Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.254 -9999.0 0.0 -0.794 38.0 38.0 IHH -0.088 0.263 -9999.0 0.0 -0.885 85.0 85.0 SHH Np/Cholesterol/GAS1 -0.056 0.166 -9999.0 0.0 -0.537 92.0 92.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.055 0.165 0.533 92.0 -9999.0 0.0 92.0 SMO/beta Arrestin2 -0.109 0.166 -9999.0 0.0 -0.663 41.0 41.0 SMO -0.079 0.206 -9999.0 0.0 -0.707 41.0 41.0 AKT1 -0.012 0.095 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.044 -9999.0 0.0 -0.737 3.0 3.0 BOC 0.013 0.041 -9999.0 0.0 -0.858 2.0 2.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.077 0.203 -9999.0 0.0 -0.693 41.0 41.0 STIL -0.065 0.193 -9999.0 0.0 -0.624 47.0 47.0 DHH N/PTCH2 -0.043 0.16 -9999.0 0.0 -0.631 61.0 61.0 DHH N/PTCH1 -0.133 0.191 -9999.0 0.0 -0.624 78.0 78.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.029 0.189 -9999.0 0.0 -0.858 44.0 44.0 PTHLH -0.233 0.366 -9999.0 0.0 -1.095 39.0 39.0 determination of left/right symmetry -0.077 0.203 -9999.0 0.0 -0.693 41.0 41.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.231 0.362 -9999.0 0.0 -1.076 39.0 39.0 IHH N/Hhip -0.157 0.298 -9999.0 0.0 -0.695 201.0 201.0 DHH N/Hhip -0.126 0.267 -9999.0 0.0 -0.674 166.0 166.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.077 0.203 -9999.0 0.0 -0.693 41.0 41.0 pancreas development -0.11 0.301 -9999.0 0.0 -0.841 129.0 129.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.035 0.202 -9999.0 0.0 -0.853 51.0 51.0 somite specification -0.077 0.203 -9999.0 0.0 -0.693 41.0 41.0 SHH Np/Cholesterol/PTCH1 -0.113 0.172 -9999.0 0.0 -0.653 45.0 45.0 SHH Np/Cholesterol/PTCH2 -0.034 0.125 -9999.0 0.0 -0.492 61.0 61.0 SHH Np/Cholesterol/Megalin -0.099 0.247 -9999.0 0.0 -0.643 137.0 137.0 SHH -0.005 0.147 -9999.0 0.0 -0.648 44.0 44.0 catabolic process -0.091 0.203 -9999.0 0.0 -0.582 81.0 81.0 SMO/Vitamin D3 -0.117 0.178 -9999.0 0.0 -0.676 47.0 47.0 SHH Np/Cholesterol/Hhip -0.1 0.226 -9999.0 0.0 -0.567 157.0 157.0 LRP2 -0.108 0.303 -9999.0 0.0 -0.856 125.0 125.0 receptor-mediated endocytosis -0.152 0.231 -9999.0 0.0 -0.759 82.0 82.0 SHH Np/Cholesterol/BOC -0.027 0.114 -9999.0 0.0 -0.516 46.0 46.0 SHH Np/Cholesterol/CDO -0.068 0.165 -9999.0 0.0 -0.463 130.0 130.0 mesenchymal cell differentiation 0.099 0.224 0.562 157.0 -9999.0 0.0 157.0 mol:Vitamin D3 -0.075 0.2 -9999.0 0.0 -0.659 45.0 45.0 IHH N/PTCH2 -0.068 0.192 -9999.0 0.0 -0.599 101.0 101.0 CDON -0.059 0.223 -9999.0 0.0 -0.737 87.0 87.0 IHH N/PTCH1 -0.094 0.205 -9999.0 0.0 -0.591 81.0 81.0 Megalin/LRPAP1 -0.093 0.229 -9999.0 0.0 -0.659 125.0 125.0 PTCH2 0.0 0.103 -9999.0 0.0 -0.737 17.0 17.0 SHH Np/Cholesterol -0.026 0.114 -9999.0 0.0 -0.526 44.0 44.0 PTCH1 -0.092 0.204 -9999.0 0.0 -0.584 81.0 81.0 HHIP -0.111 0.302 -9999.0 0.0 -0.843 129.0 129.0