Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.066 -9999.0 0.0 -0.284 39.0 39.0 epithelial cell differentiation 0.032 0.088 -9999.0 0.0 -0.359 39.0 39.0 CYFIP2 0.018 0.076 -9999.0 0.0 -0.652 11.0 11.0 ENAH 0.039 0.13 0.498 44.0 -9999.0 0.0 44.0 EGFR 0.017 0.061 -9999.0 0.0 -0.451 14.0 14.0 EPHA2 0.026 0.024 -9999.0 0.0 -0.652 1.0 1.0 MYO6 0.027 0.113 0.372 29.0 -0.362 38.0 67.0 CTNNB1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.056 -9999.0 0.0 -0.42 11.0 11.0 AQP5 -0.119 0.245 0.337 1.0 -0.534 211.0 212.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.105 0.358 26.0 -0.339 38.0 64.0 regulation of calcium-dependent cell-cell adhesion 0.01 0.122 0.35 18.0 -0.377 50.0 68.0 EGF -0.535 0.254 -9999.0 0.0 -0.649 731.0 731.0 NCKAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.073 0.225 0.344 1.0 -0.553 144.0 145.0 cortical microtubule organization 0.032 0.088 -9999.0 0.0 -0.359 39.0 39.0 GO:0000145 0.017 0.101 0.349 26.0 -0.324 38.0 64.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.036 0.09 -9999.0 0.0 -0.362 39.0 39.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.007 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.032 -9999.0 0.0 -0.384 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.013 0.079 0.353 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.014 0.087 0.345 6.0 -0.344 36.0 42.0 ARF6/GTP 0.065 0.036 -9999.0 0.0 -0.358 1.0 1.0 CDH1 -0.005 0.142 -9999.0 0.0 -0.652 40.0 40.0 EGFR/EGFR/EGF/EGF -0.256 0.171 -9999.0 0.0 -0.36 559.0 559.0 RhoA/GDP 0.034 0.084 -9999.0 0.0 -0.34 39.0 39.0 actin cytoskeleton organization 0.021 0.107 0.363 27.0 -0.631 2.0 29.0 IGF-1R heterotetramer 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.008 0.098 -9999.0 0.0 -0.483 32.0 32.0 DIAPH1 0.017 0.143 -9999.0 0.0 -0.692 9.0 9.0 Wnt receptor signaling pathway -0.032 0.088 0.359 39.0 -9999.0 0.0 39.0 RHOA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.061 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.109 0.365 27.0 -0.653 2.0 29.0 EFNA1 0.026 0.016 -9999.0 0.0 -0.417 1.0 1.0 LPP 0.013 0.087 0.349 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.025 0.082 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.002 0.066 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.009 0.124 0.353 18.0 -0.383 50.0 68.0 HGF/MET 0.009 0.112 -9999.0 0.0 -0.372 59.0 59.0 HGF -0.007 0.139 -9999.0 0.0 -0.594 45.0 45.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.067 -9999.0 0.0 -0.286 39.0 39.0 actin cable formation 0.067 0.161 0.546 60.0 -9999.0 0.0 60.0 KIAA1543 0.015 0.111 0.359 25.0 -0.359 41.0 66.0 KIFC3 0.011 0.089 -9999.0 0.0 -0.345 44.0 44.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.026 0.104 0.354 23.0 -0.344 38.0 61.0 NCK1/GIT1 0.037 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.032 0.088 -9999.0 0.0 -0.359 39.0 39.0 EXOC4 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.013 0.086 0.352 1.0 -0.344 39.0 40.0 PIP5K1C 0.028 0.106 0.361 26.0 -0.345 38.0 64.0 LIMA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.049 0.14 0.512 47.0 -9999.0 0.0 47.0 adherens junction assembly 0.034 0.14 0.488 33.0 -0.565 8.0 41.0 IGF-1R heterotetramer/IGF1 0.018 0.094 -9999.0 0.0 -0.384 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.04 -9999.0 0.0 -0.417 7.0 7.0 PLEKHA7 0.026 0.115 0.368 25.0 -0.377 41.0 66.0 mol:GTP 0.058 0.032 -9999.0 0.0 -0.382 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.035 0.103 0.383 23.0 -9999.0 0.0 23.0 cortical actin cytoskeleton stabilization 0.013 0.066 -9999.0 0.0 -0.284 39.0 39.0 regulation of cell-cell adhesion 0.021 0.107 0.363 27.0 -0.631 2.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.067 -9999.0 0.0 -0.286 39.0 39.0