), VARS2(4), WARS(2), WARS2(8), YARS(6), YARS2(4) 41343530 139 107 139 34 16 29 45 28 21 0 0.0631 1.000 1.000 385 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(4), BLVRA(3), COX10(3), COX15(4), CP(7), CPOX(1), EARS2(4), EPRS(5), FECH(1), FTMT(5), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UROD(1), UROS(3) 32200935 139 106 139 63 17 22 51 35 14 0 0.991 1.000 1.000 386 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(15), C5(10), C6(23), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELP(16), SELPLG(3), VCAM1(10) 18898282 138 106 137 38 12 36 38 24 28 0 0.0972 1.000 1.000 387 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(6), ACY3(3), ADSL(4), ADSS(4), ADSSL1(5), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(2), DLAT(4), DLD(1), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1) 28819861 131 105 131 43 19 34 40 19 19 0 0.285 1.000 1.000 388 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(4), ARHGAP4(10), ARHGAP5(10), ARHGAP6(8), ARHGEF1(8), ARHGEF11(3), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(3), PIP5K1B(9), PPP1R12B(4), ROCK1(19), SRC(1), TLN1(22), VCL(5) 34531628 154 105 154 63 23 35 47 32 17 0 0.917 1.000 1.000 389 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8) 19620773 131 104 131 60 35 17 40 21 18 0 0.649 1.000 1.000 390 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(2), F12(2), F13B(13), F2(3), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), LPA(17), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7), VWF(19) 26901816 143 102 142 41 14 38 43 25 23 0 0.204 1.000 1.000 391 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(3), BTG1(1), CBX3(1), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(2), DNAJA1(3), EIF4G2(8), ETV6(6), G0S2(1), GFRA1(7), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(1), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(2), PPP1R3C(1), PPP2CB(3), PSMA4(1), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(1), ZFR(4) 27910670 118 102 118 44 16 21 44 22 15 0 0.880 1.000 1.000 392 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(4), GTF2A1L(8), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(2), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(6), TAF1(12), TAF10(4), TAF13(1), TAF1L(24), TAF2(7), TAF4(5), TAF4B(4), TAF5(7), TAF5L(4), TAF6(5), TAF6L(2), TAF7(2), TAF7L(4), TAF9(3), TBPL1(2), TBPL2(1) 27445100 137 102 136 52 19 31 35 28 24 0 0.857 1.000 1.000 393 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(12), BTRC(1), CCND1(3), CREBBP(37), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(3), TLE1(7), WIF1(1), WNT1(2) 22412539 143 101 138 37 19 33 37 24 28 2 0.0819 1.000 1.000 394 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(2), AOC2(6), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(2), HAL(6), HARS(1), HARS2(2), HDC(4), HEMK1(1), HNMT(1), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), PRPS1(3), PRPS2(2), UROC1(3) 30139282 125 100 125 37 23 31 40 17 14 0 0.0783 1.000 1.000 395 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(5), POLM(2), POLQ(23), PRIM1(3), PRIM2(1), REV1(3), REV3L(24), RFC5(2) 30859219 123 100 122 34 20 27 31 19 26 0 0.229 1.000 1.000 396 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), FUK(3), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(4), MTMR1(2), MTMR2(3), MTMR6(3), PFKFB1(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(6), PFKP(5), PGM2(4), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2) 28257904 116 99 116 33 23 26 32 21 14 0 0.0668 1.000 1.000 397 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(6), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(11), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), OXCT2(1), PCCA(9), PCCB(1) 32787097 127 99 126 44 16 34 32 27 18 0 0.596 1.000 1.000 398 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(5), ADCY3(7), ADCY9(9), AK1(1), ARF1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(13), PDIA4(1), PLCG1(9), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6) 28168025 129 98 129 36 22 28 38 23 18 0 0.0785 1.000 1.000 399 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(6), ACADS(2), ACAT2(2), ACSM1(6), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(4), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(5), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PPME1(1), PRDX6(1), RDH11(2), RDH12(4) 30901288 135 97 135 54 18 38 40 24 15 0 0.742 1.000 1.000 400 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(2), CEBPB(1), DAZL(3), DMC1(1), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), MSH5(3), NCOR1(20), NRIP1(8), PGR(3), PRLR(9), PTGER2(5), VDR(2), ZP2(6) 26702340 124 96 120 37 14 30 38 22 20 0 0.281 1.000 1.000 401 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(6), ACACA(16), ACACB(18), ACADM(3), ACAT2(2), ACSS1(6), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 30231670 119 95 119 43 24 21 33 23 18 0 0.724 1.000 1.000 402 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4) 17536351 123 94 120 38 21 24 33 20 24 1 0.261 1.000 1.000 403 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4) 17536351 123 94 120 38 21 24 33 20 24 1 0.261 1.000 1.000 404 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), NACA(24), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5) 38615851 141 94 140 50 16 36 47 18 23 1 0.805 1.000 1.000 405 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(3), CDC42(3), CREB1(1), CREB5(7), DUSP1(2), DUSP10(3), EEF2K(5), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K10(5), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK1(9), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(8), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3) 25411163 118 94 109 35 21 25 32 22 18 0 0.242 1.000 1.000 406 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(6), CLCA4(6), CNGA3(9), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(2), PRKG1(7), PRKG2(2), PRKX(1) 23255489 114 93 114 44 16 26 34 23 15 0 0.608 1.000 1.000 407 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(2), DLG4(3), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(9) 19495200 112 91 112 41 21 28 30 19 14 0 0.234 1.000 1.000 408 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 28133165 116 91 116 40 22 24 32 22 16 0 0.587 1.000 1.000 409 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(11), IRAK1(3), JUN(1), LY96(2), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(5), TLR2(2), TLR3(1), TLR4(17), TLR6(3), TLR7(8), TLR9(4), TOLLIP(2), TRAF6(3) 27836421 116 91 115 48 17 25 40 14 20 0 0.843 1.000 1.000 410 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), GAMT(2), GATM(4), GLUD1(3), GOT1(1), GOT2(2), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3) 33655833 116 90 116 42 23 25 30 22 16 0 0.534 1.000 1.000 411 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(9), ATP4B(2), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(6), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4) 29048108 110 90 108 29 17 27 32 24 10 0 0.0767 1.000 1.000 412 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EARS2(4), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5) 30115190 107 89 107 53 18 23 27 20 19 0 0.973 1.000 1.000 413 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), AOX1(11), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), PCCA(9), PCCB(1), SDS(1) 27435349 107 89 106 36 11 23 30 25 18 0 0.675 1.000 1.000 414 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(3), GIPR(2), GLP1R(1), GLP2R(5), GPR64(6), LPHN1(11), LPHN2(10), LPHN3(22), SCTR(2), VIPR1(1), VIPR2(5) 20287718 115 88 115 39 15 15 34 35 16 0 0.468 1.000 1.000 415 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(4) 22371140 106 87 106 42 16 17 40 17 15 1 0.777 1.000 1.000 416 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(5), ALAS2(4), AMT(2), AOC2(6), AOC3(5), ATP6V0C(1), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), MAOA(1), MAOB(1), PLCB2(6), PLCG1(9), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(3), TARS(6) 31926425 114 87 114 48 29 20 36 19 10 0 0.787 1.000 1.000 417 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), CS(3), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(9), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 21604202 103 87 102 29 13 24 35 17 14 0 0.185 1.000 1.000 418 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ATP6V0C(1), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADHA(3), PLOD1(4), PLOD2(9), PLOD3(4), SDS(1), SHMT1(1), SHMT2(3), TMLHE(2) 28229761 111 87 111 49 20 19 27 23 22 0 0.894 1.000 1.000 419 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(6), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 25226371 100 87 100 32 18 17 31 19 15 0 0.585 1.000 1.000 420 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BAD(1), BRAF(10), CREB1(1), CREB5(7), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(5), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MAPK1(9), MKNK1(1), MKNK2(2), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), SHC1(2), SOS1(9), SOS2(11), TRAF3(6) 22477161 122 87 114 30 31 22 36 20 13 0 0.0512 1.000 1.000 421 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(6), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), MLYCD(2), SDS(1), SMS(3), UPB1(1) 22146251 110 86 110 33 14 30 34 22 10 0 0.248 1.000 1.000 422 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), COMT(1), DBH(8), DCT(3), DDC(7), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(2), TH(3), TPO(12), TYR(8) 24144687 104 86 103 40 17 25 31 12 19 0 0.541 1.000 1.000 423 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PLCG1(9), PRKCE(3), PRKCZ(3), RAB5A(3), RAC1(15), RPS6KB1(4), VAV2(4) 19078207 106 85 98 28 18 21 31 17 18 1 0.0886 1.000 1.000 424 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(2), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(9), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(2), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(5), TAF7(2), TAF9(3), TBP(2) 26709019 105 83 105 37 8 23 26 22 26 0 0.687 1.000 1.000 425 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), RPE(1), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), XYLB(3) 20821203 101 82 101 45 14 15 37 25 10 0 0.974 1.000 1.000 426 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(4), AMT(2), AOC2(6), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SDS(1), SHMT1(1), SHMT2(3), TARS(6), TARS2(4) 32447784 106 81 106 44 27 20 35 15 8 1 0.727 1.000 1.000 427 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(2), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(1), RPN1(2), RPN2(6), ST6GAL1(4), STT3B(2) 32298969 112 81 112 43 15 24 35 17 21 0 0.766 1.000 1.000 428 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(4), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1), WBSCR17(10) 24611456 103 81 103 36 17 28 27 15 15 1 0.519 1.000 1.000 429 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(8), DLG4(3), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(9), MAPK7(6), MAPK8(4), MYEF2(8), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RAF1(3), RASAL1(5), SRC(1), TEC(2), VAV1(7) 20954406 98 81 91 26 13 20 26 16 22 1 0.128 1.000 1.000 430 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(7), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(9), VIP(1), VIPR2(5) 21327734 101 81 99 37 21 21 30 16 13 0 0.455 1.000 1.000 431 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA2(1), GALNS(1), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(2) 26245996 93 80 93 42 23 17 18 18 17 0 0.821 1.000 1.000 432 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFAT5(12), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5) 27144403 99 80 99 39 10 35 25 16 13 0 0.560 1.000 1.000 433 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(4), AGT(4), AGTR1(13), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), REN(3) 19192028 100 79 99 38 12 30 30 17 11 0 0.824 1.000 1.000 434 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(8), ACO2(4), CLYBL(1), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), OGDHL(11), PC(14), PCK1(2), PCK2(4), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 22737982 94 79 93 36 19 19 28 15 13 0 0.578 1.000 1.000 435 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(6), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HIBCH(2), MLYCD(2), SMS(3), UPB1(1) 20581105 95 79 95 30 13 30 27 19 6 0 0.259 1.000 1.000 436 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(15), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(5), LCAT(2), LDLR(4), LIPC(5), LPL(4), LRP1(33), SCARB1(1), SOAT1(5) 20899980 88 79 87 25 12 21 26 16 13 0 0.178 1.000 1.000 437 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(4), AGT(4), AGTR1(13), AGTR2(2), CMA1(5), CPA3(7), CTSA(1), CTSG(1), ENPEP(13), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1) 16123553 95 78 95 31 13 18 32 19 13 0 0.388 1.000 1.000 438 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(1), TGFB2(4), TGFB3(1), TOLLIP(2), TRAF6(3) 22681088 91 78 90 29 17 17 26 12 19 0 0.427 1.000 1.000 439 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), GMPS(7), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5) 25303711 87 76 87 43 13 20 22 17 15 0 0.966 1.000 1.000 440 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(4), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(4), NCOA1(7), NCOA2(9), NCOA3(8), NCOR2(22), POLR2A(12), RARA(5), RXRA(4), TBP(2) 19027728 94 76 94 23 13 22 24 24 11 0 0.0553 1.000 1.000 441 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(3), CYP11B1(6), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 20807898 90 75 90 36 19 15 27 20 9 0 0.742 1.000 1.000 442 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(9) 18495542 85 75 85 32 14 16 26 18 11 0 0.546 1.000 1.000 443 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), EPRS(5), GAMT(2), GATM(4), GLUD1(3), GLUD2(10), GOT1(1), GOT2(2), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 27378586 94 75 94 33 19 16 21 24 14 0 0.568 1.000 1.000 444 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(4), ARSE(3), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD3(2), SMPD4(5), SPHK2(3), SPTLC1(5), SPTLC2(3), UGCG(1) 27302689 90 75 90 39 20 21 24 13 12 0 0.589 1.000 1.000 445 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(6), CYP4F3(2), EPX(9), GGT1(4), LTA4H(2), MPO(7), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5), TPO(12) 21298308 92 75 91 51 21 17 26 11 17 0 0.973 1.000 1.000 446 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(6), ADSL(4), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(2), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), PC(14) 19850511 86 74 86 27 15 17 28 14 12 0 0.296 1.000 1.000 447 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(16), AP2A1(4), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(6), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(8), SYT1(9) 16542029 82 73 82 34 10 16 30 14 12 0 0.883 1.000 1.000 448 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2) 24100412 86 72 86 39 18 18 25 17 8 0 0.884 1.000 1.000 449 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(3), IKBKB(11), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(17), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3) 18637126 83 71 82 30 14 17 26 13 13 0 0.583 1.000 1.000 450 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(6), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1) 19655941 86 70 86 33 11 26 24 11 14 0 0.693 1.000 1.000 451 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), GCK(4), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), KHK(3), MPI(4), PFKFB1(3), PFKFB3(2), PFKFB4(1), PFKM(6), PFKP(5), PMM2(2), SORD(2), TPI1(4) 18170948 78 70 78 21 14 21 19 13 11 0 0.0543 1.000 1.000 452 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(14), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3) 22414719 80 70 80 27 19 22 20 11 8 0 0.304 1.000 1.000 453 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), HAL(6) 16185960 78 70 78 33 16 14 23 16 9 0 0.873 1.000 1.000 454 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA3(2), ANXA4(3), ANXA6(6), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(3), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 15721510 81 70 79 23 15 12 17 13 23 1 0.218 1.000 1.000 455 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(1), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2) 18583750 81 69 81 25 13 17 29 12 10 0 0.255 1.000 1.000 456 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4) 18211464 82 69 82 33 11 15 36 10 9 1 0.706 1.000 1.000 457 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(8), GNA12(1), GNA13(2), GNB1(3), MYLK(8), PLCB1(22), PPP1R12B(4), PRKCA(7), ROCK1(19) 15753904 84 69 83 29 13 16 29 15 11 0 0.657 1.000 1.000 458 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(5), CHIT1(4), CTBS(2), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(6), HK3(8), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(5) 21848261 79 68 79 24 19 17 20 9 14 0 0.203 1.000 1.000 459 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), P4HB(1), SLC23A1(3), SLC23A2(6), SLC2A1(4), SLC2A3(2) 19044130 85 68 84 40 10 26 22 15 12 0 0.966 1.000 1.000 460 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(4), DARS(5), EPRS(5), FARS2(5), HARS(1), IARS(11), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(6) 24355967 82 67 82 19 6 15 32 19 10 0 0.150 1.000 1.000 461 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(28), PLCB1(22), PPP1CA(1), PPP3CA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 12164878 80 66 78 29 14 20 21 18 7 0 0.361 1.000 1.000 462 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2), SELP(16) 12136275 82 64 81 33 8 19 21 14 20 0 0.738 1.000 1.000 463 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCL4(1), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(1), TGFB2(4), TGFB3(1) 15237567 74 63 73 25 11 11 22 14 16 0 0.390 1.000 1.000 464 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(9), FYN(4), LRP8(5), RELN(50), VLDLR(5) 10663460 77 63 77 26 13 15 20 15 14 0 0.517 1.000 1.000 465 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(6), CRADD(2), IKBKB(11), JUN(1), LTA(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(2), TRADD(1), TRAF2(2) 18467180 69 63 69 25 13 12 21 9 14 0 0.630 1.000 1.000 466 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(9) 16014044 70 62 70 26 12 14 22 15 7 0 0.564 1.000 1.000 467 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(4), ACTN2(10), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(8), PXN(2), SRC(1), VCL(5) 14654852 79 62 77 36 10 15 30 13 10 1 0.955 1.000 1.000 468 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), HAL(6) 14478878 67 62 67 28 12 13 20 15 7 0 0.851 1.000 1.000 469 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), ESCO1(4), ESCO2(3), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX6(1), SH3GLB1(1), TAT(2), TPO(12) 26072658 74 61 73 37 16 16 24 7 11 0 0.938 1.000 1.000 470 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3) 15578679 67 61 67 26 11 13 19 15 9 0 0.537 1.000 1.000 471 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(3), CP(7), CPOX(1), EPRS(5), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UROD(1), UROS(3) 20909278 69 61 69 40 8 12 24 16 9 0 0.998 1.000 1.000 472 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(2) 15572237 69 60 69 29 13 14 13 17 12 0 0.757 1.000 1.000 473 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7) 12538130 68 60 68 21 15 14 17 12 10 0 0.186 1.000 1.000 474 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(11), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(5), QPRT(1) 16425488 72 60 72 35 9 9 25 18 11 0 0.974 1.000 1.000 475 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CMBL(2), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(4), PON2(2), PON3(8) 13740367 66 59 65 29 12 9 22 9 14 0 0.882 1.000 1.000 476 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(6), MARS(2), MARS2(5), MAT1A(1), METTL2B(3), METTL6(2), PAPSS1(6), PAPSS2(6), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SCLY(1), SEPHS1(2), SEPHS2(3) 18983679 75 59 75 22 18 20 19 11 7 0 0.117 1.000 1.000 477 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15) 15843136 64 59 64 30 13 11 24 9 7 0 0.911 1.000 1.000 478 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), GNAS(13), PLCE1(22), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAP2B(2) 11271304 74 59 73 23 19 14 23 8 10 0 0.301 1.000 1.000 479 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(13), GNB1(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 11690791 69 58 68 23 19 11 20 10 9 0 0.544 1.000 1.000 480 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(5), MAPK14(2), NFATC1(7), NFATC2(15), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 9272919 60 58 60 26 16 12 13 8 11 0 0.485 1.000 1.000 481 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(9), TPI1(4) 15396034 66 58 66 23 10 14 24 11 7 0 0.499 1.000 1.000 482 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX2(2), PRDX6(1), TAT(2), TPO(12) 16733655 68 58 67 33 16 15 22 7 8 0 0.826 1.000 1.000 483 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6) 17148266 63 58 63 21 11 14 17 7 14 0 0.396 1.000 1.000 484 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(9), COMT(1), DBH(8), DDC(7), GAD1(4), GAD2(6), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(3) 11006571 63 57 63 28 9 13 22 6 13 0 0.768 1.000 1.000 485 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), CFTR(13), GNAS(13), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1) 9990067 64 57 63 20 17 13 18 9 7 0 0.323 1.000 1.000 486 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23) 12757965 60 57 60 19 11 11 15 7 16 0 0.373 1.000 1.000 487 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(32), MAP2(19), PPP1CA(1), PRKACB(3), PRKACG(2), PRKAR2B(3), PRKCE(3) 13814838 63 56 62 19 3 7 24 12 17 0 0.787 1.000 1.000 488 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(9), F2(3), F2R(4), FGA(12), FGB(4), FGG(6), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7) 10199988 68 56 68 22 7 16 20 8 17 0 0.516 1.000 1.000 489 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(10), ENPP6(5), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1) 17686935 73 56 73 24 5 20 24 12 12 0 0.410 1.000 1.000 490 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(4), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), PC(14), PCK1(2), SDHA(6), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 15684655 63 55 62 21 11 17 18 10 7 0 0.290 1.000 1.000 491 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(5), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1), VNN1(4) 13199243 70 55 70 27 9 15 20 16 10 0 0.753 1.000 1.000 492 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(3), IL22RA1(4), IL22RA2(1), JAK1(10), JAK2(5), JAK3(6), SOCS3(1), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8) 14004048 65 55 65 28 8 19 18 11 9 0 0.648 1.000 1.000 493 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), RAC1(15), WASF1(3), WASF2(5), WASF3(6), WASL(2) 11605852 60 53 53 20 17 14 13 12 4 0 0.491 1.000 1.000 494 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(4), ARSE(3), ASAH1(1), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SPTLC1(5), SPTLC2(3), UGCG(1) 18404200 60 53 60 30 14 15 15 7 9 0 0.828 1.000 1.000 495 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1) 17875206 68 53 68 20 6 15 20 13 14 0 0.363 1.000 1.000 496 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), SOAT2(2) 17706807 62 52 62 28 11 9 17 15 10 0 0.916 1.000 1.000 497 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(10), CR2(7), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18) 11579547 60 52 59 30 3 16 16 9 16 0 0.958 1.000 1.000 498 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(11), EGF(8), EGFR(19), HGS(2), RAB5A(3), TF(5), TFRC(8) 9774048 56 52 56 22 5 11 17 12 10 1 0.869 1.000 1.000 499 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTAP(2), MTFMT(4), MTR(8), TAT(2) 15797093 66 52 66 25 8 14 16 12 16 0 0.506 1.000 1.000 500 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), OPLAH(7) 16875752 60 52 60 29 10 16 15 12 7 0 0.757 1.000 1.000 501 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(5), ST3GAL6(4), ST8SIA1(3) 12381917 56 52 54 17 8 15 23 5 5 0 0.188 1.000 1.000 502 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), GOSR1(4), GOSR2(1), SNAP25(3), STX11(6), STX12(1), STX16(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(1), VTI1A(1), YKT6(1) 12730801 58 52 57 16 11 13 16 4 14 0 0.221 1.000 1.000 503 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(6), ABCC2(9), ABCG2(4), BCHE(6), CES1(6), CES2(8), CYP3A4(4), CYP3A5(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1) 17402190 63 52 63 38 13 11 24 7 8 0 0.985 1.000 1.000 504 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(16), CPT1A(6), LEP(1), LEPR(17), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2) 11017466 56 52 56 29 9 8 18 8 13 0 0.989 1.000 1.000 505 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), GAMT(2), GATM(4), GLUD1(3), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3) 13356772 54 52 54 17 15 14 14 7 4 0 0.225 1.000 1.000 506 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(6), IFNG(2), IKBKB(11), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(1), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2) 14818860 58 50 58 19 8 8 21 7 14 0 0.607 1.000 1.000 507 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3) 13852038 54 50 54 17 9 12 15 5 13 0 0.411 1.000 1.000 508 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(6), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(2), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 11485005 53 50 53 18 10 11 15 4 13 0 0.205 1.000 1.000 509 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(4), IARS(11), IARS2(2), ILVBL(5), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(5), VARS2(4) 14201185 61 50 61 20 3 24 18 7 9 0 0.408 1.000 1.000 510 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), PHPT1(1), TYR(8) 11450654 55 50 55 16 10 6 23 6 10 0 0.560 1.000 1.000 511 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(6), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), HADHA(3), SH3GLB1(1), YOD1(4) 23572958 61 50 61 28 4 14 18 15 10 0 0.934 1.000 1.000 512 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(5), ULK1(7), ULK2(2) 16112460 58 50 58 25 7 9 27 10 5 0 0.922 1.000 1.000 513 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(8), AMT(2), ATIC(5), DHFR(2), FTCD(2), GART(5), MTFMT(4), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1) 14409956 60 49 60 26 9 7 22 9 12 1 0.889 1.000 1.000 514 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8) 14222687 57 49 57 22 5 12 16 8 16 0 0.779 1.000 1.000 515 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2) 9225121 58 49 57 27 6 14 13 10 15 0 0.861 1.000 1.000 516 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(10), PTPRU(10), REG1A(14), STAT1(8), STAT2(4), TYK2(8) 9525760 56 49 56 22 10 13 16 6 11 0 0.603 1.000 1.000 517 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(6), HK3(8), PGM3(1), RENBP(5), UAP1(5) 12907461 50 48 50 15 13 13 9 7 8 0 0.250 1.000 1.000 518 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4) 10941517 54 48 54 21 11 14 11 11 7 0 0.496 1.000 1.000 519 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(19), ABCB11(8), ABCB4(13), ABCC1(6), ABCC3(4), GSTP1(1) 10909430 51 48 51 26 7 10 18 3 13 0 0.903 1.000 1.000 520 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(16), ACACB(18), FASN(10), MCAT(3), OLAH(3), OXSM(3) 12100482 53 47 53 21 13 10 13 10 7 0 0.646 1.000 1.000 521 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1) 10634875 57 47 57 20 8 10 17 14 8 0 0.665 1.000 1.000 522 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GPHN(4), NSF(1), SRC(1), UBQLN1(2) 9131544 56 46 55 23 5 11 22 8 10 0 0.885 1.000 1.000 523 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGW(2), PIGX(2), PIGZ(2) 18117596 53 46 53 33 9 13 15 6 10 0 0.992 1.000 1.000 524 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(5), GALNT2(7), GALNT3(6), GALNT4(3), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(10) 10998633 51 46 51 18 8 16 14 4 8 1 0.434 1.000 1.000 525 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(8), AMT(2), ATIC(5), ATP6V0C(1), DHFR(2), GART(5), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1) 13614448 55 46 55 27 9 6 22 8 9 1 0.961 1.000 1.000 526 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 13402585 48 46 48 29 9 5 15 14 5 0 0.993 1.000 1.000 527 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(22), PLCB2(6), PRL(3), TRH(2), VIP(1) 8480475 50 46 49 22 6 7 23 9 5 0 0.842 1.000 1.000 528 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD5(1), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(8), TLR2(2), TLR4(17), TLR7(8), TLR9(4) 14182806 54 45 54 28 8 13 16 9 8 0 0.887 1.000 1.000 529 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(3), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(3), SLC25A20(3) 12805588 53 45 53 21 6 13 12 11 11 0 0.776 1.000 1.000 530 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(11), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5E(1), QPRT(1) 11095576 52 44 52 26 4 7 20 13 8 0 0.970 1.000 1.000 531 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4) 13774293 49 43 49 18 9 10 16 9 5 0 0.565 1.000 1.000 532 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(4), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3) 9733106 48 43 48 16 7 11 17 7 5 1 0.565 1.000 1.000 533 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(5), CYP51A1(1), DHCR24(2), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(7), GGPS1(1), HMGCR(5), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2) 14704322 49 43 49 18 11 12 9 6 11 0 0.510 1.000 1.000 534 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 15519546 48 43 48 24 15 7 10 7 9 0 0.815 1.000 1.000 535 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTR(8) 13240828 54 43 54 24 8 12 13 10 11 0 0.718 1.000 1.000 536 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(4) 15270764 57 43 57 22 10 9 15 9 14 0 0.714 1.000 1.000 537 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), PRKCE(3), SOD1(1) 5995337 50 42 49 18 4 8 20 7 11 0 0.759 1.000 1.000 538 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), PGD(2) 13775877 47 42 47 20 10 12 10 9 6 0 0.591 1.000 1.000 539 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD8A(3), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2) 8190989 45 42 45 23 3 7 10 9 16 0 0.890 1.000 1.000 540 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(1), FOS(6), JUN(1), OPRK1(6), POLR2A(12), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 9827059 43 41 43 16 8 13 10 6 6 0 0.470 1.000 1.000 541 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(19), ERBB3(17), NRG1(1) 7846179 45 41 45 16 6 9 12 12 5 1 0.710 1.000 1.000 542 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(6), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 9606047 48 41 48 25 20 8 14 2 4 0 0.883 1.000 1.000 543 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(5), CES1(6), DDHD1(4), ESCO1(4), ESCO2(3), LIPA(3), PLA1A(8), PPME1(1), PRDX6(1), SH3GLB1(1) 19334932 47 41 47 12 5 12 16 8 6 0 0.290 1.000 1.000 544 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(4), DHFR(2), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(2) 9551451 45 41 45 17 12 5 17 2 9 0 0.653 1.000 1.000 545 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(3), ARFGAP3(4), ARFGEF2(14), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(3), KDELR1(1) 12355779 46 40 46 17 5 15 12 6 8 0 0.505 1.000 1.000 546 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(6), SELL(2), SPN(3), TGFB1(1), TGFB2(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10061449 45 40 45 19 7 12 11 10 5 0 0.620 1.000 1.000 547 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2) 8595033 43 40 43 23 2 7 10 10 14 0 0.921 1.000 1.000 548 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(4), AGTR1(13), AGTR2(2), BDKRB2(3), KNG1(4), NOS3(4), REN(3) 7519856 41 39 41 16 7 12 10 7 5 0 0.461 1.000 1.000 549 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(5), GREB1(20), HSPB2(2), MTA1(7), MTA3(2), TUBA8(2) 8366204 44 39 44 20 12 4 15 7 6 0 0.768 1.000 1.000 550 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(10), JAK2(5), JAK3(6), MAPK1(9), STAT3(6), TYK2(8) 8913614 44 39 37 13 12 7 10 9 6 0 0.258 1.000 1.000 551 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(1), YOD1(4) 19815473 42 38 42 16 2 11 10 11 8 0 0.717 1.000 1.000 552 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(9), MPO(7), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12) 8848244 42 38 41 23 15 6 14 4 3 0 0.940 1.000 1.000 553 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(2), PSMD2(5) 12173900 44 38 44 14 3 8 16 11 6 0 0.605 1.000 1.000 554 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(1), CAT(4), EPX(9), MPO(7), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12) 8997307 43 38 42 23 14 6 14 6 3 0 0.938 1.000 1.000 555 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 12593698 42 38 42 20 12 6 10 7 7 0 0.783 1.000 1.000 556 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(4), MBTPS1(11), MBTPS2(4), SCAP(8), SREBF1(5), SREBF2(5) 9071949 40 38 39 14 6 7 13 9 5 0 0.640 1.000 1.000 557 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(3), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), TBXA2R(1) 8535020 43 38 42 25 8 8 16 5 6 0 0.876 1.000 1.000 558 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(3), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 11119036 38 38 37 13 4 9 12 2 11 0 0.571 1.000 1.000 559 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(2), PER3(6) 13012064 42 37 42 17 11 9 10 9 3 0 0.638 1.000 1.000 560 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(8), IRS1(2), JAK1(10), JAK3(6), RPS6KB1(4), SHC1(2), STAT6(5) 11249390 40 37 40 13 6 10 11 7 6 0 0.326 1.000 1.000 561 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), FDXR(3), SHMT1(1) 12176994 48 37 48 15 7 9 16 9 7 0 0.479 1.000 1.000 562 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), TYR(8) 7402625 40 37 40 13 5 5 19 4 7 0 0.673 1.000 1.000 563 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(2), RPL8(1), RPS10(2), RPS13(2), RPS15A(1), RPS20(1), RPS23(1), RPS25(2), RPS28(1), RPS3(2), RPS5(1) 17304999 43 36 43 24 4 10 17 4 8 0 0.954 1.000 1.000 564 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(1), IL1A(1), IL6(2), JAK1(10), STAT1(8), STAT3(6), STAT5A(3) 9275295 40 36 40 19 3 15 10 6 6 0 0.600 1.000 1.000 565 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 566 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1) 8820515 36 35 36 14 4 9 10 6 7 0 0.836 1.000 1.000 567 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 568 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), JAK2(5), STAT4(6), TYK2(8) 11195854 42 35 42 19 4 9 12 7 10 0 0.848 1.000 1.000 569 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RELA(2) 6288248 37 35 36 12 5 6 15 6 5 0 0.492 1.000 1.000 570 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 571 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1) 7619969 41 35 41 12 0 16 13 6 6 0 0.513 1.000 1.000 572 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(6), GPR161(4), GPR171(2), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(2), GPR75(5) 7498683 37 34 37 17 11 7 7 7 5 0 0.746 1.000 1.000 573 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1) 9547972 39 34 39 14 8 5 14 7 5 0 0.617 1.000 1.000 574 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), MPO(7), PRDX2(2), PRDX6(1), TPO(12), TYR(8) 7358360 39 34 38 19 11 4 16 5 3 0 0.892 1.000 1.000 575 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6) 5344444 37 33 37 19 4 10 14 4 5 0 0.874 1.000 1.000 576 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1) 19028846 38 33 38 16 3 11 6 8 10 0 0.808 1.000 1.000 577 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(8), ITGAM(8), ITGB2(3), SELE(7), SELL(2) 7905087 37 33 37 24 3 9 7 5 13 0 0.963 1.000 1.000 578 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), RAC1(15), WASF1(3), WASL(2) 6175789 35 33 28 13 10 9 7 7 2 0 0.589 1.000 1.000 579 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8) 7987723 38 33 38 15 8 8 9 7 6 0 0.674 1.000 1.000 580 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8) 7987723 38 33 38 15 8 8 9 7 6 0 0.674 1.000 1.000 581 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(8), ACO2(4), ACSS1(6), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(2) 10126876 36 32 36 14 5 11 12 2 6 0 0.569 1.000 1.000 582 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), LTA(4), TGFB1(1), TGFB2(4), TGFB3(1) 10139640 34 32 33 16 5 7 8 8 6 0 0.868 1.000 1.000 583 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 9263996 35 32 35 15 5 5 10 9 6 0 0.855 1.000 1.000 584 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(4), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(18), ZAP70(4) 6887652 36 32 35 17 3 6 9 7 11 0 0.900 1.000 1.000 585 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4) 7067770 31 30 31 11 7 8 5 4 7 0 0.449 1.000 1.000 586 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(4), PON2(2), PON3(8), RDH11(2), RDH12(4) 6856410 34 30 33 17 3 7 10 9 5 0 0.876 1.000 1.000 587 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), JAK1(10), STAT1(8), STAT2(4), TYK2(8) 8272766 34 30 34 16 5 9 7 4 9 0 0.799 1.000 1.000 588 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7026894 31 29 31 13 10 3 8 5 4 1 0.693 1.000 1.000 589 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7026894 31 29 31 13 10 3 8 5 4 1 0.693 1.000 1.000 590 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3) 10077353 31 29 31 15 5 7 6 7 6 0 0.876 1.000 1.000 591 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), CS(3), FH(3), IDH2(1), MDH1(1), OGDH(10), SDHA(6), SUCLA2(2) 7163508 30 29 29 10 5 4 12 5 4 0 0.630 1.000 1.000 592 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(3), GGT1(4), MARS(2), MARS2(5), MAT1A(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(2) 9427406 31 29 31 12 8 9 7 5 2 0 0.521 1.000 1.000 593 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7) 6503926 30 28 30 11 6 6 8 9 1 0 0.632 1.000 1.000 594 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(2), MPO(7), PRDX6(1), TPO(12) 6384044 31 28 30 17 11 4 11 3 2 0 0.914 1.000 1.000 595 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4) 10055090 29 26 29 12 9 9 3 4 4 0 0.512 1.000 1.000 596 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(3), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 9027467 31 25 31 12 0 11 10 5 5 0 0.769 1.000 1.000 597 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(3), FARS2(5), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6) 6320693 29 25 29 11 0 9 11 3 6 0 0.603 1.000 1.000 598 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(17), SP1(3), SP3(3) 5062287 25 25 25 10 0 2 5 4 14 0 0.918 1.000 1.000 599 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6087277 24 23 24 12 5 2 7 6 4 0 0.912 1.000 1.000 600 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6087277 24 23 24 12 5 2 7 6 4 0 0.912 1.000 1.000 601 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4) 8439908 26 23 26 10 10 8 2 2 4 0 0.386 1.000 1.000 602 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), DHFR(2), FPGS(1), GCH1(1), GGH(2) 4994142 25 23 25 12 5 2 12 3 3 0 0.819 1.000 1.000 603 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1) 10947614 25 23 25 17 5 8 6 2 4 0 0.939 1.000 1.000 604 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(9), PRKCA(7), PTK2B(4) 5113158 23 23 23 10 5 4 9 4 1 0 0.633 1.000 1.000 605 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6) 7546546 23 22 23 13 4 5 6 4 4 0 0.883 1.000 1.000 606 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(3) 6483880 22 22 22 10 5 3 4 7 3 0 0.765 1.000 1.000 607 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(14), GLS(1), GLUD1(3), GOT1(1) 5941839 22 22 22 10 4 4 6 5 3 0 0.822 1.000 1.000 608 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 5262994 24 21 24 15 7 3 7 2 4 1 0.901 1.000 1.000 609 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(1), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3) 7724314 24 21 24 14 3 6 9 1 5 0 0.904 1.000 1.000 610 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(1) 4552714 22 20 21 10 3 7 8 2 2 0 0.515 1.000 1.000 611 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(2), XDH(6) 6080283 22 19 22 10 3 5 9 3 2 0 0.757 1.000 1.000 612 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(4), CPO(4), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3) 5951609 18 18 18 11 2 3 6 6 1 0 0.949 1.000 1.000 613 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4) 2985343 16 16 16 7 1 6 4 5 0 0 0.692 1.000 1.000 614 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4) 6849192 17 16 17 11 3 2 4 4 4 0 0.969 1.000 1.000 615 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4) 3653050 16 15 16 7 3 3 7 3 0 0 0.695 1.000 1.000 616 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1) 12644033 16 15 16 9 0 4 3 4 5 0 0.944 1.000 1.000