Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.08 0.161 -9999.0 0.0 -0.562 32.0 32.0 IHH -0.056 0.195 -9999.0 0.0 -0.659 78.0 78.0 SHH Np/Cholesterol/GAS1 -0.01 0.115 -9999.0 0.0 -0.385 68.0 68.0 LRPAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.114 0.383 68.0 -9999.0 0.0 68.0 SMO/beta Arrestin2 -0.046 0.143 -9999.0 0.0 -0.506 37.0 37.0 SMO -0.058 0.145 -9999.0 0.0 -0.473 66.0 66.0 AKT1 -0.011 0.098 -9999.0 0.0 -0.568 11.0 11.0 ARRB2 0.024 0.03 -9999.0 0.0 -0.457 3.0 3.0 BOC 0.026 0.024 -9999.0 0.0 -0.652 1.0 1.0 ADRBK1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.057 0.143 -9999.0 0.0 -0.466 66.0 66.0 STIL -0.032 0.145 -9999.0 0.0 -0.429 43.0 43.0 DHH N/PTCH2 0.007 0.118 -9999.0 0.0 -0.428 57.0 57.0 DHH N/PTCH1 -0.063 0.153 -9999.0 0.0 -0.443 72.0 72.0 PIK3CA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.143 -9999.0 0.0 -0.652 41.0 41.0 PTHLH -0.124 0.209 -9999.0 0.0 -0.722 38.0 38.0 determination of left/right symmetry -0.057 0.143 -9999.0 0.0 -0.466 66.0 66.0 PIK3R1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.123 0.208 -9999.0 0.0 -0.715 38.0 38.0 IHH N/Hhip -0.095 0.22 -9999.0 0.0 -0.5 187.0 187.0 DHH N/Hhip -0.055 0.203 -9999.0 0.0 -0.474 160.0 160.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.057 0.143 -9999.0 0.0 -0.466 66.0 66.0 pancreas development -0.067 0.225 -9999.0 0.0 -0.613 125.0 125.0 HHAT 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.01 0.155 -9999.0 0.0 -0.636 50.0 50.0 somite specification -0.057 0.143 -9999.0 0.0 -0.466 66.0 66.0 SHH Np/Cholesterol/PTCH1 -0.054 0.13 -9999.0 0.0 -0.437 48.0 48.0 SHH Np/Cholesterol/PTCH2 0.005 0.086 -9999.0 0.0 -0.372 35.0 35.0 SHH Np/Cholesterol/Megalin -0.036 0.163 -9999.0 0.0 -0.456 102.0 102.0 SHH -0.005 0.1 0.209 2.0 -0.462 39.0 41.0 catabolic process -0.058 0.139 -9999.0 0.0 -0.425 71.0 71.0 SMO/Vitamin D3 -0.057 0.144 -9999.0 0.0 -0.487 50.0 50.0 SHH Np/Cholesterol/Hhip -0.042 0.161 -9999.0 0.0 -0.424 117.0 117.0 LRP2 -0.055 0.213 -9999.0 0.0 -0.575 121.0 121.0 receptor-mediated endocytosis -0.085 0.186 -9999.0 0.0 -0.573 76.0 76.0 SHH Np/Cholesterol/BOC 0.009 0.081 -9999.0 0.0 -0.377 35.0 35.0 SHH Np/Cholesterol/CDO -0.014 0.105 -9999.0 0.0 -0.378 35.0 35.0 mesenchymal cell differentiation 0.042 0.16 0.421 117.0 -9999.0 0.0 117.0 mol:Vitamin D3 -0.035 0.151 -9999.0 0.0 -0.439 48.0 48.0 IHH N/PTCH2 -0.029 0.137 -9999.0 0.0 -0.416 88.0 88.0 CDON -0.016 0.133 -9999.0 0.0 -0.417 87.0 87.0 IHH N/PTCH1 -0.056 0.143 -9999.0 0.0 -0.431 71.0 71.0 Megalin/LRPAP1 -0.022 0.162 -9999.0 0.0 -0.469 92.0 92.0 PTCH2 0.018 0.062 -9999.0 0.0 -0.417 17.0 17.0 SHH Np/Cholesterol -0.001 0.079 -9999.0 0.0 -0.379 35.0 35.0 PTCH1 -0.058 0.14 -9999.0 0.0 -0.427 71.0 71.0 HHIP -0.067 0.226 -9999.0 0.0 -0.614 125.0 125.0