rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 387333 2 2 2 0 0 0 0 0 2 0 0.660 0.289 1.000 2 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2) 4654771 25 23 25 2 5 7 5 5 3 0 0.0271 0.363 1.000 3 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(6) 1385935 9 9 9 2 1 3 2 2 1 0 0.347 0.596 1.000 4 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(4) 1259018 6 6 6 2 1 3 2 0 0 0 0.649 0.692 1.000 5 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(4), CDC34(4), CUL1(11), RB1(17), TFDP1(2) 5002135 38 33 38 8 3 11 5 3 16 0 0.108 0.705 1.000 6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(4), CHEK1(1), NEK1(9), WEE1(2) 5234638 19 19 19 1 4 4 6 1 4 0 0.0923 0.727 1.000 7 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(2), RAB3A(2), RAB4A(1), RAB5A(3) 3216067 13 13 13 1 5 4 2 1 1 0 0.0409 0.737 1.000 8 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(6) 1540877 12 12 12 3 0 4 5 2 1 0 0.411 0.761 1.000 9 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(3), UXS1(2) 2930825 10 10 10 0 0 1 5 3 1 0 0.131 0.779 1.000 10 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2) 1803977 7 7 6 2 0 1 0 3 3 0 0.747 0.790 1.000 11 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 550302 1 1 1 1 0 0 0 1 0 0 0.924 0.819 1.000 12 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(10), RDH5(1) 2972225 12 12 12 2 1 1 5 2 3 0 0.404 0.824 1.000 13 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 1699430 7 7 7 2 1 4 1 0 1 0 0.418 0.838 1.000 14 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(3), UGP2(2), UXS1(2) 3731305 12 12 12 0 0 1 7 3 1 0 0.0936 0.850 1.000 15 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(1), RXRA(4) 4408546 15 15 15 1 2 4 5 2 2 0 0.0366 0.854 1.000 16 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(4), SNCA(1), SNCAIP(4), UBE2L3(2), UBE2L6(2) 4900386 23 21 23 4 4 5 5 7 2 0 0.140 0.896 1.000 17 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(5), PRKCA(7), TGM2(4) 3767281 19 19 19 4 2 6 5 3 3 0 0.104 0.925 1.000 18 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(2), GRIA2(16), JUND(1) 2848398 22 22 22 7 4 5 10 2 1 0 0.393 0.940 1.000 19 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1163469 1 1 1 0 0 0 0 1 0 0 0.757 0.950 1.000 20 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(15), C5(10), C7(12), C8A(8), C9(15) 8116618 60 52 59 11 10 17 19 10 4 0 0.0272 0.953 1.000 21 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT2(2), FUT9(11), GCNT2(5), ST8SIA1(3) 4707553 24 23 23 5 3 6 13 2 0 0 0.153 0.957 1.000 22 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(6), CHST13(7), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2) 7066234 43 39 43 7 11 7 11 8 6 0 0.0371 0.963 1.000 23 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(5), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2) 2309391 11 11 10 4 0 3 4 0 4 0 0.699 0.969 1.000 24 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2) 6648166 27 25 27 4 1 5 10 7 4 0 0.128 0.971 1.000 25 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 862651 1 1 1 1 0 0 1 0 0 0 0.944 0.972 1.000 26 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(13), GNB1(3), PRKACA(4), PRKAR1A(4) 5059800 45 38 44 8 15 6 14 6 4 0 0.0427 0.979 1.000 27 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(4) 3907972 15 14 15 3 3 3 6 2 1 0 0.191 0.983 1.000 28 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(5), CES1(6), ESD(3) 4610630 20 19 20 4 3 9 6 0 2 0 0.101 0.987 1.000 29 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(1), IL12B(3), IL18(1), IL2(2) 2272852 11 11 11 4 1 1 2 4 3 0 0.838 0.988 1.000 30 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4) 1302996 4 4 4 3 0 1 2 0 1 0 0.872 0.989 1.000 31 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(3), AASS(3), KARS(4) 3590576 13 13 13 3 1 2 2 3 5 0 0.441 0.990 1.000 32 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(3) 4066446 22 20 22 6 1 1 11 1 8 0 0.486 0.992 1.000 33 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2), TAT(2) 2001633 5 5 5 2 0 0 3 1 1 0 0.768 0.992 1.000 34 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(4), GAD1(4), GAD2(6), GGT1(4) 4389193 22 22 22 5 4 6 5 2 5 0 0.173 0.992 1.000 35 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(2) 1605413 7 7 7 3 1 2 3 1 0 0 0.692 0.994 1.000 36 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CASP9(1), CHUK(6), GH1(4), GHR(9), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3R1(9), RELA(2), YWHAH(2) 9093067 46 41 45 9 5 11 11 7 12 0 0.127 0.996 1.000 37 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(6), FOSL1(3), FOSL2(10), IFNAR1(2), IFNAR2(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3) 8459745 41 38 41 8 6 9 10 7 9 0 0.226 0.997 1.000 38 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(1), SPCS1(2), SPCS3(1) 2326227 6 6 6 5 0 2 1 0 3 0 0.911 0.997 1.000 39 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(2), CASP3(2), CASP9(1), GZMB(2), JUN(1), PRF1(5) 8942139 38 35 38 7 5 9 5 11 8 0 0.149 0.998 1.000 40 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4) 4292194 13 12 13 4 1 3 2 2 5 0 0.634 0.998 1.000 41 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SEC61A2(4), SRP54(2), SRP68(5), SRP72(1), SRPR(3) 5742620 18 17 18 3 3 8 5 1 1 0 0.168 0.998 1.000 42 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(3), CD3D(1), CD80(4), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3R1(9), PTPN11(2) 8067800 37 32 36 7 0 7 7 9 14 0 0.177 0.999 1.000 43 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2) 2762619 18 14 18 6 1 8 5 2 2 0 0.389 0.999 1.000 44 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4) 6173621 34 32 34 9 5 7 12 6 4 0 0.286 0.999 1.000 45 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1) 3023870 14 14 13 5 0 4 3 4 3 0 0.703 0.999 1.000 46 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 3691094 12 10 12 3 0 4 3 3 2 0 0.472 0.999 1.000 47 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(5), CD3D(1), CD4(1), CD58(2), CD8A(3), IL3(1), IL6(2), KITLG(1) 4712361 17 16 17 5 2 2 2 4 7 0 0.535 0.999 1.000 48 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1) 3259670 9 9 9 3 2 5 1 1 0 0 0.406 0.999 1.000 49 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(2), HMGCL(1), OXCT1(1) 2574695 4 4 4 2 1 0 1 0 2 0 0.857 0.999 1.000 50 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(4), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(4) 4151822 19 18 18 5 4 5 5 1 4 0 0.308 0.999 1.000 51 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 4121663 14 14 14 4 2 3 4 4 1 0 0.547 0.999 1.000 52 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3) 7784242 33 32 33 6 7 9 8 3 6 0 0.0490 0.999 1.000 53 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(3), STX1A(5) 2478478 8 8 8 3 4 0 3 1 0 0 0.726 0.999 1.000 54 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(4), CDC34(4), CUL1(11), RB1(17), SKP2(4), TFDP1(2) 6487151 49 43 49 12 4 11 12 5 17 0 0.218 1.000 1.000 55 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(3), GLUD2(10) 3476172 16 16 16 6 4 1 4 3 4 0 0.749 1.000 1.000 56 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(6), CTH(3), MUT(5) 3737326 18 17 18 5 2 6 4 3 3 0 0.473 1.000 1.000 57 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(10), JAK2(5), STAT1(8) 6237387 33 29 32 9 2 9 8 5 9 0 0.257 1.000 1.000 58 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(2), TAT(2), TYR(8) 3584284 20 18 20 6 2 3 10 1 4 0 0.520 1.000 1.000 59 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(2), IDI1(1) 2437437 7 7 7 3 2 4 1 0 0 0 0.550 1.000 1.000 60 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(2) 3054940 16 15 16 6 2 3 6 2 3 0 0.686 1.000 1.000 61 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(4), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2) 6778760 25 22 25 5 4 8 10 1 2 0 0.137 1.000 1.000 62 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(5), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2) 4060506 18 18 17 6 1 4 8 2 3 0 0.600 1.000 1.000 63 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(3), CD3D(1), CD4(1) 2444270 5 5 5 3 0 0 1 3 1 0 0.904 1.000 1.000 64 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5051402 26 25 26 7 4 3 7 7 5 0 0.331 1.000 1.000 65 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5051402 26 25 26 7 4 3 7 7 5 0 0.331 1.000 1.000 66 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(6), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(3) 8163969 38 34 38 9 5 7 8 13 5 0 0.302 1.000 1.000 67 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 6045395 23 21 23 5 6 3 7 2 5 0 0.307 1.000 1.000 68 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(1), FARSB(8), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6), YARS2(4) 6628304 36 34 36 9 2 11 13 5 5 0 0.159 1.000 1.000 69 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1) 5951533 17 16 17 4 2 4 5 4 2 0 0.379 1.000 1.000 70 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(6), SDHB(1), SDHC(1), UQCRC1(1) 5040611 16 16 15 4 1 4 6 4 1 0 0.399 1.000 1.000 71 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(3), HTR2C(4), PLCB1(22), TUB(3) 5443928 32 32 31 9 7 5 13 5 2 0 0.331 1.000 1.000 72 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6) 10687545 47 41 47 8 11 11 12 6 7 0 0.0219 1.000 1.000 73 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(1), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PRKCA(7) 4461363 21 19 21 7 1 6 6 3 5 0 0.510 1.000 1.000 74 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(4) 5293186 18 18 18 5 1 2 3 6 6 0 0.542 1.000 1.000 75 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C9(15) 11896421 76 64 75 16 10 25 24 12 5 0 0.0221 1.000 1.000 76 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(5), ST6GALNAC2(2), ST8SIA1(3) 4308320 17 17 17 5 4 4 4 2 3 0 0.295 1.000 1.000 77 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(1), FOS(6), FYN(4), JUN(1), MAPK14(2), THBS1(8) 5649868 24 22 24 7 3 6 5 6 4 0 0.310 1.000 1.000 78 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NFS1(1), PHPT1(1), TPK1(3) 4877663 14 13 14 4 3 3 4 3 1 0 0.567 1.000 1.000 79 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIK(2), BIRC2(3), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), DIABLO(1) 9340788 38 35 38 7 4 14 4 6 10 0 0.0786 1.000 1.000 80 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(7), ELK1(2), FOS(6), INSR(3), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(9), PTPN11(2), RAF1(3), SHC1(2), SLC2A4(3), SOS1(9), SRF(1) 15860323 59 52 59 9 7 9 20 9 14 0 0.0164 1.000 1.000 81 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(7), ELK1(2), FOS(6), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(1), PIK3R1(9), PLCG1(9), RAF1(3), SHC1(2), SOS1(9) 12537919 60 54 60 10 10 8 22 7 13 0 0.0436 1.000 1.000 82 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(12), BAD(1), BAK1(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(6) 8339516 29 29 29 6 4 9 4 5 7 0 0.240 1.000 1.000 83 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(3) 4614627 23 23 23 8 3 2 11 2 5 0 0.621 1.000 1.000 84 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(22), NRG2(5), NRG3(19), PRKCA(7) 6848799 58 52 58 15 4 10 22 12 10 0 0.333 1.000 1.000 85 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(3) 3169211 9 9 9 5 3 0 3 1 2 0 0.886 1.000 1.000 86 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(37), GZMA(2), GZMB(2), HMGB2(2), PRF1(5), SET(1) 8090593 51 44 50 12 9 8 14 10 9 1 0.145 1.000 1.000 87 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), IMPA2(2), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3) 8888555 39 37 39 9 9 10 10 3 7 0 0.0645 1.000 1.000 88 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1), PPT2(2) 6455846 26 23 26 7 2 3 9 8 4 0 0.433 1.000 1.000 89 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), IL6(2), IL6R(6), IL6ST(5), JAK1(10), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT3(6) 17812851 79 70 79 12 14 12 26 16 11 0 0.00246 1.000 1.000 90 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6) 6576401 22 21 22 5 6 6 2 5 3 0 0.290 1.000 1.000 91 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(4), GH1(4), GHR(9), IGF1(1), IGF1R(11), PIK3R1(9), SHC1(2), SOD1(1), SOD2(1), SOD3(4) 8144395 48 42 48 11 10 10 12 9 7 0 0.114 1.000 1.000 92 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(11), PDXK(1), PSAT1(1) 3694776 13 11 13 6 1 2 2 6 2 0 0.850 1.000 1.000 93 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(2), IL6(2), LDLR(4), LPL(4) 4050270 14 14 13 5 2 4 6 1 1 0 0.567 1.000 1.000 94 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(11), RB1(17), WEE1(2), YWHAH(2) 12748481 65 58 65 11 7 15 13 8 22 0 0.0933 1.000 1.000 95 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(11), WEE1(2), YWHAH(2) 10473104 43 37 43 8 7 10 10 8 8 0 0.169 1.000 1.000 96 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(6), DNAJC3(3), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2) 6870155 25 24 25 9 4 5 5 4 7 0 0.669 1.000 1.000 97 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C9(15), MASP1(7), MASP2(5), MBL2(2) 14797003 90 72 88 19 12 27 24 19 8 0 0.0156 1.000 1.000 98 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1) 6363842 18 16 18 5 1 3 7 5 2 0 0.569 1.000 1.000 99 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3) 5296122 15 14 15 4 3 5 5 1 1 0 0.423 1.000 1.000 100 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(3), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), IL9(2) 4632206 20 20 20 9 4 3 7 3 3 0 0.751 1.000 1.000 101 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(1), FHL5(5), FSHB(2), FSHR(12), GNAS(13), XPO1(6) 7324088 60 51 59 13 14 11 19 13 3 0 0.127 1.000 1.000 102 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 6 CREBBP(37), LPL(4), NCOA1(7), NCOA2(9), PPARG(1), RXRA(4) 10330966 62 50 61 14 6 13 18 15 9 1 0.138 1.000 1.000 103 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6) 10275904 47 41 47 9 3 9 18 6 11 0 0.0963 1.000 1.000 104 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(3), OAT(1), PRODH(1) 4223754 7 7 7 3 0 1 1 3 2 0 0.754 1.000 1.000 105 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6) 9816929 38 33 38 8 1 8 14 10 5 0 0.213 1.000 1.000 106 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(5), ITPKB(5) 4623535 11 9 11 4 1 3 4 1 2 0 0.609 1.000 1.000 107 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(24), CDC25C(4), CHEK1(1), CHEK2(4), YWHAH(2) 11559436 51 47 51 9 4 15 10 14 8 0 0.161 1.000 1.000 108 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(3), MDH1(1), ME1(2), PC(14), PDHA1(4) 7071633 28 28 28 8 4 8 6 5 5 0 0.279 1.000 1.000 109 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(2), CCL2(2), CCL4(1), CXCL12(3), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(9), PRKCA(7), PTK2B(4), SYT1(9) 10511573 55 49 55 13 8 10 19 14 4 0 0.0943 1.000 1.000 110 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 13 CUZD1(2), FOS(6), JUN(1), MAP2K1(5), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RAF1(3), RELA(2) 11025003 60 56 57 15 8 13 24 8 7 0 0.0825 1.000 1.000 111 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GGT1(4), SHMT1(1), SHMT2(3) 4201908 11 11 11 5 5 1 2 1 2 0 0.722 1.000 1.000 112 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(5), DLL1(5), FURIN(1) 3967260 11 11 11 5 3 3 2 1 2 0 0.738 1.000 1.000 113 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(9), GLI2(16), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3) 12690994 71 62 70 16 12 18 24 8 9 0 0.0393 1.000 1.000 114 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 16 IL18(1), ITGB1(15), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LAT(3), MAP2K1(5), PAK1(3), PIK3R1(9), PTK2B(4), PTPN6(3), SYK(8), VAV1(7) 11415072 64 53 63 13 14 7 14 9 20 0 0.132 1.000 1.000 115 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), WT1(3) 4756021 17 17 15 7 0 4 8 3 2 0 0.770 1.000 1.000 116 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(11), EPHB1(15), FYN(4), ITGA1(4), ITGB1(15), L1CAM(10), LYN(8), RAP1B(3), SELP(16) 12031630 90 63 88 19 13 17 24 18 18 0 0.0606 1.000 1.000 117 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(4), BMPR1B(4), BMPR2(6) 4770080 14 14 14 5 3 4 4 1 2 0 0.655 1.000 1.000 118 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(14) 6426979 16 16 16 9 3 4 5 0 4 0 0.956 1.000 1.000 119 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHB(1), LDHC(4), MPST(2) 5220421 18 16 18 6 4 1 10 2 1 0 0.635 1.000 1.000 120 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(7), ELK1(2), FOS(6), IGF1(1), IGF1R(11), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(9), PTPN11(2), RAF1(3), SHC1(2), SOS1(9), SRF(1) 15328284 65 57 65 11 11 11 20 10 13 0 0.0185 1.000 1.000 121 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(9), PLCB1(22), PLCG1(9), PRKCA(7), VAV1(7) 8098139 56 51 55 14 7 8 21 9 11 0 0.337 1.000 1.000 122 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), EPO(2), EPOR(1), GRIN1(4), HIF1A(4), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1) 9683106 34 34 34 9 5 11 6 7 5 0 0.175 1.000 1.000 123 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C8B(9), C9(15), MASP1(7) 14408376 92 74 90 22 12 26 28 18 8 0 0.0505 1.000 1.000 124 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 11 APC(27), CDH1(5), CREBBP(37), MAP2K1(5), MAP3K7(8), SKIL(4), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2) 14914179 94 73 91 19 10 15 30 20 18 1 0.127 1.000 1.000 125 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(4), CDKN1B(2), CKS1B(3), CUL1(11), RB1(17), RBX1(3), SKP2(4), TFDP1(2), UBE2M(3) 6398753 49 45 49 14 3 12 9 7 18 0 0.340 1.000 1.000 126 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(1), OXCT2(1) 5482791 12 11 12 8 3 2 2 3 2 0 0.943 1.000 1.000 127 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8) 9637613 52 46 50 14 4 9 15 8 16 0 0.291 1.000 1.000 128 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(4), ST3GAL4(1) 5514832 16 15 16 7 4 2 6 2 2 0 0.779 1.000 1.000 129 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST7(1), CHSY1(3), DSE(2), UST(2), XYLT1(10), XYLT2(3) 10714043 56 50 56 12 14 5 18 11 8 0 0.0709 1.000 1.000 130 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 13 AKT1(2), CREB1(1), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), NTRK1(3), PIK3R1(9), PLCG1(9), RPS6KA1(10), SHC1(2) 11234200 51 45 51 11 10 8 13 12 8 0 0.158 1.000 1.000 131 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 19 F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), ITGA1(4), ITGB1(15), MAP2K1(5), PLA2G4A(3), PLCB1(22), PRKCA(7), PTGS1(7), PTK2(8), RAF1(3), SRC(1), SYK(8), TBXAS1(5) 17740314 103 84 101 22 15 17 33 19 19 0 0.0283 1.000 1.000 132 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4) 6732916 19 16 19 9 2 6 6 2 3 0 0.937 1.000 1.000 133 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3) 7727050 35 32 35 10 7 7 13 4 4 0 0.196 1.000 1.000 134 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(13), GNB1(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7) 7329209 40 35 40 10 13 9 9 4 5 0 0.185 1.000 1.000 135 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(13), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3R1(9), RELA(2), SYT1(9) 12010112 63 51 63 13 13 12 15 12 11 0 0.103 1.000 1.000 136 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(2), SRC(1) 7005394 24 23 24 8 5 8 5 2 4 0 0.412 1.000 1.000 137 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(21), ARHGEF1(8), F2(3), F2R(4), F2RL3(3), GNA12(1), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3R1(9), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2B(4), ROCK1(19) 18058312 120 97 117 26 19 22 41 22 16 0 0.0185 1.000 1.000 138 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(4), TGFB3(1) 6301711 23 20 23 9 6 2 8 5 2 0 0.655 1.000 1.000 139 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1) 5585129 17 17 16 6 3 2 6 5 1 0 0.740 1.000 1.000 140 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(7), CCNA2(4), CCND1(3), CCNE1(4), CCNE2(4), CDK4(5), CDKN1B(2), E2F2(3), E2F4(3), PRB1(7) 6412605 42 40 42 13 1 10 12 13 6 0 0.580 1.000 1.000 141 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(12), ATM(16), BCL2(1), CCND1(3), CCNE1(4), CDK4(5), GADD45A(1), MDM2(3), PCNA(1), RB1(17) 13183801 63 58 63 14 2 15 11 13 22 0 0.254 1.000 1.000 142 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 5 CREBBP(37), ESR1(5), PELP1(2), SRC(1) 6969166 45 39 44 14 4 7 14 9 10 1 0.429 1.000 1.000 143 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(2), IL1B(1), MST1R(9) 4965226 14 14 14 9 1 5 7 0 1 0 0.882 1.000 1.000 144 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(7), ELK1(2), EPO(2), EPOR(1), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(9), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5) 16022908 67 60 67 14 12 16 25 5 9 0 0.0317 1.000 1.000 145 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(2), HDAC9(15), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), YWHAH(2) 5176837 32 30 32 10 7 5 8 9 3 0 0.454 1.000 1.000 146 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), BRAF(10), CREB1(1), CREB5(7), RAF1(3), SNX13(2), SRC(1), TERF2IP(1) 7971683 26 19 26 9 2 4 9 6 5 0 0.755 1.000 1.000 147 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 CDC34(4), TAX1BP3(1), UBE2D2(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2S(1), UBE3A(6) 7246312 22 20 22 8 3 10 5 1 3 0 0.574 1.000 1.000 148 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(14), GNA12(1), PRKACB(3), PRKACG(2), PRKAR2B(3) 7662733 23 22 23 8 3 8 6 3 3 0 0.609 1.000 1.000 149 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL12A(1), IL12B(3), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4) 7576239 35 33 35 11 7 8 10 6 4 0 0.424 1.000 1.000 150 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 17 AKT1(2), BAD(1), BCL2L1(2), CASP9(1), CDC42(3), CHUK(6), ELK1(2), H2AFX(1), MAP2K1(5), NFKB1(5), PIK3R1(9), RAF1(3), RALBP1(3), RALGDS(6), RELA(2) 11911833 51 44 51 12 10 8 15 4 14 0 0.209 1.000 1.000 151 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6) 11431730 49 45 49 12 10 13 11 8 7 0 0.0924 1.000 1.000 152 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(4), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(3) 5750455 13 13 13 8 1 3 4 4 1 0 0.935 1.000 1.000 153 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(8), MDM2(3), MYC(6), PIK3R1(9), POLR1A(9), POLR1B(3), POLR1C(2), RB1(17), TBX2(4), TWIST1(1) 12402108 62 56 59 16 6 8 14 11 23 0 0.380 1.000 1.000 154 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 12 AKT1(2), BAD(1), IGF1R(11), IRS1(2), MAP2K1(5), PIK3R1(9), RAF1(3), SHC1(2), SOS1(9), YWHAH(2) 11949147 46 40 46 11 9 10 13 7 7 0 0.166 1.000 1.000 155 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(1), PTK2B(4), SHC1(2), SOS1(9), SRC(1) 6387405 17 16 17 8 6 2 5 3 1 0 0.836 1.000 1.000 156 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 CISH(1), IFNG(2), IFNGR1(4), JAK1(10), JAK2(5), PLA2G2A(2), PTPRU(10), STAT1(8) 8445306 42 39 41 12 9 13 6 5 9 0 0.158 1.000 1.000 157 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3) 8200744 36 33 36 11 7 7 14 4 4 0 0.241 1.000 1.000 158 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(2), BCAR1(3), CDKN1B(2), ILK(4), ITGB1(15), PDK2(1), PDPK1(4), PIK3R1(9), PTK2(8), SHC1(2), SOS1(9) 11953810 59 49 57 15 8 11 15 8 17 0 0.315 1.000 1.000 159 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(5), CREB1(1), CREBBP(37), NCOA3(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RARA(5), RXRA(4) 11981192 76 65 75 22 13 19 16 12 15 1 0.236 1.000 1.000 160 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(5), APC(27), AXIN1(12), BTRC(1), CTNNB1(6), DLL1(5), DVL1(8), FZD1(6), GSK3B(3), WNT1(2) 13267518 75 55 74 20 15 18 16 13 12 1 0.170 1.000 1.000 161 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(3), F2R(4), F3(2), F5(19), F7(2), FGA(12), FGB(4), FGG(6), PROC(2), PROS1(10), SERPINC1(4), TFPI(2) 12478498 73 57 73 19 6 23 21 13 10 0 0.158 1.000 1.000 162 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(12), ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), GZMB(2), LMNA(1), LMNB1(2), LMNB2(8), PRF1(5) 13831187 56 48 56 13 9 15 10 13 9 0 0.121 1.000 1.000 163 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9) 7035680 32 29 32 10 6 8 10 6 2 0 0.343 1.000 1.000 164 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(4), AFMID(5), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3) 10194513 53 46 53 16 7 14 18 8 5 1 0.385 1.000 1.000 165 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(1), CAMKK2(6), CREB1(1), SYT1(9) 8808971 36 36 36 11 4 8 13 8 3 0 0.497 1.000 1.000 166 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(12), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP7(3), CASP9(1), GZMB(2), PRF1(5), SCAP(8), SREBF1(5), SREBF2(5) 12986829 50 45 50 13 9 13 11 9 8 0 0.209 1.000 1.000 167 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 20 ACTA1(4), ADCY1(21), CAP1(3), CCNB1(2), CDC25C(4), GNAI1(2), GNAS(13), GNB1(3), MYT1(11), PIN1(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10), SRC(1) 14844057 91 72 90 23 26 18 24 12 11 0 0.0467 1.000 1.000 168 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 22 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(4), HDAC5(3), MEF2A(3), MEF2B(5), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(3), SYT1(9), YWHAH(2) 14751533 54 49 53 14 5 16 17 14 2 0 0.120 1.000 1.000 169 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(1), IL6(2), IL6R(6), JAK1(10), JAK2(5), JAK3(6), PIAS3(4), PTPRU(10), SRC(1), STAT3(6) 11315209 51 50 51 14 13 8 14 10 6 0 0.163 1.000 1.000 170 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(4), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), LALBA(1), LCT(17), MGAM(29), PFKM(6), PFKP(5), PGM1(5), PGM3(1) 24759228 116 96 115 25 20 29 31 15 20 1 0.00492 1.000 1.000 171 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(8), ATM(16), ATR(24), CCNA1(7), CCND1(3), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), DHFR(2), GSK3B(3), HDAC1(1), RB1(17), SKP2(4), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1) 21933607 108 94 107 25 9 20 27 24 28 0 0.165 1.000 1.000 172 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(2), EGF(8), EGFR(19), MET(4), PDGFRA(13), PRKCA(7), SH3GLB1(1), SH3GLB2(3), SH3KBP1(8), SRC(1) 14777379 69 65 69 20 9 13 23 12 11 1 0.239 1.000 1.000 173 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 19 CSNK2A1(7), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), THPO(1) 19284222 90 75 90 21 13 21 27 11 18 0 0.0628 1.000 1.000 174 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(19), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(22), RARA(5), RXRA(4), THRA(5), THRB(1) 13159977 77 65 77 22 13 11 23 15 14 1 0.254 1.000 1.000 175 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(2), KLK2(2), NTRK1(3), PIK3R1(9), PLCG1(9), PRKCA(7), SHC1(2), SOS1(9) 9865585 43 39 43 12 6 9 14 8 6 0 0.409 1.000 1.000 176 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB5(7), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4) 21306365 93 77 92 22 14 25 23 15 16 0 0.0596 1.000 1.000 177 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(6), CREBBP(37), FADD(3), HDAC3(4), IKBKB(11), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3) 13346267 79 71 78 22 11 15 23 15 14 1 0.209 1.000 1.000 178 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(3), LCT(17), MPI(4), PGM1(5), PYGL(9), PYGM(8), TPI1(4) 10161153 54 43 54 17 10 14 14 9 7 0 0.195 1.000 1.000 179 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(6), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(3) 8624495 38 36 38 12 5 13 9 6 5 0 0.396 1.000 1.000 180 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 185 ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(1), BCAR1(3), BCL2(1), BIRC2(3), BIRC3(2), BRAF(10), CAPN2(5), CAV1(1), CCND1(3), CCND2(2), CDC42(3), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(8), EGFR(19), ELK1(2), ERBB2(12), FARP2(4), FIGF(1), FLNA(24), FLNB(9), FLNC(19), FLT1(17), FN1(18), FYN(4), GSK3B(3), HGF(11), IBSP(4), IGF1(1), IGF1R(11), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), JUN(1), KDR(14), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), MAP2K1(5), MAPK10(4), MAPK8(4), MAPK9(4), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PDPK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(50), ROCK1(19), ROCK2(11), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SPP1(2), SRC(1), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TLN1(22), TLN2(12), TNC(12), TNN(21), TNR(21), TNXB(25), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2) 277738019 1461 416 1449 480 230 310 462 226 227 6 0.160 1.000 1.000 181 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY7(6), ADCY8(28), ADCY9(9), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ATP2A1(9), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), ATP2B4(6), AVPR1A(9), AVPR1B(6), BDKRB1(2), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(3), CD38(5), CHRM2(5), CHRM3(9), CHRM5(4), CHRNA7(2), CYSLTR1(2), CYSLTR2(6), DRD1(2), EDNRA(2), EDNRB(7), EGFR(19), ERBB2(12), ERBB3(17), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(13), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), LHCGR(9), LTB4R2(2), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(13), PDGFRB(9), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(6), PTGFR(2), PTK2B(4), RYR1(34), RYR2(76), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(15), SPHK2(3), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), TNNC2(1), TRHR(5), TRPC1(10) 204660483 1212 394 1206 419 259 257 345 195 155 1 0.00657 1.000 1.000 182 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(6), ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(3), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CNR1(3), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(6), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHB(2), FSHR(12), GABBR1(4), GABBR2(6), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GABRB1(6), GABRB2(7), GABRB3(13), GABRD(2), GABRE(9), GABRG1(11), GABRG2(8), GABRG3(6), GABRP(5), GABRQ(9), GABRR1(4), GABRR2(3), GALR1(3), GALR2(4), GALR3(2), GH1(4), GH2(4), GHR(9), GHRHR(3), GHSR(3), GIPR(2), GLP1R(1), GLP2R(5), GLRA1(4), GLRA2(5), GLRA3(3), GLRB(4), GNRHR(2), GPR156(5), GPR35(2), GPR50(7), GPR63(6), GPR83(1), GRIA1(16), GRIA2(16), GRIA3(8), GRIA4(11), GRID1(20), GRID2(19), GRIK1(8), GRIK2(16), GRIK3(7), GRIK4(6), GRIK5(8), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM6(4), GRM7(20), GRM8(24), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LEP(1), LEPR(17), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(2), MAS1(2), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), MCHR1(2), MCHR2(4), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR2(4), NPY1R(5), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), P2RY1(5), P2RY10(5), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), P2RY8(3), PARD3(14), PRL(3), PRLHR(5), PRLR(9), PRSS1(9), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(6), PTGER4(8), PTGFR(2), PTGIR(3), PTH2R(11), RXFP1(6), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), THRA(5), THRB(1), TRHR(5), TRPV1(6), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(5) 167780230 1197 389 1189 432 212 225 397 200 162 1 0.0497 1.000 1.000 183 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 240 ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(1), ARRB2(1), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(4), CACNB2(6), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(3), CACNG6(5), CACNG7(5), CACNG8(7), CASP3(2), CD14(1), CDC25B(4), CDC42(3), CHUK(6), CRK(2), CRKL(3), DAXX(6), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(3), EGF(8), EGFR(19), ELK1(2), ELK4(3), FAS(5), FASLG(1), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FLNA(24), FLNB(9), FLNC(19), FOS(6), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAPT(9), MAX(1), MKNK1(1), MKNK2(2), MOS(7), MYC(6), NF1(14), NFATC2(15), NFATC4(3), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(13), PDGFRB(9), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(4), PTPRR(5), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA2(7), RASGRF1(17), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(2), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(2), TAOK1(5), TAOK2(11), TAOK3(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TNFRSF1A(2), TRAF2(2), TRAF6(3), ZAK(5) 213015419 1078 388 1068 359 215 227 313 158 163 2 0.0360 1.000 1.000 184 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 197 ABI2(3), ACTN1(4), ACTN2(10), ACTN4(6), APC(27), APC2(6), ARAF(3), ARHGEF1(8), ARHGEF12(11), ARHGEF4(5), ARHGEF6(7), ARHGEF7(2), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), BCAR1(3), BDKRB1(2), BDKRB2(3), BRAF(10), CD14(1), CDC42(3), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CRK(2), CRKL(3), CSK(1), CYFIP1(8), CYFIP2(8), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(8), EGFR(19), F2(3), F2R(4), FGD1(11), FGD3(5), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FN1(18), GIT1(5), GNA12(1), GNA13(2), GNG12(1), GSN(5), IQGAP1(11), IQGAP2(7), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(6), MAP2K1(5), MAP2K2(6), MOS(7), MSN(3), MYH10(24), MYH14(7), MYH9(23), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), NCKAP1(8), NCKAP1L(7), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(13), PDGFRB(9), PFN1(1), PFN2(1), PFN4(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(4), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), RDX(1), ROCK1(19), ROCK2(11), RRAS(2), RRAS2(2), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(6), SSH2(7), SSH3(4), TIAM1(15), TIAM2(14), TMSB4Y(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), WAS(2), WASF1(3), WASF2(5), WASL(2) 205786228 977 370 965 352 180 195 286 158 156 2 0.657 1.000 1.000 185 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(4), ACTG1(3), CHAD(5), COL11A1(67), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(8), DSG2(4), DSG3(2), DSG4(5), FN1(18), GJA1(2), GJA10(8), GJA3(2), GJA4(1), GJA5(6), GJA8(7), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(4), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(12), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(3), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(8), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(5), KRT35(4), KRT36(5), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(4), KRT72(5), KRT73(4), KRT74(8), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(3), KRT8(1), KRT82(6), KRT83(6), KRT84(1), KRT85(6), KRT86(4), KRT9(3), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), LMNA(1), LMNB1(2), LMNB2(8), NES(13), RELN(50), SPP1(2), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VIM(4), VTN(2), VWF(19) 189529707 1046 366 1040 356 169 211 356 148 157 5 0.362 1.000 1.000 186 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 121 ABL1(8), ABLIM1(5), ABLIM2(5), ABLIM3(6), ARHGEF12(11), CDC42(3), CDK5(3), CFL1(2), CXCL12(3), CXCR4(2), DCC(27), DPYSL2(4), DPYSL5(6), EFNA1(2), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA3(18), EPHA4(11), EPHA5(25), EPHA6(17), EPHA7(24), EPHA8(6), EPHB1(15), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(7), FYN(4), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), ITGB1(15), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(6), LRRC4C(30), MET(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLXNA1(23), PLXNA2(17), PLXNA3(16), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PTK2(8), RAC2(3), RAC3(3), RGS3(10), RHOD(1), ROBO1(12), ROBO2(16), ROBO3(5), ROCK1(19), ROCK2(11), SEMA3A(13), SEMA3C(8), SEMA3D(5), SEMA3E(10), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(1), SEMA4C(3), SEMA4D(9), SEMA4F(5), SEMA4G(8), SEMA5A(27), SEMA5B(14), SEMA6A(3), SEMA6B(6), SEMA6C(2), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(26), SLIT3(9), SRGAP1(10), SRGAP2(2), SRGAP3(7), UNC5A(6), UNC5B(9), UNC5C(20), UNC5D(18) 145688612 888 357 881 270 138 182 279 148 139 2 0.00617 1.000 1.000 187 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(9), CD36(1), CD44(3), CD47(1), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DAG1(5), FN1(18), FNDC1(15), FNDC3A(11), FNDC4(4), FNDC5(1), GP5(4), GP6(1), GP9(2), HMMR(3), HSPG2(23), IBSP(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), RELN(50), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VTN(2), VWF(19) 169557748 920 350 915 315 146 195 296 141 138 4 0.475 1.000 1.000 188 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(6), ARRB1(1), ARRB2(1), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(15), CACNB1(4), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), ITPR1(15), ITPR2(25), ITPR3(10), KCNB1(3), KCNJ3(9), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(15), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 142816320 838 346 834 297 177 191 229 130 109 2 0.0383 1.000 1.000 189 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(6), ASH1L(20), CASK(4), CDC42(3), CDK4(5), CGN(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTTN(10), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(23), EXOC3(3), EXOC4(15), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(1), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(13), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(8), MYH1(22), MYH10(24), MYH11(11), MYH13(27), MYH14(7), MYH15(13), MYH2(26), MYH3(15), MYH4(18), MYH6(19), MYH7(16), MYH7B(6), MYH8(26), MYH9(23), MYL7(2), MYL9(4), NRAS(1), OCLN(1), PARD3(14), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP2R3A(12), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), RAB13(2), RRAS(2), RRAS2(2), SPTAN1(23), SRC(1), SYMPK(7), TJAP1(4), TJP1(13), TJP2(5), TJP3(6), VAPA(1), YES1(2), ZAK(5) 146717716 817 330 805 261 135 185 251 129 115 2 0.0512 1.000 1.000 190 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(3), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(7), CACNB3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(6), GJA1(2), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), GSTO1(2), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(1), IL6(2), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(3), PDE4B(7), PDE4D(6), PKIG(1), PLCB3(9), PLCD1(5), PLCG1(9), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RAMP3(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(25), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 131871121 738 329 735 253 141 178 209 115 93 2 0.0430 1.000 1.000 191 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(4), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(1), CCL3(1), CCL4(1), CCL8(3), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(4), CNTFR(1), CRLF2(3), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(7), CSF3R(3), CX3CL1(4), CX3CR1(1), CXCL1(3), CXCL10(3), CXCL12(3), CXCL13(1), CXCL14(1), CXCL2(1), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(3), EDA2R(1), EDAR(2), EGF(8), EGFR(19), EPO(2), EPOR(1), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(14), GDF5(4), GH1(4), GH2(4), GHR(9), HGF(11), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(7), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(5), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), INHBA(3), INHBB(4), INHBC(3), INHBE(1), KDR(14), KIT(12), KITLG(1), LEP(1), LEPR(17), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(1), OSMR(3), PDGFB(1), PDGFC(3), PDGFRA(13), PDGFRB(9), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(3), PRLR(9), RELT(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(3), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(12), TSLP(3), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3) 134146762 665 307 661 223 104 125 212 119 104 1 0.288 1.000 1.000 192 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 139 APC(27), APC2(6), AXIN1(12), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(3), CCND2(2), CER1(1), CHD8(18), CREBBP(37), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTBP1(2), CTBP2(2), CTNNB1(6), CUL1(11), CXXC4(3), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(8), DVL2(1), DVL3(9), FBXW11(3), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(5), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(4), MMP7(1), MYC(6), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKD1(8), NKD2(3), NLK(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PORCN(3), PPARD(3), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAC2(3), RAC3(3), RBX1(3), ROCK1(19), ROCK2(11), SENP2(3), SFRP1(2), SFRP4(11), SFRP5(1), SIAH1(4), SKP1(1), SMAD2(4), SMAD3(4), SOX17(2), TBL1X(6), TBL1XR1(4), TBL1Y(3), TCF7(2), TCF7L1(2), TCF7L2(1), VANGL1(1), VANGL2(6), WIF1(1), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3) 117477161 648 296 642 199 108 134 200 108 96 2 0.0230 1.000 1.000 193 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADK(1), ADSL(4), ADSS(4), ADSSL1(5), AK1(1), AK2(1), AK7(2), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), FHIT(1), GART(5), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NME4(2), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE11A(4), PDE1A(6), PDE1C(14), PDE2A(5), PDE3B(4), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PDE9A(3), PFAS(11), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), XDH(6) 122342095 573 290 570 194 103 121 174 92 83 0 0.295 1.000 1.000 194 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(3), ACTN2(10), ACTN4(6), DES(3), DMD(57), MYBPC1(11), MYBPC2(8), MYBPC3(5), MYH3(15), MYH6(19), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(38), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(2), TNNT3(2), TPM1(2), TPM2(2), TPM4(1), TTN(371), VIM(4) 103976175 637 288 632 185 87 154 229 98 65 4 0.234 1.000 1.000 195 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(7), CADM1(4), CADM3(4), CD2(1), CD22(3), CD226(6), CD274(1), CD276(1), CD28(3), CD34(5), CD4(1), CD40(7), CD40LG(4), CD58(2), CD6(1), CD80(4), CD86(2), CD8A(3), CD8B(2), CDH1(5), CDH15(4), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(9), CNTN2(9), CNTNAP1(9), CNTNAP2(24), CTLA4(2), ESAM(4), F11R(1), GLG1(5), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(14), ITGA6(4), ITGA9(3), ITGAL(8), ITGAM(8), ITGAV(6), ITGB1(15), ITGB2(3), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(6), NCAM2(14), NEGR1(6), NEO1(4), NFASC(7), NLGN1(19), NLGN2(6), NLGN3(4), NRCAM(15), NRXN1(32), NRXN2(10), NRXN3(19), OCLN(1), PDCD1(1), PTPRC(18), PTPRF(16), PTPRM(21), PVR(3), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SELE(7), SELL(2), SELP(16), SELPLG(3), SIGLEC1(12), SPN(3), VCAM1(10), VCAN(32) 109801964 629 286 624 239 99 131 178 114 107 0 0.688 1.000 1.000 196 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(8), EGFR(19), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(13), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), HTR2A(5), HTR2B(2), HTR2C(4), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(2), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), SRC(1), TJP1(13), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3) 99856556 578 286 572 176 106 127 171 104 69 1 0.00384 1.000 1.000 197 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(3), CCND2(2), CISH(1), CNTFR(1), CREBBP(37), CRLF2(3), CSF2RA(1), CSF2RB(7), CSF3R(3), EPO(2), EPOR(1), GH1(4), GH2(4), GHR(9), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL13RA2(4), IL19(5), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), IRF9(2), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(3), PIAS1(1), PIAS2(4), PIAS3(4), PIAS4(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIM1(3), PRL(3), PRLR(9), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(6), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(8), STAT2(4), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(12), TSLP(3), TYK2(8) 105389273 538 285 530 170 70 108 167 106 86 1 0.163 1.000 1.000 198 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(3), CGA(1), EGFR(19), ELK1(2), FSHB(2), GNA11(4), GNAS(13), GNRHR(2), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(4), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLD1(15), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11), SRC(1) 95902403 532 284 527 176 106 119 153 89 65 0 0.0399 1.000 1.000 199 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(16), ACACB(18), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(3), FOXO1(4), G6PC(2), G6PC2(6), GCK(4), GSK3B(3), GYS1(6), GYS2(6), IKBKB(11), INPP5D(8), INSR(3), IRS1(2), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK10(4), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(4), PDE3A(19), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(14), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(16), PYGB(6), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(3), TSC2(7) 119627908 556 283 551 184 113 112 152 91 88 0 0.143 1.000 1.000 200 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(9), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(7), GPR6(3), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LHCGR(9), LTB4R(3), MAS1(2), MC1R(3), MC3R(2), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(6), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(3), P2RY1(5), P2RY10(5), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), RGR(3), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(5) 92196187 558 282 555 226 109 116 185 85 63 0 0.152 1.000 1.000 201 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), AKAP1(9), AKAP10(5), AKAP11(9), AKAP12(14), AKAP2(14), AKAP3(8), AKAP4(11), AKAP5(5), AKAP6(26), AKAP7(5), AKAP8(3), AKAP9(32), ARHGEF1(8), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(1), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB5(2), GNG10(1), GNG12(1), GNG13(2), ITPR1(15), KCNJ3(9), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PLCB3(9), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RRAS(2), SLC9A1(4), USP5(5) 88391946 529 281 525 151 103 123 143 89 71 0 0.00273 1.000 1.000 202 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADK(1), ADSL(4), ADSS(4), AK1(1), AK2(1), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(5), GDA(7), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(11), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1) 96901726 483 263 480 152 83 102 156 70 72 0 0.0812 1.000 1.000 203 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(4), ACTN2(10), ACTN4(6), ARHGAP5(10), BCAR1(3), CDC42(3), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), CXCL12(3), CXCR4(2), CYBB(3), ESAM(4), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), ITK(3), JAM2(2), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), NCF1(2), NCF2(6), NCF4(2), NOX1(6), NOX3(8), OCLN(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAC2(3), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOH(1), ROCK1(19), ROCK2(11), SIPA1(3), THY1(2), TXK(6), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCAM1(10), VCL(5) 92539513 486 261 479 173 81 92 133 90 89 1 0.595 1.000 1.000 204 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3L1(4), CREB3L2(3), CREB3L3(9), CREB3L4(2), CREBBP(37), CTNNB1(6), DCT(3), DVL1(8), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GSK3B(3), KIT(12), KITLG(1), KRAS(1), LEF1(5), MAP2K1(5), MAP2K2(6), MC1R(3), MITF(5), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(2), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3) 78622772 471 260 466 147 103 86 138 83 59 2 0.00810 1.000 1.000 205 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(8), ABL2(9), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), BTC(3), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(2), CRK(2), CRKL(3), EGF(8), EGFR(19), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(17), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK9(4), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(1), NRG2(5), NRG3(19), NRG4(2), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), RAF1(3), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SRC(1), STAT5A(3), STAT5B(5) 75986783 436 256 430 138 63 87 142 84 59 1 0.285 1.000 1.000 206 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 69 ACP1(1), ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(2), CDC42(3), CDH1(5), CREBBP(37), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), EGFR(19), ERBB2(12), FARP2(4), FER(6), FGFR1(1), FYN(4), IGF1R(11), INSR(3), IQGAP1(11), LEF1(5), LMO7(7), MAP3K7(8), MET(4), MLLT4(13), NLK(1), PARD3(14), PTPN1(3), PTPN6(3), PTPRB(22), PTPRF(16), PTPRJ(7), PTPRM(21), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(4), RAC2(3), RAC3(3), SMAD2(4), SMAD3(4), SNAI2(1), SORBS1(7), SRC(1), SSX2IP(6), TCF7(2), TCF7L1(2), TCF7L2(1), TGFBR1(2), TJP1(13), VCL(5), WAS(2), WASF1(3), WASF2(5), WASF3(6), WASL(2), YES1(2) 84554520 454 255 448 145 70 94 131 86 71 2 0.309 1.000 1.000 207 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(21), ADCY8(28), ARAF(3), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(37), GRIA1(16), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP1CA(1), PPP1R12A(5), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8) 71081181 472 253 467 160 81 109 130 91 60 1 0.0911 1.000 1.000 208 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), AMY2B(8), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(6), GAA(3), GANC(6), GBA(2), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), IFIH1(7), LYZL1(1), MGAM(29), MOV10L1(5), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SI(59), SKIV2L2(4), SMARCA2(15), SMARCA5(2), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UXS1(2) 94222153 460 252 455 141 55 88 146 96 74 1 0.370 1.000 1.000 209 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(4), ACVR1B(5), ACVRL1(3), AKT1(2), AURKB(4), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(7), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MAP3K10(5), MOS(7), NEK1(9), NEK3(1), OCRL(3), PAK4(1), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9), PLK3(5), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(7), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KB1(4), STK11(6), TGFBR1(2), VRK1(1) 84256903 449 249 443 139 82 84 133 71 79 0 0.0951 1.000 1.000 210 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(8), INPP5E(1), INPPL1(8), ITPK1(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), OCRL(3), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3C3(5), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PRKCA(7), PRKCG(14), PTPMT1(2), SYNJ1(10), SYNJ2(8) 92466944 464 248 458 149 73 98 128 88 77 0 0.108 1.000 1.000 211 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(3), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(1), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GNAZ(6), GRIA1(16), GRIA2(16), GRIA3(8), GRID2(19), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), IGF1(1), IGF1R(11), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), RAF1(3), RYR1(34) 82942897 474 247 472 152 88 96 139 90 61 0 0.109 1.000 1.000 212 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(15), ABCA10(11), ABCA12(20), ABCA13(41), ABCA2(17), ABCA3(10), ABCA4(14), ABCA5(6), ABCA6(10), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(19), ABCB11(8), ABCB4(13), ABCB5(10), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(6), ABCC10(9), ABCC11(9), ABCC12(10), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(8), ABCG8(13), CFTR(13), TAP1(6), TAP2(3) 90008118 429 244 426 145 66 88 129 70 76 0 0.153 1.000 1.000 213 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(8), ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(24), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(1), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(4), CDC26(1), CDC27(9), CDC6(2), CDC7(1), CDK4(5), CDK6(1), CDKN1B(2), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(4), CREBBP(37), CUL1(11), DBF4(3), E2F2(3), E2F3(3), ESPL1(9), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(17), RBL1(12), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMC1A(3), SMC1B(7), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 97955701 400 238 397 126 41 96 99 86 77 1 0.454 1.000 1.000 214 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(3), CAPN11(2), CAPN2(5), CAPN3(6), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(5), CAPNS1(2), CAV1(1), CDC42(3), CRK(2), CSK(1), DOCK1(15), FYN(4), GIT2(4), ILK(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(7), MAPK6(4), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(11), SDCCAG8(6), SEPP1(1), SHC1(2), SHC3(6), SORBS1(7), SOS1(9), SRC(1), TLN1(22), TNS1(9), VASP(1), VAV2(4), VAV3(4), VCL(5), ZYX(2) 100170207 453 237 448 155 74 96 135 74 74 0 0.271 1.000 1.000 215 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(4), CD8A(3), CD8B(2), CDC42(3), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(4), GRAP2(3), ICOS(1), IFNG(2), IKBKB(11), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDCD1(1), PDK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCQ(8), PTPN6(3), PTPRC(18), RASGRP1(8), SOS1(9), SOS2(11), TEC(2), VAV1(7), VAV2(4), VAV3(4), ZAP70(4) 75173229 377 235 375 124 61 68 110 66 72 0 0.439 1.000 1.000 216 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 119 ARAF(3), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FYN(4), GZMB(2), HLA-C(5), HLA-E(1), HLA-G(2), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(8), ITGB2(3), KIR2DL3(1), KIR3DL1(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MICB(3), NCR1(6), NCR2(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NRAS(1), PAK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRF1(5), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC2(3), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(7), VAV2(4), VAV3(4), ZAP70(4) 82183378 407 231 403 138 75 77 116 65 74 0 0.281 1.000 1.000 217 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 83 ACVR1(4), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BMPR1B(4), BMPR2(6), CHRD(11), CREBBP(37), CUL1(11), DCN(4), E2F4(3), E2F5(6), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MYC(6), NODAL(1), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), RBL1(12), RBL2(6), RBX1(3), ROCK1(19), ROCK2(11), RPS6KB1(4), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(4), SMURF2(6), SP1(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), THBS1(8), THBS2(10), THBS3(3), THBS4(7), ZFYVE16(10), ZFYVE9(8) 69188331 360 215 357 91 36 80 107 71 65 1 0.00528 1.000 1.000 218 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 73 ABL1(8), ACTN1(4), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(10), CAV1(1), CDC42(3), CRK(2), CSE1L(3), DOCK1(15), EPHB2(3), FYN(4), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CB(6), PKLR(3), PLCG1(9), PLCG2(9), PTK2(8), RAF1(3), RHO(3), ROCK1(19), ROCK2(11), SHC1(2), SOS1(9), SOS2(11), SRC(1), TERF2IP(1), TLN1(22), TLN2(12), VASP(1), WAS(2), ZYX(2) 88373600 366 214 364 135 59 64 113 75 55 0 0.796 1.000 1.000 219 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(5), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(2), CHPF(7), CHST1(4), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST2(6), CHST4(4), CHST6(8), CHST7(1), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GANAB(4), GCNT1(1), GCNT3(1), GCNT4(4), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(10), XYLT1(10), XYLT2(3) 84248498 356 213 356 139 73 73 112 49 48 1 0.759 1.000 1.000 220 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(2), AKT2(4), AKT3(6), CCL3(1), CCL4(1), CD14(1), CD40(7), CD80(4), CD86(2), CHUK(6), CXCL10(3), CXCL9(3), FADD(3), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IKBKB(11), IKBKE(5), IL12A(1), IL12B(3), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(1), IRF5(3), IRF7(3), JUN(1), LBP(7), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), RELA(2), RIPK1(2), SPP1(2), STAT1(8), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(2), TLR3(1), TLR4(17), TLR5(3), TLR6(3), TLR7(8), TLR8(7), TLR9(4), TOLLIP(2), TRAF3(6), TRAF6(3) 65080330 329 213 326 117 54 70 101 50 54 0 0.406 1.000 1.000 221 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(7), BDKRB1(2), BDKRB2(3), C1QA(2), C1QC(1), C1R(3), C1S(6), C2(5), C3(15), C3AR1(5), C4BPA(6), C4BPB(2), C5(10), C5AR1(2), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(2), CD59(1), CFB(4), CFH(18), CFI(4), CPB2(4), CR1(10), CR2(7), F10(3), F11(2), F12(2), F13A1(9), F13B(13), F2(3), F2R(4), F3(2), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), KNG1(4), MASP1(7), MASP2(5), MBL2(2), PLAT(4), PLG(13), PROC(2), PROS1(10), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(7), SERPING1(5), TFPI(2), THBD(2), VWF(19) 67536252 373 210 371 131 46 96 106 69 55 1 0.560 1.000 1.000 222 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(8), ATM(16), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND2(2), CCNE1(4), CCNE2(4), CDAN1(5), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(3), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CHEK1(1), CHEK2(4), DTX4(5), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), ESPL1(9), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), HDAC8(1), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(2), RB1(17), RBL1(12), SKP2(4), TBC1D8(4), TFDP1(2), TGFB1(1), WEE1(2) 78072177 299 202 298 100 35 69 73 58 64 0 0.618 1.000 1.000 223 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(4), BAD(1), BCL2(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(3), CREBBP(37), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(8), GSK3A(2), GSK3B(3), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(4), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB2(5), NFKBIB(1), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(18), RELA(2), RPL13A(2), SFN(7), SLA(1), SP1(3), SP3(3), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(7), VAV2(4), VAV3(4), XPO5(4) 65424515 310 201 309 110 40 60 94 63 52 1 0.549 1.000 1.000 224 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(6), ELK1(2), FOS(6), IKBKB(11), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAP4K5(1), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(7), MAPK6(4), MAPK7(6), MAPK8(4), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MKNK2(2), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(3), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 70956762 320 196 315 105 54 66 102 50 48 0 0.395 1.000 1.000 225 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(18), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(1), CAMKK2(6), CD36(1), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(6), IKBKB(11), IRS1(2), IRS2(6), IRS4(16), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), MAPK10(4), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(5), PCK1(2), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(4), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(3), SOCS3(1), STAT3(6), STK11(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8) 63324449 305 191 305 97 52 60 86 52 54 1 0.117 1.000 1.000 226 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(4), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(7), FCGR2B(1), FOS(6), GSK3B(3), IKBKB(11), INPP5D(8), JUN(1), KRAS(1), LILRB3(4), LYN(8), MALT1(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG2(9), PPP3CA(2), PPP3CB(1), PTPN6(3), RAC2(3), RAC3(3), RASGRP3(9), SYK(8), VAV1(7), VAV2(4), VAV3(4) 54526337 276 190 274 95 52 55 74 47 47 1 0.370 1.000 1.000 227 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2L1(2), CDC42(3), CDKN1B(2), CREB1(1), CREB5(7), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARD3(14), PARD6A(1), PDK1(3), PIK3CD(8), PPP1R13B(2), PREX1(14), PTK2(8), PTPN1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SLC2A4(3), SOS1(9), SOS2(11), TSC1(3), TSC2(7), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 56229248 278 187 276 86 40 61 79 50 48 0 0.159 1.000 1.000 228 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CAPN1(3), CAPN2(5), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(7), FADD(3), FAS(5), FASLG(1), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(2), TNFSF10(1), TRADD(1), TRAF2(2) 60550736 258 186 255 79 42 59 59 46 52 0 0.152 1.000 1.000 229 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(4), GAB2(4), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(8), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MS4A2(4), NRAS(1), PDK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC2(3), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(7), VAV2(4), VAV3(4) 52132051 274 184 272 97 48 45 85 46 49 1 0.657 1.000 1.000 230 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(5), MIOX(4), OCRL(3), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PTPMT1(2), SYNJ1(10), SYNJ2(8) 54361599 269 183 264 93 54 49 82 47 37 0 0.265 1.000 1.000 231 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(10), EZH1(5), EZH2(5), FBXO11(6), HCFC1(8), HSF4(1), JMJD4(1), JMJD6(2), KDM6A(17), MEN1(3), OGT(4), PAXIP1(4), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(35), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), RBBP5(2), SATB1(6), SETD1A(10), SETD2(12), SETD7(4), SETD8(1), SETDB1(9), SETDB2(2), SETMAR(2), SMYD3(3), STK38(2), SUV39H1(4), SUV39H2(2), SUV420H1(6), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6) 86383086 272 178 268 84 42 50 78 49 53 0 0.353 1.000 1.000 232 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(10), CPEB1(5), EGFR(19), ERBB2(12), ERBB4(22), ETS1(5), ETS2(7), ETV6(6), ETV7(4), FMN2(40), KRAS(1), MAP2K1(5), NOTCH2(22), NOTCH3(22), NOTCH4(8), PIWIL1(9), PIWIL2(10), PIWIL3(8), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1) 36261336 247 177 244 74 35 49 78 41 44 0 0.487 1.000 1.000 233 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(7), CPSF2(5), CPSF3(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(3), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(2), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(12), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(12), PTBP1(3), PTBP2(4), RBM17(1), RBM5(8), RNGTT(1), RNMT(5), RNPS1(3), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(5), SF3B2(3), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(6), SRPK1(1), SRPK2(10), SRRM1(4), SUPT5H(4), U2AF1(2), U2AF2(2), XRN2(8) 80690535 287 177 285 100 34 70 83 46 54 0 0.794 1.000 1.000 234 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(2), GRPR(1), LHCGR(9), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), NMBR(3), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), TACR1(4), TACR2(4), TACR3(5), TRHR(5), TSHR(4) 39384568 257 175 257 98 45 60 81 37 34 0 0.138 1.000 1.000 235 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(2), AKT2(4), AKT3(6), BAD(1), CASP9(1), CDC42(3), KDR(14), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NOS3(4), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PRKCG(14), PTGS2(3), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), SHC2(5), SPHK2(3), SRC(1) 52166642 256 172 254 98 53 50 71 41 41 0 0.631 1.000 1.000 236 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(3), ALG6(4), CCKBR(3), CCR2(4), CCR3(5), CELSR1(24), CELSR2(27), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(3), GNRHR(2), GPR116(8), GPR132(4), GPR133(9), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR56(3), GPR61(3), GPR84(3), GRM1(28), GRPR(1), HRH4(3), LGR6(10), LPHN2(10), LPHN3(22), LTB4R2(2), NTSR1(3), OR2M4(7), P2RY13(2), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2) 50757056 271 167 270 103 51 60 80 43 37 0 0.305 1.000 1.000 237 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(10), ARHGEF11(3), BTK(8), CDC42(3), CFL1(2), GDI1(5), GDI2(5), INPPL1(8), ITPR1(15), ITPR2(25), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CD(8), PIK3CG(20), PIK3R1(9), PITX2(2), PPP1R13B(2), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(11), SAG(1), WASF1(3), WASL(2) 51049210 251 167 249 100 42 63 64 44 37 1 0.763 1.000 1.000 238 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), AMY2B(8), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(4), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), MGAM(29), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), SI(59), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UXS1(2) 43293602 244 166 241 82 30 46 77 49 41 1 0.579 1.000 1.000 239 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(6), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(3), CHUK(6), CSK(1), CXCL1(3), EGFR(19), F11R(1), GIT1(5), IGSF5(4), IKBKB(11), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(7), PAK1(3), PLCG1(9), PLCG2(9), PTPN11(2), PTPRZ1(16), RELA(2), SRC(1), TCIRG1(7), TJP1(13) 53224303 237 165 236 76 27 51 74 47 38 0 0.410 1.000 1.000 240 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(16), CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG2(4), CDC25A(3), CDK4(5), CDKN1B(2), CDKN2C(1), CDKN2D(1), CREB3L1(4), CREB3L3(9), CREB3L4(2), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), GADD45A(1), GBA2(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MNAT1(1), MYC(6), MYT1(11), NACA(24), PCNA(1), POLA2(2), POLE(11), PRIM1(3), RB1(17), RBL1(12), RPA1(5), RPA2(1), TFDP1(2), TFDP2(1), TNXB(25), WEE1(2) 57838056 249 164 246 71 30 62 70 39 47 1 0.121 1.000 1.000 241 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 CD14(1), CD19(4), CD1A(8), CD1B(2), CD1C(5), CD1D(5), CD2(1), CD22(3), CD33(2), CD34(5), CD36(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD59(1), CD8A(3), CD8B(2), CD9(1), CR1(10), CR2(7), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(2), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL7(2), IL7R(6), IL9R(6), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(6), KIT(12), KITLG(1), MME(16), MS4A1(4), TFRC(8), THPO(1), TPO(12) 61562363 268 163 265 110 41 54 75 55 43 0 0.932 1.000 1.000 242 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), BCR(2), BLNK(4), BTK(8), CD19(4), CD22(3), CR2(7), CSK(1), DAG1(5), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), INPP5D(8), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), MAP4K1(5), NFATC1(7), NFATC2(15), NR0B2(1), PDK1(3), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(18), RAF1(3), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7) 54159644 244 160 243 92 40 55 55 53 40 1 0.624 1.000 1.000 243 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(16), GLI3(12), GSK3B(3), HHIP(5), IHH(2), LRP2(40), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), PTCH1(13), PTCH2(10), RAB23(2), SHH(2), SMO(3), STK36(6), SUFU(3), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3), ZIC2(6) 46433064 236 158 235 82 51 43 85 33 24 0 0.364 1.000 1.000 244 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(19), EPHB2(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), PI3(2), PIK3CB(6), PITX2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), RAF1(3), RGS20(4), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT3(6), TERF2IP(1) 43964357 222 158 221 75 34 47 64 51 26 0 0.357 1.000 1.000 245 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ANGPTL4(3), APOA5(2), AQP7(3), CD36(1), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(2), CYP4A11(12), CYP4A22(9), CYP7A1(6), CYP8B1(6), DBI(4), EHHADH(5), FABP1(3), FABP2(2), FABP3(1), FABP4(3), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(5), GK2(7), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(6), NR1H3(1), OLR1(1), PCK1(2), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(3), PPARG(1), RXRA(4), RXRB(3), RXRG(7), SCD(1), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1) 49890908 229 157 228 82 37 56 63 32 40 1 0.393 1.000 1.000 246 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 ADAM17(5), APH1A(4), CREBBP(37), CTBP1(2), CTBP2(2), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(8), DVL2(1), DVL3(9), HDAC1(1), HDAC2(3), JAG1(9), JAG2(7), LFNG(2), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(22), NCSTN(2), NOTCH2(22), NOTCH3(22), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(5), RBPJL(5), RFNG(3), SNW1(4) 46109642 235 156 234 96 46 53 59 28 48 1 0.823 1.000 1.000 247 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UPB1(1), UPP1(3), UPP2(3), UPRT(2) 61670726 229 155 229 94 40 37 65 50 37 0 0.959 1.000 1.000 248 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(27), AXIN1(12), CCND1(3), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(8), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(4), MAPK10(4), MAPK9(4), MYC(6), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), SFRP4(11), TCF7(2), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1) 45251322 242 152 238 87 40 51 78 48 24 1 0.402 1.000 1.000 249 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(12), ATM(16), ATR(24), BAI1(8), BID(3), CASP3(2), CASP9(1), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(1), CHEK1(1), CHEK2(4), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(9), IGF1(1), IGFBP3(1), MDM2(3), MDM4(1), PERP(1), PMAIP1(2), PPM1D(7), RCHY1(1), RFWD2(2), RRM2(1), RRM2B(1), SERPINB5(1), SERPINE1(7), SESN1(2), SESN2(4), SESN3(4), SFN(7), SIAH1(4), STEAP3(4), THBS1(8), TNFRSF10B(1), TSC2(7), ZMAT3(2) 47338806 202 151 202 58 20 49 44 48 41 0 0.207 1.000 1.000 250 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(14), KDR(14), NOS3(4), PDE2A(5), PDE3A(19), PDE3B(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKG1(7), PRKG2(2), RYR2(76), SLC7A1(4), SYT1(9) 30803422 206 151 206 74 32 54 57 36 26 1 0.499 1.000 1.000 251 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 47 ACOX1(2), CD36(1), CPT1B(4), CREBBP(37), DUSP1(2), EHHADH(5), FABP1(3), HSD17B4(5), JUN(1), LPL(4), ME1(2), MYC(6), NCOA1(7), NCOR1(20), NCOR2(22), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(8), PIK3R1(9), PPARA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(3), RB1(17), RELA(2), RXRA(4), SP1(3), STAT5A(3), STAT5B(5) 42311719 206 149 199 66 21 51 55 27 51 1 0.286 1.000 1.000 252 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(7), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CRADD(2), DAXX(6), FADD(3), GSN(5), LMNA(1), LMNB1(2), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(3), NFKB1(5), NFKBIA(1), NUMA1(19), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(8), RB1(17), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 50437276 227 148 227 73 29 51 62 37 48 0 0.406 1.000 1.000 253 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT2(2), ACMSD(6), AFMID(5), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), NFX1(2), OGDH(10), OGDHL(11), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), TDO2(4), TPH1(3), TPH2(6), WARS(2), WARS2(8) 46073837 203 148 203 64 30 44 62 33 34 0 0.278 1.000 1.000 254 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(13), GNAS(13), GNAT3(6), GNB1(3), GNB3(6), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(6), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(5), SCNN1G(5), TAS1R1(8), TAS1R2(5), TAS1R3(3), TAS2R1(4), TAS2R10(2), TAS2R13(1), TAS2R14(4), TAS2R16(4), TAS2R3(1), TAS2R38(3), TAS2R39(1), TAS2R40(5), TAS2R41(3), TAS2R42(1), TAS2R43(1), TAS2R46(6), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(5) 43464946 221 148 219 111 51 40 52 44 34 0 0.976 1.000 1.000 255 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(2), AKT2(4), AKT3(6), BRD4(10), CAP1(3), CBL(3), CDC42(3), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), LNPEP(5), PARD3(14), PARD6A(1), PDK1(3), PIK3CD(8), PIK3R1(9), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SERPINB6(4), SFN(7), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 42171541 203 144 202 58 35 45 55 34 34 0 0.139 1.000 1.000 256 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(5), DGAT1(1), DGAT2(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), GK(5), GK2(7), GLA(2), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 44612162 198 142 198 63 27 44 49 41 37 0 0.173 1.000 1.000 257 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), GRAP2(3), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), NCK1(5), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLCG1(9), PTPRC(18), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), SOS1(9), SOS2(11), VAV1(7), ZAP70(4) 40849103 189 140 189 65 25 35 59 28 42 0 0.649 1.000 1.000 258 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB5(7), CREBBP(37), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(11), PIK3CD(8), PIK3R1(9), PTPN11(2), RPS6KA3(4), SHC1(2), SRC(1), TERF2IP(1), TH(3) 37056632 179 139 177 50 27 33 50 33 35 1 0.155 1.000 1.000 259 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(2), ACMSD(6), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(3), WARS(2), WARS2(8) 41929402 187 138 187 63 26 40 60 31 29 1 0.452 1.000 1.000 260 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(6), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(6), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 44294154 183 137 183 75 30 48 44 28 33 0 0.734 1.000 1.000 261 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHFR(2), DHX58(2), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), FPGS(1), GCH1(1), GGH(2), IFIH1(7), MOV10L1(5), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SKIV2L2(4), SMARCA2(15), SMARCA5(2) 47925115 184 137 182 54 24 34 58 38 30 0 0.357 1.000 1.000 262 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 47 ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(37), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), IGF1(1), LIF(2), MAP2K1(5), MAPK14(2), MAPK8(4), MYH2(26), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKX2-5(1), NPPA(3), PIK3R1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(4), SYT1(9) 35518398 191 137 190 64 29 43 57 29 32 1 0.283 1.000 1.000 263 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), RRM1(2), RRM2(1), TXNRD1(6), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(3) 43710626 183 137 183 61 27 32 58 32 34 0 0.481 1.000 1.000 264 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(2), BAK1(1), BTK(8), CAD(5), CASP10(2), CASP3(2), CSNK1A1(1), DAXX(6), DEDD(1), DEDD2(5), DIABLO(1), EGFR(19), EPHB2(3), FADD(3), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MET(4), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(1), PFN1(1), PFN2(1), PTPN13(12), RALBP1(3), RIPK1(2), ROCK1(19), TNFRSF6B(4), TPX2(5), TRAF2(2) 53581095 185 137 185 61 27 44 53 25 35 1 0.414 1.000 1.000 265 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(3), CARM1(5), CYP11B1(6), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7) 38284188 184 136 184 62 35 33 58 38 20 0 0.445 1.000 1.000 266 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(19), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), MAPK10(4), MAPK14(2), PHKA2(10), PIK3CD(8), PIK3R1(9), PITX2(2), PTX3(4), RAF1(3), SRC(1) 38359170 193 136 192 62 30 43 52 36 32 0 0.258 1.000 1.000 267 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(12), BAD(1), BAK1(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(3), BIRC3(2), BIRC5(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CHUK(6), FADD(3), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(11), IRF1(7), IRF2(7), IRF3(1), IRF4(4), IRF5(3), IRF6(5), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), PLEKHG5(7), PRF1(5), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2), TRAF3(6) 42343644 184 135 182 54 32 49 43 21 39 0 0.0830 1.000 1.000 268 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(4), IGF1(1), PDPK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), STK11(6), TSC1(3), TSC2(7), ULK1(7), VEGFB(1), VEGFC(6) 36791741 186 135 183 53 34 39 48 29 36 0 0.142 1.000 1.000 269 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST3(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7) 43816385 197 134 197 84 27 38 65 38 28 1 0.942 1.000 1.000 270 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39728526 193 134 190 76 29 45 59 25 34 1 0.730 1.000 1.000 271 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39728526 193 134 190 76 29 45 59 25 34 1 0.730 1.000 1.000 272 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(3), CFL1(2), FLNA(24), FLNC(19), FSCN1(3), FSCN2(1), FSCN3(6), GDI1(5), GDI2(5), LIMK1(5), MYH2(26), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PFN1(1), PFN2(1), RHO(3), ROCK1(19), ROCK2(11), VASP(1), WASF1(3), WASL(2) 36527951 198 134 198 77 32 48 56 28 34 0 0.620 1.000 1.000 273 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MIOX(4), OCRL(3), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9) 32455913 173 133 168 47 34 28 54 30 27 0 0.0800 1.000 1.000 274 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), FLOT1(2), FLOT2(3), GAB1(5), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PHF11(1), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(14), PTPRC(18), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SAG(1), SYK(8), TEC(2), VAV1(7) 39219799 186 133 185 67 28 46 40 38 33 1 0.489 1.000 1.000 275 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 23 BRCA1(12), CARM1(5), CCND1(3), CREBBP(37), ERCC3(5), ESR1(5), GRIP1(12), GTF2A1(4), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), NCOR2(22), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(12), TBP(2) 30624887 174 128 173 58 19 33 52 36 33 1 0.459 1.000 1.000 276 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), OGDH(10), OGDHL(11), PIPOX(2), PLOD1(4), PLOD2(9), PLOD3(4), RDH11(2), RDH12(4), SETD1A(10), SETD7(4), SETDB1(9), SHMT1(1), SHMT2(3), SPCS1(2), SPCS3(1), SUV39H1(4), SUV39H2(2), TMLHE(2) 40036938 172 128 172 68 34 31 46 33 28 0 0.733 1.000 1.000 277 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCR(2), BLNK(4), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PI3(2), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7) 38116453 167 128 167 55 33 29 44 28 32 1 0.393 1.000 1.000 278 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(1), CHUK(6), DAXX(6), EGF(8), EGFR(19), ETS1(5), ETS2(7), FOS(6), HOXA7(4), IKBKB(11), JUN(1), MAP2K1(5), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 36771633 172 126 172 68 27 37 53 26 28 1 0.750 1.000 1.000 279 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(35), B3GALT4(3), CDR1(6), DGKI(13), IL6ST(5), MRPL19(2), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL17(1), RPL18A(1), RPL22(2), RPL23(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(2), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(1), RPS10(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS23(1), RPS25(2), RPS27A(1), RPS28(1), RPS3(2), RPS5(1), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5) 39912118 175 126 175 75 20 40 65 23 27 0 0.960 1.000 1.000 280 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), ATP5L(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(2), NDUFA9(3), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(1), PPA1(1), SDHA(6), SDHB(1), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRC2(1), UQCRFS1(4) 42504142 165 125 164 45 18 35 54 32 26 0 0.119 1.000 1.000 281 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), GK(5), GLA(2), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 36655248 161 123 161 54 22 31 41 31 36 0 0.335 1.000 1.000 282 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), CARM1(5), COMT(1), DBH(8), DCT(3), DDC(7), ECH1(2), ESCO1(4), ESCO2(3), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PNMT(1), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SH3GLB1(1), TAT(2), TH(3), TPO(12), TYR(8), TYRP1(4) 45290323 162 123 161 52 27 40 46 22 27 0 0.215 1.000 1.000 283 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), F10(3), F11(2), F12(2), F2(3), F2R(4), F5(19), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), PROC(2), PROS1(10), SERPINC1(4), SERPING1(5) 33810396 169 122 168 54 16 51 47 30 25 0 0.567 1.000 1.000 284 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(3), ETNK1(1), ETNK2(3), GNPAT(5), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(1) 49892679 183 121 183 55 19 39 52 29 44 0 0.212 1.000 1.000 285 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(3), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(4), MYEF2(8), NFATC3(5), NR2C2(1), PAPPA(13), SHC1(2), TRAF6(3), ZAK(5) 37853259 166 121 163 44 23 37 57 25 24 0 0.147 1.000 1.000 286 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(4), AKT3(6), ANKRD6(4), APC(27), AXIN1(12), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(8), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(33), MVP(4), NKD1(8), NKD2(3), PIN1(1), PTPRA(2), SENP2(3), SFRP1(2), TSHB(2), WIF1(1) 30830754 160 121 159 54 24 38 41 31 25 1 0.400 1.000 1.000 287 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PAK2(8), PIK3R1(9), PLA2G4A(3), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7) 30292716 153 120 153 41 26 25 45 29 27 1 0.189 1.000 1.000 288 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 34 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(6), GNA15(4), GNB1(3), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK14(2), NCF1(2), NCF2(6), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(11), PLCB1(22), PPP3CA(2), PPP3CB(1), RAF1(3), RELA(2), SYT1(9) 27988381 146 119 144 49 30 22 51 22 21 0 0.522 1.000 1.000 289 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(3), ALOX12B(4), ALOX15B(6), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP4A11(12), CYP4A22(9), CYP4F2(6), CYP4F3(2), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 29663622 148 118 148 55 20 31 46 23 27 1 0.463 1.000 1.000 290 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 21 ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(3), EPHB2(3), GNAI1(2), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), PITX2(2), PTX3(4), RHO(3), RYR1(34) 33993612 152 118 151 60 30 34 38 23 27 0 0.525 1.000 1.000 291 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(4), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PIK3R1(9), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(4), RAF1(3), RELA(2), SHC1(2), SOS1(9), SYT1(9), VAV1(7), ZAP70(4) 32599433 148 118 148 41 27 25 44 22 30 0 0.174 1.000 1.000 292 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(5), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(6), PLCG1(9), PLCG2(9), PPAP2A(1), PPAP2B(1) 38034000 156 117 156 51 21 26 47 26 36 0 0.335 1.000 1.000 293 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37207275 150 116 150 56 23 38 37 24 28 0 0.576 1.000 1.000 294 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37207275 150 116 150 56 23 38 37 24 28 0 0.576 1.000 1.000 295 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(16), ACACB(18), ACAT2(2), ACOT12(3), ACSS1(6), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 35606563 145 115 145 53 31 26 39 27 22 0 0.703 1.000 1.000 296 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(4), GCNT2(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(5), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1) 37034758 153 115 151 59 30 37 49 18 19 0 0.421 1.000 1.000 297 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CFLAR(2), DAXX(6), FADD(3), FAF1(2), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(12), RB1(17), RIPK2(6), SPTAN1(23) 30249903 155 114 154 39 18 34 44 24 35 0 0.171 1.000 1.000 298 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(4), AKT3(6), ARHGEF11(3), BCL2(1), CDC42(3), DLG4(3), GNA13(2), LPA(17), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PI3(2), PIK3CB(6), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RDX(1), ROCK1(19), ROCK2(11), SERPINA4(7), SRF(1), TBXA2R(1) 37471753 160 114 159 59 12 42 50 26 30 0 0.759 1.000 1.000 299 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(5), ACAT2(2), ACOX1(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(12), CYP4A22(9), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5) 37283483 145 112 145 50 16 34 40 31 24 0 0.503 1.000 1.000 300 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(9), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PIK3CB(6), PITX2(2), PLD1(15), PLD2(1), PLD3(2), VN1R1(2) 34128794 136 112 136 52 15 42 31 24 24 0 0.544 1.000 1.000 301 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(18), AR(6), ESR1(5), ESR2(1), ESRRA(4), HNF4A(6), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(3), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(7), NR2F1(3), NR2F2(8), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(4), PGR(3), PPARA(2), PPARD(3), PPARG(1), RARA(5), RARB(6), ROR1(9), RORA(3), RORC(3), RXRA(4), RXRB(3), RXRG(7), THRA(5), THRB(1), VDR(2) 31342395 153 111 151 51 27 26 50 22 27 1 0.426 1.000 1.000 302 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 32 BLNK(4), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7) 28496873 139 110 139 36 26 25 40 25 22 1 0.0772 1.000 1.000 303 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(16), EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(5), EEF2K(5), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G3(8), EIF5(3), EIF5A(5), EIF5B(6), ETF1(2), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1) 33415084 149 110 148 42 17 32 49 27 24 0 0.319 1.000 1.000 304 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 35 AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(4), GNA11(4), GNAI1(2), GNB1(3), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(9), PRKCA(7), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), SYT1(9) 30825197 139 109 139 49 30 32 42 22 13 0 0.352 1.000 1.000 305 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(2), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4) 32322727 149 109 149 56 25 40 38 23 23 0 0.441 1.000 1.000 306 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(21), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(13), GNB1(3), JUN(1), MAP2K1(5), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(9) 26301904 140 109 139 37 32 27 41 22 18 0 0.0408 1.000 1.000 307 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(6), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(29), PFKL(6), PFKM(6), PFKP(5), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2) 29369150 143 109 142 34 26 32 42 20 22 1 0.00873 1.000 1.000 308 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 30 ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(11), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(5), MAPK8(4), MET(4), PAK1(3), PIK3R1(9), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAF1(3), RAP1B(3), SOS1(9), SRC(1), STAT3(6) 28914169 142 109 139 35 23 22 45 30 22 0 0.100 1.000 1.000 309 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(7), CASP2(3), CASP3(2), CRADD(2), FADD(3), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(17), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TRADD(1), TRAF2(2) 28801391 146 109 145 44 20 27 46 24 29 0 0.454 1.000 1.000 310 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(9), EIF1(2), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(14), HIF1A(4), KDR(14), NOS3(4), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PXN(2), SHC1(2) 23880167 134 108 134 31 27 30 34 23 20 0 0.0341 1.000 1.000 311 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(9), GABBR1(4), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM7(20), GRM8(24) 15942015 144 107 142 44 31 29 39 30 15 0 0.0567 1.000 1.000 312 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(4), EPRS(5), FARS2(5), FARSA(1), FARSB(8), HARS(1), HARS2(2), IARS(11), IARS2(2), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), TARS(6), TARS2(4), VARS(5), VARS2(4), WARS(2), WARS2(8), YARS(6), YARS2(4) 41343530 139 107 139 34 16 29 45 28 21 0 0.0631 1.000 1.000 313 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(1), ITGA9(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), MAP2K1(5), NR1I3(1), PAK1(3), PDE3A(19), PDE3B(4), PI3(2), PIK3C2G(11), PIK3CD(8), PIK3R1(9), PSME1(1), RIPK3(1), SGCB(3), VASP(1) 34812406 145 107 144 56 18 32 38 26 31 0 0.842 1.000 1.000 314 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(12), BAD(1), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CD40(7), CD40LG(4), CRADD(2), DAXX(6), FADD(3), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(1), NR3C1(6), NTRK1(3), PTPN13(12), RIPK1(2), TFG(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3) 32286019 128 106 128 36 19 36 29 21 23 0 0.131 1.000 1.000 315 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(4), BLVRA(3), COX10(3), COX15(4), CP(7), CPOX(1), EARS2(4), EPRS(5), FECH(1), FTMT(5), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UROD(1), UROS(3) 32200935 139 106 139 63 17 22 51 35 14 0 0.991 1.000 1.000 316 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(7), EGF(8), EGFR(19), ELK1(2), FOS(6), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3) 24982164 127 105 127 32 16 26 38 22 24 1 0.0812 1.000 1.000 317 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 EGFR(19), ELK1(2), GNAS(13), GNB1(3), IGF1R(11), ITGB1(15), KLK2(2), MAP2K1(5), MAP2K2(6), MKNK1(1), MKNK2(2), MYC(6), NGFR(1), PDGFRA(13), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(2), SOS1(9), SRC(1), STAT3(6) 24356937 140 105 137 32 35 26 46 18 15 0 0.0163 1.000 1.000 318 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(6), ACY3(3), ADSL(4), ADSS(4), ADSSL1(5), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(2), DLAT(4), DLD(1), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1) 28819861 131 105 131 43 19 34 40 19 19 0 0.285 1.000 1.000 319 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(4), ARHGAP4(10), ARHGAP5(10), ARHGAP6(8), ARHGEF1(8), ARHGEF11(3), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(3), PIP5K1B(9), PPP1R12B(4), ROCK1(19), SRC(1), TLN1(22), VCL(5) 34531628 154 105 154 63 23 35 47 32 17 0 0.917 1.000 1.000 320 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8) 19620773 131 104 131 60 35 17 40 21 18 0 0.649 1.000 1.000 321 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(24), BRCA1(12), BRCA2(17), CHEK1(1), CHEK2(4), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(10), RAD51(1), RAD9A(2), TREX1(4) 32937946 126 103 126 30 8 38 32 27 21 0 0.160 1.000 1.000 322 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 69 CALR(2), CANX(3), CD4(1), CD74(2), CD8A(3), CD8B(2), CIITA(13), CREB1(1), CTSS(4), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(6), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), KIR2DL3(1), KIR3DL1(3), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LGMN(4), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(3), TAP1(6), TAP2(3), TAPBP(4) 33706037 141 103 140 53 16 39 39 20 27 0 0.580 1.000 1.000 323 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 33 ACTA1(4), ACTN1(4), ACTN2(10), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(4), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAPK8(4), PPP1R12B(4), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SOS1(9), SRC(1), TLN1(22), VCL(5), ZYX(2) 35151449 151 103 150 42 26 24 57 26 18 0 0.206 1.000 1.000 324 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(2), F12(2), F13B(13), F2(3), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), LPA(17), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7), VWF(19) 26901816 143 102 142 41 14 38 43 25 23 0 0.204 1.000 1.000 325 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(3), BTG1(1), CBX3(1), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(2), DNAJA1(3), EIF4G2(8), ETV6(6), G0S2(1), GFRA1(7), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(1), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(2), PPP1R3C(1), PPP2CB(3), PSMA4(1), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(1), ZFR(4) 27910670 118 102 118 44 16 21 44 22 15 0 0.880 1.000 1.000 326 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(4), GTF2A1L(8), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(2), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(6), TAF1(12), TAF10(4), TAF13(1), TAF1L(24), TAF2(7), TAF4(5), TAF4B(4), TAF5(7), TAF5L(4), TAF6(5), TAF6L(2), TAF7(2), TAF7L(4), TAF9(3), TBPL1(2), TBPL2(1) 27445100 137 102 136 52 19 31 35 28 24 0 0.857 1.000 1.000 327 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(12), BTRC(1), CCND1(3), CREBBP(37), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(3), TLE1(7), WIF1(1), WNT1(2) 22412539 143 101 138 37 19 33 37 24 28 2 0.0819 1.000 1.000 328 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(2), AOC2(6), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(2), HAL(6), HARS(1), HARS2(2), HDC(4), HEMK1(1), HNMT(1), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), PRPS1(3), PRPS2(2), UROC1(3) 30139282 125 100 125 37 23 31 40 17 14 0 0.0783 1.000 1.000 329 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(5), POLM(2), POLQ(23), PRIM1(3), PRIM2(1), REV1(3), REV3L(24), RFC5(2) 30859219 123 100 122 34 20 27 31 19 26 0 0.229 1.000 1.000 330 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(4), APC(27), ATF2(1), AXIN1(12), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(11), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), MAP3K7(8), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR3(5), WNT1(2) 26272597 138 99 136 35 22 30 35 27 23 1 0.0786 1.000 1.000 331 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(16), ATR(24), BRCA1(12), CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CDC34(4), CDKN2D(1), CHEK1(1), CHEK2(4), GADD45A(1), MDM2(3), MYT1(11), PRKDC(28), RPS6KA1(10), WEE1(2), YWHAH(2), YWHAQ(3) 27584710 135 99 135 30 17 30 39 28 21 0 0.109 1.000 1.000 332 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), FUK(3), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(4), MTMR1(2), MTMR2(3), MTMR6(3), PFKFB1(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(6), PFKP(5), PGM2(4), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2) 28257904 116 99 116 33 23 26 32 21 14 0 0.0668 1.000 1.000 333 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(6), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(11), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), OXCT2(1), PCCA(9), PCCB(1) 32787097 127 99 126 44 16 34 32 27 18 0 0.596 1.000 1.000 334 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 AGT(4), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(19), ELK1(2), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK8(4), MEF2A(3), MEF2B(5), MEF2D(1), PAK1(3), PRKCA(7), PTK2(8), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9) 23083528 110 98 110 34 17 18 41 23 11 0 0.392 1.000 1.000 335 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(5), ADCY3(7), ADCY9(9), AK1(1), ARF1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(13), PDIA4(1), PLCG1(9), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6) 28168025 129 98 129 36 22 28 38 23 18 0 0.0785 1.000 1.000 336 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(6), ACADS(2), ACAT2(2), ACSM1(6), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(4), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(5), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PPME1(1), PRDX6(1), RDH11(2), RDH12(4) 30901288 135 97 135 54 18 38 40 24 15 0 0.742 1.000 1.000 337 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(1), BTK(8), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(8), PDK1(3), PPP1R13B(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 24738025 127 97 127 43 14 29 39 26 18 1 0.599 1.000 1.000 338 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 22 ACTA1(4), CAPN1(3), CAPN2(5), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(8), EGFR(19), ITGA1(4), ITGB1(15), MYLK(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTK2(8), PXN(2), TLN1(22) 24081070 119 96 117 43 23 19 36 23 17 1 0.645 1.000 1.000 339 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(2), CEBPB(1), DAZL(3), DMC1(1), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), MSH5(3), NCOR1(20), NRIP1(8), PGR(3), PRLR(9), PTGER2(5), VDR(2), ZP2(6) 26702340 124 96 120 37 14 30 38 22 20 0 0.281 1.000 1.000 340 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), BCL2(1), EGFR(19), IGF1R(11), MYC(6), POLR2A(12), PRKCA(7), RB1(17), TEP1(15), TERF1(5), TERT(3), TNKS(7), XRCC5(4) 20921990 109 96 107 38 13 30 27 17 21 1 0.336 1.000 1.000 341 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(6), ACACA(16), ACACB(18), ACADM(3), ACAT2(2), ACSS1(6), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 30231670 119 95 119 43 24 21 33 23 18 0 0.724 1.000 1.000 342 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4) 17536351 123 94 120 38 21 24 33 20 24 1 0.261 1.000 1.000 343 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4) 17536351 123 94 120 38 21 24 33 20 24 1 0.261 1.000 1.000 344 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), NACA(24), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5) 38615851 141 94 140 50 16 36 47 18 23 1 0.805 1.000 1.000 345 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(27), AXIN1(12), CCND1(3), CD14(1), CTNNB1(6), DVL1(8), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(7), LEF1(5), LY96(2), NFKB1(5), PDPK1(4), PIK3R1(9), RELA(2), TIRAP(1), TLR4(17), TOLLIP(2), WNT1(2) 21852761 131 94 129 41 20 31 33 19 27 1 0.263 1.000 1.000 346 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(6), CLCA4(6), CNGA3(9), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(2), PRKG1(7), PRKG2(2), PRKX(1) 23255489 114 93 114 44 16 26 34 23 15 0 0.608 1.000 1.000 347 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(7), ELK1(2), FOS(6), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(13), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3) 23029212 113 93 113 27 16 24 35 15 23 0 0.0576 1.000 1.000 348 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(27), AXIN1(12), CREBBP(37), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(5), PITX2(2), TRRAP(22), WNT1(2) 21559222 133 93 131 32 24 29 31 26 21 2 0.0183 1.000 1.000 349 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(8), JAK1(10), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(4), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT6(5), TYK2(8) 26448405 116 93 116 44 16 23 39 24 14 0 0.718 1.000 1.000 350 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(13), PIK3R1(9), PLD1(15), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(20), VAV1(7), WASF1(3) 24623023 119 92 119 55 19 27 38 13 22 0 0.983 1.000 1.000 351 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 19 ARHGAP5(10), DIAPH1(7), FYN(4), GSN(5), ITGA1(4), ITGB1(15), MAP2K1(5), MYLK(8), PFN1(1), PIK3R1(9), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SRC(1), TLN1(22) 25945350 125 91 124 36 20 19 35 28 23 0 0.416 1.000 1.000 352 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(2), DLG4(3), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(9) 19495200 112 91 112 41 21 28 30 19 14 0 0.234 1.000 1.000 353 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 28133165 116 91 116 40 22 24 32 22 16 0 0.587 1.000 1.000 354 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(11), IRAK1(3), JUN(1), LY96(2), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(5), TLR2(2), TLR3(1), TLR4(17), TLR6(3), TLR7(8), TLR9(4), TOLLIP(2), TRAF6(3) 27836421 116 91 115 48 17 25 40 14 20 0 0.843 1.000 1.000 355 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), GAMT(2), GATM(4), GLUD1(3), GOT1(1), GOT2(2), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3) 33655833 116 90 116 42 23 25 30 22 16 0 0.534 1.000 1.000 356 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(15), C5(10), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELP(16), SELPLG(3), VCAM1(10) 17430493 115 90 114 36 11 31 33 20 20 0 0.222 1.000 1.000 357 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(9), ATP4B(2), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(6), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4) 29048108 110 90 108 29 17 27 32 24 10 0 0.0767 1.000 1.000 358 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 36 ATF2(1), CDC42(3), CREB1(1), DAXX(6), ELK1(2), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RIPK1(2), RPS6KA5(5), SHC1(2), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 26553627 99 90 96 35 16 23 29 14 17 0 0.660 1.000 1.000 359 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 19 CCR3(5), CFL1(2), GNAS(13), GNB1(3), LIMK1(5), MAP2K1(5), NOX1(6), PIK3C2G(11), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2(8), RAF1(3), ROCK2(11) 18339009 105 89 103 32 18 19 40 12 16 0 0.492 1.000 1.000 360 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(2), AVP(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(11), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), NFATC1(7), NFATC2(15), PIK3R1(9), PPP3CA(2), PPP3CB(1), SYT1(9), YWHAH(2) 24217788 109 89 109 41 19 23 26 26 15 0 0.434 1.000 1.000 361 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EARS2(4), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5) 30115190 107 89 107 53 18 23 27 20 19 0 0.973 1.000 1.000 362 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(2), ATF1(3), CDC42(3), CREB1(1), CREB5(7), DUSP1(2), DUSP10(3), EEF2K(5), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K10(5), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(8), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3) 24904271 109 89 107 35 14 24 32 22 17 0 0.431 1.000 1.000 363 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), AOX1(11), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), PCCA(9), PCCB(1), SDS(1) 27435349 107 89 106 36 11 23 30 25 18 0 0.675 1.000 1.000 364 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(3), GIPR(2), GLP1R(1), GLP2R(5), GPR64(6), LPHN1(11), LPHN2(10), LPHN3(22), SCTR(2), VIPR1(1), VIPR2(5) 20287718 115 88 115 39 15 15 34 35 16 0 0.468 1.000 1.000 365 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 21 ATF2(1), BCR(2), BLNK(4), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK8IP3(9), PAPPA(13), RPS6KA1(10), RPS6KA3(4), SHC1(2), SOS1(9), SYK(8), VAV1(7), VAV2(4), VAV3(4) 23285378 105 88 105 26 25 14 29 15 22 0 0.108 1.000 1.000 366 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 22 ADCY1(21), AKT1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(13), MAPK14(2), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RPS6KA1(10), RPS6KA5(5), SOS1(9) 19383426 105 87 104 27 21 23 30 14 17 0 0.1000 1.000 1.000 367 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(21), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(6), PDGFRA(13), PIK3R1(9), PLCB1(22), PRKCA(7), PTK2(8), SRC(1) 18404354 101 87 99 31 13 19 35 16 18 0 0.278 1.000 1.000 368 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(4) 22371140 106 87 106 42 16 17 40 17 15 1 0.777 1.000 1.000 369 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(5), ALAS2(4), AMT(2), AOC2(6), AOC3(5), ATP6V0C(1), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), MAOA(1), MAOB(1), PLCB2(6), PLCG1(9), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(3), TARS(6) 31926425 114 87 114 48 29 20 36 19 10 0 0.787 1.000 1.000 370 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 31 AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), IL2RA(2), IL2RB(3), IRS1(2), JAK1(10), JAK3(6), MYC(6), NMI(6), PIK3R1(9), PTPN6(3), RAF1(3), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 25040678 103 87 101 30 13 29 28 15 18 0 0.0940 1.000 1.000 371 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), CS(3), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(9), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 21604202 103 87 102 29 13 24 35 17 14 0 0.185 1.000 1.000 372 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ATP6V0C(1), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADHA(3), PLOD1(4), PLOD2(9), PLOD3(4), SDS(1), SHMT1(1), SHMT2(3), TMLHE(2) 28229761 111 87 111 49 20 19 27 23 22 0 0.894 1.000 1.000 373 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(6), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 25226371 100 87 100 32 18 17 31 19 15 0 0.585 1.000 1.000 374 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(6), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), MLYCD(2), SDS(1), SMS(3), UPB1(1) 22146251 110 86 110 33 14 30 34 22 10 0 0.248 1.000 1.000 375 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(8), PIK3R1(9), SYT1(9), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 23536043 98 86 98 28 21 18 25 11 23 0 0.103 1.000 1.000 376 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(2), IRS2(6), JAK1(10), JAK3(6), MAP4K1(5), PDK1(3), PIK3CD(8), PIK3R1(9), PPP1R13B(2), RAF1(3), SHC1(2), SOCS1(1), SOS1(9), SOS2(11), STAT6(5) 25739652 109 86 109 33 18 22 31 23 15 0 0.230 1.000 1.000 377 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), COMT(1), DBH(8), DCT(3), DDC(7), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(2), TH(3), TPO(12), TYR(8) 24144687 104 86 103 40 17 25 31 12 19 0 0.541 1.000 1.000 378 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(4), ACTN2(10), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(15), ITGB3(6), PTK2(8), PXN(2), SPTAN1(23), SRC(1), TLN1(22) 21456063 106 85 105 24 17 17 40 19 13 0 0.0507 1.000 1.000 379 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(2), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(9), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(2), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(5), TAF7(2), TAF9(3), TBP(2) 26709019 105 83 105 37 8 23 26 22 26 0 0.687 1.000 1.000 380 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), RPE(1), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), XYLB(3) 20821203 101 82 101 45 14 15 37 25 10 0 0.974 1.000 1.000 381 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 20 CHUK(6), CREBBP(37), DUSP1(2), IKBKB(11), IL1B(1), MAP2K3(5), MAP2K6(1), MAP3K7(8), MAPK11(3), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TLR2(2) 18005239 94 82 92 26 12 16 29 16 20 1 0.273 1.000 1.000 382 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(3), BAD(1), BRAF(10), CREB1(1), CREB5(7), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(5), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MKNK1(1), MKNK2(2), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), SHC1(2), SOS1(9), SOS2(11), TRAF3(6) 21970269 113 82 112 30 24 21 36 20 12 0 0.129 1.000 1.000 383 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), FADD(3), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(5), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(1), TRADD(1), TRAF2(2) 27090128 102 81 100 27 16 27 27 14 18 0 0.0979 1.000 1.000 384 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(4), AMT(2), AOC2(6), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SDS(1), SHMT1(1), SHMT2(3), TARS(6), TARS2(4) 32447784 106 81 106 44 27 20 35 15 8 1 0.727 1.000 1.000 385 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(2), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(1), RPN1(2), RPN2(6), ST6GAL1(4), STT3B(2) 32298969 112 81 112 43 15 24 35 17 21 0 0.766 1.000 1.000 386 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(4), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1), WBSCR17(10) 24611456 103 81 103 36 17 28 27 15 15 1 0.519 1.000 1.000 387 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(7), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(9), VIP(1), VIPR2(5) 21327734 101 81 99 37 21 21 30 16 13 0 0.455 1.000 1.000 388 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA2(1), GALNS(1), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(2) 26245996 93 80 93 42 23 17 18 18 17 0 0.821 1.000 1.000 389 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFAT5(12), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5) 27144403 99 80 99 39 10 35 25 16 13 0 0.560 1.000 1.000 390 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(8), EGFR(19), FOS(6), JUN(1), MYC(6), NFKB1(5), PLCG1(9), PRKCA(7), RELA(2) 15341627 85 79 83 26 12 19 31 14 8 1 0.282 1.000 1.000 391 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(8), ACO2(4), CLYBL(1), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), OGDHL(11), PC(14), PCK1(2), PCK2(4), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 22737982 94 79 93 36 19 19 28 15 13 0 0.578 1.000 1.000 392 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(6), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HIBCH(2), MLYCD(2), SMS(3), UPB1(1) 20581105 95 79 95 30 13 30 27 19 6 0 0.259 1.000 1.000 393 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(15), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(5), LCAT(2), LDLR(4), LIPC(5), LPL(4), LRP1(33), SCARB1(1), SOAT1(5) 20899980 88 79 87 25 12 21 26 16 13 0 0.178 1.000 1.000 394 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(8), PXN(2), STAT1(8), TLN1(22) 20255787 97 78 97 26 10 28 22 19 18 0 0.186 1.000 1.000 395 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GH1(4), GHR(9), INSR(3), IRS1(2), JAK2(5), MAP2K1(5), PIK3R1(9), PLCG1(9), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(2), SLC2A4(3), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5) 22702678 93 78 93 24 14 23 33 11 12 0 0.0743 1.000 1.000 396 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(4), CDC26(1), CDC27(9), CUL1(11), CUL2(3), FBXW11(3), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(4), SMURF2(6), TCEB1(2), UBA1(3), UBE2D2(1), UBE2D4(1), WWP1(7), WWP2(7) 28084918 97 78 96 36 12 28 21 21 15 0 0.747 1.000 1.000 397 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(1), TGFB2(4), TGFB3(1), TOLLIP(2), TRAF6(3) 22681088 91 78 90 29 17 17 26 12 19 0 0.427 1.000 1.000 398 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(12), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), FADD(3), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2) 24634274 92 77 92 23 17 25 21 11 18 0 0.0453 1.000 1.000 399 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), GMPS(7), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5) 25303711 87 76 87 43 13 20 22 17 15 0 0.966 1.000 1.000 400 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(1), CREBBP(37), FYN(4), IL7(2), IL7R(6), JAK1(10), JAK3(6), LCK(5), NMI(6), PIK3R1(9), PTK2B(4), STAT5A(3), STAT5B(5) 15872900 98 76 97 29 9 20 25 21 22 1 0.163 1.000 1.000 401 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(4), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(4), NCOA1(7), NCOA2(9), NCOA3(8), NCOR2(22), POLR2A(12), RARA(5), RXRA(4), TBP(2) 19027728 94 76 94 23 13 22 24 24 11 0 0.0553 1.000 1.000 402 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(3), CYP11B1(6), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 20807898 90 75 90 36 19 15 27 20 9 0 0.742 1.000 1.000 403 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(21), AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CSF2RB(7), IGF1(1), IGF1R(11), IL3(1), IL3RA(5), KIT(12), KITLG(1), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), YWHAH(2) 15051887 92 75 91 28 13 22 23 16 18 0 0.150 1.000 1.000 404 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(9) 18495542 85 75 85 32 14 16 26 18 11 0 0.546 1.000 1.000 405 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), EPRS(5), GAMT(2), GATM(4), GLUD1(3), GLUD2(10), GOT1(1), GOT2(2), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 27378586 94 75 94 33 19 16 21 24 14 0 0.568 1.000 1.000 406 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(4), ARSE(3), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD3(2), SMPD4(5), SPHK2(3), SPTLC1(5), SPTLC2(3), UGCG(1) 27302689 90 75 90 39 20 21 24 13 12 0 0.589 1.000 1.000 407 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(6), CYP4F3(2), EPX(9), GGT1(4), LTA4H(2), MPO(7), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5), TPO(12) 21298308 92 75 91 51 21 17 26 11 17 0 0.973 1.000 1.000 408 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(2), AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PLCG1(9), PRKCE(3), PRKCZ(3), RAB5A(3), RPS6KB1(4), VAV2(4) 18760404 91 75 90 28 12 17 29 14 18 1 0.329 1.000 1.000 409 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 15 CBL(3), EGF(8), EGFR(19), MAP2K1(5), PTPRB(22), RAF1(3), SHC1(2), SOS1(9), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), SRC(1) 16621013 84 75 84 27 12 12 29 19 11 1 0.565 1.000 1.000 410 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(6), ADSL(4), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(2), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), PC(14) 19850511 86 74 86 27 15 17 28 14 12 0 0.296 1.000 1.000 411 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(37), DAXX(6), PAX3(6), PML(1), RARA(5), RB1(17), SIRT1(3), SP100(8), TNFRSF1A(2), TNFRSF1B(2) 13562238 87 74 86 28 7 19 25 10 25 1 0.517 1.000 1.000 412 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 25 BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP3K1(6), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(9), PRKCA(7), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9) 20558341 89 74 89 30 20 13 32 13 11 0 0.547 1.000 1.000 413 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(8), DLG4(3), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK7(6), MAPK8(4), MYEF2(8), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RAF1(3), RASAL1(5), SRC(1), TEC(2), VAV1(7) 20447514 89 74 89 26 6 19 26 16 21 1 0.282 1.000 1.000 414 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(2), CSF1R(2), DDX20(4), E2F4(3), ETS1(5), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), JUN(1), NCOR2(22), RBL1(12), RBL2(6), SIN3A(7), SIN3B(11) 19504894 94 73 94 28 16 28 23 14 13 0 0.0990 1.000 1.000 415 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(16), AP2A1(4), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(6), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(8), SYT1(9) 16542029 82 73 82 34 10 16 30 14 12 0 0.883 1.000 1.000 416 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2) 24100412 86 72 86 39 18 18 25 17 8 0 0.884 1.000 1.000 417 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(14), BAIAP2(2), CASP1(2), CASP3(2), CASP7(3), GAPDH(2), INSR(3), ITCH(7), MAGI1(13), MAGI2(20), RERE(7), WWP1(7), WWP2(7) 17394674 89 71 89 37 13 25 22 16 13 0 0.845 1.000 1.000 418 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(3), IKBKB(11), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(17), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3) 18637126 83 71 82 30 14 17 26 13 13 0 0.583 1.000 1.000 419 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(4), AGT(4), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), REN(3) 18638104 87 70 86 37 10 25 28 13 11 0 0.943 1.000 1.000 420 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(6), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1) 19655941 86 70 86 33 11 26 24 11 14 0 0.693 1.000 1.000 421 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), GCK(4), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), KHK(3), MPI(4), PFKFB1(3), PFKFB3(2), PFKFB4(1), PFKM(6), PFKP(5), PMM2(2), SORD(2), TPI1(4) 18170948 78 70 78 21 14 21 19 13 11 0 0.0543 1.000 1.000 422 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(14), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3) 22414719 80 70 80 27 19 22 20 11 8 0 0.304 1.000 1.000 423 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), HAL(6) 16185960 78 70 78 33 16 14 23 16 9 0 0.873 1.000 1.000 424 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(7), ELK1(2), FOS(6), IL2(2), IL2RA(2), IL2RB(3), JAK1(10), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 17423023 83 70 83 23 10 18 28 11 16 0 0.102 1.000 1.000 425 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA3(2), ANXA4(3), ANXA6(6), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(3), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 15721510 81 70 79 23 15 12 17 13 23 1 0.218 1.000 1.000 426 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(1), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2) 18583750 81 69 81 25 13 17 29 12 10 0 0.255 1.000 1.000 427 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4) 18211464 82 69 82 33 11 15 36 10 9 1 0.706 1.000 1.000 428 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(8), ACE2(4), AGT(4), AGTR2(2), CMA1(5), CPA3(7), CTSA(1), CTSG(1), ENPEP(13), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1) 15569629 82 69 82 30 11 13 30 15 13 0 0.633 1.000 1.000 429 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(8), GNA12(1), GNA13(2), GNB1(3), MYLK(8), PLCB1(22), PPP1R12B(4), PRKCA(7), ROCK1(19) 15753904 84 69 83 29 13 16 29 15 11 0 0.657 1.000 1.000 430 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 BCAR1(3), CRK(2), CXCL12(3), CXCR4(2), GNAI1(2), GNB1(3), MAP2K1(5), NFKB1(5), PIK3C2G(11), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PTK2B(4), PXN(2), RAF1(3), RELA(2) 18588908 80 68 79 29 14 10 24 15 17 0 0.801 1.000 1.000 431 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), GHR(9), IRS1(2), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3R1(9), PRKCA(7), RPS6KB1(4) 18685069 85 68 84 26 4 23 22 12 24 0 0.541 1.000 1.000 432 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3R1(9), RAF1(3), SOS1(9), STAT1(8), STAT5A(3), STAT5B(5) 19458658 80 68 78 26 9 23 25 8 15 0 0.395 1.000 1.000 433 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(5), CHIT1(4), CTBS(2), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(6), HK3(8), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(5) 21848261 79 68 79 24 19 17 20 9 14 0 0.203 1.000 1.000 434 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), P4HB(1), SLC23A1(3), SLC23A2(6), SLC2A1(4), SLC2A3(2) 19044130 85 68 84 40 10 26 22 15 12 0 0.966 1.000 1.000 435 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(4), DARS(5), EPRS(5), FARS2(5), HARS(1), IARS(11), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(6) 24355967 82 67 82 19 6 15 32 19 10 0 0.150 1.000 1.000 436 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(4), GADD45A(1), JUN(1), MAPK8(4), MDM2(3), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(10), RAD51(1), RBBP8(5), RELA(2) 22112705 77 66 76 24 6 19 25 13 14 0 0.709 1.000 1.000 437 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(28), PLCB1(22), PPP1CA(1), PPP3CA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 12164878 80 66 78 29 14 20 21 18 7 0 0.361 1.000 1.000 438 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(4), PIK3R1(9), RPS6KB1(4), TSC1(3), TSC2(7) 18801269 81 65 80 22 7 20 22 9 23 0 0.357 1.000 1.000 439 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAPN2(5), CAPNS1(2), CAPNS2(2), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(7), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(9) 14846695 74 64 73 26 11 18 20 17 8 0 0.365 1.000 1.000 440 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2), SELP(16) 12136275 82 64 81 33 8 19 21 14 20 0 0.738 1.000 1.000 441 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCL4(1), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(1), TGFB2(4), TGFB3(1) 15237567 74 63 73 25 11 11 22 14 16 0 0.390 1.000 1.000 442 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(9), FYN(4), LRP8(5), RELN(50), VLDLR(5) 10663460 77 63 77 26 13 15 20 15 14 0 0.517 1.000 1.000 443 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(6), CRADD(2), IKBKB(11), JUN(1), LTA(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(2), TRADD(1), TRAF2(2) 18467180 69 63 69 25 13 12 21 9 14 0 0.630 1.000 1.000 444 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(9) 16014044 70 62 70 26 12 14 22 15 7 0 0.564 1.000 1.000 445 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(4), ACTN2(10), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(8), PXN(2), SRC(1), VCL(5) 14654852 79 62 77 36 10 15 30 13 10 1 0.955 1.000 1.000 446 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), HAL(6) 14478878 67 62 67 28 12 13 20 15 7 0 0.851 1.000 1.000 447 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), ESCO1(4), ESCO2(3), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX6(1), SH3GLB1(1), TAT(2), TPO(12) 26072658 74 61 73 37 16 16 24 7 11 0 0.938 1.000 1.000 448 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3) 15578679 67 61 67 26 11 13 19 15 9 0 0.537 1.000 1.000 449 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(3), CP(7), CPOX(1), EPRS(5), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UROD(1), UROS(3) 20909278 69 61 69 40 8 12 24 16 9 0 0.998 1.000 1.000 450 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(11), JAK2(5), LIN7A(4), NFKB1(5), NFKBIA(1), RB1(17), RELA(2), TNFRSF1A(2), TNFRSF1B(2), USH1C(3), WT1(3) 13254616 68 61 67 23 5 11 22 8 22 0 0.572 1.000 1.000 451 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(2) 15572237 69 60 69 29 13 14 13 17 12 0 0.757 1.000 1.000 452 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7) 12538130 68 60 68 21 15 14 17 12 10 0 0.186 1.000 1.000 453 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(11), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(5), QPRT(1) 16425488 72 60 72 35 9 9 25 18 11 0 0.974 1.000 1.000 454 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK14(2), NFKB1(5), PIK3R1(9), RB1(17), RELA(2), SP1(3) 12607665 64 59 64 24 10 6 17 5 26 0 0.926 1.000 1.000 455 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CMBL(2), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(4), PON2(2), PON3(8) 13740367 66 59 65 29 12 9 22 9 14 0 0.882 1.000 1.000 456 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(6), MARS(2), MARS2(5), MAT1A(1), METTL2B(3), METTL6(2), PAPSS1(6), PAPSS2(6), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SCLY(1), SEPHS1(2), SEPHS2(3) 18983679 75 59 75 22 18 20 19 11 7 0 0.117 1.000 1.000 457 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15) 15843136 64 59 64 30 13 11 24 9 7 0 0.911 1.000 1.000 458 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), GNAS(13), PLCE1(22), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAP2B(2) 11271304 74 59 73 23 19 14 23 8 10 0 0.301 1.000 1.000 459 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(13), GNB1(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 11690791 69 58 68 23 19 11 20 10 9 0 0.544 1.000 1.000 460 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(5), MAPK14(2), NFATC1(7), NFATC2(15), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 9272919 60 58 60 26 16 12 13 8 11 0 0.485 1.000 1.000 461 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(9), TPI1(4) 15396034 66 58 66 23 10 14 24 11 7 0 0.499 1.000 1.000 462 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX2(2), PRDX6(1), TAT(2), TPO(12) 16733655 68 58 67 33 16 15 22 7 8 0 0.826 1.000 1.000 463 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6) 17148266 63 58 63 21 11 14 17 7 14 0 0.396 1.000 1.000 464 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(9), COMT(1), DBH(8), DDC(7), GAD1(4), GAD2(6), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(3) 11006571 63 57 63 28 9 13 22 6 13 0 0.768 1.000 1.000 465 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), CDKN2C(1), CDKN2D(1), RB1(17), RBL1(12), TFDP1(2) 11774141 62 57 62 18 4 13 12 11 22 0 0.388 1.000 1.000 466 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), CFTR(13), GNAS(13), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1) 9990067 64 57 63 20 17 13 18 9 7 0 0.323 1.000 1.000 467 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23) 12757965 60 57 60 19 11 11 15 7 16 0 0.373 1.000 1.000 468 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(19), AKT1(2), ATM(16), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(1), GADD45A(1), HIC1(1), HIF1A(4), IGFBP3(1), MAPK8(4), MDM2(3), NFKBIB(1), NQO1(3) 15231406 62 57 62 24 9 11 19 10 13 0 0.867 1.000 1.000 469 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(32), MAP2(19), PPP1CA(1), PRKACB(3), PRKACG(2), PRKAR2B(3), PRKCE(3) 13814838 63 56 62 19 3 7 24 12 17 0 0.787 1.000 1.000 470 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(9), F2(3), F2R(4), FGA(12), FGB(4), FGG(6), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7) 10199988 68 56 68 22 7 16 20 8 17 0 0.516 1.000 1.000 471 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(10), ENPP6(5), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1) 17686935 73 56 73 24 5 20 24 12 12 0 0.410 1.000 1.000 472 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 18 AKT1(2), CCND1(3), CCNE1(4), CDK4(5), CDK6(1), CDKN1B(2), NFKB1(5), NFKBIA(1), PAK1(3), PIK3R1(9), RAF1(3), RB1(17), RELA(2), TFDP1(2) 12592534 59 56 59 19 4 9 12 8 26 0 0.589 1.000 1.000 473 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(4), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), PC(14), PCK1(2), SDHA(6), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3) 15684655 63 55 62 21 11 17 18 10 7 0 0.290 1.000 1.000 474 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(5), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1), VNN1(4) 13199243 70 55 70 27 9 15 20 16 10 0 0.753 1.000 1.000 475 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(3), IL22RA1(4), IL22RA2(1), JAK1(10), JAK2(5), JAK3(6), SOCS3(1), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8) 14004048 65 55 65 28 8 19 18 11 9 0 0.648 1.000 1.000 476 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(4), ARSE(3), ASAH1(1), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SPTLC1(5), SPTLC2(3), UGCG(1) 18404200 60 53 60 30 14 15 15 7 9 0 0.828 1.000 1.000 477 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1) 17875206 68 53 68 20 6 15 20 13 14 0 0.363 1.000 1.000 478 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), SOAT2(2) 17706807 62 52 62 28 11 9 17 15 10 0 0.916 1.000 1.000 479 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(10), CR2(7), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18) 11579547 60 52 59 30 3 16 16 9 16 0 0.958 1.000 1.000 480 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(11), EGF(8), EGFR(19), HGS(2), RAB5A(3), TF(5), TFRC(8) 9774048 56 52 56 22 5 11 17 12 10 1 0.869 1.000 1.000 481 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTAP(2), MTFMT(4), MTR(8), TAT(2) 15797093 66 52 66 25 8 14 16 12 16 0 0.506 1.000 1.000 482 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), OPLAH(7) 16875752 60 52 60 29 10 16 15 12 7 0 0.757 1.000 1.000 483 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(5), ST3GAL6(4), ST8SIA1(3) 12381917 56 52 54 17 8 15 23 5 5 0 0.188 1.000 1.000 484 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), GOSR1(4), GOSR2(1), SNAP25(3), STX11(6), STX12(1), STX16(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(1), VTI1A(1), YKT6(1) 12730801 58 52 57 16 11 13 16 4 14 0 0.221 1.000 1.000 485 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(6), ABCC2(9), ABCG2(4), BCHE(6), CES1(6), CES2(8), CYP3A4(4), CYP3A5(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1) 17402190 63 52 63 38 13 11 24 7 8 0 0.985 1.000 1.000 486 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(16), CPT1A(6), LEP(1), LEPR(17), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2) 11017466 56 52 56 29 9 8 18 8 13 0 0.989 1.000 1.000 487 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), GAMT(2), GATM(4), GLUD1(3), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3) 13356772 54 52 54 17 15 14 14 7 4 0 0.225 1.000 1.000 488 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(7), BIRC2(3), BIRC3(2), CASP3(2), CFLAR(2), FADD(3), JUN(1), MAP2K4(2), MAP3K3(2), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR2C2(1), RALBP1(3), RIPK1(2), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 19975878 65 51 64 24 15 21 13 7 9 0 0.416 1.000 1.000 489 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(6), IFNG(2), IKBKB(11), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(1), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2) 14818860 58 50 58 19 8 8 21 7 14 0 0.607 1.000 1.000 490 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3) 13852038 54 50 54 17 9 12 15 5 13 0 0.411 1.000 1.000 491 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(6), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(2), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5) 11485005 53 50 53 18 10 11 15 4 13 0 0.205 1.000 1.000 492 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(4), IARS(11), IARS2(2), ILVBL(5), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(5), VARS2(4) 14201185 61 50 61 20 3 24 18 7 9 0 0.408 1.000 1.000 493 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), PHPT1(1), TYR(8) 11450654 55 50 55 16 10 6 23 6 10 0 0.560 1.000 1.000 494 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(6), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), HADHA(3), SH3GLB1(1), YOD1(4) 23572958 61 50 61 28 4 14 18 15 10 0 0.934 1.000 1.000 495 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(8), AMT(2), ATIC(5), DHFR(2), FTCD(2), GART(5), MTFMT(4), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1) 14409956 60 49 60 26 9 7 22 9 12 1 0.889 1.000 1.000 496 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(2), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(11), INPPL1(8), PDK2(1), PDPK1(4), PIK3R1(9), RPS6KB1(4) 12744407 60 49 59 17 10 16 10 9 15 0 0.295 1.000 1.000 497 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8) 14222687 57 49 57 22 5 12 16 8 16 0 0.779 1.000 1.000 498 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2) 9225121 58 49 57 27 6 14 13 10 15 0 0.861 1.000 1.000 499 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(6), HK3(8), PGM3(1), RENBP(5), UAP1(5) 12907461 50 48 50 15 13 13 9 7 8 0 0.250 1.000 1.000 500 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4) 10941517 54 48 54 21 11 14 11 11 7 0 0.496 1.000 1.000 501 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(5), ULK1(7) 14555643 56 48 56 23 7 9 26 10 4 0 0.889 1.000 1.000 502 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(7), FOS(6), IL3(1), IL3RA(5), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5) 13148465 54 48 54 16 8 15 18 7 6 0 0.207 1.000 1.000 503 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(19), ABCB11(8), ABCB4(13), ABCC1(6), ABCC3(4), GSTP1(1) 10909430 51 48 51 26 7 10 18 3 13 0 0.903 1.000 1.000 504 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 13 AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), PDK1(3), PIK3CD(8), PTK2B(4), RBL2(6), SHC1(2), SOS1(9) 12780337 50 48 50 16 11 9 14 11 5 0 0.451 1.000 1.000 505 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(16), ACACB(18), FASN(10), MCAT(3), OLAH(3), OXSM(3) 12100482 53 47 53 21 13 10 13 10 7 0 0.646 1.000 1.000 506 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1) 10634875 57 47 57 20 8 10 17 14 8 0 0.665 1.000 1.000 507 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GPHN(4), NSF(1), SRC(1), UBQLN1(2) 9131544 56 46 55 23 5 11 22 8 10 0 0.885 1.000 1.000 508 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGW(2), PIGX(2), PIGZ(2) 18117596 53 46 53 33 9 13 15 6 10 0 0.992 1.000 1.000 509 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(5), GALNT2(7), GALNT3(6), GALNT4(3), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(10) 10998633 51 46 51 18 8 16 14 4 8 1 0.434 1.000 1.000 510 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(8), AMT(2), ATIC(5), ATP6V0C(1), DHFR(2), GART(5), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1) 13614448 55 46 55 27 9 6 22 8 9 1 0.961 1.000 1.000 511 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 13402585 48 46 48 29 9 5 15 14 5 0 0.993 1.000 1.000 512 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(22), PLCB2(6), PRL(3), TRH(2), VIP(1) 8480475 50 46 49 22 6 7 23 9 5 0 0.842 1.000 1.000 513 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD5(1), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(8), TLR2(2), TLR4(17), TLR7(8), TLR9(4) 14182806 54 45 54 28 8 13 16 9 8 0 0.887 1.000 1.000 514 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(3), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(3), SLC25A20(3) 12805588 53 45 53 21 6 13 12 11 11 0 0.776 1.000 1.000 515 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(11), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5E(1), QPRT(1) 11095576 52 44 52 26 4 7 20 13 8 0 0.970 1.000 1.000 516 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(2), AKT2(4), AKT3(6), ELK1(2), MAP2K1(5), MAP2K2(6), NGFR(1), NTRK1(3), PIK3CD(8), SHC1(2), SOS1(9) 10319331 48 44 48 18 14 6 13 11 4 0 0.650 1.000 1.000 517 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4) 13774293 49 43 49 18 9 10 16 9 5 0 0.565 1.000 1.000 518 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(4), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3) 9733106 48 43 48 16 7 11 17 7 5 1 0.565 1.000 1.000 519 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(5), CYP51A1(1), DHCR24(2), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(7), GGPS1(1), HMGCR(5), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2) 14704322 49 43 49 18 11 12 9 6 11 0 0.510 1.000 1.000 520 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 15519546 48 43 48 24 15 7 10 7 9 0 0.815 1.000 1.000 521 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTR(8) 13240828 54 43 54 24 8 12 13 10 11 0 0.718 1.000 1.000 522 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(4) 15270764 57 43 57 22 10 9 15 9 14 0 0.714 1.000 1.000 523 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), BAD(1), CHRNB1(1), CHRNG(8), MUSK(8), PIK3R1(9), PTK2(8), PTK2B(4), SRC(1), TERT(3), YWHAH(2) 10826331 47 42 47 21 6 8 14 8 11 0 0.790 1.000 1.000 524 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), PRKCE(3), SOD1(1) 5995337 50 42 49 18 4 8 20 7 11 0 0.759 1.000 1.000 525 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), PGD(2) 13775877 47 42 47 20 10 12 10 9 6 0 0.591 1.000 1.000 526 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD8A(3), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2) 8190989 45 42 45 23 3 7 10 9 16 0 0.890 1.000 1.000 527 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(1), FOS(6), JUN(1), OPRK1(6), POLR2A(12), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3) 9827059 43 41 43 16 8 13 10 6 6 0 0.470 1.000 1.000 528 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(19), ERBB3(17), NRG1(1) 7846179 45 41 45 16 6 9 12 12 5 1 0.710 1.000 1.000 529 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(6), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 9606047 48 41 48 25 20 8 14 2 4 0 0.883 1.000 1.000 530 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(5), CES1(6), DDHD1(4), ESCO1(4), ESCO2(3), LIPA(3), PLA1A(8), PPME1(1), PRDX6(1), SH3GLB1(1) 19334932 47 41 47 12 5 12 16 8 6 0 0.290 1.000 1.000 531 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(4), DHFR(2), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(2) 9551451 45 41 45 17 12 5 17 2 9 0 0.653 1.000 1.000 532 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 CISH(1), JAK1(10), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(10), SOAT1(5) 10163525 42 41 42 13 11 7 10 7 7 0 0.362 1.000 1.000 533 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), WASF1(3), WASF2(5), WASF3(6), WASL(2) 11288049 45 40 45 20 11 10 11 9 4 0 0.884 1.000 1.000 534 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(3), ARFGAP3(4), ARFGEF2(14), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(3), KDELR1(1) 12355779 46 40 46 17 5 15 12 6 8 0 0.505 1.000 1.000 535 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 19 BAD(1), BCL2(1), FADD(3), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), TNFRSF1A(2), TRADD(1), TRAF2(2) 14290201 45 40 45 22 10 5 16 6 8 0 0.952 1.000 1.000 536 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(6), SELL(2), SPN(3), TGFB1(1), TGFB2(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10061449 45 40 45 19 7 12 11 10 5 0 0.620 1.000 1.000 537 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2) 8595033 43 40 43 23 2 7 10 10 14 0 0.921 1.000 1.000 538 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(5), GREB1(20), HSPB2(2), MTA1(7), MTA3(2), TUBA8(2) 8366204 44 39 44 20 12 4 15 7 6 0 0.768 1.000 1.000 539 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(1), YOD1(4) 19815473 42 38 42 16 2 11 10 11 8 0 0.717 1.000 1.000 540 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(9), MPO(7), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12) 8848244 42 38 41 23 15 6 14 4 3 0 0.940 1.000 1.000 541 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(2), PSMD2(5) 12173900 44 38 44 14 3 8 16 11 6 0 0.605 1.000 1.000 542 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(1), CAT(4), EPX(9), MPO(7), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12) 8997307 43 38 42 23 14 6 14 6 3 0 0.938 1.000 1.000 543 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 12593698 42 38 42 20 12 6 10 7 7 0 0.783 1.000 1.000 544 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(4), MBTPS1(11), MBTPS2(4), SCAP(8), SREBF1(5), SREBF2(5) 9071949 40 38 39 14 6 7 13 9 5 0 0.640 1.000 1.000 545 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(3), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), TBXA2R(1) 8535020 43 38 42 25 8 8 16 5 6 0 0.876 1.000 1.000 546 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(3), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 11119036 38 38 37 13 4 9 12 2 11 0 0.571 1.000 1.000 547 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(2), PER3(6) 13012064 42 37 42 17 11 9 10 9 3 0 0.638 1.000 1.000 548 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(8), IRS1(2), JAK1(10), JAK3(6), RPS6KB1(4), SHC1(2), STAT6(5) 11249390 40 37 40 13 6 10 11 7 6 0 0.326 1.000 1.000 549 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), FDXR(3), SHMT1(1) 12176994 48 37 48 15 7 9 16 9 7 0 0.479 1.000 1.000 550 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), TYR(8) 7402625 40 37 40 13 5 5 19 4 7 0 0.673 1.000 1.000 551 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(13), PIK3R1(9), WASL(2) 8196067 38 36 38 14 4 6 13 6 9 0 0.871 1.000 1.000 552 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(2), RPL8(1), RPS10(2), RPS13(2), RPS15A(1), RPS20(1), RPS23(1), RPS25(2), RPS28(1), RPS3(2), RPS5(1) 17304999 43 36 43 24 4 10 17 4 8 0 0.954 1.000 1.000 553 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(1), IL1A(1), IL6(2), JAK1(10), STAT1(8), STAT3(6), STAT5A(3) 9275295 40 36 40 19 3 15 10 6 6 0 0.600 1.000 1.000 554 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 7 IFNAR1(2), JAK1(10), PTPRU(10), STAT1(8), STAT2(4), TYK2(8) 9259532 42 36 42 20 10 10 8 4 10 0 0.793 1.000 1.000 555 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 556 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1) 8820515 36 35 36 14 4 9 10 6 7 0 0.836 1.000 1.000 557 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 558 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(9), ASPH(10), COPS5(2), CREB1(1), EDN1(1), EPO(2), HIF1A(4), JUN(1), LDHA(1), NOS3(4), P4HB(1) 9188341 36 35 36 13 7 11 7 8 3 0 0.539 1.000 1.000 559 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), JAK2(5), STAT4(6), TYK2(8) 11195854 42 35 42 19 4 9 12 7 10 0 0.848 1.000 1.000 560 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RELA(2) 6288248 37 35 36 12 5 6 15 6 5 0 0.492 1.000 1.000 561 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11439698 45 35 45 13 6 9 14 9 7 0 0.369 1.000 1.000 562 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1) 7619969 41 35 41 12 0 16 13 6 6 0 0.513 1.000 1.000 563 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(6), GPR161(4), GPR171(2), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(2), GPR75(5) 7498683 37 34 37 17 11 7 7 7 5 0 0.746 1.000 1.000 564 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1) 9547972 39 34 39 14 8 5 14 7 5 0 0.617 1.000 1.000 565 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), MPO(7), PRDX2(2), PRDX6(1), TPO(12), TYR(8) 7358360 39 34 38 19 11 4 16 5 3 0 0.892 1.000 1.000 566 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6) 5344444 37 33 37 19 4 10 14 4 5 0 0.874 1.000 1.000 567 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1) 19028846 38 33 38 16 3 11 6 8 10 0 0.808 1.000 1.000 568 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(8), ITGAM(8), ITGB2(3), SELE(7), SELL(2) 7905087 37 33 37 24 3 9 7 5 13 0 0.963 1.000 1.000 569 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8) 7987723 38 33 38 15 8 8 9 7 6 0 0.674 1.000 1.000 570 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8) 7987723 38 33 38 15 8 8 9 7 6 0 0.674 1.000 1.000 571 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(8), ACO2(4), ACSS1(6), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(2) 10126876 36 32 36 14 5 11 12 2 6 0 0.569 1.000 1.000 572 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), LTA(4), TGFB1(1), TGFB2(4), TGFB3(1) 10139640 34 32 33 16 5 7 8 8 6 0 0.868 1.000 1.000 573 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 9263996 35 32 35 15 5 5 10 9 6 0 0.855 1.000 1.000 574 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(4), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(18), ZAP70(4) 6887652 36 32 35 17 3 6 9 7 11 0 0.900 1.000 1.000 575 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4) 7067770 31 30 31 11 7 8 5 4 7 0 0.449 1.000 1.000 576 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(4), PON2(2), PON3(8), RDH11(2), RDH12(4) 6856410 34 30 33 17 3 7 10 9 5 0 0.876 1.000 1.000 577 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), JAK1(10), STAT1(8), STAT2(4), TYK2(8) 8272766 34 30 34 16 5 9 7 4 9 0 0.799 1.000 1.000 578 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(10), JAK2(5), JAK3(6), STAT3(6), TYK2(8) 8406722 35 30 35 13 5 6 10 9 5 0 0.572 1.000 1.000 579 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7026894 31 29 31 13 10 3 8 5 4 1 0.693 1.000 1.000 580 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7026894 31 29 31 13 10 3 8 5 4 1 0.693 1.000 1.000 581 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3) 10077353 31 29 31 15 5 7 6 7 6 0 0.876 1.000 1.000 582 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), CS(3), FH(3), IDH2(1), MDH1(1), OGDH(10), SDHA(6), SUCLA2(2) 7163508 30 29 29 10 5 4 12 5 4 0 0.630 1.000 1.000 583 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(3), GGT1(4), MARS(2), MARS2(5), MAT1A(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(2) 9427406 31 29 31 12 8 9 7 5 2 0 0.521 1.000 1.000 584 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7) 6503926 30 28 30 11 6 6 8 9 1 0 0.632 1.000 1.000 585 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(2), MPO(7), PRDX6(1), TPO(12) 6384044 31 28 30 17 11 4 11 3 2 0 0.914 1.000 1.000 586 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 7 ACE(8), AGT(4), AGTR2(2), BDKRB2(3), KNG1(4), NOS3(4), REN(3) 6965932 28 27 28 15 5 7 8 3 5 0 0.815 1.000 1.000 587 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4) 10055090 29 26 29 12 9 9 3 4 4 0 0.512 1.000 1.000 588 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR3(5), TOB2(3) 7172045 27 26 27 10 2 5 8 8 4 0 0.769 1.000 1.000 589 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(3), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 9027467 31 25 31 12 0 11 10 5 5 0 0.769 1.000 1.000 590 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(3), FARS2(5), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6) 6320693 29 25 29 11 0 9 11 3 6 0 0.603 1.000 1.000 591 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(17), SP1(3), SP3(3) 5062287 25 25 25 10 0 2 5 4 14 0 0.918 1.000 1.000 592 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 8 CD3D(1), GZMB(2), ICAM1(6), ITGAL(8), ITGB2(3), PRF1(5) 5911191 25 24 25 14 4 5 5 2 9 0 0.754 1.000 1.000 593 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(3), CDK4(5), CDKN1B(2), CFL1(2), E2F2(3), MDM2(3), PRB1(7) 5376969 26 24 26 11 1 6 10 6 3 0 0.824 1.000 1.000 594 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6087277 24 23 24 12 5 2 7 6 4 0 0.912 1.000 1.000 595 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6087277 24 23 24 12 5 2 7 6 4 0 0.912 1.000 1.000 596 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4) 8439908 26 23 26 10 10 8 2 2 4 0 0.386 1.000 1.000 597 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), DHFR(2), FPGS(1), GCH1(1), GGH(2) 4994142 25 23 25 12 5 2 12 3 3 0 0.819 1.000 1.000 598 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1) 10947614 25 23 25 17 5 8 6 2 4 0 0.939 1.000 1.000 599 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(9), PRKCA(7), PTK2B(4) 5113158 23 23 23 10 5 4 9 4 1 0 0.633 1.000 1.000 600 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 10 CDK5(3), CDK5R1(1), EGR1(4), KLK2(2), MAP2K1(5), MAP2K2(6), NGFR(1), RAF1(3) 5391156 25 22 25 12 8 4 8 2 3 0 0.628 1.000 1.000 601 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6) 7546546 23 22 23 13 4 5 6 4 4 0 0.883 1.000 1.000 602 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(3) 6483880 22 22 22 10 5 3 4 7 3 0 0.765 1.000 1.000 603 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1) 5397957 23 22 23 18 2 8 5 6 2 0 0.989 1.000 1.000 604 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(14), GLS(1), GLUD1(3), GOT1(1) 5941839 22 22 22 10 4 4 6 5 3 0 0.822 1.000 1.000 605 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 5262994 24 21 24 15 7 3 7 2 4 1 0.901 1.000 1.000 606 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(1), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3) 7724314 24 21 24 14 3 6 9 1 5 0 0.904 1.000 1.000 607 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(1) 4552714 22 20 21 10 3 7 8 2 2 0 0.515 1.000 1.000 608 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), WASF1(3), WASL(2) 5857986 20 20 20 13 4 5 5 4 2 0 0.973 1.000 1.000 609 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(2), XDH(6) 6080283 22 19 22 10 3 5 9 3 2 0 0.757 1.000 1.000 610 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(4), CPO(4), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3) 5951609 18 18 18 11 2 3 6 6 1 0 0.949 1.000 1.000 611 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(7), BIRC3(2), FADD(3), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 5535900 21 18 21 11 5 6 5 3 2 0 0.779 1.000 1.000 612 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4) 2985343 16 16 16 7 1 6 4 5 0 0 0.692 1.000 1.000 613 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4) 6849192 17 16 17 11 3 2 4 4 4 0 0.969 1.000 1.000 614 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4) 3653050 16 15 16 7 3 3 7 3 0 0 0.695 1.000 1.000 615 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1) 12644033 16 15 16 9 0 4 3 4 5 0 0.944 1.000 1.000 616 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 BCL2(1), CASP3(2), CFL1(2), CFLAR(2) 2064270 7 7 7 5 2 5 0 0 0 0 0.743 1.000 1.000