Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.14 0.228 -9999.0 0.0 -0.535 13.0 13.0 IHH -0.106 0.199 -9999.0 0.0 -0.469 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.013 0.136 -9999.0 0.0 -0.468 5.0 5.0 LRPAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.014 0.135 0.464 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 -0.081 0.154 -9999.0 0.0 -0.55 2.0 2.0 SMO -0.096 0.162 -9999.0 0.0 -0.515 4.0 4.0 AKT1 -0.049 0.176 -9999.0 0.0 -0.672 5.0 5.0 ARRB2 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.039 0.19 -9999.0 0.0 -0.637 8.0 8.0 ADRBK1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.095 0.16 -9999.0 0.0 -0.507 4.0 4.0 STIL -0.062 0.149 -9999.0 0.0 -0.548 3.0 3.0 DHH N/PTCH2 0.019 0.077 -9999.0 0.0 -0.485 2.0 2.0 DHH N/PTCH1 -0.075 0.153 -9999.0 0.0 -0.54 3.0 3.0 PIK3CA 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.072 -9999.0 0.0 -0.661 1.0 1.0 PTHLH -0.245 0.394 -9999.0 0.0 -1.053 13.0 13.0 determination of left/right symmetry -0.095 0.16 -9999.0 0.0 -0.507 4.0 4.0 PIK3R1 -0.016 0.15 -9999.0 0.0 -0.622 5.0 5.0 skeletal system development -0.242 0.389 -9999.0 0.0 -1.036 13.0 13.0 IHH N/Hhip -0.106 0.185 -9999.0 0.0 -0.41 19.0 19.0 DHH N/Hhip -0.034 0.156 -9999.0 0.0 -0.375 14.0 14.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.095 0.16 -9999.0 0.0 -0.507 4.0 4.0 pancreas development -0.061 0.19 -9999.0 0.0 -0.495 14.0 14.0 HHAT -0.009 0.123 -9999.0 0.0 -0.507 5.0 5.0 PI3K 0.003 0.113 -9999.0 0.0 -0.452 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.164 -9999.0 0.0 -0.54 8.0 8.0 somite specification -0.095 0.16 -9999.0 0.0 -0.507 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.07 0.141 -9999.0 0.0 -0.493 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.011 0.112 -9999.0 0.0 -0.531 3.0 3.0 SHH Np/Cholesterol/Megalin -0.072 0.196 -9999.0 0.0 -0.414 20.0 20.0 SHH 0.007 0.117 -9999.0 0.0 -0.44 5.0 5.0 catabolic process -0.094 0.163 -9999.0 0.0 -0.602 2.0 2.0 SMO/Vitamin D3 -0.081 0.146 -9999.0 0.0 -0.556 2.0 2.0 SHH Np/Cholesterol/Hhip -0.03 0.152 -9999.0 0.0 -0.488 5.0 5.0 LRP2 -0.127 0.28 -9999.0 0.0 -0.661 19.0 19.0 receptor-mediated endocytosis -0.124 0.195 -9999.0 0.0 -0.523 8.0 8.0 SHH Np/Cholesterol/BOC -0.019 0.17 -9999.0 0.0 -0.506 8.0 8.0 SHH Np/Cholesterol/CDO -0.02 0.152 -9999.0 0.0 -0.448 8.0 8.0 mesenchymal cell differentiation 0.03 0.15 0.483 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.069 0.144 -9999.0 0.0 -0.494 3.0 3.0 IHH N/PTCH2 -0.048 0.137 -9999.0 0.0 -0.38 7.0 7.0 CDON -0.039 0.19 -9999.0 0.0 -0.637 8.0 8.0 IHH N/PTCH1 -0.094 0.165 -9999.0 0.0 -0.607 2.0 2.0 Megalin/LRPAP1 -0.081 0.212 -9999.0 0.0 -0.485 19.0 19.0 PTCH2 0.013 0.072 -9999.0 0.0 -0.661 1.0 1.0 SHH Np/Cholesterol 0.002 0.093 -9999.0 0.0 -0.503 2.0 2.0 PTCH1 -0.094 0.164 -9999.0 0.0 -0.605 2.0 2.0 HHIP -0.061 0.191 -9999.0 0.0 -0.496 14.0 14.0