Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.118 -9999.0 0.0 -0.328 4.0 4.0 epithelial cell differentiation -0.017 0.125 -9999.0 0.0 -0.338 7.0 7.0 CYFIP2 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.006 0.138 -9999.0 0.0 -0.377 2.0 2.0 EGFR -0.096 0.241 -9999.0 0.0 -0.582 17.0 17.0 EPHA2 0.005 0.102 -9999.0 0.0 -0.661 2.0 2.0 MYO6 -0.009 0.136 -9999.0 0.0 -0.666 1.0 1.0 CTNNB1 -0.002 0.102 -9999.0 0.0 -0.468 4.0 4.0 ABI1/Sra1/Nap1 0.032 0.054 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.069 0.151 -9999.0 0.0 -0.682 3.0 3.0 CTNND1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.123 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.091 0.197 -9999.0 0.0 -0.55 7.0 7.0 EGF -0.175 0.263 -9999.0 0.0 -0.516 32.0 32.0 NCKAP1 0.004 0.089 -9999.0 0.0 -0.468 3.0 3.0 AQP3 -0.113 0.212 -9999.0 0.0 -0.647 10.0 10.0 cortical microtubule organization -0.017 0.125 -9999.0 0.0 -0.338 7.0 7.0 GO:0000145 -0.009 0.118 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.128 -9999.0 0.0 -0.341 7.0 7.0 MLLT4 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.076 0.139 -9999.0 0.0 -0.478 6.0 6.0 ARF6 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.007 0.158 -9999.0 0.0 -0.392 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.009 0.135 -9999.0 0.0 -0.405 3.0 3.0 PVRL2 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.008 0.122 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.002 0.146 -9999.0 0.0 -0.675 1.0 1.0 CDH1 -0.072 0.217 -9999.0 0.0 -0.564 14.0 14.0 EGFR/EGFR/EGF/EGF -0.178 0.222 -9999.0 0.0 -0.554 17.0 17.0 RhoA/GDP -0.055 0.106 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.001 0.13 -9999.0 0.0 -0.616 1.0 1.0 IGF-1R heterotetramer 0.013 0.072 -9999.0 0.0 -0.66 1.0 1.0 GIT1 0.013 0.072 -9999.0 0.0 -0.661 1.0 1.0 IGF1R 0.013 0.072 -9999.0 0.0 -0.661 1.0 1.0 IGF1 -0.086 0.229 -9999.0 0.0 -0.564 16.0 16.0 DIAPH1 0.002 0.03 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.017 0.125 0.338 7.0 -9999.0 0.0 7.0 RHOA 0.005 0.102 -9999.0 0.0 -0.661 2.0 2.0 RhoA/GTP -0.082 0.141 -9999.0 0.0 -0.477 6.0 6.0 CTNNA1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.0 0.132 -9999.0 0.0 -0.637 1.0 1.0 EFNA1 -0.057 0.216 -9999.0 0.0 -0.661 10.0 10.0 LPP -0.024 0.158 -9999.0 0.0 -0.547 3.0 3.0 Ephrin A1/EPHA2 -0.088 0.159 -9999.0 0.0 -0.567 5.0 5.0 SEC6/SEC8 -0.056 0.107 -9999.0 0.0 -0.582 1.0 1.0 MGAT3 -0.092 0.2 -9999.0 0.0 -0.562 7.0 7.0 HGF/MET -0.068 0.12 -9999.0 0.0 -0.519 2.0 2.0 HGF -0.019 0.15 -9999.0 0.0 -0.564 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.119 -9999.0 0.0 -0.331 4.0 4.0 actin cable formation 0.028 0.132 -9999.0 0.0 -0.377 1.0 1.0 KIAA1543 -0.007 0.144 -9999.0 0.0 -0.576 2.0 2.0 KIFC3 -0.009 0.136 -9999.0 0.0 -0.666 1.0 1.0 NCK1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 -0.024 0.165 -9999.0 0.0 -0.629 6.0 6.0 ACTN1 -0.036 0.165 -9999.0 0.0 -0.585 3.0 3.0 NCK1/GIT1 0.025 0.055 -9999.0 0.0 -0.485 1.0 1.0 mol:GDP -0.017 0.125 -9999.0 0.0 -0.338 7.0 7.0 EXOC4 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.14 -9999.0 0.0 -0.666 1.0 1.0 PIP5K1C -0.009 0.125 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.015 0.133 -9999.0 0.0 -0.5 6.0 6.0 ABI1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.009 0.158 -9999.0 0.0 -0.407 6.0 6.0 adherens junction assembly 0.008 0.164 -9999.0 0.0 -0.714 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.096 0.169 -9999.0 0.0 -0.505 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.004 0.089 -9999.0 0.0 -0.468 3.0 3.0 PLEKHA7 -0.005 0.121 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.009 0.156 -9999.0 0.0 -0.39 12.0 12.0 establishment of epithelial cell apical/basal polarity 0.006 0.158 -9999.0 0.0 -0.68 2.0 2.0 cortical actin cytoskeleton stabilization -0.013 0.118 -9999.0 0.0 -0.328 4.0 4.0 regulation of cell-cell adhesion 0.001 0.13 -9999.0 0.0 -0.616 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.119 -9999.0 0.0 -0.331 4.0 4.0