Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	424.0	14421.0	34.0	-0.499	0.028	1000.0	-1000.0	-0.043	-1000.0
EGFR-dependent Endothelin signaling events	278.0	5858.0	21.0	-0.535	0.037	1000.0	-1000.0	-0.054	-1000.0
FOXA2 and FOXA3 transcription factor networks	217.0	10005.0	46.0	-1.041	0.031	1000.0	-1000.0	-0.092	-1000.0
PDGFR-alpha signaling pathway	202.0	8888.0	44.0	-0.242	0.036	1000.0	-1000.0	-0.048	-1000.0
HIF-1-alpha transcription factor network	187.0	14282.0	76.0	-0.65	0.043	1000.0	-1000.0	-0.136	-1000.0
TCR signaling in naïve CD8+ T cells	167.0	15614.0	93.0	-0.353	0.155	1000.0	-1000.0	-0.058	-1000.0
Glypican 1 network	150.0	7230.0	48.0	-0.41	0.048	1000.0	-1000.0	-0.041	-1000.0
TCGA08_p53	142.0	996.0	7.0	-0.259	0.146	1000.0	-1000.0	-0.014	-1000.0
Angiopoietin receptor Tie2-mediated signaling	140.0	12330.0	88.0	-0.46	0.032	1000.0	-1000.0	-0.077	-1000.0
TCGA08_retinoblastoma	133.0	1067.0	8.0	-0.373	0.097	1000.0	-1000.0	-0.007	-1000.0
BMP receptor signaling	113.0	9205.0	81.0	-0.447	0.055	1000.0	-1000.0	-0.078	-1000.0
Glypican 2 network	112.0	450.0	4.0	-0.023	-1000.0	1000.0	-1000.0	-0.005	-1000.0
Aurora B signaling	112.0	7544.0	67.0	-0.263	0.036	1000.0	-1000.0	-0.057	-1000.0
amb2 Integrin signaling	111.0	9114.0	82.0	-0.437	0.034	1000.0	-1000.0	-0.06	-1000.0
IL12-mediated signaling events	96.0	8367.0	87.0	-0.224	0.07	1000.0	-1000.0	-0.103	-1000.0
IL4-mediated signaling events	87.0	7987.0	91.0	-0.698	0.495	1000.0	-1000.0	-0.13	-1000.0
Syndecan-4-mediated signaling events	84.0	5673.0	67.0	-0.303	0.1	1000.0	-1000.0	-0.064	-1000.0
Effects of Botulinum toxin	80.0	2103.0	26.0	-0.195	0.028	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	74.0	5772.0	78.0	-0.273	0.05	1000.0	-1000.0	-0.066	-1000.0
Arf6 signaling events	69.0	4308.0	62.0	-0.535	0.06	1000.0	-1000.0	-0.049	-1000.0
Thromboxane A2 receptor signaling	66.0	6936.0	105.0	-0.535	0.034	1000.0	-1000.0	-0.061	-1000.0
Endothelins	65.0	6262.0	96.0	-0.491	0.027	1000.0	-1000.0	-0.069	-1000.0
FOXM1 transcription factor network	65.0	3353.0	51.0	-0.363	0.027	1000.0	-1000.0	-0.164	-1000.0
Syndecan-1-mediated signaling events	62.0	2132.0	34.0	-0.142	0.028	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-alpha and p38-beta	62.0	2745.0	44.0	-0.087	0.027	1000.0	-1000.0	-0.041	-1000.0
LPA4-mediated signaling events	61.0	742.0	12.0	-0.079	0.009	1000.0	-1000.0	-0.029	-1000.0
JNK signaling in the CD4+ TCR pathway	60.0	1030.0	17.0	-0.09	0.027	1000.0	-1000.0	-0.044	-1000.0
S1P1 pathway	60.0	2161.0	36.0	-0.111	0.026	1000.0	-1000.0	-0.05	-1000.0
Coregulation of Androgen receptor activity	59.0	4491.0	76.0	-0.769	0.054	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by the Hedgehog family	56.0	2921.0	52.0	-0.124	0.042	1000.0	-1000.0	-0.058	-1000.0
Ephrin A  reverse signaling	54.0	384.0	7.0	-0.021	-0.0	1000.0	-1000.0	-0.028	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	54.0	3705.0	68.0	-0.329	0.067	1000.0	-1000.0	-0.093	-1000.0
Caspase cascade in apoptosis	53.0	3952.0	74.0	-0.318	0.038	1000.0	-1000.0	-0.049	-1000.0
Aurora C signaling	53.0	375.0	7.0	-0.154	0.024	1000.0	-1000.0	-0.022	-1000.0
Reelin signaling pathway	53.0	2981.0	56.0	-0.118	0.072	1000.0	-1000.0	-0.061	-1000.0
Calcium signaling in the CD4+ TCR pathway	53.0	1654.0	31.0	-0.214	0.027	1000.0	-1000.0	-0.06	-1000.0
Integrins in angiogenesis	51.0	4305.0	84.0	-0.321	0.06	1000.0	-1000.0	-0.069	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	48.0	1606.0	33.0	-0.367	0.065	1000.0	-1000.0	-0.05	-1000.0
Fc-epsilon receptor I signaling in mast cells	47.0	4646.0	97.0	-0.131	0.047	1000.0	-1000.0	-0.071	-1000.0
PLK1 signaling events	47.0	4030.0	85.0	-0.155	0.038	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	47.0	5914.0	125.0	-0.135	0.04	1000.0	-1000.0	-0.069	-1000.0
p75(NTR)-mediated signaling	46.0	5784.0	125.0	-0.314	0.076	1000.0	-1000.0	-0.091	-1000.0
IL2 signaling events mediated by STAT5	45.0	992.0	22.0	-0.138	0.03	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	44.0	3409.0	76.0	-0.538	0.055	1000.0	-1000.0	-0.054	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	44.0	3303.0	74.0	-0.535	0.067	1000.0	-1000.0	-0.085	-1000.0
Ceramide signaling pathway	43.0	3268.0	76.0	-0.535	0.191	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	43.0	2764.0	64.0	-0.625	0.072	1000.0	-1000.0	-0.065	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	41.0	2240.0	54.0	-0.323	0.04	1000.0	-1000.0	-0.09	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	41.0	4941.0	120.0	-0.177	0.1	1000.0	-1000.0	-0.068	-1000.0
IL27-mediated signaling events	40.0	2045.0	51.0	-0.696	0.087	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Rods	40.0	2124.0	52.0	-0.124	0.043	1000.0	-1000.0	-0.053	-1000.0
IL23-mediated signaling events	39.0	2358.0	60.0	-0.191	0.028	1000.0	-1000.0	-0.114	-1000.0
Glucocorticoid receptor regulatory network	37.0	4298.0	114.0	-0.323	0.147	1000.0	-1000.0	-0.069	-1000.0
IL2 signaling events mediated by PI3K	37.0	2191.0	58.0	-0.137	0.048	1000.0	-1000.0	-0.051	-1000.0
Wnt signaling	36.0	252.0	7.0	-0.047	0.027	1000.0	-1000.0	-0.034	-1000.0
Signaling events regulated by Ret tyrosine kinase	35.0	2881.0	82.0	-0.039	0.028	1000.0	-1000.0	-0.088	-1000.0
Plasma membrane estrogen receptor signaling	35.0	3062.0	86.0	-0.083	0.048	1000.0	-1000.0	-0.078	-1000.0
Noncanonical Wnt signaling pathway	33.0	859.0	26.0	-0.126	0.027	1000.0	-1000.0	-0.063	-1000.0
Nongenotropic Androgen signaling	33.0	1738.0	52.0	-0.055	0.044	1000.0	-1000.0	-0.049	-1000.0
Syndecan-2-mediated signaling events	32.0	2229.0	69.0	-0.437	0.054	1000.0	-1000.0	-0.045	-1000.0
HIF-2-alpha transcription factor network	32.0	1394.0	43.0	-0.221	0.072	1000.0	-1000.0	-0.064	-1000.0
BCR signaling pathway	32.0	3222.0	99.0	-0.09	0.055	1000.0	-1000.0	-0.074	-1000.0
PLK2 and PLK4 events	31.0	94.0	3.0	0.003	0.025	1000.0	-1000.0	-0.023	-1000.0
Regulation of Telomerase	30.0	3074.0	102.0	-0.536	0.069	1000.0	-1000.0	-0.078	-1000.0
VEGFR1 specific signals	30.0	1684.0	56.0	-0.124	0.028	1000.0	-1000.0	-0.064	-1000.0
ceramide signaling pathway	29.0	1457.0	49.0	-0.023	0.041	1000.0	-1000.0	-0.06	-1000.0
Regulation of Androgen receptor activity	29.0	2044.0	70.0	-0.853	0.043	1000.0	-1000.0	-0.061	-1000.0
IFN-gamma pathway	27.0	1857.0	68.0	-0.187	0.04	1000.0	-1000.0	-0.087	-1000.0
S1P3 pathway	27.0	1135.0	42.0	-0.108	0.034	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	26.0	3618.0	136.0	-0.327	0.096	1000.0	-1000.0	-0.055	-1000.0
Sphingosine 1-phosphate (S1P) pathway	26.0	738.0	28.0	-0.042	0.036	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	26.0	1588.0	61.0	-0.139	0.076	1000.0	-1000.0	-0.071	-1000.0
Syndecan-3-mediated signaling events	26.0	936.0	35.0	-0.028	0.076	1000.0	-1000.0	-0.043	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	26.0	1210.0	45.0	-0.172	0.075	1000.0	-1000.0	-0.073	-1000.0
LPA receptor mediated events	24.0	2463.0	102.0	-0.142	0.045	1000.0	-1000.0	-0.086	-1000.0
E-cadherin signaling events	24.0	120.0	5.0	-0.005	0.026	1000.0	-1000.0	-0.004	-1000.0
TCGA08_rtk_signaling	23.0	602.0	26.0	-0.24	0.059	1000.0	-1000.0	-0.02	-1000.0
Ephrin B reverse signaling	22.0	1100.0	48.0	-0.039	0.037	1000.0	-1000.0	-0.043	-1000.0
Regulation of p38-alpha and p38-beta	22.0	1215.0	54.0	-0.044	0.059	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in keratinocytes	22.0	956.0	43.0	-0.231	0.038	1000.0	-1000.0	-0.054	-1000.0
ErbB4 signaling events	21.0	1495.0	69.0	-0.14	0.095	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	21.0	1591.0	75.0	-0.171	0.05	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	21.0	358.0	17.0	-0.0	0.048	1000.0	-1000.0	-0.032	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	20.0	1736.0	85.0	-0.052	0.061	1000.0	-1000.0	-0.064	-1000.0
EPO signaling pathway	20.0	1144.0	55.0	-0.067	0.043	1000.0	-1000.0	-0.067	-1000.0
Canonical Wnt signaling pathway	20.0	1058.0	51.0	-0.138	0.068	1000.0	-1000.0	-0.064	-1000.0
Class IB PI3K non-lipid kinase events	20.0	60.0	3.0	-0.014	0.014	1000.0	-1000.0	-0.009	-1000.0
Aurora A signaling	19.0	1148.0	60.0	-0.105	0.065	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	19.0	908.0	47.0	-0.138	0.041	1000.0	-1000.0	-0.052	-1000.0
Class I PI3K signaling events	19.0	1421.0	73.0	-0.124	0.051	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by PRL	19.0	667.0	34.0	-0.043	0.039	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	18.0	595.0	32.0	-0.072	0.049	1000.0	-1000.0	-0.041	-1000.0
S1P5 pathway	18.0	319.0	17.0	-0.036	0.027	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	18.0	1568.0	85.0	-0.046	0.058	1000.0	-1000.0	-0.084	-1000.0
Osteopontin-mediated events	17.0	650.0	38.0	-0.014	0.052	1000.0	-1000.0	-0.06	-1000.0
a4b1 and a4b7 Integrin signaling	17.0	87.0	5.0	0.012	0.028	1000.0	-1000.0	-0.01	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	17.0	638.0	37.0	-0.076	0.052	1000.0	-1000.0	-0.051	-1000.0
Visual signal transduction: Cones	16.0	641.0	38.0	-0.029	0.04	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	16.0	1559.0	97.0	-0.04	0.065	1000.0	-1000.0	-0.069	-1000.0
ErbB2/ErbB3 signaling events	15.0	1013.0	65.0	-0.078	0.037	1000.0	-1000.0	-0.066	-1000.0
IL1-mediated signaling events	15.0	984.0	62.0	-0.107	0.063	1000.0	-1000.0	-0.071	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	15.0	781.0	52.0	-0.068	0.088	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	15.0	1195.0	76.0	-0.027	0.048	1000.0	-1000.0	-0.081	-1000.0
S1P4 pathway	15.0	394.0	25.0	-0.036	0.038	1000.0	-1000.0	-0.037	-1000.0
Cellular roles of Anthrax toxin	14.0	565.0	39.0	-0.059	0.034	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	13.0	849.0	65.0	-0.004	0.049	1000.0	-1000.0	-0.056	-1000.0
mTOR signaling pathway	13.0	705.0	53.0	-0.018	0.05	1000.0	-1000.0	-0.05	-1000.0
Nectin adhesion pathway	13.0	851.0	63.0	-0.006	0.061	1000.0	-1000.0	-0.054	-1000.0
BARD1 signaling events	11.0	636.0	57.0	-0.066	0.063	1000.0	-1000.0	-0.056	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	11.0	956.0	83.0	-0.072	0.054	1000.0	-1000.0	-0.052	-1000.0
p38 MAPK signaling pathway	11.0	491.0	44.0	-0.059	0.05	1000.0	-1000.0	-0.045	-1000.0
Canonical NF-kappaB pathway	10.0	394.0	39.0	-0.053	0.062	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-gamma and p38-delta	9.0	143.0	15.0	-0.0	0.028	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	8.0	571.0	68.0	-0.072	0.054	1000.0	-1000.0	-0.048	-1000.0
Retinoic acid receptors-mediated signaling	8.0	481.0	58.0	-0.023	0.054	1000.0	-1000.0	-0.052	-1000.0
Arf6 trafficking events	8.0	578.0	71.0	-0.153	0.047	1000.0	-1000.0	-0.049	-1000.0
Insulin Pathway	8.0	633.0	74.0	-0.033	0.069	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class I	7.0	743.0	104.0	-0.053	0.066	1000.0	-1000.0	-0.061	-1000.0
IGF1 pathway	7.0	453.0	57.0	-0.034	0.062	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by HDAC Class III	5.0	211.0	40.0	-0.049	0.049	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class II	4.0	369.0	75.0	-0.034	0.069	1000.0	-1000.0	-0.04	-1000.0
Circadian rhythm pathway	4.0	103.0	22.0	-0.012	0.055	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	169.0	36.0	-0.046	0.05	1000.0	-1000.0	-0.052	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	75.0	23.0	-0.008	0.052	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	3.0	161.0	48.0	-0.006	0.069	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	3.0	118.0	31.0	0.0	0.039	1000.0	-1000.0	-0.048	-1000.0
Rapid glucocorticoid signaling	3.0	76.0	20.0	-0.016	0.035	1000.0	-1000.0	-0.007	-1000.0
Arf1 pathway	3.0	215.0	54.0	-0.0	0.042	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	2.0	92.0	43.0	-0.043	0.044	1000.0	-1000.0	-0.035	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	34.0	27.0	-0.0	0.064	1000.0	-1000.0	-0.043	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.069	1000.0	-1000.0	-0.009	-1000.0
Total	6049	331470	7203	-24.7947187552	-992.734557854	131000	-131000	-7.22408746809	-131000