Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	423.0	14390.0	34.0	-0.661	0.015	1000.0	-1000.0	-0.09	-1000.0
HIF-1-alpha transcription factor network	224.0	17054.0	76.0	-0.917	0.025	1000.0	-1000.0	-0.175	-1000.0
TCGA08_p53	223.0	1565.0	7.0	-0.495	0.251	1000.0	-1000.0	-0.023	-1000.0
FOXA2 and FOXA3 transcription factor networks	208.0	9610.0	46.0	-1.213	0.024	1000.0	-1000.0	-0.074	-1000.0
PDGFR-alpha signaling pathway	206.0	9068.0	44.0	-0.331	0.034	1000.0	-1000.0	-0.095	-1000.0
FOXM1 transcription factor network	186.0	9493.0	51.0	-0.642	0.033	1000.0	-1000.0	-0.19	-1000.0
Aurora B signaling	179.0	12006.0	67.0	-0.378	0.015	1000.0	-1000.0	-0.099	-1000.0
TCR signaling in naïve CD8+ T cells	177.0	16490.0	93.0	-0.658	0.307	1000.0	-1000.0	-0.122	-1000.0
Syndecan-4-mediated signaling events	170.0	11408.0	67.0	-0.484	0.099	1000.0	-1000.0	-0.139	-1000.0
Glypican 2 network	167.0	670.0	4.0	-0.152	-1000.0	1000.0	-1000.0	-0.05	-1000.0
Glypican 1 network	166.0	7997.0	48.0	-0.571	0.043	1000.0	-1000.0	-0.069	-1000.0
EGFR-dependent Endothelin signaling events	152.0	3195.0	21.0	-0.711	0.015	1000.0	-1000.0	-0.103	-1000.0
IL12-mediated signaling events	140.0	12192.0	87.0	-0.454	0.136	1000.0	-1000.0	-0.144	-1000.0
amb2 Integrin signaling	138.0	11360.0	82.0	-0.59	0.015	1000.0	-1000.0	-0.11	-1000.0
Angiopoietin receptor Tie2-mediated signaling	137.0	12101.0	88.0	-0.524	0.03	1000.0	-1000.0	-0.16	-1000.0
IL4-mediated signaling events	124.0	11365.0	91.0	-0.756	0.554	1000.0	-1000.0	-0.173	-1000.0
BMP receptor signaling	114.0	9281.0	81.0	-0.671	0.015	1000.0	-1000.0	-0.139	-1000.0
Aurora C signaling	110.0	773.0	7.0	-0.305	0.008	1000.0	-1000.0	-0.06	-1000.0
TCGA08_retinoblastoma	107.0	861.0	8.0	-0.657	0.172	1000.0	-1000.0	-0.038	-1000.0
Effects of Botulinum toxin	91.0	2368.0	26.0	-0.36	0.015	1000.0	-1000.0	-0.091	-1000.0
IL23-mediated signaling events	91.0	5519.0	60.0	-0.296	0.021	1000.0	-1000.0	-0.174	-1000.0
Syndecan-1-mediated signaling events	86.0	2936.0	34.0	-0.281	0.015	1000.0	-1000.0	-0.105	-1000.0
Arf6 signaling events	84.0	5242.0	62.0	-0.711	0.015	1000.0	-1000.0	-0.098	-1000.0
Caspase cascade in apoptosis	74.0	5530.0	74.0	-0.317	0.086	1000.0	-1000.0	-0.092	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	74.0	5065.0	68.0	-0.443	0.078	1000.0	-1000.0	-0.163	-1000.0
LPA4-mediated signaling events	72.0	865.0	12.0	-0.157	0.026	1000.0	-1000.0	-0.034	-1000.0
Fc-epsilon receptor I signaling in mast cells	72.0	7008.0	97.0	-0.311	0.041	1000.0	-1000.0	-0.128	-1000.0
Endothelins	67.0	6480.0	96.0	-0.499	0.016	1000.0	-1000.0	-0.116	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	67.0	2215.0	33.0	-0.646	0.015	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	66.0	5149.0	78.0	-0.394	0.06	1000.0	-1000.0	-0.109	-1000.0
JNK signaling in the CD4+ TCR pathway	65.0	1119.0	17.0	-0.242	0.015	1000.0	-1000.0	-0.098	-1000.0
S1P1 pathway	65.0	2357.0	36.0	-0.219	0.015	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by the Hedgehog family	62.0	3235.0	52.0	-0.233	0.099	1000.0	-1000.0	-0.12	-1000.0
IL27-mediated signaling events	62.0	3202.0	51.0	-0.725	0.064	1000.0	-1000.0	-0.119	-1000.0
Ephrin A  reverse signaling	59.0	413.0	7.0	-0.053	0.0	1000.0	-1000.0	-0.039	-1000.0
Thromboxane A2 receptor signaling	57.0	6051.0	105.0	-0.711	0.03	1000.0	-1000.0	-0.115	-1000.0
HIF-2-alpha transcription factor network	56.0	2432.0	43.0	-0.398	0.13	1000.0	-1000.0	-0.12	-1000.0
Calcium signaling in the CD4+ TCR pathway	55.0	1712.0	31.0	-0.332	0.015	1000.0	-1000.0	-0.154	-1000.0
p75(NTR)-mediated signaling	54.0	6818.0	125.0	-0.437	0.015	1000.0	-1000.0	-0.158	-1000.0
PLK1 signaling events	52.0	4457.0	85.0	-0.316	0.015	1000.0	-1000.0	-0.091	-1000.0
Coregulation of Androgen receptor activity	51.0	3933.0	76.0	-0.874	0.036	1000.0	-1000.0	-0.066	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	51.0	2795.0	54.0	-0.573	0.029	1000.0	-1000.0	-0.148	-1000.0
Integrins in angiogenesis	51.0	4338.0	84.0	-0.453	0.039	1000.0	-1000.0	-0.155	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	49.0	6202.0	125.0	-0.281	0.016	1000.0	-1000.0	-0.15	-1000.0
Reelin signaling pathway	47.0	2652.0	56.0	-0.234	0.015	1000.0	-1000.0	-0.136	-1000.0
IL2 signaling events mediated by STAT5	45.0	1009.0	22.0	-0.264	0.022	1000.0	-1000.0	-0.076	-1000.0
Glucocorticoid receptor regulatory network	44.0	5065.0	114.0	-0.44	0.174	1000.0	-1000.0	-0.1	-1000.0
IL2 signaling events mediated by PI3K	43.0	2510.0	58.0	-0.261	0.032	1000.0	-1000.0	-0.109	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	43.0	5194.0	120.0	-0.251	0.166	1000.0	-1000.0	-0.117	-1000.0
IL6-mediated signaling events	42.0	3163.0	75.0	-0.232	0.075	1000.0	-1000.0	-0.122	-1000.0
Regulation of Telomerase	42.0	4371.0	102.0	-0.712	0.035	1000.0	-1000.0	-0.137	-1000.0
BCR signaling pathway	42.0	4177.0	99.0	-0.19	0.032	1000.0	-1000.0	-0.13	-1000.0
Signaling events mediated by PTP1B	41.0	3155.0	76.0	-0.714	0.06	1000.0	-1000.0	-0.115	-1000.0
Visual signal transduction: Rods	40.0	2114.0	52.0	-0.21	0.015	1000.0	-1000.0	-0.121	-1000.0
Signaling events regulated by Ret tyrosine kinase	39.0	3263.0	82.0	-0.119	0.015	1000.0	-1000.0	-0.118	-1000.0
Syndecan-2-mediated signaling events	35.0	2421.0	69.0	-0.59	0.047	1000.0	-1000.0	-0.079	-1000.0
Sphingosine 1-phosphate (S1P) pathway	34.0	978.0	28.0	-0.132	0.015	1000.0	-1000.0	-0.088	-1000.0
PLK2 and PLK4 events	33.0	100.0	3.0	-0.023	0.011	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	33.0	2027.0	61.0	-0.216	0.098	1000.0	-1000.0	-0.1	-1000.0
Wnt signaling	33.0	234.0	7.0	-0.084	0.015	1000.0	-1000.0	-0.076	-1000.0
Aurora A signaling	32.0	1927.0	60.0	-0.222	0.05	1000.0	-1000.0	-0.098	-1000.0
VEGFR1 specific signals	32.0	1810.0	56.0	-0.24	0.039	1000.0	-1000.0	-0.129	-1000.0
Nongenotropic Androgen signaling	31.0	1635.0	52.0	-0.107	0.04	1000.0	-1000.0	-0.089	-1000.0
Regulation of nuclear SMAD2/3 signaling	30.0	4086.0	136.0	-0.443	0.099	1000.0	-1000.0	-0.127	-1000.0
E-cadherin signaling events	29.0	149.0	5.0	-0.036	0.015	1000.0	-1000.0	-0.08	-1000.0
Regulation of Androgen receptor activity	26.0	1841.0	70.0	-0.919	0.039	1000.0	-1000.0	-0.102	-1000.0
ErbB4 signaling events	25.0	1734.0	69.0	-0.158	0.121	1000.0	-1000.0	-0.127	-1000.0
Ceramide signaling pathway	25.0	1937.0	76.0	-0.711	0.233	1000.0	-1000.0	-0.1	-1000.0
S1P3 pathway	25.0	1060.0	42.0	-0.212	0.035	1000.0	-1000.0	-0.086	-1000.0
Plasma membrane estrogen receptor signaling	24.0	2068.0	86.0	-0.125	0.052	1000.0	-1000.0	-0.113	-1000.0
Noncanonical Wnt signaling pathway	23.0	600.0	26.0	-0.154	0.015	1000.0	-1000.0	-0.123	-1000.0
FoxO family signaling	23.0	1526.0	64.0	-0.658	0.117	1000.0	-1000.0	-0.103	-1000.0
Canonical Wnt signaling pathway	23.0	1186.0	51.0	-0.215	0.102	1000.0	-1000.0	-0.088	-1000.0
LPA receptor mediated events	23.0	2436.0	102.0	-0.282	0.043	1000.0	-1000.0	-0.125	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	23.0	1746.0	74.0	-0.711	0.089	1000.0	-1000.0	-0.141	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	22.0	833.0	37.0	-0.153	0.015	1000.0	-1000.0	-0.116	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	22.0	998.0	45.0	-0.335	0.068	1000.0	-1000.0	-0.13	-1000.0
Visual signal transduction: Cones	21.0	802.0	38.0	-0.04	0.015	1000.0	-1000.0	-0.089	-1000.0
S1P5 pathway	21.0	365.0	17.0	-0.093	0.041	1000.0	-1000.0	-0.074	-1000.0
Ephrin B reverse signaling	21.0	1029.0	48.0	-0.096	0.074	1000.0	-1000.0	-0.118	-1000.0
Class IB PI3K non-lipid kinase events	21.0	63.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.023	-1000.0
IFN-gamma pathway	20.0	1394.0	68.0	-0.28	0.04	1000.0	-1000.0	-0.137	-1000.0
FAS signaling pathway (CD95)	19.0	933.0	47.0	-0.257	0.025	1000.0	-1000.0	-0.067	-1000.0
a4b1 and a4b7 Integrin signaling	18.0	90.0	5.0	-0.019	0.015	1000.0	-1000.0	-0.051	-1000.0
Insulin-mediated glucose transport	18.0	583.0	32.0	-0.148	0.071	1000.0	-1000.0	-0.093	-1000.0
IL1-mediated signaling events	18.0	1121.0	62.0	-0.171	0.054	1000.0	-1000.0	-0.144	-1000.0
Osteopontin-mediated events	17.0	666.0	38.0	-0.058	0.053	1000.0	-1000.0	-0.15	-1000.0
EPO signaling pathway	17.0	987.0	55.0	-0.146	0.038	1000.0	-1000.0	-0.143	-1000.0
Syndecan-3-mediated signaling events	17.0	603.0	35.0	-0.083	0.015	1000.0	-1000.0	-0.093	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	760.0	44.0	-0.093	0.021	1000.0	-1000.0	-0.077	-1000.0
TCGA08_rtk_signaling	17.0	453.0	26.0	-0.331	0.037	1000.0	-1000.0	-0.034	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1388.0	85.0	-0.062	0.059	1000.0	-1000.0	-0.104	-1000.0
Class I PI3K signaling events	16.0	1229.0	73.0	-0.24	0.033	1000.0	-1000.0	-0.103	-1000.0
EPHB forward signaling	15.0	1324.0	85.0	-0.096	0.054	1000.0	-1000.0	-0.133	-1000.0
S1P4 pathway	15.0	386.0	25.0	-0.093	0.03	1000.0	-1000.0	-0.072	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	14.0	742.0	52.0	-0.123	0.081	1000.0	-1000.0	-0.083	-1000.0
E-cadherin signaling in the nascent adherens junction	14.0	1126.0	76.0	-0.038	0.056	1000.0	-1000.0	-0.125	-1000.0
Signaling events mediated by PRL	14.0	505.0	34.0	-0.064	0.032	1000.0	-1000.0	-0.08	-1000.0
p38 MAPK signaling pathway	12.0	569.0	44.0	-0.134	0.042	1000.0	-1000.0	-0.092	-1000.0
BARD1 signaling events	11.0	641.0	57.0	-0.161	0.031	1000.0	-1000.0	-0.105	-1000.0
Cellular roles of Anthrax toxin	10.0	393.0	39.0	-0.09	0.026	1000.0	-1000.0	-0.046	-1000.0
Arf6 trafficking events	10.0	772.0	71.0	-0.227	0.043	1000.0	-1000.0	-0.107	-1000.0
PDGFR-beta signaling pathway	10.0	1031.0	97.0	-0.131	0.078	1000.0	-1000.0	-0.129	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	175.0	17.0	-0.018	0.046	1000.0	-1000.0	-0.06	-1000.0
ErbB2/ErbB3 signaling events	9.0	603.0	65.0	-0.15	0.048	1000.0	-1000.0	-0.105	-1000.0
Canonical NF-kappaB pathway	9.0	368.0	39.0	-0.117	0.085	1000.0	-1000.0	-0.134	-1000.0
Regulation of p38-alpha and p38-beta	9.0	501.0	54.0	-0.077	0.069	1000.0	-1000.0	-0.088	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	673.0	83.0	-0.148	0.074	1000.0	-1000.0	-0.119	-1000.0
Retinoic acid receptors-mediated signaling	8.0	496.0	58.0	-0.072	0.048	1000.0	-1000.0	-0.113	-1000.0
Nectin adhesion pathway	7.0	451.0	63.0	-0.04	0.07	1000.0	-1000.0	-0.114	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	106.0	15.0	-0.0	0.033	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling in keratinocytes	7.0	343.0	43.0	-0.343	0.049	1000.0	-1000.0	-0.129	-1000.0
Circadian rhythm pathway	6.0	146.0	22.0	-0.035	0.049	1000.0	-1000.0	-0.1	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	413.0	65.0	-0.039	0.084	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by HDAC Class III	6.0	277.0	40.0	-0.037	0.029	1000.0	-1000.0	-0.07	-1000.0
IGF1 pathway	6.0	357.0	57.0	-0.054	0.06	1000.0	-1000.0	-0.143	-1000.0
Signaling events mediated by HDAC Class II	5.0	425.0	75.0	-0.065	0.05	1000.0	-1000.0	-0.094	-1000.0
Arf6 downstream pathway	4.0	195.0	43.0	-0.032	0.032	1000.0	-1000.0	-0.067	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	309.0	68.0	-0.148	0.057	1000.0	-1000.0	-0.103	-1000.0
ceramide signaling pathway	4.0	200.0	49.0	-0.071	0.054	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by HDAC Class I	4.0	514.0	104.0	-0.065	0.061	1000.0	-1000.0	-0.107	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	179.0	36.0	-0.052	0.029	1000.0	-1000.0	-0.106	-1000.0
Insulin Pathway	4.0	318.0	74.0	-0.041	0.047	1000.0	-1000.0	-0.14	-1000.0
Rapid glucocorticoid signaling	4.0	81.0	20.0	-0.022	0.015	1000.0	-1000.0	-0.069	-1000.0
Atypical NF-kappaB pathway	3.0	99.0	31.0	-0.023	0.033	1000.0	-1000.0	-0.104	-1000.0
mTOR signaling pathway	2.0	111.0	53.0	-0.004	0.042	1000.0	-1000.0	-0.092	-1000.0
TRAIL signaling pathway	2.0	132.0	48.0	-0.01	0.063	1000.0	-1000.0	-0.109	-1000.0
Arf1 pathway	1.0	73.0	54.0	-0.016	0.033	1000.0	-1000.0	-0.065	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	-0.004	0.06	1000.0	-1000.0	-0.105	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.037	1000.0	-1000.0	-0.078	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.001	0.015	1000.0	-1000.0	-0.103	-1000.0
Total	6616	365846	7203	-36.7495182392	-1992.86232652	131000	-131000	-13.6461714673	-131000