This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 12 different clustering approaches and 14 clinical features across 894 patients, 93 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 5 subtypes that correlate to 'PATHOLOGY_T_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', and 'RACE'.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', 'YEAR_OF_TOBACCO_SMOKING_ONSET', and 'RACE'.
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5 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', and 'HISTOLOGICAL_TYPE'.
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CNMF clustering analysis on RPPA data identified 4 subtypes that correlate to 'Time to Death', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_M_STAGE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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Consensus hierarchical clustering analysis on RPPA data identified 7 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'KARNOFSKY_PERFORMANCE_SCORE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', and 'RACE'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 9 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'KARNOFSKY_PERFORMANCE_SCORE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'Time to Death', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', and 'RACE'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'HISTOLOGICAL_TYPE', and 'RACE'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', 'KARNOFSKY_PERFORMANCE_SCORE', and 'HISTOLOGICAL_TYPE'.
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7 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'PATHOLOGY_M_STAGE', 'GENDER', and 'HISTOLOGICAL_TYPE'.
Clinical Features |
Statistical Tests |
mRNA CNMF subtypes |
mRNA cHierClus subtypes |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.211 (0.31) |
0.0913 (0.153) |
7.35e-07 (1.24e-05) |
1.11e-16 (1.87e-14) |
1.39e-09 (3.33e-08) |
5.59e-12 (1.88e-10) |
7.77e-16 (4.35e-14) |
2.22e-16 (1.87e-14) |
6.25e-07 (1.17e-05) |
1.07e-14 (4.48e-13) |
3.15e-09 (6.61e-08) |
8.3e-10 (2.32e-08) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
0.317 (0.413) |
0.214 (0.31) |
0.0393 (0.0717) |
1.07e-05 (3.26e-05) |
0.0532 (0.0951) |
0.00264 (0.00577) |
0.000578 (0.00135) |
3.46e-06 (3.11e-05) |
0.135 (0.206) |
1.31e-05 (3.94e-05) |
0.00195 (0.00438) |
0.0129 (0.026) |
PATHOLOGIC STAGE | Fisher's exact test |
0.0236 (0.0451) |
0.0639 (0.113) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
PATHOLOGY T STAGE | Fisher's exact test |
0.0073 (0.0155) |
0.0234 (0.0451) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
PATHOLOGY N STAGE | Fisher's exact test |
0.113 (0.176) |
0.322 (0.416) |
0.0135 (0.0269) |
1e-05 (3.11e-05) |
0.201 (0.302) |
0.00042 (0.00101) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
0.00011 (0.000276) |
1e-05 (3.11e-05) |
6e-05 (0.00016) |
PATHOLOGY M STAGE | Fisher's exact test |
0.221 (0.317) |
0.245 (0.34) |
9e-05 (0.000229) |
1e-05 (3.11e-05) |
2e-05 (5.6e-05) |
1e-05 (3.11e-05) |
0.00315 (0.00678) |
2e-05 (5.6e-05) |
0.0794 (0.135) |
2e-05 (5.6e-05) |
0.00899 (0.0188) |
0.0136 (0.027) |
GENDER | Fisher's exact test |
0.578 (0.66) |
0.00019 (0.000469) |
0.012 (0.0246) |
4e-05 (0.000108) |
0.405 (0.497) |
0.0233 (0.0451) |
8e-05 (0.00021) |
1e-05 (3.11e-05) |
0.0736 (0.126) |
3e-05 (8.26e-05) |
0.00232 (0.00513) |
0.00024 (0.000584) |
RADIATION THERAPY | Fisher's exact test |
0.237 (0.332) |
0.306 (0.401) |
0.376 (0.472) |
0.735 (0.807) |
0.393 (0.486) |
0.429 (0.515) |
0.167 (0.253) |
0.655 (0.729) |
0.294 (0.389) |
0.231 (0.326) |
||
KARNOFSKY PERFORMANCE SCORE | Kruskal-Wallis (anova) |
0.208 (0.309) |
0.0976 (0.159) |
0.414 (0.504) |
0.0332 (0.0619) |
0.335 (0.426) |
0.00151 (0.00343) |
0.249 (0.34) |
0.0691 (0.12) |
0.0398 (0.0719) |
0.108 (0.17) |
||
HISTOLOGICAL TYPE | Fisher's exact test |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
9e-05 (0.000229) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
NUMBER PACK YEARS SMOKED | Kruskal-Wallis (anova) |
0.1 (0.16) |
0.908 (0.96) |
0.545 (0.628) |
0.968 (1.00) |
0.806 (0.862) |
0.533 (0.618) |
0.898 (0.955) |
0.787 (0.847) |
0.604 (0.681) |
0.438 (0.522) |
||
YEAR OF TOBACCO SMOKING ONSET | Kruskal-Wallis (anova) |
0.0244 (0.0461) |
0.477 (0.561) |
0.745 (0.812) |
0.453 (0.535) |
0.529 (0.617) |
0.367 (0.463) |
0.214 (0.31) |
0.099 (0.16) |
0.273 (0.37) |
0.422 (0.51) |
||
RACE | Fisher's exact test |
2e-05 (5.6e-05) |
1e-05 (3.11e-05) |
0.00058 (0.00135) |
0.0917 (0.153) |
0.0377 (0.0696) |
0.00907 (0.0188) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
1e-05 (3.11e-05) |
0.00062 (0.00143) |
0.766 (0.831) |
0.122 (0.188) |
ETHNICITY | Fisher's exact test |
0.106 (0.169) |
0.0662 (0.116) |
0.283 (0.381) |
0.681 (0.752) |
0.595 (0.676) |
0.249 (0.34) |
0.381 (0.474) |
0.225 (0.321) |
0.288 (0.384) |
0.327 (0.419) |
0.65 (0.728) |
0.0937 (0.154) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 32 | 25 | 14 | 17 |
P value = 0.211 (logrank test), Q value = 0.31
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 88 | 19 | 0.5 - 117.8 (38.0) |
subtype1 | 32 | 5 | 1.4 - 115.0 (38.7) |
subtype2 | 25 | 8 | 0.5 - 114.4 (43.2) |
subtype3 | 14 | 1 | 12.1 - 117.8 (40.4) |
subtype4 | 17 | 5 | 0.5 - 76.6 (29.0) |
P value = 0.317 (Kruskal-Wallis (anova)), Q value = 0.41
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 87 | 60.1 (12.2) |
subtype1 | 31 | 61.2 (13.6) |
subtype2 | 25 | 58.5 (11.2) |
subtype3 | 14 | 64.2 (11.4) |
subtype4 | 17 | 56.9 (11.2) |
P value = 0.0236 (Fisher's exact test), Q value = 0.045
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 45 | 16 | 15 | 6 |
subtype1 | 22 | 3 | 6 | 1 |
subtype2 | 8 | 5 | 8 | 4 |
subtype3 | 9 | 5 | 0 | 0 |
subtype4 | 6 | 3 | 1 | 1 |
P value = 0.0073 (Fisher's exact test), Q value = 0.016
nPatients | T1 | T2 | T3 |
---|---|---|---|
ALL | 48 | 21 | 19 |
subtype1 | 22 | 3 | 7 |
subtype2 | 9 | 6 | 10 |
subtype3 | 9 | 5 | 0 |
subtype4 | 8 | 7 | 2 |
P value = 0.113 (Fisher's exact test), Q value = 0.18
nPatients | N0 | N1 |
---|---|---|
ALL | 37 | 4 |
subtype1 | 17 | 0 |
subtype2 | 12 | 3 |
subtype3 | 5 | 0 |
subtype4 | 3 | 1 |
P value = 0.221 (Fisher's exact test), Q value = 0.32
nPatients | 0 | 1 |
---|---|---|
ALL | 77 | 6 |
subtype1 | 31 | 1 |
subtype2 | 21 | 4 |
subtype3 | 14 | 0 |
subtype4 | 11 | 1 |
P value = 0.578 (Fisher's exact test), Q value = 0.66
nPatients | FEMALE | MALE |
---|---|---|
ALL | 33 | 55 |
subtype1 | 15 | 17 |
subtype2 | 9 | 16 |
subtype3 | 4 | 10 |
subtype4 | 5 | 12 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|
ALL | 72 | 16 |
subtype1 | 32 | 0 |
subtype2 | 24 | 1 |
subtype3 | 13 | 1 |
subtype4 | 3 | 14 |
P value = 2e-05 (Fisher's exact test), Q value = 5.6e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 1 | 12 | 71 |
subtype1 | 0 | 0 | 30 |
subtype2 | 0 | 1 | 22 |
subtype3 | 0 | 2 | 12 |
subtype4 | 1 | 9 | 7 |
P value = 0.106 (Fisher's exact test), Q value = 0.17
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 58 |
subtype1 | 4 | 19 |
subtype2 | 3 | 11 |
subtype3 | 0 | 12 |
subtype4 | 0 | 16 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 21 | 24 | 18 | 13 | 12 |
P value = 0.0913 (logrank test), Q value = 0.15
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 88 | 19 | 0.5 - 117.8 (38.0) |
subtype1 | 21 | 2 | 1.4 - 115.0 (35.9) |
subtype2 | 24 | 8 | 0.5 - 114.4 (46.1) |
subtype3 | 18 | 6 | 0.5 - 76.6 (28.6) |
subtype4 | 13 | 3 | 11.1 - 106.2 (48.4) |
subtype5 | 12 | 0 | 12.1 - 117.8 (43.1) |
P value = 0.214 (Kruskal-Wallis (anova)), Q value = 0.31
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 87 | 60.1 (12.2) |
subtype1 | 20 | 57.6 (13.7) |
subtype2 | 24 | 59.2 (10.8) |
subtype3 | 18 | 57.0 (10.9) |
subtype4 | 13 | 64.1 (13.5) |
subtype5 | 12 | 66.2 (10.8) |
P value = 0.0639 (Fisher's exact test), Q value = 0.11
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 45 | 16 | 15 | 6 |
subtype1 | 16 | 2 | 3 | 0 |
subtype2 | 8 | 4 | 8 | 4 |
subtype3 | 7 | 3 | 1 | 1 |
subtype4 | 7 | 2 | 3 | 1 |
subtype5 | 7 | 5 | 0 | 0 |
P value = 0.0234 (Fisher's exact test), Q value = 0.045
nPatients | T1 | T2 | T3 |
---|---|---|---|
ALL | 48 | 21 | 19 |
subtype1 | 16 | 2 | 3 |
subtype2 | 9 | 5 | 10 |
subtype3 | 9 | 7 | 2 |
subtype4 | 7 | 2 | 4 |
subtype5 | 7 | 5 | 0 |
P value = 0.322 (Fisher's exact test), Q value = 0.42
nPatients | N0 | N1 |
---|---|---|
ALL | 37 | 4 |
subtype1 | 9 | 0 |
subtype2 | 11 | 3 |
subtype3 | 4 | 1 |
subtype4 | 9 | 0 |
subtype5 | 4 | 0 |
P value = 0.245 (Fisher's exact test), Q value = 0.34
nPatients | 0 | 1 |
---|---|---|
ALL | 77 | 6 |
subtype1 | 21 | 0 |
subtype2 | 20 | 4 |
subtype3 | 12 | 1 |
subtype4 | 12 | 1 |
subtype5 | 12 | 0 |
P value = 0.00019 (Fisher's exact test), Q value = 0.00047
nPatients | FEMALE | MALE |
---|---|---|
ALL | 33 | 55 |
subtype1 | 3 | 18 |
subtype2 | 9 | 15 |
subtype3 | 5 | 13 |
subtype4 | 12 | 1 |
subtype5 | 4 | 8 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|
ALL | 72 | 16 |
subtype1 | 21 | 0 |
subtype2 | 23 | 1 |
subtype3 | 4 | 14 |
subtype4 | 13 | 0 |
subtype5 | 11 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 1 | 12 | 71 |
subtype1 | 0 | 0 | 19 |
subtype2 | 0 | 1 | 21 |
subtype3 | 1 | 10 | 7 |
subtype4 | 0 | 0 | 13 |
subtype5 | 0 | 1 | 11 |
P value = 0.0662 (Fisher's exact test), Q value = 0.12
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 7 | 58 |
subtype1 | 2 | 12 |
subtype2 | 2 | 11 |
subtype3 | 0 | 16 |
subtype4 | 3 | 7 |
subtype5 | 0 | 12 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 328 | 200 | 354 |
P value = 7.35e-07 (logrank test), Q value = 1.2e-05
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 876 | 228 | 0.1 - 194.8 (35.9) |
subtype1 | 324 | 58 | 0.1 - 194.8 (29.2) |
subtype2 | 198 | 38 | 0.1 - 149.2 (37.4) |
subtype3 | 354 | 132 | 0.1 - 133.7 (38.4) |
P value = 0.0393 (Kruskal-Wallis (anova)), Q value = 0.072
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 876 | 60.1 (12.5) |
subtype1 | 324 | 59.8 (12.9) |
subtype2 | 200 | 58.6 (12.8) |
subtype3 | 352 | 61.3 (11.9) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 454 | 103 | 190 | 104 |
subtype1 | 182 | 43 | 52 | 24 |
subtype2 | 127 | 21 | 37 | 14 |
subtype3 | 145 | 39 | 101 | 66 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 480 | 127 | 258 | 15 |
subtype1 | 200 | 53 | 66 | 7 |
subtype2 | 130 | 24 | 45 | 1 |
subtype3 | 150 | 50 | 147 | 7 |
P value = 0.0135 (Fisher's exact test), Q value = 0.027
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 323 | 44 | 6 |
subtype1 | 92 | 19 | 4 |
subtype2 | 74 | 3 | 0 |
subtype3 | 157 | 22 | 2 |
P value = 9e-05 (Fisher's exact test), Q value = 0.00023
nPatients | 0 | 1 |
---|---|---|
ALL | 546 | 89 |
subtype1 | 136 | 13 |
subtype2 | 155 | 13 |
subtype3 | 255 | 63 |
P value = 0.012 (Fisher's exact test), Q value = 0.025
nPatients | FEMALE | MALE |
---|---|---|
ALL | 292 | 590 |
subtype1 | 93 | 235 |
subtype2 | 82 | 118 |
subtype3 | 117 | 237 |
P value = 0.237 (Fisher's exact test), Q value = 0.33
nPatients | NO | YES |
---|---|---|
ALL | 408 | 3 |
subtype1 | 234 | 1 |
subtype2 | 80 | 0 |
subtype3 | 94 | 2 |
P value = 0.208 (Kruskal-Wallis (anova)), Q value = 0.31
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 143 | 87.7 (22.8) |
subtype1 | 72 | 91.7 (13.7) |
subtype2 | 29 | 92.4 (11.5) |
subtype3 | 42 | 77.6 (35.0) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 528 | 288 |
subtype1 | 52 | 40 | 236 |
subtype2 | 10 | 164 | 26 |
subtype3 | 4 | 324 | 26 |
P value = 0.1 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 106 | 30.8 (24.9) |
subtype1 | 71 | 31.1 (21.5) |
subtype2 | 14 | 42.8 (44.4) |
subtype3 | 21 | 21.7 (12.6) |
P value = 0.0244 (Kruskal-Wallis (anova)), Q value = 0.046
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 74 | 1973.7 (16.0) |
subtype1 | 49 | 1970.6 (15.2) |
subtype2 | 11 | 1976.5 (18.2) |
subtype3 | 14 | 1982.6 (14.0) |
P value = 0.00058 (Fisher's exact test), Q value = 0.0014
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 16 | 121 | 719 |
subtype1 | 2 | 8 | 59 | 244 |
subtype2 | 0 | 4 | 32 | 163 |
subtype3 | 0 | 4 | 30 | 312 |
P value = 0.283 (Fisher's exact test), Q value = 0.38
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 42 | 622 |
subtype1 | 14 | 254 |
subtype2 | 7 | 138 |
subtype3 | 21 | 230 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 104 | 123 | 172 | 71 | 190 |
P value = 1.11e-16 (logrank test), Q value = 1.9e-14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 654 | 154 | 0.1 - 194.8 (30.6) |
subtype1 | 103 | 16 | 0.2 - 153.7 (54.9) |
subtype2 | 120 | 46 | 0.4 - 131.1 (22.2) |
subtype3 | 171 | 39 | 0.1 - 149.2 (37.2) |
subtype4 | 71 | 37 | 0.6 - 133.7 (21.6) |
subtype5 | 189 | 16 | 0.1 - 194.8 (27.1) |
P value = 1.07e-05 (Kruskal-Wallis (anova)), Q value = 3.3e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 655 | 60.5 (12.6) |
subtype1 | 103 | 53.7 (14.6) |
subtype2 | 120 | 61.4 (11.7) |
subtype3 | 172 | 61.5 (12.6) |
subtype4 | 71 | 63.1 (9.7) |
subtype5 | 189 | 61.8 (11.8) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 344 | 74 | 138 | 79 |
subtype1 | 46 | 28 | 20 | 8 |
subtype2 | 47 | 8 | 45 | 21 |
subtype3 | 108 | 16 | 27 | 19 |
subtype4 | 7 | 8 | 28 | 26 |
subtype5 | 136 | 14 | 18 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 367 | 92 | 187 | 12 |
subtype1 | 47 | 28 | 27 | 2 |
subtype2 | 51 | 9 | 56 | 7 |
subtype3 | 110 | 20 | 41 | 1 |
subtype4 | 9 | 16 | 45 | 1 |
subtype5 | 150 | 19 | 18 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 221 | 34 | 6 |
subtype1 | 51 | 5 | 3 |
subtype2 | 46 | 13 | 0 |
subtype3 | 69 | 0 | 0 |
subtype4 | 24 | 12 | 2 |
subtype5 | 31 | 4 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 353 | 63 |
subtype1 | 57 | 5 |
subtype2 | 76 | 17 |
subtype3 | 135 | 18 |
subtype4 | 34 | 21 |
subtype5 | 51 | 2 |
P value = 4e-05 (Fisher's exact test), Q value = 0.00011
nPatients | FEMALE | MALE |
---|---|---|
ALL | 214 | 446 |
subtype1 | 46 | 58 |
subtype2 | 38 | 85 |
subtype3 | 71 | 101 |
subtype4 | 18 | 53 |
subtype5 | 41 | 149 |
P value = 0.306 (Fisher's exact test), Q value = 0.4
nPatients | NO | YES |
---|---|---|
ALL | 383 | 3 |
subtype1 | 86 | 0 |
subtype2 | 47 | 0 |
subtype3 | 71 | 1 |
subtype4 | 29 | 1 |
subtype5 | 150 | 1 |
P value = 0.0976 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 134 | 89.9 (17.7) |
subtype1 | 22 | 91.4 (15.8) |
subtype2 | 13 | 91.5 (9.0) |
subtype3 | 25 | 91.6 (9.9) |
subtype4 | 14 | 67.9 (40.2) |
subtype5 | 60 | 93.5 (8.4) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 319 | 275 |
subtype1 | 64 | 20 | 20 |
subtype2 | 2 | 82 | 39 |
subtype3 | 0 | 168 | 4 |
subtype4 | 0 | 46 | 25 |
subtype5 | 0 | 3 | 187 |
P value = 0.908 (Kruskal-Wallis (anova)), Q value = 0.96
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 102 | 31.3 (25.2) |
subtype1 | 15 | 26.2 (20.0) |
subtype2 | 17 | 37.8 (41.4) |
subtype3 | 8 | 28.0 (19.4) |
subtype4 | 9 | 29.9 (14.5) |
subtype5 | 53 | 31.3 (22.2) |
P value = 0.477 (Kruskal-Wallis (anova)), Q value = 0.56
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 72 | 1973.0 (16.0) |
subtype1 | 12 | 1975.9 (14.4) |
subtype2 | 12 | 1979.3 (19.1) |
subtype3 | 4 | 1978.0 (26.7) |
subtype4 | 5 | 1970.4 (5.0) |
subtype5 | 39 | 1970.0 (15.1) |
P value = 0.0917 (Fisher's exact test), Q value = 0.15
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 9 | 107 | 522 |
subtype1 | 0 | 4 | 20 | 77 |
subtype2 | 0 | 2 | 14 | 101 |
subtype3 | 0 | 0 | 24 | 148 |
subtype4 | 0 | 1 | 12 | 55 |
subtype5 | 2 | 2 | 37 | 141 |
P value = 0.681 (Fisher's exact test), Q value = 0.75
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 26 | 519 |
subtype1 | 5 | 64 |
subtype2 | 3 | 100 |
subtype3 | 6 | 133 |
subtype4 | 2 | 59 |
subtype5 | 10 | 163 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 185 | 185 | 189 | 197 |
P value = 1.39e-09 (logrank test), Q value = 3.3e-08
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 754 | 206 | 0.1 - 194.8 (36.9) |
subtype1 | 185 | 72 | 0.1 - 153.7 (35.2) |
subtype2 | 185 | 36 | 0.2 - 194.8 (37.4) |
subtype3 | 187 | 22 | 0.9 - 137.1 (37.0) |
subtype4 | 197 | 76 | 0.1 - 130.7 (36.5) |
P value = 0.0532 (Kruskal-Wallis (anova)), Q value = 0.095
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 751 | 60.0 (12.6) |
subtype1 | 185 | 58.3 (12.1) |
subtype2 | 183 | 59.4 (13.4) |
subtype3 | 188 | 61.6 (12.7) |
subtype4 | 195 | 60.8 (11.9) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 382 | 91 | 172 | 101 |
subtype1 | 75 | 22 | 50 | 37 |
subtype2 | 102 | 23 | 41 | 16 |
subtype3 | 128 | 20 | 33 | 6 |
subtype4 | 77 | 26 | 48 | 42 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 396 | 109 | 236 | 15 |
subtype1 | 78 | 25 | 76 | 6 |
subtype2 | 105 | 27 | 51 | 2 |
subtype3 | 131 | 20 | 38 | 0 |
subtype4 | 82 | 37 | 71 | 7 |
P value = 0.201 (Fisher's exact test), Q value = 0.3
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 300 | 39 | 5 |
subtype1 | 84 | 17 | 3 |
subtype2 | 66 | 5 | 1 |
subtype3 | 67 | 5 | 0 |
subtype4 | 83 | 12 | 1 |
P value = 2e-05 (Fisher's exact test), Q value = 5.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 487 | 86 |
subtype1 | 116 | 33 |
subtype2 | 121 | 12 |
subtype3 | 122 | 5 |
subtype4 | 128 | 36 |
P value = 0.405 (Fisher's exact test), Q value = 0.5
nPatients | FEMALE | MALE |
---|---|---|
ALL | 243 | 513 |
subtype1 | 64 | 121 |
subtype2 | 63 | 122 |
subtype3 | 62 | 127 |
subtype4 | 54 | 143 |
P value = 0.376 (Fisher's exact test), Q value = 0.47
nPatients | NO | YES |
---|---|---|
ALL | 331 | 3 |
subtype1 | 76 | 1 |
subtype2 | 89 | 2 |
subtype3 | 99 | 0 |
subtype4 | 67 | 0 |
P value = 0.414 (Kruskal-Wallis (anova)), Q value = 0.5
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 118 | 89.8 (19.8) |
subtype1 | 29 | 86.9 (26.2) |
subtype2 | 34 | 91.2 (15.7) |
subtype3 | 27 | 95.2 (6.4) |
subtype4 | 28 | 86.1 (24.2) |
P value = 9e-05 (Fisher's exact test), Q value = 0.00023
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 63 | 478 | 215 |
subtype1 | 17 | 122 | 46 |
subtype2 | 17 | 112 | 56 |
subtype3 | 21 | 96 | 72 |
subtype4 | 8 | 148 | 41 |
P value = 0.545 (Kruskal-Wallis (anova)), Q value = 0.63
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 84 | 29.8 (24.4) |
subtype1 | 18 | 28.7 (16.3) |
subtype2 | 21 | 25.9 (20.0) |
subtype3 | 24 | 31.6 (35.5) |
subtype4 | 21 | 32.6 (19.4) |
P value = 0.745 (Kruskal-Wallis (anova)), Q value = 0.81
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 60 | 1971.7 (15.2) |
subtype1 | 14 | 1969.1 (12.2) |
subtype2 | 15 | 1973.5 (17.2) |
subtype3 | 16 | 1970.1 (14.8) |
subtype4 | 15 | 1974.0 (17.1) |
P value = 0.0377 (Fisher's exact test), Q value = 0.07
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 16 | 93 | 625 |
subtype1 | 0 | 9 | 24 | 146 |
subtype2 | 0 | 2 | 23 | 153 |
subtype3 | 1 | 2 | 30 | 153 |
subtype4 | 0 | 3 | 16 | 173 |
P value = 0.595 (Fisher's exact test), Q value = 0.68
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 32 | 523 |
subtype1 | 7 | 125 |
subtype2 | 12 | 136 |
subtype3 | 6 | 125 |
subtype4 | 7 | 137 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 200 | 65 | 116 | 149 | 60 | 71 | 95 |
P value = 5.59e-12 (logrank test), Q value = 1.9e-10
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 754 | 206 | 0.1 - 194.8 (36.9) |
subtype1 | 200 | 47 | 0.1 - 194.8 (36.3) |
subtype2 | 64 | 3 | 1.1 - 137.1 (38.0) |
subtype3 | 116 | 56 | 0.1 - 122.6 (33.1) |
subtype4 | 148 | 29 | 0.1 - 129.9 (47.1) |
subtype5 | 60 | 23 | 1.9 - 118.8 (36.4) |
subtype6 | 71 | 8 | 0.6 - 152.0 (23.7) |
subtype7 | 95 | 40 | 0.2 - 133.7 (30.6) |
P value = 0.00264 (Kruskal-Wallis (anova)), Q value = 0.0058
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 751 | 60.0 (12.6) |
subtype1 | 198 | 60.0 (11.9) |
subtype2 | 65 | 62.4 (13.2) |
subtype3 | 116 | 59.7 (12.6) |
subtype4 | 147 | 61.0 (12.6) |
subtype5 | 59 | 64.4 (12.3) |
subtype6 | 71 | 58.1 (12.1) |
subtype7 | 95 | 56.1 (13.2) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 382 | 91 | 172 | 101 |
subtype1 | 101 | 28 | 41 | 27 |
subtype2 | 38 | 9 | 15 | 1 |
subtype3 | 32 | 17 | 35 | 29 |
subtype4 | 101 | 17 | 24 | 7 |
subtype5 | 20 | 7 | 22 | 11 |
subtype6 | 44 | 8 | 14 | 4 |
subtype7 | 46 | 5 | 21 | 22 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 396 | 109 | 236 | 15 |
subtype1 | 103 | 37 | 59 | 1 |
subtype2 | 40 | 9 | 16 | 0 |
subtype3 | 34 | 19 | 52 | 11 |
subtype4 | 102 | 18 | 28 | 1 |
subtype5 | 24 | 9 | 27 | 0 |
subtype6 | 45 | 9 | 17 | 0 |
subtype7 | 48 | 8 | 37 | 2 |
P value = 0.00042 (Fisher's exact test), Q value = 0.001
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 300 | 39 | 5 |
subtype1 | 87 | 4 | 0 |
subtype2 | 19 | 3 | 0 |
subtype3 | 60 | 12 | 0 |
subtype4 | 46 | 1 | 1 |
subtype5 | 28 | 4 | 1 |
subtype6 | 25 | 2 | 0 |
subtype7 | 35 | 13 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 487 | 86 |
subtype1 | 125 | 24 |
subtype2 | 28 | 0 |
subtype3 | 71 | 25 |
subtype4 | 121 | 5 |
subtype5 | 41 | 9 |
subtype6 | 41 | 4 |
subtype7 | 60 | 19 |
P value = 0.0233 (Fisher's exact test), Q value = 0.045
nPatients | FEMALE | MALE |
---|---|---|
ALL | 243 | 513 |
subtype1 | 59 | 141 |
subtype2 | 20 | 45 |
subtype3 | 27 | 89 |
subtype4 | 63 | 86 |
subtype5 | 15 | 45 |
subtype6 | 23 | 48 |
subtype7 | 36 | 59 |
P value = 0.735 (Fisher's exact test), Q value = 0.81
nPatients | NO | YES |
---|---|---|
ALL | 331 | 3 |
subtype1 | 104 | 2 |
subtype2 | 48 | 0 |
subtype3 | 45 | 0 |
subtype4 | 43 | 0 |
subtype5 | 18 | 0 |
subtype6 | 38 | 0 |
subtype7 | 35 | 1 |
P value = 0.0332 (Kruskal-Wallis (anova)), Q value = 0.062
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 118 | 89.8 (19.8) |
subtype1 | 33 | 88.5 (21.1) |
subtype2 | 14 | 96.4 (6.3) |
subtype3 | 16 | 96.2 (7.2) |
subtype4 | 20 | 93.5 (7.5) |
subtype5 | 7 | 74.3 (33.1) |
subtype6 | 13 | 93.1 (7.5) |
subtype7 | 15 | 79.3 (34.7) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 63 | 478 | 215 |
subtype1 | 19 | 122 | 59 |
subtype2 | 18 | 1 | 46 |
subtype3 | 19 | 73 | 24 |
subtype4 | 4 | 120 | 25 |
subtype5 | 1 | 49 | 10 |
subtype6 | 1 | 44 | 26 |
subtype7 | 1 | 69 | 25 |
P value = 0.968 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 84 | 29.8 (24.4) |
subtype1 | 24 | 26.5 (21.1) |
subtype2 | 14 | 38.2 (45.4) |
subtype3 | 11 | 29.2 (14.4) |
subtype4 | 9 | 29.7 (22.1) |
subtype5 | 9 | 30.9 (17.8) |
subtype6 | 8 | 25.6 (11.5) |
subtype7 | 9 | 29.1 (14.6) |
P value = 0.453 (Kruskal-Wallis (anova)), Q value = 0.54
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 60 | 1971.7 (15.2) |
subtype1 | 18 | 1967.4 (15.9) |
subtype2 | 11 | 1968.2 (14.0) |
subtype3 | 5 | 1969.4 (9.2) |
subtype4 | 4 | 1987.0 (15.2) |
subtype5 | 7 | 1972.4 (13.9) |
subtype6 | 6 | 1975.8 (17.4) |
subtype7 | 9 | 1975.6 (16.2) |
P value = 0.00907 (Fisher's exact test), Q value = 0.019
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 16 | 93 | 625 |
subtype1 | 0 | 1 | 18 | 175 |
subtype2 | 1 | 0 | 14 | 48 |
subtype3 | 0 | 5 | 12 | 96 |
subtype4 | 0 | 1 | 20 | 124 |
subtype5 | 0 | 3 | 5 | 51 |
subtype6 | 0 | 1 | 12 | 57 |
subtype7 | 0 | 5 | 12 | 74 |
P value = 0.249 (Fisher's exact test), Q value = 0.34
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 32 | 523 |
subtype1 | 10 | 151 |
subtype2 | 5 | 49 |
subtype3 | 2 | 75 |
subtype4 | 8 | 90 |
subtype5 | 3 | 39 |
subtype6 | 0 | 50 |
subtype7 | 4 | 69 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 125 | 200 | 288 | 276 |
P value = 7.77e-16 (logrank test), Q value = 4.4e-14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 883 | 228 | 0.1 - 194.8 (35.9) |
subtype1 | 123 | 22 | 0.2 - 153.7 (50.0) |
subtype2 | 200 | 96 | 0.1 - 133.7 (31.2) |
subtype3 | 287 | 68 | 0.1 - 149.2 (45.5) |
subtype4 | 273 | 42 | 0.1 - 194.8 (25.6) |
P value = 0.000578 (Kruskal-Wallis (anova)), Q value = 0.0014
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 883 | 60.2 (12.5) |
subtype1 | 124 | 55.4 (14.5) |
subtype2 | 200 | 60.3 (11.9) |
subtype3 | 287 | 60.7 (12.4) |
subtype4 | 272 | 61.8 (11.6) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 460 | 103 | 189 | 105 |
subtype1 | 59 | 33 | 19 | 12 |
subtype2 | 61 | 21 | 70 | 47 |
subtype3 | 169 | 29 | 57 | 31 |
subtype4 | 171 | 20 | 43 | 15 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 487 | 127 | 258 | 15 |
subtype1 | 60 | 34 | 29 | 2 |
subtype2 | 65 | 26 | 99 | 10 |
subtype3 | 170 | 35 | 81 | 2 |
subtype4 | 192 | 32 | 49 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 330 | 43 | 6 |
subtype1 | 61 | 6 | 3 |
subtype2 | 89 | 18 | 1 |
subtype3 | 126 | 1 | 0 |
subtype4 | 54 | 18 | 2 |
P value = 0.00315 (Fisher's exact test), Q value = 0.0068
nPatients | 0 | 1 |
---|---|---|
ALL | 551 | 90 |
subtype1 | 75 | 9 |
subtype2 | 146 | 42 |
subtype3 | 239 | 29 |
subtype4 | 91 | 10 |
P value = 8e-05 (Fisher's exact test), Q value = 0.00021
nPatients | FEMALE | MALE |
---|---|---|
ALL | 291 | 598 |
subtype1 | 48 | 77 |
subtype2 | 52 | 148 |
subtype3 | 120 | 168 |
subtype4 | 71 | 205 |
P value = 0.393 (Fisher's exact test), Q value = 0.49
nPatients | NO | YES |
---|---|---|
ALL | 415 | 3 |
subtype1 | 88 | 0 |
subtype2 | 39 | 0 |
subtype3 | 87 | 2 |
subtype4 | 201 | 1 |
P value = 0.335 (Kruskal-Wallis (anova)), Q value = 0.43
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 143 | 88.4 (21.5) |
subtype1 | 21 | 94.3 (11.2) |
subtype2 | 21 | 77.6 (35.3) |
subtype3 | 28 | 91.8 (9.4) |
subtype4 | 73 | 88.5 (21.3) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 533 | 290 |
subtype1 | 64 | 42 | 19 |
subtype2 | 2 | 187 | 11 |
subtype3 | 0 | 286 | 2 |
subtype4 | 0 | 18 | 258 |
P value = 0.806 (Kruskal-Wallis (anova)), Q value = 0.86
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 107 | 30.6 (24.8) |
subtype1 | 13 | 27.4 (21.2) |
subtype2 | 8 | 29.1 (17.1) |
subtype3 | 10 | 25.9 (19.4) |
subtype4 | 76 | 32.0 (26.8) |
P value = 0.529 (Kruskal-Wallis (anova)), Q value = 0.62
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 75 | 1973.6 (15.9) |
subtype1 | 10 | 1974.9 (15.4) |
subtype2 | 6 | 1980.0 (14.7) |
subtype3 | 6 | 1978.5 (21.9) |
subtype4 | 53 | 1972.0 (15.6) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 16 | 121 | 726 |
subtype1 | 0 | 4 | 20 | 98 |
subtype2 | 0 | 4 | 13 | 180 |
subtype3 | 0 | 2 | 27 | 254 |
subtype4 | 2 | 6 | 61 | 194 |
P value = 0.381 (Fisher's exact test), Q value = 0.47
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 42 | 629 |
subtype1 | 5 | 82 |
subtype2 | 7 | 128 |
subtype3 | 18 | 186 |
subtype4 | 12 | 233 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
---|---|---|---|---|---|---|---|---|---|
Number of samples | 90 | 62 | 151 | 84 | 122 | 38 | 111 | 59 | 172 |
P value = 2.22e-16 (logrank test), Q value = 1.9e-14
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 883 | 228 | 0.1 - 194.8 (35.9) |
subtype1 | 89 | 12 | 2.5 - 153.7 (54.7) |
subtype2 | 61 | 24 | 0.2 - 105.4 (19.3) |
subtype3 | 151 | 34 | 0.1 - 131.2 (44.9) |
subtype4 | 84 | 18 | 0.2 - 194.8 (20.4) |
subtype5 | 122 | 66 | 0.4 - 133.7 (34.9) |
subtype6 | 37 | 13 | 0.1 - 130.7 (39.0) |
subtype7 | 110 | 30 | 0.1 - 149.2 (49.2) |
subtype8 | 59 | 14 | 1.4 - 107.5 (31.7) |
subtype9 | 170 | 17 | 0.1 - 129.9 (26.4) |
P value = 3.46e-06 (Kruskal-Wallis (anova)), Q value = 3.1e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 883 | 60.2 (12.5) |
subtype1 | 90 | 54.0 (14.2) |
subtype2 | 61 | 59.7 (13.3) |
subtype3 | 150 | 59.8 (12.3) |
subtype4 | 83 | 63.2 (12.5) |
subtype5 | 122 | 62.7 (11.0) |
subtype6 | 37 | 57.8 (11.7) |
subtype7 | 111 | 62.9 (12.0) |
subtype8 | 59 | 56.4 (13.7) |
subtype9 | 170 | 60.8 (11.3) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 460 | 103 | 189 | 105 |
subtype1 | 38 | 30 | 15 | 5 |
subtype2 | 29 | 3 | 14 | 15 |
subtype3 | 84 | 15 | 29 | 23 |
subtype4 | 36 | 5 | 30 | 7 |
subtype5 | 31 | 14 | 45 | 31 |
subtype6 | 8 | 6 | 14 | 10 |
subtype7 | 72 | 9 | 22 | 8 |
subtype8 | 38 | 6 | 10 | 3 |
subtype9 | 124 | 15 | 10 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 487 | 127 | 258 | 15 |
subtype1 | 39 | 30 | 20 | 1 |
subtype2 | 29 | 5 | 22 | 6 |
subtype3 | 85 | 21 | 43 | 2 |
subtype4 | 42 | 9 | 32 | 1 |
subtype5 | 33 | 16 | 69 | 4 |
subtype6 | 10 | 8 | 19 | 1 |
subtype7 | 72 | 10 | 29 | 0 |
subtype8 | 40 | 6 | 13 | 0 |
subtype9 | 137 | 22 | 11 | 0 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 330 | 43 | 6 |
subtype1 | 51 | 2 | 2 |
subtype2 | 11 | 16 | 2 |
subtype3 | 54 | 1 | 0 |
subtype4 | 25 | 12 | 1 |
subtype5 | 60 | 7 | 0 |
subtype6 | 17 | 4 | 0 |
subtype7 | 60 | 0 | 0 |
subtype8 | 23 | 1 | 0 |
subtype9 | 29 | 0 | 1 |
P value = 2e-05 (Fisher's exact test), Q value = 5.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 551 | 90 |
subtype1 | 55 | 3 |
subtype2 | 30 | 9 |
subtype3 | 125 | 21 |
subtype4 | 35 | 5 |
subtype5 | 86 | 31 |
subtype6 | 23 | 9 |
subtype7 | 93 | 8 |
subtype8 | 52 | 3 |
subtype9 | 52 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | FEMALE | MALE |
---|---|---|
ALL | 291 | 598 |
subtype1 | 34 | 56 |
subtype2 | 26 | 36 |
subtype3 | 9 | 142 |
subtype4 | 33 | 51 |
subtype5 | 31 | 91 |
subtype6 | 17 | 21 |
subtype7 | 108 | 3 |
subtype8 | 3 | 56 |
subtype9 | 30 | 142 |
P value = 0.429 (Fisher's exact test), Q value = 0.52
nPatients | NO | YES |
---|---|---|
ALL | 415 | 3 |
subtype1 | 77 | 0 |
subtype2 | 29 | 0 |
subtype3 | 45 | 2 |
subtype4 | 54 | 0 |
subtype5 | 19 | 0 |
subtype6 | 12 | 0 |
subtype7 | 36 | 0 |
subtype8 | 11 | 0 |
subtype9 | 132 | 1 |
P value = 0.00151 (Kruskal-Wallis (anova)), Q value = 0.0034
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 143 | 88.4 (21.5) |
subtype1 | 15 | 97.3 (4.6) |
subtype2 | 11 | 74.5 (31.4) |
subtype3 | 15 | 94.0 (8.3) |
subtype4 | 17 | 77.6 (33.5) |
subtype5 | 13 | 70.0 (40.6) |
subtype6 | 2 | 90.0 (14.1) |
subtype7 | 13 | 89.2 (10.4) |
subtype8 | 5 | 100.0 (0.0) |
subtype9 | 52 | 93.8 (8.0) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 533 | 290 |
subtype1 | 64 | 19 | 7 |
subtype2 | 2 | 23 | 37 |
subtype3 | 0 | 151 | 0 |
subtype4 | 0 | 11 | 73 |
subtype5 | 0 | 122 | 0 |
subtype6 | 0 | 34 | 4 |
subtype7 | 0 | 111 | 0 |
subtype8 | 0 | 58 | 1 |
subtype9 | 0 | 4 | 168 |
P value = 0.533 (Kruskal-Wallis (anova)), Q value = 0.62
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 107 | 30.6 (24.8) |
subtype1 | 12 | 27.2 (22.1) |
subtype2 | 5 | 31.4 (12.6) |
subtype3 | 4 | 40.2 (22.8) |
subtype4 | 23 | 38.2 (40.2) |
subtype5 | 5 | 32.0 (13.0) |
subtype6 | 6 | 23.7 (19.6) |
subtype7 | 3 | 13.0 (6.1) |
subtype8 | 2 | 23.5 (13.4) |
subtype9 | 47 | 29.1 (18.6) |
P value = 0.367 (Kruskal-Wallis (anova)), Q value = 0.46
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 75 | 1973.6 (15.9) |
subtype1 | 9 | 1976.0 (15.9) |
subtype2 | 5 | 1974.4 (12.6) |
subtype3 | 3 | 1971.0 (27.8) |
subtype4 | 18 | 1974.1 (15.8) |
subtype5 | 3 | 1975.7 (17.6) |
subtype6 | 4 | 1989.8 (13.9) |
subtype8 | 2 | 1983.5 (21.9) |
subtype9 | 31 | 1969.7 (15.1) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 16 | 121 | 726 |
subtype1 | 0 | 2 | 10 | 76 |
subtype2 | 0 | 3 | 14 | 42 |
subtype3 | 0 | 1 | 11 | 135 |
subtype4 | 0 | 3 | 24 | 55 |
subtype5 | 0 | 2 | 7 | 113 |
subtype6 | 0 | 0 | 5 | 32 |
subtype7 | 0 | 1 | 12 | 97 |
subtype8 | 0 | 2 | 4 | 52 |
subtype9 | 2 | 2 | 34 | 124 |
P value = 0.225 (Fisher's exact test), Q value = 0.32
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 42 | 629 |
subtype1 | 4 | 53 |
subtype2 | 3 | 48 |
subtype3 | 7 | 102 |
subtype4 | 5 | 66 |
subtype5 | 4 | 81 |
subtype6 | 1 | 30 |
subtype7 | 11 | 67 |
subtype8 | 2 | 32 |
subtype9 | 5 | 150 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 346 | 197 | 330 |
P value = 6.25e-07 (logrank test), Q value = 1.2e-05
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 867 | 225 | 0.1 - 194.8 (35.3) |
subtype1 | 342 | 50 | 0.1 - 194.8 (29.4) |
subtype2 | 196 | 68 | 0.1 - 131.1 (33.5) |
subtype3 | 329 | 107 | 0.2 - 149.2 (41.8) |
P value = 0.135 (Kruskal-Wallis (anova)), Q value = 0.21
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 868 | 60.2 (12.5) |
subtype1 | 342 | 59.6 (13.0) |
subtype2 | 197 | 59.1 (12.0) |
subtype3 | 329 | 61.4 (12.1) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 447 | 101 | 189 | 104 |
subtype1 | 191 | 50 | 59 | 18 |
subtype2 | 93 | 15 | 52 | 34 |
subtype3 | 163 | 36 | 78 | 52 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 474 | 125 | 257 | 15 |
subtype1 | 212 | 62 | 66 | 4 |
subtype2 | 96 | 16 | 76 | 9 |
subtype3 | 166 | 47 | 115 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 318 | 44 | 6 |
subtype1 | 94 | 24 | 2 |
subtype2 | 79 | 14 | 4 |
subtype3 | 145 | 6 | 0 |
P value = 0.0794 (Fisher's exact test), Q value = 0.13
nPatients | 0 | 1 |
---|---|---|
ALL | 535 | 89 |
subtype1 | 135 | 13 |
subtype2 | 134 | 26 |
subtype3 | 266 | 50 |
P value = 0.0736 (Fisher's exact test), Q value = 0.13
nPatients | FEMALE | MALE |
---|---|---|
ALL | 285 | 588 |
subtype1 | 98 | 248 |
subtype2 | 73 | 124 |
subtype3 | 114 | 216 |
P value = 0.167 (Fisher's exact test), Q value = 0.25
nPatients | NO | YES |
---|---|---|
ALL | 410 | 3 |
subtype1 | 266 | 1 |
subtype2 | 61 | 0 |
subtype3 | 83 | 2 |
P value = 0.249 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 144 | 87.8 (22.7) |
subtype1 | 82 | 90.9 (17.7) |
subtype2 | 27 | 79.3 (32.6) |
subtype3 | 35 | 87.1 (23.0) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 516 | 291 |
subtype1 | 59 | 29 | 258 |
subtype2 | 6 | 160 | 31 |
subtype3 | 1 | 327 | 2 |
P value = 0.898 (Kruskal-Wallis (anova)), Q value = 0.95
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 108 | 30.4 (24.8) |
subtype1 | 82 | 31.3 (26.9) |
subtype2 | 17 | 27.4 (14.9) |
subtype3 | 9 | 27.6 (20.8) |
P value = 0.214 (Kruskal-Wallis (anova)), Q value = 0.31
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 76 | 1973.4 (15.9) |
subtype1 | 57 | 1971.6 (15.1) |
subtype2 | 14 | 1977.9 (14.5) |
subtype3 | 5 | 1982.2 (25.0) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 16 | 121 | 710 |
subtype1 | 2 | 9 | 66 | 254 |
subtype2 | 0 | 3 | 35 | 156 |
subtype3 | 0 | 4 | 20 | 300 |
P value = 0.288 (Fisher's exact test), Q value = 0.38
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 40 | 620 |
subtype1 | 14 | 271 |
subtype2 | 7 | 132 |
subtype3 | 19 | 217 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 77 | 350 | 234 | 212 |
P value = 1.07e-14 (logrank test), Q value = 4.5e-13
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 867 | 225 | 0.1 - 194.8 (35.3) |
subtype1 | 76 | 11 | 2.5 - 153.7 (67.0) |
subtype2 | 349 | 137 | 0.1 - 133.7 (30.6) |
subtype3 | 233 | 59 | 0.1 - 149.2 (45.5) |
subtype4 | 209 | 18 | 0.1 - 194.8 (25.9) |
P value = 1.31e-05 (Kruskal-Wallis (anova)), Q value = 3.9e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 868 | 60.2 (12.5) |
subtype1 | 77 | 53.0 (14.0) |
subtype2 | 347 | 60.3 (12.5) |
subtype3 | 234 | 60.9 (12.1) |
subtype4 | 210 | 61.8 (11.6) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 447 | 101 | 189 | 104 |
subtype1 | 28 | 29 | 15 | 4 |
subtype2 | 139 | 32 | 103 | 70 |
subtype3 | 138 | 23 | 48 | 25 |
subtype4 | 142 | 17 | 23 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 474 | 125 | 257 | 15 |
subtype1 | 29 | 29 | 19 | 0 |
subtype2 | 145 | 41 | 151 | 13 |
subtype3 | 140 | 29 | 64 | 1 |
subtype4 | 160 | 26 | 23 | 1 |
P value = 0.00011 (Fisher's exact test), Q value = 0.00028
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 318 | 44 | 6 |
subtype1 | 48 | 2 | 2 |
subtype2 | 134 | 32 | 4 |
subtype3 | 100 | 3 | 0 |
subtype4 | 36 | 7 | 0 |
P value = 2e-05 (Fisher's exact test), Q value = 5.6e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 535 | 89 |
subtype1 | 50 | 2 |
subtype2 | 227 | 61 |
subtype3 | 196 | 24 |
subtype4 | 62 | 2 |
P value = 3e-05 (Fisher's exact test), Q value = 8.3e-05
nPatients | FEMALE | MALE |
---|---|---|
ALL | 285 | 588 |
subtype1 | 28 | 49 |
subtype2 | 112 | 238 |
subtype3 | 99 | 135 |
subtype4 | 46 | 166 |
P value = 0.655 (Fisher's exact test), Q value = 0.73
nPatients | NO | YES |
---|---|---|
ALL | 410 | 3 |
subtype1 | 67 | 0 |
subtype2 | 108 | 2 |
subtype3 | 70 | 0 |
subtype4 | 165 | 1 |
P value = 0.0691 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 144 | 87.8 (22.7) |
subtype1 | 10 | 98.0 (4.2) |
subtype2 | 53 | 81.1 (30.7) |
subtype3 | 22 | 87.7 (21.4) |
subtype4 | 59 | 92.0 (13.5) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 66 | 516 | 291 |
subtype1 | 60 | 15 | 2 |
subtype2 | 6 | 262 | 82 |
subtype3 | 0 | 234 | 0 |
subtype4 | 0 | 5 | 207 |
P value = 0.787 (Kruskal-Wallis (anova)), Q value = 0.85
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 108 | 30.4 (24.8) |
subtype1 | 10 | 25.6 (23.0) |
subtype2 | 32 | 34.0 (32.5) |
subtype3 | 6 | 31.7 (22.4) |
subtype4 | 60 | 29.1 (20.6) |
P value = 0.099 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 76 | 1973.4 (15.9) |
subtype1 | 7 | 1975.0 (16.2) |
subtype2 | 22 | 1980.3 (16.3) |
subtype3 | 3 | 1971.0 (27.8) |
subtype4 | 44 | 1970.0 (14.1) |
P value = 0.00062 (Fisher's exact test), Q value = 0.0014
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 16 | 121 | 710 |
subtype1 | 0 | 2 | 6 | 67 |
subtype2 | 0 | 9 | 47 | 288 |
subtype3 | 0 | 2 | 22 | 206 |
subtype4 | 2 | 3 | 46 | 149 |
P value = 0.327 (Fisher's exact test), Q value = 0.42
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 40 | 620 |
subtype1 | 4 | 41 |
subtype2 | 17 | 245 |
subtype3 | 12 | 152 |
subtype4 | 7 | 182 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 158 | 69 | 65 | 124 |
P value = 3.15e-09 (logrank test), Q value = 6.6e-08
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 411 | 89 | 0.1 - 194.8 (30.2) |
subtype1 | 156 | 14 | 0.1 - 194.8 (26.0) |
subtype2 | 68 | 10 | 1.2 - 153.7 (41.8) |
subtype3 | 64 | 27 | 0.2 - 129.9 (19.3) |
subtype4 | 123 | 38 | 0.1 - 149.2 (36.1) |
P value = 0.00195 (Kruskal-Wallis (anova)), Q value = 0.0044
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 412 | 59.8 (12.6) |
subtype1 | 156 | 61.5 (11.6) |
subtype2 | 67 | 54.0 (14.2) |
subtype3 | 65 | 61.2 (13.0) |
subtype4 | 124 | 60.1 (11.9) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 221 | 47 | 81 | 46 |
subtype1 | 107 | 10 | 20 | 4 |
subtype2 | 27 | 17 | 18 | 6 |
subtype3 | 25 | 4 | 19 | 15 |
subtype4 | 62 | 16 | 24 | 21 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 238 | 56 | 111 | 9 |
subtype1 | 119 | 16 | 20 | 1 |
subtype2 | 27 | 17 | 24 | 1 |
subtype3 | 27 | 5 | 27 | 6 |
subtype4 | 65 | 18 | 40 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 126 | 31 | 6 |
subtype1 | 27 | 7 | 0 |
subtype2 | 33 | 5 | 2 |
subtype3 | 15 | 15 | 4 |
subtype4 | 51 | 4 | 0 |
P value = 0.00899 (Fisher's exact test), Q value = 0.019
nPatients | 0 | 1 |
---|---|---|
ALL | 198 | 33 |
subtype1 | 48 | 1 |
subtype2 | 34 | 4 |
subtype3 | 28 | 8 |
subtype4 | 88 | 20 |
P value = 0.00232 (Fisher's exact test), Q value = 0.0051
nPatients | FEMALE | MALE |
---|---|---|
ALL | 133 | 283 |
subtype1 | 35 | 123 |
subtype2 | 31 | 38 |
subtype3 | 26 | 39 |
subtype4 | 41 | 83 |
P value = 0.294 (Fisher's exact test), Q value = 0.39
nPatients | NO | YES |
---|---|---|
ALL | 254 | 1 |
subtype1 | 119 | 0 |
subtype2 | 61 | 0 |
subtype3 | 31 | 0 |
subtype4 | 43 | 1 |
P value = 0.0398 (Kruskal-Wallis (anova)), Q value = 0.072
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 94 | 89.9 (18.6) |
subtype1 | 47 | 94.5 (7.2) |
subtype2 | 13 | 90.8 (21.8) |
subtype3 | 16 | 73.8 (33.6) |
subtype4 | 18 | 91.7 (11.0) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 48 | 144 | 224 |
subtype1 | 0 | 1 | 157 |
subtype2 | 46 | 5 | 18 |
subtype3 | 2 | 16 | 47 |
subtype4 | 0 | 122 | 2 |
P value = 0.604 (Kruskal-Wallis (anova)), Q value = 0.68
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 79 | 31.6 (27.2) |
subtype1 | 45 | 30.6 (21.3) |
subtype2 | 15 | 35.4 (46.0) |
subtype3 | 13 | 33.9 (20.8) |
subtype4 | 6 | 24.7 (21.2) |
P value = 0.273 (Kruskal-Wallis (anova)), Q value = 0.37
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 59 | 1972.3 (17.0) |
subtype1 | 33 | 1968.5 (15.8) |
subtype2 | 13 | 1977.5 (18.0) |
subtype3 | 9 | 1975.4 (14.6) |
subtype4 | 4 | 1979.0 (26.2) |
P value = 0.766 (Fisher's exact test), Q value = 0.83
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 71 | 318 |
subtype1 | 2 | 2 | 25 | 122 |
subtype2 | 0 | 2 | 11 | 52 |
subtype3 | 0 | 3 | 14 | 47 |
subtype4 | 0 | 3 | 21 | 97 |
P value = 0.65 (Fisher's exact test), Q value = 0.73
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 20 | 308 |
subtype1 | 7 | 134 |
subtype2 | 4 | 36 |
subtype3 | 3 | 49 |
subtype4 | 6 | 89 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 92 | 84 | 50 | 20 | 46 | 78 | 46 |
P value = 8.3e-10 (logrank test), Q value = 2.3e-08
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 411 | 89 | 0.1 - 194.8 (30.2) |
subtype1 | 91 | 7 | 0.5 - 123.6 (26.4) |
subtype2 | 84 | 33 | 0.2 - 96.7 (19.7) |
subtype3 | 49 | 3 | 0.1 - 194.8 (25.6) |
subtype4 | 20 | 2 | 11.7 - 100.9 (30.2) |
subtype5 | 45 | 17 | 0.5 - 131.1 (35.2) |
subtype6 | 77 | 20 | 0.1 - 149.2 (36.1) |
subtype7 | 45 | 7 | 2.5 - 153.7 (66.5) |
P value = 0.0129 (Kruskal-Wallis (anova)), Q value = 0.026
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 412 | 59.8 (12.6) |
subtype1 | 91 | 61.5 (10.5) |
subtype2 | 82 | 61.0 (13.3) |
subtype3 | 50 | 60.3 (13.3) |
subtype4 | 19 | 55.1 (12.6) |
subtype5 | 46 | 59.3 (11.3) |
subtype6 | 78 | 61.4 (12.1) |
subtype7 | 46 | 53.1 (14.6) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV |
---|---|---|---|---|
ALL | 221 | 47 | 81 | 46 |
subtype1 | 59 | 9 | 11 | 2 |
subtype2 | 30 | 8 | 28 | 15 |
subtype3 | 43 | 0 | 2 | 1 |
subtype4 | 14 | 0 | 4 | 1 |
subtype5 | 24 | 2 | 5 | 13 |
subtype6 | 38 | 11 | 19 | 10 |
subtype7 | 13 | 17 | 12 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 238 | 56 | 111 | 9 |
subtype1 | 68 | 12 | 12 | 0 |
subtype2 | 34 | 11 | 37 | 2 |
subtype3 | 44 | 1 | 2 | 1 |
subtype4 | 14 | 0 | 6 | 0 |
subtype5 | 25 | 2 | 13 | 6 |
subtype6 | 40 | 13 | 25 | 0 |
subtype7 | 13 | 17 | 16 | 0 |
P value = 6e-05 (Fisher's exact test), Q value = 0.00016
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 126 | 31 | 6 |
subtype1 | 17 | 4 | 0 |
subtype2 | 21 | 20 | 4 |
subtype3 | 7 | 1 | 0 |
subtype4 | 4 | 1 | 0 |
subtype5 | 20 | 1 | 0 |
subtype6 | 28 | 2 | 0 |
subtype7 | 29 | 2 | 2 |
P value = 0.0136 (Fisher's exact test), Q value = 0.027
nPatients | 0 | 1 |
---|---|---|
ALL | 198 | 33 |
subtype1 | 26 | 0 |
subtype2 | 38 | 12 |
subtype3 | 14 | 0 |
subtype4 | 6 | 1 |
subtype5 | 29 | 9 |
subtype6 | 57 | 9 |
subtype7 | 28 | 2 |
P value = 0.00024 (Fisher's exact test), Q value = 0.00058
nPatients | FEMALE | MALE |
---|---|---|
ALL | 133 | 283 |
subtype1 | 18 | 74 |
subtype2 | 32 | 52 |
subtype3 | 10 | 40 |
subtype4 | 12 | 8 |
subtype5 | 10 | 36 |
subtype6 | 31 | 47 |
subtype7 | 20 | 26 |
P value = 0.231 (Fisher's exact test), Q value = 0.33
nPatients | NO | YES |
---|---|---|
ALL | 254 | 1 |
subtype1 | 70 | 0 |
subtype2 | 44 | 0 |
subtype3 | 38 | 0 |
subtype4 | 14 | 0 |
subtype5 | 15 | 0 |
subtype6 | 29 | 1 |
subtype7 | 44 | 0 |
P value = 0.108 (Kruskal-Wallis (anova)), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 94 | 89.9 (18.6) |
subtype1 | 32 | 93.8 (7.9) |
subtype2 | 18 | 76.7 (32.5) |
subtype3 | 14 | 95.0 (6.5) |
subtype4 | 8 | 86.2 (27.2) |
subtype5 | 3 | 100.0 (0.0) |
subtype6 | 14 | 90.0 (11.8) |
subtype7 | 5 | 98.0 (4.5) |
P value = 1e-05 (Fisher's exact test), Q value = 3.1e-05
nPatients | KIDNEY CHROMOPHOBE | KIDNEY CLEAR CELL RENAL CARCINOMA | KIDNEY PAPILLARY RENAL CELL CARCINOMA |
---|---|---|---|
ALL | 48 | 144 | 224 |
subtype1 | 0 | 1 | 91 |
subtype2 | 0 | 18 | 66 |
subtype3 | 0 | 0 | 50 |
subtype4 | 4 | 2 | 14 |
subtype5 | 2 | 43 | 1 |
subtype6 | 0 | 77 | 1 |
subtype7 | 42 | 3 | 1 |
P value = 0.438 (Kruskal-Wallis (anova)), Q value = 0.52
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 79 | 31.6 (27.2) |
subtype1 | 21 | 35.4 (24.6) |
subtype2 | 16 | 30.3 (15.3) |
subtype3 | 21 | 29.1 (20.8) |
subtype4 | 6 | 51.5 (66.7) |
subtype5 | 3 | 14.7 (5.0) |
subtype6 | 3 | 28.0 (32.0) |
subtype7 | 9 | 24.6 (24.2) |
P value = 0.422 (Kruskal-Wallis (anova)), Q value = 0.51
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 59 | 1972.3 (17.0) |
subtype1 | 16 | 1968.5 (13.5) |
subtype2 | 12 | 1975.0 (16.7) |
subtype3 | 14 | 1967.5 (17.0) |
subtype4 | 7 | 1980.0 (19.3) |
subtype5 | 2 | 1984.5 (20.5) |
subtype6 | 2 | 1973.5 (38.9) |
subtype7 | 6 | 1974.7 (17.7) |
P value = 0.122 (Fisher's exact test), Q value = 0.19
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 2 | 10 | 71 | 318 |
subtype1 | 2 | 1 | 17 | 69 |
subtype2 | 0 | 4 | 17 | 58 |
subtype3 | 0 | 1 | 6 | 40 |
subtype4 | 0 | 0 | 8 | 12 |
subtype5 | 0 | 1 | 8 | 37 |
subtype6 | 0 | 2 | 13 | 61 |
subtype7 | 0 | 1 | 2 | 41 |
P value = 0.0937 (Fisher's exact test), Q value = 0.15
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 20 | 308 |
subtype1 | 1 | 81 |
subtype2 | 4 | 64 |
subtype3 | 4 | 42 |
subtype4 | 1 | 16 |
subtype5 | 2 | 29 |
subtype6 | 4 | 58 |
subtype7 | 4 | 18 |
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Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/KIPAN-TP/22570984/KIPAN-TP.mergedcluster.txt
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Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/KIPAN-TP/22506733/KIPAN-TP.merged_data.txt
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Number of patients = 894
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Number of clustering approaches = 12
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Number of selected clinical features = 14
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Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.