E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.031 0.131 -9999.0 0.0 -0.58 48.0 48.0 KLHL20 -0.016 0.049 -9999.0 0.0 -0.34 2.0 2.0 CYFIP2 0.004 0.096 -9999.0 0.0 -0.858 11.0 11.0 Rac1/GDP 0.056 0.097 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.031 0.131 -9999.0 0.0 -0.58 48.0 48.0 AP1M1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.016 0.065 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.012 0.038 -9999.0 0.0 -0.235 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.028 0.117 -9999.0 0.0 -0.519 48.0 48.0 RAPGEF1 0.041 0.125 -9999.0 0.0 -0.481 48.0 48.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.137 -9999.0 0.0 -0.606 48.0 48.0 CRK 0.029 0.136 -9999.0 0.0 -0.534 48.0 48.0 E-cadherin/gamma catenin/alpha catenin -0.033 0.135 -9999.0 0.0 -0.582 50.0 50.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.031 0.131 -9999.0 0.0 -0.58 48.0 48.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.046 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.003 0.034 -9999.0 0.0 -0.45 5.0 5.0 PI3K -0.014 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.038 0.156 -9999.0 0.0 -0.672 50.0 50.0 TIAM1 0.014 0.029 -9999.0 0.0 -0.858 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.027 0.111 -9999.0 0.0 -0.493 48.0 48.0 AKT1 -0.008 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.197 -9999.0 0.0 -0.858 48.0 48.0 RhoA/GDP 0.056 0.097 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.012 0.036 -9999.0 0.0 -0.239 2.0 2.0 CDC42/GDP 0.056 0.097 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.02 0.083 -9999.0 0.0 -0.356 50.0 50.0 ITGB7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.028 0.117 -9999.0 0.0 -0.519 48.0 48.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.027 0.114 -9999.0 0.0 -0.503 48.0 48.0 mol:GDP 0.051 0.112 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.012 0.051 -9999.0 0.0 -0.858 3.0 3.0 p120 catenin/RhoA/GDP -0.019 0.08 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.031 0.063 -9999.0 0.0 -0.241 36.0 36.0 NME1 0.012 0.05 -9999.0 0.0 -0.737 4.0 4.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.031 0.131 -9999.0 0.0 -0.58 48.0 48.0 regulation of cell-cell adhesion -0.014 0.057 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.006 0.019 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.018 0.075 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.028 0.115 -9999.0 0.0 -0.975 1.0 1.0 CCND1 -0.017 0.062 -9999.0 0.0 -0.305 36.0 36.0 VAV2 0.036 0.131 -9999.0 0.0 -0.508 48.0 48.0 RAP1/GDP -0.018 0.076 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.019 0.138 -9999.0 0.0 -0.559 48.0 48.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.026 0.108 -9999.0 0.0 -0.933 1.0 1.0 E-cadherin/beta catenin -0.028 0.116 -9999.0 0.0 -0.514 48.0 48.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.132 -9999.0 0.0 -0.58 48.0 48.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.025 0.079 -9999.0 0.0 -0.631 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.031 0.129 -9999.0 0.0 -0.571 48.0 48.0 ITGAE 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.034 0.141 -9999.0 0.0 -0.623 48.0 48.0