E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.126 -9999.0 0.0 -0.509 40.0 40.0 KLHL20 0.023 0.069 0.208 3.0 -0.311 2.0 5.0 CYFIP2 0.018 0.076 -9999.0 0.0 -0.652 11.0 11.0 Rac1/GDP 0.023 0.091 0.313 13.0 -0.367 2.0 15.0 ENAH -0.005 0.125 -9999.0 0.0 -0.513 40.0 40.0 AP1M1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.021 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.036 -9999.0 0.0 -0.202 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.094 -9999.0 0.0 -0.384 37.0 37.0 RAPGEF1 0.004 0.116 0.263 4.0 -0.444 34.0 38.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.006 0.131 -9999.0 0.0 -0.528 40.0 40.0 CRK -0.005 0.116 -9999.0 0.0 -0.479 35.0 35.0 E-cadherin/gamma catenin/alpha catenin 0.026 0.1 -9999.0 0.0 -0.43 36.0 36.0 alphaE/beta7 Integrin 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.005 0.126 -9999.0 0.0 -0.513 39.0 39.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.036 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.045 0.027 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.004 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.012 0.111 -9999.0 0.0 -0.472 42.0 42.0 TIAM1 0.026 0.024 -9999.0 0.0 -0.651 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.036 0.09 -9999.0 0.0 -0.362 39.0 39.0 AKT1 0.014 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.005 0.142 -9999.0 0.0 -0.652 40.0 40.0 RhoA/GDP 0.04 0.103 0.338 29.0 -0.36 2.0 31.0 actin cytoskeleton organization 0.022 0.057 0.17 17.0 -0.22 2.0 19.0 CDC42/GDP 0.047 0.128 0.396 51.0 -0.365 2.0 53.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.069 -9999.0 0.0 -0.3 36.0 36.0 ITGB7 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.04 0.096 -9999.0 0.0 -0.383 39.0 39.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.023 0.086 -9999.0 0.0 -0.363 39.0 39.0 mol:GDP 0.034 0.139 0.442 42.0 -0.401 5.0 47.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.04 -9999.0 0.0 -0.652 3.0 3.0 p120 catenin/RhoA/GDP 0.033 0.097 0.31 13.0 -0.368 2.0 15.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.068 0.218 42.0 -0.17 33.0 75.0 NME1 0.024 0.027 -9999.0 0.0 -0.417 3.0 3.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.006 0.127 -9999.0 0.0 -0.513 40.0 40.0 regulation of cell-cell adhesion 0.011 0.051 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.012 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.027 0.074 0.244 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.095 -9999.0 0.0 -0.372 36.0 36.0 CCND1 0.023 0.067 0.189 24.0 -0.21 33.0 57.0 VAV2 0.005 0.146 -9999.0 0.0 -0.566 17.0 17.0 RAP1/GDP 0.037 0.09 0.321 16.0 -0.354 1.0 17.0 adherens junction assembly -0.005 0.123 -9999.0 0.0 -0.495 40.0 40.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.092 -9999.0 0.0 -0.668 1.0 1.0 E-cadherin/beta catenin -0.005 0.092 -9999.0 0.0 -0.426 40.0 40.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.125 -9999.0 0.0 -0.511 38.0 38.0 PIK3CA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.027 0.073 -9999.0 0.0 -0.549 2.0 2.0 E-cadherin/beta catenin/alpha catenin 0.026 0.099 -9999.0 0.0 -0.419 39.0 39.0 ITGAE 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.134 -9999.0 0.0 -0.541 40.0 40.0