Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.272 0.231 -9999.0 0.0 -0.944 14.0 14.0 IHH -0.054 0.074 -9999.0 0.0 -0.764 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.043 0.137 -9999.0 0.0 -0.492 43.0 43.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.136 0.488 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 -0.141 0.154 -9999.0 0.0 -0.599 24.0 24.0 SMO -0.156 0.163 -9999.0 0.0 -0.631 25.0 25.0 AKT1 -0.059 0.083 -9999.0 0.0 -0.605 2.0 2.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.04 0.171 -9999.0 0.0 -0.582 47.0 47.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 STIL -0.132 0.166 -9999.0 0.0 -0.628 32.0 32.0 DHH N/PTCH2 -0.015 0.087 -9999.0 0.0 -0.51 15.0 15.0 DHH N/PTCH1 -0.135 0.142 -9999.0 0.0 -0.771 9.0 9.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.009 0.051 -9999.0 0.0 -0.807 2.0 2.0 PTHLH -0.448 0.333 -9999.0 0.0 -0.652 369.0 369.0 determination of left/right symmetry -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 PIK3R1 0.011 0.037 -9999.0 0.0 -0.577 2.0 2.0 skeletal system development -0.444 0.33 -9999.0 0.0 -0.646 369.0 369.0 IHH N/Hhip -0.054 0.166 -9999.0 0.0 -0.672 34.0 34.0 DHH N/Hhip -0.039 0.15 -9999.0 0.0 -0.612 33.0 33.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 pancreas development -0.037 0.192 -9999.0 0.0 -0.798 31.0 31.0 HHAT 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.026 -9999.0 0.0 -0.415 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.091 -9999.0 0.0 -0.721 8.0 8.0 somite specification -0.154 0.16 -9999.0 0.0 -0.62 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.145 0.174 -9999.0 0.0 -0.67 31.0 31.0 SHH Np/Cholesterol/PTCH2 -0.045 0.148 -9999.0 0.0 -0.527 40.0 40.0 SHH Np/Cholesterol/Megalin -0.061 0.18 -9999.0 0.0 -0.549 58.0 58.0 SHH -0.028 0.166 -9999.0 0.0 -0.619 38.0 38.0 catabolic process -0.161 0.155 -9999.0 0.0 -0.727 11.0 11.0 SMO/Vitamin D3 -0.152 0.176 -9999.0 0.0 -0.656 31.0 31.0 SHH Np/Cholesterol/Hhip -0.065 0.185 -9999.0 0.0 -0.554 60.0 60.0 LRP2 -0.031 0.182 -9999.0 0.0 -0.807 27.0 27.0 receptor-mediated endocytosis -0.168 0.166 -9999.0 0.0 -0.65 37.0 37.0 SHH Np/Cholesterol/BOC -0.065 0.153 -9999.0 0.0 -0.499 39.0 39.0 SHH Np/Cholesterol/CDO -0.044 0.135 -9999.0 0.0 -0.491 38.0 38.0 mesenchymal cell differentiation 0.064 0.183 0.549 60.0 -9999.0 0.0 60.0 mol:Vitamin D3 -0.144 0.174 -9999.0 0.0 -0.67 31.0 31.0 IHH N/PTCH2 -0.025 0.099 -9999.0 0.0 -0.556 16.0 16.0 CDON -0.001 0.092 -9999.0 0.0 -0.577 13.0 13.0 IHH N/PTCH1 -0.162 0.157 -9999.0 0.0 -0.734 11.0 11.0 Megalin/LRPAP1 -0.032 0.137 -9999.0 0.0 -0.618 27.0 27.0 PTCH2 -0.004 0.107 -9999.0 0.0 -0.666 13.0 13.0 SHH Np/Cholesterol -0.033 0.131 -9999.0 0.0 -0.5 38.0 38.0 PTCH1 -0.161 0.156 -9999.0 0.0 -0.732 11.0 11.0 HHIP -0.038 0.192 -9999.0 0.0 -0.8 31.0 31.0