Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.008 0.112 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.041 0.214 -9999.0 0.0 -0.66 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.109 0.186 -9999.0 0.0 -0.38 21.0 21.0 LRPAP1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.185 0.378 21.0 -9999.0 0.0 21.0 SMO/beta Arrestin2 -0.043 0.176 -9999.0 0.0 -0.495 7.0 7.0 SMO -0.061 0.177 -9999.0 0.0 -0.522 7.0 7.0 AKT1 -0.014 0.086 -9999.0 0.0 -0.317 1.0 1.0 ARRB2 0.029 0.026 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.174 -9999.0 0.0 -0.513 7.0 7.0 STIL -0.094 0.184 -9999.0 0.0 -0.386 14.0 14.0 DHH N/PTCH2 -0.015 0.146 -9999.0 0.0 -0.476 6.0 6.0 DHH N/PTCH1 -0.038 0.158 -9999.0 0.0 -0.354 13.0 13.0 PIK3CA 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.037 0.189 -9999.0 0.0 -0.635 6.0 6.0 PTHLH -0.018 0.139 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.059 0.174 -9999.0 0.0 -0.513 7.0 7.0 PIK3R1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.018 0.138 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.014 0.141 -9999.0 0.0 -0.422 7.0 7.0 DHH N/Hhip -0.017 0.147 -9999.0 0.0 -0.479 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.174 -9999.0 0.0 -0.513 7.0 7.0 pancreas development 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.175 -9999.0 0.0 -0.635 5.0 5.0 somite specification -0.059 0.174 -9999.0 0.0 -0.513 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.097 0.192 -9999.0 0.0 -0.387 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.079 0.17 -9999.0 0.0 -0.379 16.0 16.0 SHH Np/Cholesterol/Megalin -0.348 0.232 -9999.0 0.0 -0.456 50.0 50.0 SHH -0.125 0.2 -9999.0 0.0 -0.479 16.0 16.0 catabolic process -0.012 0.127 -9999.0 0.0 -0.375 7.0 7.0 SMO/Vitamin D3 -0.109 0.206 -9999.0 0.0 -0.563 6.0 6.0 SHH Np/Cholesterol/Hhip -0.084 0.168 -9999.0 0.0 -0.38 16.0 16.0 LRP2 -0.455 0.287 -9999.0 0.0 -0.629 48.0 48.0 receptor-mediated endocytosis -0.293 0.249 -9999.0 0.0 -0.649 17.0 17.0 SHH Np/Cholesterol/BOC -0.079 0.17 -9999.0 0.0 -0.38 16.0 16.0 SHH Np/Cholesterol/CDO -0.079 0.171 -9999.0 0.0 -0.38 16.0 16.0 mesenchymal cell differentiation 0.083 0.167 0.378 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.092 0.197 -9999.0 0.0 -0.387 17.0 17.0 IHH N/PTCH2 -0.011 0.141 -9999.0 0.0 -0.417 7.0 7.0 CDON 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.004 0.131 -9999.0 0.0 -0.379 7.0 7.0 Megalin/LRPAP1 -0.33 0.225 -9999.0 0.0 -0.464 48.0 48.0 PTCH2 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.09 0.163 -9999.0 0.0 -0.376 16.0 16.0 PTCH1 -0.013 0.127 -9999.0 0.0 -0.376 7.0 7.0 HHIP 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0