Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.018 0.076 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.026 0.11 -9999.0 0.0 -0.487 48.0 48.0 CYFIP2 0.004 0.096 -9999.0 0.0 -0.858 11.0 11.0 ENAH 0.069 0.083 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.002 0.099 -9999.0 0.0 -0.753 15.0 15.0 EPHA2 0.013 0.039 -9999.0 0.0 -0.797 2.0 2.0 MYO6 0.021 0.122 -9999.0 0.0 -0.94 2.0 2.0 CTNNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.063 -9999.0 0.0 -0.571 11.0 11.0 AQP5 -0.169 0.269 -9999.0 0.0 -0.608 223.0 223.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.022 0.113 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.164 -9999.0 0.0 -0.896 7.0 7.0 EGF -0.711 0.327 -9999.0 0.0 -0.858 739.0 739.0 NCKAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.144 0.27 -9999.0 0.0 -0.64 187.0 187.0 cortical microtubule organization -0.026 0.11 -9999.0 0.0 -0.487 48.0 48.0 GO:0000145 0.023 0.108 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.027 0.111 -9999.0 0.0 -0.493 48.0 48.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.021 0.085 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.002 0.026 -9999.0 0.0 -0.519 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.039 0.111 -9999.0 0.0 -0.617 1.0 1.0 PVRL2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.022 0.115 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.001 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.032 0.197 -9999.0 0.0 -0.858 48.0 48.0 EGFR/EGFR/EGF/EGF -0.4 0.205 -9999.0 0.0 -0.892 54.0 54.0 RhoA/GDP -0.025 0.103 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.031 0.116 -9999.0 0.0 -0.849 2.0 2.0 IGF-1R heterotetramer 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.018 0.158 -9999.0 0.0 -0.773 37.0 37.0 DIAPH1 -0.01 0.081 -9999.0 0.0 -0.731 11.0 11.0 Wnt receptor signaling pathway 0.026 0.11 0.487 48.0 -9999.0 0.0 48.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.086 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.031 0.119 -9999.0 0.0 -0.891 2.0 2.0 EFNA1 0.014 0.025 -9999.0 0.0 -0.737 1.0 1.0 LPP 0.032 0.114 -9999.0 0.0 -0.795 1.0 1.0 Ephrin A1/EPHA2 -0.025 0.101 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.021 0.09 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.005 0.167 -9999.0 0.0 -0.928 7.0 7.0 HGF/MET -0.068 0.182 -9999.0 0.0 -0.868 20.0 20.0 HGF -0.049 0.225 -9999.0 0.0 -0.836 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.018 0.077 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.089 0.084 -9999.0 0.0 -0.415 1.0 1.0 KIAA1543 0.025 0.148 -9999.0 0.0 -1.032 8.0 8.0 KIFC3 0.019 0.122 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.021 0.119 -9999.0 0.0 -0.854 1.0 1.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.026 0.11 -9999.0 0.0 -0.487 48.0 48.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.022 0.115 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.022 0.115 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.018 0.075 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.145 -9999.0 0.0 -0.914 9.0 9.0 IGF-1R heterotetramer/IGF1 -0.039 0.124 -9999.0 0.0 -0.902 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.01 0.134 -9999.0 0.0 -0.737 29.0 29.0 PLEKHA7 0.018 0.134 -9999.0 0.0 -0.94 5.0 5.0 mol:GTP -0.002 0.026 -9999.0 0.0 -0.515 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.058 0.103 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.018 0.076 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.031 0.116 -9999.0 0.0 -0.849 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.018 0.077 -9999.0 0.0 -9999.0 0.0 0.0