Hybridization REF p difference q subclass Composite Element REF p difference q subclass VHL|VHL 1.72554907293698e-10 0.789468694997045 5.01341960380339e-10 1 GYS1|GYS_PS641 1.4936141302252e-13 0.710154610919938 6.69014662496704e-13 1 GAPDH|GAPDH 9.23351602505171e-13 0.648125536496832 3.67630730627059e-12 1 TUBA1B|ACETYL-A-TUBULIN-LYS40 1.7744884147977e-16 0.64669085785955 1.1221029681809e-15 1 PKM2|PKM2 9.76549209905172e-16 0.645883499583161 5.3835405161439e-15 1 LDHA|LDHA 2.44870792757227e-11 0.576739521897211 8.92325770217014e-11 1 BRAF|B-RAF 2.54381676906673e-38 0.542576435515928 5.46920605349347e-36 1 GYS1|GYS 9.57902863202827e-09 0.540832458096591 2.48131464564588e-08 1 CTNNB2|BETA-CATENIN 5.71627211257519e-33 0.534164246113304 3.07249626050916e-31 1 PKC|PKC-PAN_BETAII_PS660 9.58048862561356e-30 0.52489441275579 2.57475631813364e-28 1 ATM|ATM 1.1157521722249e-22 0.510647487578682 1.49929198142721e-21 1 RBM15|RBM15 1.95412247056289e-26 0.502499048064744 4.20136331171021e-25 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.2153128470683e-21 0.428728477391256 1.45162367844269e-20 1 MAPK1|ERK2 2.93942110584448e-23 0.426854863355216 4.21317025171042e-22 1 PRKAA1|AMPK_ALPHA 2.13588793127219e-34 0.421581854678501 1.5307196840784e-32 1 MAPK14|P38 5.01511691880293e-14 0.420271346082681 2.3961114167614e-13 1 MAPK14|P38_PT180_Y182 1.39559655063122e-08 0.413159423563753 3.48899137657805e-08 1 TSC2|TUBERIN 2.49124616314245e-21 0.404856181315999 2.67808962537813e-20 1 AKT1 AKT2 AKT3|AKT 2.24021989725421e-21 0.39986648818535 2.53498567320871e-20 1 RPS6KA1|P90RSK 6.4025861637814e-21 0.399091180067169 6.25707284187728e-20 1 FRAP1|MTOR 1.29389092517452e-26 0.389909811521838 3.09096165458358e-25 1 ERBB2|HER2 6.16853490940392e-17 0.36334340332553 4.27817743716723e-16 1 STAT5A|STAT5-ALPHA 1.57720849099145e-10 0.362425081406834 4.64520308990632e-10 1 PRKCA |PKC-ALPHA_PS657 5.14620624454369e-11 0.360332952233261 1.65139454115954e-10 1 NF2|NF2 2.59860497583447e-20 0.35933130789551 2.42913073828005e-19 1 GSK3A GSK3B|GSK3_PS9 4.64059201294639e-13 0.352797922003988 1.88250430713863e-12 1 PYGL|PYGL 0.00136619849892924 0.336267115423037 0.00216846105513483 1 PDK1|PDK1_PS241 1.1224415214574e-37 0.327889932892947 1.2066246355667e-35 1 PRKAA1|AMPK_PT172 4.07562548646527e-06 0.327721979549781 8.34532837704793e-06 1 AR|AR 2.1670521107884e-16 0.321573919372861 1.33118915377002e-15 1 TGM2|TRANSGLUTAMINASE 0.00159710970031164 0.321287212255158 0.00250641303333579 1 NDRG1|NDRG1_PT346 0.00927433014641408 0.316509607162035 0.0129479284511625 1 TP53BP1|53BP1 8.62708651318376e-14 0.293484065828844 3.94643319220108e-13 1 NFKB1|NF-KB-P65_PS536 2.09736547169306e-06 0.2931420811716 4.50933576414008e-06 1 RPS6|S6 7.39457197447533e-14 0.289167027685845 3.4561586402439e-13 1 PYGB|PYGB 7.83769890013567e-06 0.279535581629649 1.53191387593561e-05 1 PTEN|PTEN 3.90458944125338e-14 0.277599695862681 1.90792438606699e-13 1 ACACA|ACC1 8.93622037449482e-09 0.27663300325287 2.34303339087364e-08 1 ACACA ACACB|ACC_PS79 6.21130401167284e-11 0.259167787349853 1.93540632247777e-10 1 ERBB3|HER3 8.64308203582568e-05 0.241362919228615 0.000154855219808543 1 EGFR|EGFR 1.46044235767791e-15 0.232012156427501 7.84987767251877e-15 1 RPS6KB1|P70S6K 7.37656149841171e-22 0.231512340385534 9.32918071857952e-21 1 LDHB|LDHB 0.00137167769068994 0.222514562951963 0.00216846105513483 1 XRCC5|KU80 5.05994343516602e-11 0.220385658068758 1.64831490691014e-10 1 TSC1|TSC1 1.9949964279415e-11 0.213213855450406 7.39524537943832e-11 1 PXN|PAXILLIN 5.92476445974438e-09 0.205374084782948 1.57262266524079e-08 1 BCL2|BCL-2 4.2910318447781e-05 0.204720846669926 7.8184054798923e-05 1 EEF2K|EEF2K 4.92917389826444e-08 0.199853648667859 1.20428680468961e-07 1 TSC2|TUBERIN_PT1462 6.02794678847221e-10 0.187564553751896 1.70527442042306e-09 1 PIK3R1|PI3K-P85 5.79063353321159e-11 0.187466622996046 1.83086207300072e-10 1 EIF4G1|EIF4G 5.36620579548358e-06 0.184317613291865 1.07635541850649e-05 1 BAD|BAD_PS112 1.17747294502263e-10 0.178322029326419 3.61652404542665e-10 1 MAPK9|JNK2 3.2766110771641e-11 0.177961408221749 1.15487111736112e-10 1 PRKCA |PKC-ALPHA 2.34790944949912e-05 0.175753236724704 4.38956984036792e-05 1 GSK3A GSK3B|GSK3-ALPHA-BETA 2.62033466766319e-11 0.16225615232138 9.38953255912643e-11 1 PDK1|PDK1 6.93163180754997e-15 0.160946862907654 3.63488009420303e-14 1 DIABLO|SMAC 0.00989539721797942 0.159688334515359 0.0137258735604231 1 MAPK14|P38_MAPK 5.40680861389305e-06 0.158954020652614 1.07635541850649e-05 1 MTCO2|MITOCHONDRIA 0.00673236951163829 0.148600981804236 0.00958582413908763 1 FRAP1|MTOR_PS2448 5.17739369199579e-07 0.142922921854875 1.1717259408201e-06 1 AKT1S1|PRAS40_PT246 0.000812229196391562 0.139863416966274 0.00133136076729461 1 NRG1|HEREGULIN 2.5463840396627e-05 0.139398476516884 4.71959110799552e-05 1 SDHB|COMPLEX-II_SUBUNIT30 0.0041589375243023 0.132988550311467 0.00608279978044214 1 EIF4EBP1|4E-BP1_PS65 2.22555069090317e-06 0.131903773123313 4.73755840142754e-06 1 CTNNB1|ALPHA-CATENIN 2.59771005654928e-06 0.127787146047549 5.47556531527544e-06 1 AKT1 AKT2 AKT3|AKT_PT308 0.0319096971811978 0.120043933022316 0.0408368148449853 1 BIRC2 |CIAP 3.61899394521133e-09 0.115010041912334 9.97543202846713e-09 1 EEF2|EEF2 1.61535481778128e-05 0.112221011964532 3.07346270639801e-05 1 PYGB|PYGB-AB2 0.000150424161382295 0.111414933159607 0.000262936542253605 1 PRKCD|PKC-DELTA_PS664 2.27599860337195e-08 0.110990846489128 5.62459424971229e-08 1 KDR|VEGFR2 0.023490804895871 0.110122304737634 0.0306092306218925 1 RAD50|RAD50 1.46582383237544e-07 0.100908410072618 3.4632101534145e-07 1 RPTOR|RAPTOR 0.00339147515549425 0.0919339305144416 0.00506366082243933 1 PARK7|DJ-1 0.000344378912261886 0.0880710009441892 0.00058300367036461 1 PIK3CA |PI3K-P110-ALPHA 9.69367795207677e-05 0.0821298488112168 0.000170831209811189 1 CHEK2|CHK2 0.0025313675654876 0.0805277954557357 0.00385988671333216 1 SMAD3|SMAD3 0.00460307657413142 0.0666865865649831 0.00665505458527614 1 ERCC1|ERCC1 0.00461210759630765 0.064281068368693 0.00665505458527614 1 MSH6|MSH6 0.0102595672373491 0.0615741308294077 0.0141397881796798 1 SCD|SCD 0.0113881922600987 0.0575044198127451 0.0154965907336786 1 RAF1|C-RAF 0.0128146654715354 0.0556545510712346 0.0172197067273757 1 RICTOR|RICTOR_PT1135 0.0398037790433703 -0.0351863512905322 0.0503400734960271 1 CDKN1B|P27_PT157 0.000460169306426751 -0.0471845629844823 0.000761049237551934 1 STK11|LKB1 0.00534172427878124 -0.047593650057963 0.00765647146625311 1 YWHAE|14-3-3_EPSILON 0.00245920049661787 -0.052059574991844 0.00377662933409173 1 XRCC1|XRCC1 0.000253142654754463 -0.0527663907887558 0.000431949768033409 1 CCNE2|CYCLIN_E2 0.0170327393780396 -0.0548060946992023 0.0226051788041884 1 ARID1A|ARID1A 0.00915297263841231 -0.0590658993217975 0.0128620203742395 1 EIF4EBP1|4E-BP1_PT70 0.0107557177115156 -0.061918416049918 0.0147291675667252 1 GYG1|GYG-GLYCOGENIN1 0.0173177099647929 -0.0642561407670455 0.0228423781744201 1 EGFR|EGFR_PY1173 0.000431434682719705 -0.0685860918357616 0.000719057804532842 1 PCNA|PCNA 9.69221401546165e-05 -0.0727670895844549 0.000170831209811189 1 RB1|RB_PS807_S811 0.0370769410156487 -0.0763804229835087 0.0471688894577779 1 FOXO3|FOXO3A_PS318_S321 5.08868276258657e-07 -0.0808437502039849 1.16390084463416e-06 1 PARP1|PARP_CLEAVED 0.000157297192697347 -0.0825506916859477 0.000272733035725239 1 CASP8|CASPASE-8 0.00392022533064926 -0.0827132212264706 0.00581274790406614 1 RAB11A RAB11B|RAB11 0.0122454073001487 -0.0839144870596539 0.0165582551542891 1 ARHI|ARHI 0.00314382431842439 -0.085780016889007 0.00476001569338904 1 CDH3|P-CADHERIN 0.00689604774898926 -0.086054182439492 0.00975427806600455 1 ERRFI1|MIG-6 0.0262451968963986 -0.0887538475947716 0.0337887265432677 1 ASNS|ASNS 0.0237830193966463 -0.0906040220211885 0.0308033082546925 1 PREX1|PREX1 0.00188178862845039 -0.0955487767838537 0.00291068025263909 1 EIF4E|EIF4E 3.64392028103414e-05 -0.0963599121607198 6.69609282412256e-05 1 NRAS|N-RAS 6.38298792680263e-08 -0.0972173248710501 1.54195775759839e-07 1 RAB25|RAB25 0.00397295957025967 -0.0973993466324514 0.00585059114798513 1 YWHAB|14-3-3_BETA 1.19163861504242e-08 -0.0998242907729904 3.05002740754905e-08 1 ERBB3|HER3_PY1289 1.58209463911819e-07 -0.100963348011453 3.69728638489577e-07 1 C12ORF5|TIGAR 1.14453291112684e-06 -0.107469956014834 2.51096506012521e-06 1 BID|BID 4.26094132121017e-09 -0.11094252574971 1.15962327096226e-08 1 CCNE1|CYCLIN_E1 3.36085857073538e-07 -0.112376995564146 7.76972680331298e-07 1 MAP2K1|MEK1 0.0158844275951066 -0.112725552794187 0.0212121238071299 1 MET|C-MET_PY1235 3.10713822294398e-13 -0.115468569816034 1.33606943586591e-12 1 PRDX1|PRDX1 1.41131373720003e-05 -0.122857564525732 2.70921833480363e-05 1 ITGA2|CD49B 1.30460191442686e-10 -0.123625274201303 3.89568627224687e-10 1 CDKN1B|P27_PT198 9.45393698201762e-17 -0.126815772020283 6.35186390979309e-16 1 CCND1|CYCLIN_D1 1.75074332658363e-05 -0.12689574913544 3.30184048434632e-05 1 MS4A1|CD20 9.88697534917073e-13 -0.13074747376059 3.86490854558492e-12 1 SHC1|SHC_PY317 3.57255347282646e-06 -0.137011921603363 7.3855672755547e-06 1 JUN|C-JUN_PS73 5.92105717395519e-09 -0.139320041034631 1.57262266524079e-08 1 STAT3|STAT3_PY705 0.00187239721436442 -0.143311049230528 0.00291068025263909 1 MAPK8|JNK_PT183_PY185 4.44294169136283e-06 -0.14734140710116 9.01162701550008e-06 1 IRS1|IRS1 4.78355019630913e-11 -0.147413678795571 1.6069738940726e-10 1 NOTCH1|NOTCH1 1.43663954694465e-12 -0.153026405599862 5.5156696891625e-12 1 BAK1|BAK 3.8398340671306e-13 -0.153062864277141 1.58762370083284e-12 1 RPS6|S6_PS240_S244 0.00324021501431781 -0.154960584045904 0.0048716519446037 1 ETS1|ETS-1 4.9575095131073e-11 -0.167309664177134 1.63979160818165e-10 1 INPP4B|INPP4B 5.34215136109724e-07 -0.167759193526227 1.19641931524574e-06 1 SNAI1|SNAIL 8.06979510732921e-07 -0.168175356408824 1.78866592585132e-06 1 CDKN1A|P21 0.000231767262552927 -0.17063783297285 0.000398639691591034 1 YAP1|YAP 9.61943777602656e-12 -0.170937205460262 3.62838442429072e-11 1 COL6A1|COLLAGEN_VI 7.15110229633318e-05 -0.175856183185265 0.00012920058770686 1 BRCA2|BRCA2 5.20987654166625e-21 -0.177578802156393 5.33392122122973e-20 1 SETD2|SETD2 4.53368807027022e-11 -0.180798970158497 1.54721100810809e-10 1 FOXO3|FOXO3A 7.71107127431866e-20 -0.182222109194437 6.9078346832438e-19 1 ESR1|ER-ALPHA 5.65932220706586e-06 -0.18422006483554 1.11628832524694e-05 1 PECAM1|CD31 3.45432260541166e-13 -0.185137096340408 1.45623403953629e-12 1 CHEK2|CHK2_PT68 1.75220373895174e-16 -0.185371116909584 1.1221029681809e-15 1 MRE11A|MRE11 2.15419426282855e-31 -0.185645208065496 7.71919610846897e-30 1 RAF1|C-RAF_PS338 1.74967176367706e-19 -0.186573035722979 1.44684395842526e-18 1 FOXM1|FOXM1 2.91887850051645e-14 -0.193985079030634 1.45943925025823e-13 1 HIF1A|HIF-1_ALPHA 0.000817393587362272 -0.195988759194731 0.00133136076729461 1 CHEK1|CHK1 4.01090390936301e-16 -0.197487352887755 2.39540094586958e-15 1 RPS6KB1|P70S6K_PT389 1.15304918070921e-14 -0.200832306297467 5.90251366315429e-14 1 RPS6|S6_PS235_S236 0.000885673982669924 -0.20685196989486 0.00143172861860176 1 SCD1|SCD1 5.14631734028238e-10 -0.213057476295254 1.47527763754762e-09 1 TP53|P53 3.08343692985281e-13 -0.215097513917783 1.33606943586591e-12 1 CCNB1|CYCLIN_B1 1.26881173612994e-06 -0.217576784722791 2.75550023502967e-06 1 TTF1|TTF1 0.000412763787971727 -0.218123703541152 0.00069331417510876 1 STMN1|STATHMIN 1.4117834990678e-31 -0.220811685881213 6.07066904599154e-30 1 MYC|C-MYC 2.29178348129733e-18 -0.22665040257243 1.75976231599616e-17 1 PGR|PR 1.15075906746536e-07 -0.226735913638498 2.74903555005614e-07 1 SRC|SRC_PY416 1.23913046518587e-05 -0.226816231477325 2.40011756770236e-05 1 CAV1|CAVEOLIN-1 0.00131441154505547 -0.238584357469622 0.00210894389691736 1 CASP7|CASPASE-7_CLEAVEDD198 4.3942507519954e-11 -0.239177822330535 1.5238127607726e-10 1 LCK|LCK 1.22853057933367e-10 -0.247015347531403 3.72019823319351e-10 1 CA9|CA9 0.02158302097292 -0.249543363880682 0.0282948140803524 1 RB1|RB 3.96162239629571e-26 -0.251969313327778 7.09790679336315e-25 1 CDC2|CDK1 8.2184884539675e-19 -0.254245281445795 6.5443519170482e-18 1 RICTOR|RICTOR 6.64557796250741e-10 -0.261570638667603 1.85558345706376e-09 1 G6PD|G6PD 2.65649131727331e-06 -0.284839427074685 5.54510323508506e-06 1 XBP1|XBP1 3.78909082658609e-25 -0.289689098138652 5.81896091225721e-24 1 GATA3|GATA3 2.86200566047213e-18 -0.338191006750529 2.12183178276382e-17 1 KIT|C-KIT 4.2989592299788e-16 -0.369129130037381 2.49804387687957e-15 1 RAD51|RAD51 8.63095785458608e-31 -0.41050339430874 2.65093705533715e-29 1 MAPK1 MAPK3|MAPK_PT202_Y204 1.35714546630941e-08 -0.445810797629719 3.43277970890027e-08 1 IGFBP2|IGFBP2 2.34887390307707e-26 -0.467114370492322 4.59098081055973e-25 1 FN1|FIBRONECTIN 4.41478908293754e-17 -0.617098947244825 3.16393217610524e-16 1 HSPA1A|HSP70 1.60410790451886e-19 -0.705172268054701 1.37953279788622e-18 1 SERPINE1|PAI-1 1.32967035487673e-25 -0.781392982806656 2.19907020229613e-24 1 MYH11|MYH11 6.12597366994015e-16 -1.10676374398906 3.46601141851877e-15 1 GATA3|GATA3 7.01206555724325e-10 1.07042453378718 2.56210087668503e-09 2 TP53|P53 4.22427595454795e-20 0.797854435372488 2.6753747712137e-18 2 MYH11|MYH11 0.000268138043396823 0.709972444018504 0.000461870810690968 2 EGFR|EGFR_PY1068 1.03487147534293e-18 0.69068862574907 2.8089368616451e-17 2 FOXM1|FOXM1 1.07855111740497e-15 0.651343178029725 2.27694124785494e-14 2 ARHI|ARHI 1.84339054973972e-19 0.650670216013646 8.75610511126367e-18 2 FOXO3|FOXO3A 2.68964563517029e-21 0.614328356666622 2.55516335341178e-19 2 CHEK1|CHK1 8.01030741117488e-19 0.599499501186277 2.53659734687205e-17 2 ESR1|ER-ALPHA 5.67632923508545e-14 0.542230773067707 6.34413267450727e-13 2 PECAM1|CD31 1.81612210669319e-15 0.524162607861465 3.13693818428824e-14 2 CDC2|CDK1 8.35382475412901e-13 0.520820678910668 6.6134445970188e-12 2 RPS6KB1|P70S6K_PT389 5.45164510561773e-16 0.480301152271713 1.29476571258421e-14 2 CCNB1|CYCLIN_B1 4.25642585497838e-09 0.437271848756175 1.34786818740982e-08 2 CDH3|P-CADHERIN 1.19878632261074e-12 0.436532590351439 8.13462147485859e-12 2 SCD1|SCD1 2.9842008161215e-12 0.429377008080396 1.95516605194167e-11 2 SQSTM1|P62-LCK-LIGAND 3.47480812681929e-10 0.429372038298207 1.46714120910148e-09 2 SHC1|SHC_PY317 3.17909392118892e-19 0.424790533475078 1.20805569005179e-17 2 XBP1|XBP1 1.13031846299965e-10 0.405254150985082 5.36901269924834e-10 2 MYC|C-MYC 4.20510406764852e-07 0.377514930777114 1.06529303047096e-06 2 INPP4B|INPP4B 3.5647132451745e-09 0.377143336435303 1.14795850268331e-08 2 MAPK1 MAPK3|MAPK_PT202_Y204 1.15343467296116e-09 0.363667735279305 3.9845925065931e-09 2 RAB25|RAB25 2.99643236771403e-06 0.339985608026051 6.54393275707662e-06 2 MSH2|MSH2 7.18481858710616e-10 0.329573513657725 2.57568968217013e-09 2 JUN|C-JUN_PS73 1.09254384337334e-12 0.320600534541589 7.68827149040498e-12 2 NRAS|N-RAS 5.80631557287272e-10 0.313981452456264 2.20639991769163e-09 2 RPS6KA1|P90RSK_PT359_S363 4.4335513910142e-13 0.312446703065471 4.21187382146349e-12 2 RAD51|RAD51 1.40646572206051e-06 0.310518313626405 3.25888399014021e-06 2 NOTCH1|NOTCH1 1.19388554080096e-10 0.293703894769146 5.53264031102884e-10 2 VHL|VHL 0.000650158327749266 0.289152103020524 0.00106491450234794 2 SMAD4|SMAD4 3.68206278133493e-13 0.278853183519633 3.68206278133493e-12 2 MAPK8|JNK_PT183_PY185 3.5806630789257e-12 0.258677234571372 2.26775328331961e-11 2 BAK1|BAK 1.58216742620477e-08 0.257463661889398 4.55472440877131e-08 2 IGFBP2|IGFBP2 7.78222076190078e-09 0.249776114186565 2.38487410445346e-08 2 SRC|SRC_PY416 2.73660703903092e-06 0.246566703818681 6.11712161665735e-06 2 CDH1|E-CADHERIN 0.0208567683059362 0.244893385807016 0.0283056141294848 2 BECN1|BECLIN 1.44869064899379e-13 0.239390264413989 1.52917346282678e-12 2 TTF1|TTF1 0.001755109423355 0.231053052678585 0.00275595694576405 2 PREX1|PREX1 1.44954941022571e-08 0.230161648911532 4.23714442989054e-08 2 MAP2K1|MEK1 0.00252257322805467 0.223134208680434 0.00389665783195437 2 CHEK2|CHK2_PT68 1.40463268692644e-06 0.206656556282603 3.25888399014021e-06 2 EIF4G1|EIF4G 0.000544292943717734 0.195341482264188 0.000907154906196223 2 RB1|RB_PS807_S811 0.000307777427366122 0.195227478818725 0.000522122421424671 2 PGR|PR 2.91600183163032e-10 0.194156600728619 1.28846592560409e-09 2 BRCA2|BRCA2 4.52158198287817e-11 0.1914478370265 2.45457307641958e-10 2 RPS6|S6_PS240_S244 0.0117026259326661 0.18741158059046 0.0164703624237523 2 ERBB2|HER2_PY1248 4.46415487950228e-07 0.174693595081098 1.10154471052654e-06 2 PRDX1|PRDX1 2.91922041235621e-06 0.174686830641434 6.44944044590325e-06 2 XRCC1|XRCC1 5.99012695524602e-13 0.156445706292209 5.41963867379402e-12 2 SFRS1|SF2 2.72428471894353e-05 0.150702802232669 5.28177649591093e-05 2 ITGA2|CD49B 4.28669952818768e-07 0.148222449896547 1.07167488204692e-06 2 BAP1|BAP1-C-4 3.89090230718635e-06 0.131753277883406 8.30642065579108e-06 2 FASN|FASN 0.00512229322425968 0.128639143814188 0.00766327332763259 2 PRKCA |PKC-ALPHA 0.00768343091285473 0.12305869539938 0.0112296297957108 2 PRKCD|PKC-DELTA_PS664 0.00122273425719678 0.110349607355666 0.00193599590722823 2 EIF4EBP1|4E-BP1 0.00939601246268335 0.10617504894398 0.0135245633932563 2 ADAR|ADAR1 7.33778089204572e-05 0.097897152594929 0.000132778892332256 2 CHEK1|CHK1_PS345 6.61001466716425e-05 0.0905100579149624 0.000121932309394292 2 CDKN1B|P27_PT198 0.00109005160017045 0.0879224606447986 0.00174041852128055 2 CDKN1B|P27_PT157 0.0135173612543926 0.0816755095150067 0.0187467053893036 2 PCNA|PCNA 0.0033568304359097 0.0815258614513945 0.00514353050663583 2 FOXO3|FOXO3A_PS318_S321 2.60261340760659e-05 0.075733277269035 5.09790255098198e-05 2 YWHAB|14-3-3_BETA 0.000848367850877074 0.0665321561237714 0.00137769138176619 2 MS4A1|CD20 0.00865063735739002 0.0638332552279106 0.0125467259381993 2 PIK3CA |PI3K-P110-ALPHA 0.0106965943476889 0.0603556060708942 0.0151668128810514 2 CCNE2|CYCLIN_E2 0.000608774334750959 0.0603159057414121 0.00100580107480593 2 IRS1|IRS1 0.0370995674114943 0.0486182270250996 0.0486132262633374 2 EGFR|EGFR_PY1173 7.86417891514343e-05 -0.0736555254476981 0.00014096169753559 2 CDH2|N-CADHERIN 0.00214944534341542 -0.0792740559717795 0.0033474968463027 2 CHEK2|CHK2 0.0274034299344314 -0.0829341828652058 0.0369266077130636 2 TSC2|TUBERIN_PT1462 0.0104592847298315 -0.0834317380627269 0.0149418353283307 2 ERBB3|HER3_PY1289 0.000269829789403671 -0.0937625795655157 0.000461870810690968 2 MET|C-MET_PY1235 1.29275723730237e-07 -0.0974943509630589 3.45949119841479e-07 2 RPS6KA1|P90RSK 0.0348013389114989 -0.100810111965449 0.0459184332860055 2 BIRC2 |CIAP 2.70224245600496e-06 -0.101006597814785 6.11221507905884e-06 2 YAP1|YAP 4.96086721757718e-05 -0.101779869047919 9.24083109156534e-05 2 XRCC5|KU80 0.00687952752090091 -0.106869489181319 0.0101326374338851 2 YWHAE|14-3-3_EPSILON 0.0150720324777751 -0.117681195640992 0.0207513490636034 2 EIF4EBP1|4E-BP1_PT70 1.66550093713386e-07 -0.129696170270407 4.33486545281416e-07 2 TP53BP1|53BP1 0.0486344879554486 -0.131883364901062 0.0632914569283235 2 SMAD1|SMAD1 4.02485623898613e-10 -0.139010186156596 1.62706954341993e-09 2 PDK1|PDK1 1.27838925904174e-07 -0.140933437647012 3.45949119841479e-07 2 BCL2|BCL-2 0.0036458011762562 -0.146487516046525 0.00554161778790942 2 MAP2K1|MEK1_PS217_S221 5.10175011905629e-12 -0.146564302490903 3.12687910522805e-11 2 ANXA1|ANNEXIN-1 0.0178449302055424 -0.147229937813692 0.0243923506406695 2 AKT1S1|PRAS40_PT246 0.000876477436720988 -0.153576909848406 0.00141127722861854 2 STK11|LKB1 4.72570399635628e-05 -0.157755666556485 8.88993821096726e-05 2 YBX1|YB-1_PS102 7.52314269505139e-09 -0.161433161363081 2.34327395419633e-08 2 RBM15|RBM15 0.0285934908305787 -0.165155044000509 0.0382588961817602 2 RAD50|RAD50 3.30863992277141e-05 -0.170815151475653 6.28641585326568e-05 2 PARK7|DJ-1 4.47941438969959e-10 -0.206576316168083 1.77310152925609e-09 2 WWTR1|TAZ 1.31663319804808e-09 -0.206686001806972 4.46714835052027e-09 2 AR|AR 9.30179287740232e-06 -0.207662810469854 1.92102244207222e-05 2 LCK|LCK 1.33230258079893e-05 -0.208672471550465 2.69295202501911e-05 2 RICTOR|RICTOR_PT1135 9.73533078694599e-11 -0.214111880633466 4.74285346030702e-10 2 EGFR|EGFR 2.74650151974872e-15 -0.215257705866268 4.34862740626881e-14 2 GSK3A GSK3B|GSK3_PS9 0.0130113617006251 -0.218195487765073 0.0181776376699909 2 SMAD3|SMAD3 5.7091206097431e-07 -0.218498324385746 1.39068322545024e-06 2 BAD|BAD_PS112 7.08975899011478e-07 -0.224500705406684 1.70513190901495e-06 2 EIF4EBP1|4E-BP1_PS65 8.83054352236356e-11 -0.227346593119987 4.41527176118178e-10 2 RAF1|C-RAF 4.43494833781334e-11 -0.233311462531208 2.45457307641958e-10 2 YBX1|YB-1 0.000190195645388326 -0.23739491597189 0.000334603450220203 2 CLDN7|CLAUDIN-7 0.0299750244670185 -0.24350979920799 0.0398269555855491 2 BRAF|B-RAF 1.51436254532095e-05 -0.246401136239509 3.0287250906419e-05 2 FN1|FIBRONECTIN 0.00527469464374788 -0.264291253745861 0.00782962486181326 2 NF2|NF2 0.000249139073364194 -0.271104283629969 0.000434279118708228 2 PKC|PKC-PAN_BETAII_PS660 6.81114195494376e-05 -0.273293963221647 0.000124434324176857 2 MAPK14|P38 1.67688753054132e-05 -0.276285999982378 3.31883990419636e-05 2 PDK1|PDK1_PS241 3.39024793921637e-10 -0.280629197912926 1.46397070102525e-09 2 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0050697502082196 -0.287442038866128 0.00764486142509305 2 ERBB2|HER2 4.49850297365797e-06 -0.288661725038822 9.49683961105571e-06 2 COL6A1|COLLAGEN_VI 1.88840699963414e-06 -0.288741887781496 4.32285939675285e-06 2 EEF2|EEF2 5.09739851013152e-10 -0.289064326544555 1.97654227943875e-09 2 PDCD4|PDCD4 0.000458556142329556 -0.291505317793891 0.000771023602147041 2 BID|BID 6.25643838466374e-15 -0.297236007906574 9.14402533143162e-14 2 CCND1|CYCLIN_D1 1.25662837675281e-10 -0.297278688897698 5.68474741864366e-10 2 CTNNB2|BETA-CATENIN 3.28500033040695e-06 -0.305923356594533 7.09261434974228e-06 2 TSC1|TSC1 3.94632302289141e-10 -0.314841841002236 1.62706954341993e-09 2 BAX|BAX 2.02134226635021e-09 -0.316307847345463 6.62163845873345e-09 2 SRC|SRC 2.16056882132529e-14 -0.318662700269013 2.93220054322718e-13 2 C12ORF5|TIGAR 7.24601113578245e-13 -0.323323985232514 5.98583528608115e-12 2 RPS6|S6 6.40422927121211e-12 -0.323741588174989 3.80251112978219e-11 2 MAPK14|P38_PT180_Y182 7.47499610094817e-06 -0.335895326648694 1.56071347162654e-05 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.10356720492242e-05 -0.344353827087251 2.25459966597054e-05 2 PEA15|PEA15 3.9079852196353e-14 -0.350393056721071 4.64073244831692e-13 2 GSK3A GSK3B|GSK3-ALPHA-BETA 1.72028024873985e-15 -0.355597895153608 3.13693818428824e-14 2 BCL2L1|BCL-XL 1.39009559744646e-09 -0.358961792192784 4.6336519914882e-09 2 KDR|VEGFR2 4.52784824878229e-08 -0.361109083287096 1.2651340695127e-07 2 PEA15|PEA15_PS116 3.2934378784285e-05 -0.379108292327379 6.28641585326568e-05 2 PRKAA1|AMPK_ALPHA 8.83665084346778e-10 -0.381676387671846 3.10919196344237e-09 2 AKT1 AKT2 AKT3|AKT_PT308 1.3873319693012e-07 -0.402805160466357 3.66101491898928e-07 2 TFRC|TFRC 1.66758555074119e-08 -0.408649872511244 4.72897394986308e-08 2 ACACA|ACC1 1.27195376325488e-08 -0.412221762352612 3.83605103203853e-08 2 ATM|ATM 2.54084921130316e-07 -0.418439059942475 6.52380202902163e-07 2 PIK3R1|PI3K-P85 1.00683055189168e-12 -0.421617581406529 7.58844411692484e-12 2 CAV1|CAVEOLIN-1 0.000108435956794143 -0.422403063081895 0.000192549829821375 2 MAPK1|ERK2 6.3584992706356e-13 -0.43473026891691 5.4914311882762e-12 2 FRAP1|MTOR 7.45361320135399e-11 -0.436072248431563 3.82753110339799e-10 2 TGM2|TRANSGLUTAMINASE 6.89770699840293e-12 -0.437927363841611 3.97140705968654e-11 2 YAP1|YAP_PS127 6.39521117028416e-11 -0.438976600281386 3.3752503398722e-10 2 AKT1 AKT2 AKT3|AKT 9.76243000794633e-08 -0.465750914093006 2.68820536450696e-07 2 RPTOR|RAPTOR 2.75009903419025e-14 -0.475868749610115 3.48345877664098e-13 2 EIF4EBP1|4E-BP1_PT37_T46 6.27442963951999e-10 -0.477793243784661 2.33753261080157e-09 2 YWHAZ|14-3-3_ZETA 1.53982051111807e-21 -0.52382068339232 2.55516335341178e-19 2 CDKN1A|P21 9.24380421813666e-07 -0.539744642136808 2.19540350180746e-06 2 SYK|SYK 1.4289526119457e-08 -0.575199695296459 4.23714442989054e-08 2 GAPDH|GAPDH 1.03841866863182e-12 -0.744323805830633 7.58844411692484e-12 2 SERPINE1|PAI-1 2.43586808375938e-06 0.845112480815057 1.00713776540051e-05 3 TFRC|TFRC 2.77880048742446e-12 0.719144311036328 3.73401315497662e-11 3 DIABLO|SMAC 4.34623153312403e-08 0.560271231782026 2.27912141371138e-07 3 CA9|CA9 0.000612498578570994 0.549208072373591 0.00146319104880849 3 MTCO2|MITOCHONDRIA 7.09825887087329e-06 0.481909980249195 2.59488470422234e-05 3 G6PD|G6PD 4.19651031859115e-07 0.427540363773678 1.84132595611652e-06 3 CCNB1|CYCLIN_B1 0.000276280770233154 0.423203998356738 0.000724394702440587 3 SDHB|COMPLEX-II_SUBUNIT30 7.13093582805283e-06 0.392776072751208 2.59488470422234e-05 3 LDHB|LDHB 0.000786681206962028 0.370310941714976 0.00185864241205314 3 GYG1|GYG-GLYCOGENIN1 7.04483558813901e-09 0.368287450491143 4.7332489107809e-08 3 KIT|C-KIT 0.00242586786034954 0.363545525280552 0.00511334892132501 3 FN1|FIBRONECTIN 0.00113525165327074 0.351918541004597 0.00256925374161273 3 YWHAZ|14-3-3_ZETA 7.47845903683194e-06 0.323981510237824 2.63585031626044e-05 3 IGFBP2|IGFBP2 0.000845433851382037 0.31402741589171 0.00197574215268628 3 BCL2L1|BCL-XL 4.75122956706534e-20 0.306483493521484 5.10757178459524e-18 3 BAX|BAX 5.48476350230984e-09 0.289760563873941 3.93074717665539e-08 3 CDKN1A|P21 7.07475198783847e-07 0.286631569496551 3.04214335477054e-06 3 YAP1|YAP 2.5192257494865e-06 0.2710979915967 1.02195006818792e-05 3 HSPA1A|HSP70 0.0256279625112028 0.258062343661082 0.0420611598466306 3 PEA15|PEA15 9.29519929552508e-07 0.252566244751936 3.91856440889783e-06 3 EEF2|EEF2 5.82191305533557e-08 0.249389734665218 2.98026501642178e-07 3 CCNE1|CYCLIN_E1 7.89279947074505e-10 0.24381982006396 6.78780754484074e-09 3 YBX1|YB-1_PS102 0.000211794240129406 0.24285797493686 0.000569197020347779 3 CASP7|CASPASE-7_CLEAVEDD198 5.13695422419748e-06 0.24190934315832 2.00808210582265e-05 3 TTF1|TTF1 0.0206869390281225 0.238612206331841 0.0344782317135375 3 PEA15|PEA15_PS116 0.00105686611275944 0.229073783162885 0.00241730015152425 3 C12ORF5|TIGAR 1.23250452426332e-12 0.227079076406012 2.03837286705088e-11 3 PCNA|PCNA 3.33925971781351e-12 0.211306967355603 4.22318140782297e-11 3 PARK7|DJ-1 2.78230301205945e-07 0.210031402403654 1.27275563317613e-06 3 PGR|PR 0.00673987322933606 0.207116781097444 0.0127111644237478 3 ESR1|ER-ALPHA_PS118 0.000225722130341879 0.201061364522695 0.000599138987944494 3 RAD51|RAD51 5.19974335453008e-05 0.199733370557604 0.000157457017073798 3 PRDX1|PRDX1 8.1558602393927e-06 0.199719180576571 2.82824185720876e-05 3 STMN1|STATHMIN 7.17404616904173e-10 0.190076357411006 6.42674969309988e-09 3 YBX1|YB-1 0.00784257498059229 0.188601795332398 0.0145358070760978 3 ACVRL1|ACVRL1 9.74048813693932e-05 0.188167473247396 0.000283000668843507 3 YWHAB|14-3-3_BETA 2.32858532568126e-05 0.187216110423769 7.47232604509658e-05 3 ATP5A1|OXPHOS-COMPLEX-V_SUBUNITB 0.000604539066787599 0.185158486696457 0.00146040336358802 3 MET|C-MET_PY1235 7.00018502526147e-12 0.184570941872099 7.92126200226956e-11 3 LCK|LCK 0.0022965050546466 0.180470199909177 0.00488859986880217 3 SRC|SRC 9.35405295716602e-06 0.172753123328804 3.19225616792174e-05 3 YWHAE|14-3-3_EPSILON 1.75179808378484e-08 0.169125989621898 1.07610453718212e-07 3 ASNS|ASNS 0.0156938700919281 0.164307017836585 0.0274323745509312 3 MET|C-MET 0.000351023890501621 0.163110319814099 0.00088788395832763 3 CCND1|CYCLIN_D1 1.55345926484447e-05 0.158928629027828 5.1383652606394e-05 3 EIF4EBP1|4E-BP1_PT70 5.36714144360426e-05 0.156367781937806 0.000160268806996516 3 ITGA2|CD49B 7.2415387094577e-06 0.146166182348289 2.59488470422234e-05 3 WWTR1|TAZ 0.000296392012882063 0.142691669218679 0.000767762443007753 3 XBP1|XBP1 0.000181114828733219 0.142599812683985 0.000492907445286609 3 IRS1|IRS1 3.84821596482719e-05 0.140100963694099 0.000119908178614181 3 BID|BID 3.37638914186057e-06 0.138994826412444 1.3443030842593e-05 3 SNAI1|SNAIL 0.00203080865465976 0.135224631212342 0.00441034202779645 3 SETD2|SETD2 0.00497546082699494 0.129685989122995 0.0096371538540893 3 STK11|LKB1 3.31748108076462e-08 0.12792236820946 1.83097721259173e-07 3 CHEK2|CHK2 0.0108489826548658 0.124254505200153 0.0197672141592894 3 CCNE2|CYCLIN_E2 5.63313687093779e-06 0.123818479946621 2.16272219152076e-05 3 BRCA2|BRCA2 0.00116945989790701 0.114438852782811 0.00261910289635424 3 BCL2L11|BIM 0.00661214883064346 0.114211372950203 0.0125806371556491 3 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0123206400703266 0.108452171515317 0.0222599799589934 3 CDKN1B|P27_PT198 0.000356458051714973 0.106815089969839 0.000891145129287433 3 MS4A1|CD20 1.7084521439366e-05 0.102047065876539 5.5654122870662e-05 3 SFRS1|SF2 0.00207003302370831 0.0955263520542362 0.00445057100097287 3 CDC2|CDK1 0.0311635711254917 0.0935039649979001 0.050377201443464 3 MRE11A|MRE11 0.000587783452198215 0.0932920298875864 0.00143606184343882 3 CHEK2|CHK2_PT68 0.0186636323145771 0.0877980647501702 0.031846674187572 3 BAK1|BAK 0.00324063761551768 0.0870319802245434 0.00669939507054136 3 EIF4E|EIF4E 0.0158527434771813 0.0847054016562768 0.027486611674145 3 FOXO3|FOXO3A_PS318_S321 0.00469369689872017 0.0841887864309577 0.0091740439384076 3 ETS1|ETS-1 0.0194676716216572 0.0833493732901239 0.0326996046770023 3 XRCC1|XRCC1 0.0124843352397948 0.0760773683606101 0.0223677673046324 3 PDK1|PDK1 0.0453990039931612 -0.0616162261028792 0.0717704842538945 3 NOTCH1|NOTCH1 0.0254397010833789 -0.0677561825110036 0.0420611598466306 3 BIRC2 |CIAP 0.0128784172518395 -0.0680143501394277 0.0228831380921115 3 JUN|C-JUN_PS73 0.0190013373046889 -0.0949328707751161 0.0321676182717174 3 MAP2K1|MEK1_PS217_S221 0.00337012376972459 -0.0995841543501677 0.00686621119702466 3 RAD50|RAD50 0.00424739251084267 -0.100860466146995 0.00846068488681855 3 PREX1|PREX1 0.00879705461280635 -0.113886560695398 0.0161655277072937 3 FRAP1|MTOR 0.00425001845477397 -0.143582324497787 0.00846068488681855 3 PDCD4|PDCD4 0.0276906148341098 -0.144294025918813 0.0451021377979819 3 RICTOR|RICTOR 0.0452991516244245 -0.146532674859261 0.0717704842538945 3 BAD|BAD_PS112 0.00056082666186673 -0.147510582483775 0.00138595094599249 3 RPS6KB1|P70S6K 0.000125240893889094 -0.167498202519088 0.000354299897186253 3 BRAF|B-RAF 0.00659453961616477 -0.173166623657084 0.0125806371556491 3 MAP2K1|MEK1 0.00263450760997924 -0.19425110418995 0.00549921491403434 3 XRCC5|KU80 0.00144104555720215 -0.203591141005442 0.00319407004946868 3 PRKCA |PKC-ALPHA 0.00184728370746181 -0.205763717812837 0.00405271425616622 3 ERBB2|HER2_PY1248 3.68125342169504e-10 -0.206799546366891 3.65710584096799e-09 3 NF2|NF2 0.000316165278233594 -0.207870081164235 0.000809232557383604 3 TSC2|TUBERIN_PT1462 1.99266180534159e-08 -0.208240573717468 1.19006191152345e-07 3 BCL2|BCL-2 0.00734678901867317 -0.211730280249918 0.0137353012088238 3 EIF4G1|EIF4G 0.00466217017218096 -0.21995764054899 0.0091740439384076 3 RPS6KA1|P90RSK_PT359_S363 1.68420211174997e-09 -0.236844814547388 1.36828466133666e-08 3 SHC1|SHC_PY317 3.32130750191058e-08 -0.244523806303908 1.83097721259173e-07 3 MAPK9|JNK2 8.26487172571147e-11 -0.24872769141431 8.88473710513983e-10 3 RPS6KA1|P90RSK 3.70204154512292e-08 -0.255651333274876 1.98984733050357e-07 3 ERRFI1|MIG-6 1.45189505096735e-08 -0.259855001367219 9.18110105758765e-08 3 LDHA|LDHA 0.0356967933572305 -0.262630193261272 0.0572747057597355 3 PRKAA1|AMPK_ALPHA 1.02511198382096e-07 -0.263083344398117 5.00906992094333e-07 3 MAPK14|P38_MAPK 2.57507588886878e-05 -0.265955342247757 8.14178406039394e-05 3 ERBB2|HER2 5.91640535243181e-06 -0.27064123368657 2.23162658030323e-05 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0165436508236862 -0.271634505856125 0.0284550794167403 3 PXN|PAXILLIN 0.000117924435203202 -0.272941663854405 0.000338050047582512 3 SRC|SRC_PY416 4.57751675142857e-05 -0.275433174276894 0.000140595157365306 3 PDK1|PDK1_PS241 3.74215481401376e-10 -0.278069629623524 3.65710584096799e-09 3 FRAP1|MTOR_PS2448 2.885112498014e-09 -0.289858198098894 2.21535423954646e-08 3 AR|AR 2.80457112021953e-13 -0.33240500031145 5.48166173497454e-12 3 PKM2|PKM2 0.0145050096698423 -0.336586062995572 0.02556210720505 3 TSC1|TSC1 6.51130832684016e-08 -0.341408196030489 3.25565416342008e-07 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 2.94989755417696e-07 -0.343876715180617 1.3213082794751e-06 3 PRKCA |PKC-ALPHA_PS657 7.66368206427168e-05 -0.346799883177754 0.000225711184084714 3 GSK3A GSK3B|GSK3_PS9 1.35693600491442e-07 -0.385808142504193 6.34220089253479e-07 3 HIF1A|HIF-1_ALPHA 0.000955145667067504 -0.403545320228663 0.0022081324561238 3 PKC|PKC-PAN_BETAII_PS660 3.1465556584041e-08 -0.406895353140109 1.82840396366725e-07 3 STAT5A|STAT5-ALPHA 1.212765528644e-07 -0.415026563499414 5.79432419241022e-07 3 GYS1|GYS 0.00016739120874645 -0.431024884142512 0.000461398844621625 3 NFKB1|NF-KB-P65_PS536 1.71831097005069e-09 -0.433093539890424 1.36828466133666e-08 3 ERBB3|HER3 1.52153283225777e-05 -0.433490919440379 5.11139935836595e-05 3 TSC2|TUBERIN 1.18701236709098e-08 -0.463139341980736 7.73356542195638e-08 3 AKT1 AKT2 AKT3|AKT 6.70991627919336e-09 -0.467740499224417 4.65365161298894e-08 3 STAT3|STAT3_PY705 1.928068190785e-18 -0.491622309838603 1.03633665254694e-16 3 AKT1 AKT2 AKT3|AKT_PS473 1.62700219743876e-12 -0.523497587784436 2.49861051749524e-11 3 RBM15|RBM15 4.73630813760094e-12 -0.539664526423706 5.65725694213446e-11 3 PTEN|PTEN 8.96578833007349e-14 -0.54098095398259 1.9276444909658e-12 3 MAPK14|P38 4.65791368819262e-10 -0.542665649581618 4.35413670852788e-09 3 ATM|ATM 2.11116462658808e-12 -0.608005120023514 3.02600263144292e-11 3 CTNNB2|BETA-CATENIN 1.28823175155843e-14 -0.619707886891509 3.46212283231328e-13 3 EGFR|EGFR_PY1068 9.43191817076387e-16 -0.64313385158965 3.37977067785705e-14 3 MYH11|MYH11 0.00338520179946332 -0.673091512338628 0.00686621119702466 3 PYGL|PYGL 0.000144994627167902 -0.701442318851852 0.00040485512780648 3 MAPK1 MAPK3|MAPK_PT202_Y204 1.13155670056597e-12 -0.732052011690101 2.02737242184736e-11 3 MAPK14|P38_PT180_Y182 2.77788168648028e-16 -0.752340191335828 1.19448912518652e-14 3 GYS1|GYS_PS641 3.37811157016569e-09 -0.811872885314815 2.50446202615732e-08 3 PRKAA1|AMPK_PT172 4.47083582530086e-19 -1.04093066988669 3.20409900813228e-17 3 SRC|SRC_PY527 1.13790341730117e-23 -1.13926804535166 2.44649234719752e-21 3 NDRG1|NDRG1_PT346 4.85889283166e-15 -1.56908241226156 1.492374226867e-13 3 VHL|VHL 7.28494685235466e-14 -1.65881378057362 1.74029285917361e-12 3 NDRG1|NDRG1_PT346 3.44971969392531e-18 1.01534706168112 3.62220567862158e-16 4 MAPK1 MAPK3|MAPK_PT202_Y204 1.36880338408386e-15 0.745606427699413 9.58162368858702e-14 4 SRC|SRC_PY527 6.6227635576117e-25 0.715933032156771 1.39078034709846e-22 4 AKT1 AKT2 AKT3|AKT_PS473 1.47903200904638e-13 0.621886073844252 7.7649180474935e-12 4 PYGL|PYGL 2.05423262402329e-08 0.534645462178037 2.53758147673465e-07 4 PKM2|PKM2 8.40890580689e-10 0.512128859026023 1.35836170726685e-08 4 PRKAA1|AMPK_PT172 2.78320263137198e-11 0.426636501139878 8.64082607847876e-10 4 VHL|VHL 0.00497054283796536 0.380371967557017 0.011728247145761 4 RPS6|S6_PS235_S236 1.25684821510232e-05 0.345938107074547 7.13346284247263e-05 4 STAT3|STAT3_PY705 2.38115553637696e-09 0.345822172295373 3.57173330456544e-08 4 MAPK14|P38_PT180_Y182 6.76267359313279e-07 0.3380560292509 5.68064581823154e-06 4 LDHA|LDHA 0.000379423676977006 0.278886961724435 0.00128514471234147 4 CTNNB2|BETA-CATENIN 1.52283360345576e-08 0.270930525391354 1.99871910453569e-07 4 EGFR|EGFR_PY1068 4.69496395865829e-06 0.269114842860445 3.0810700978695e-05 4 RPS6|S6_PS240_S244 0.00129980647480109 0.246328858949876 0.00349947897061832 4 SRC|SRC_PY416 4.16228620241056e-05 0.245251082797711 0.000208114310120528 4 SHC1|SHC_PY317 6.33119474605109e-10 0.245240408497517 1.10795908055894e-08 4 AKT1 AKT2 AKT3|AKT_PT308 3.47508018475918e-05 0.235713961937616 0.000182441709699857 4 PTEN|PTEN 3.95391906441456e-08 0.218681903719883 4.37012107119504e-07 4 GAPDH|GAPDH 0.0386908978441818 0.207375705974978 0.0759354069839082 4 ATM|ATM 8.05130250678089e-05 0.20026807534881 0.000359739048175316 4 TSC1|TSC1 2.30278115423752e-07 0.185898109580387 2.19810928359036e-06 4 TSC2|TUBERIN 7.41037832122187e-06 0.177133185562815 4.44622699273312e-05 4 GSK3A GSK3B|GSK3_PS9 8.69494708130322e-05 0.176761312744737 0.000380158648076256 4 PDCD4|PDCD4 0.000488947541012919 0.170546748532498 0.00157967667096482 4 MAPK14|P38_MAPK 5.6935219472133e-07 0.167380914261128 4.98183170381164e-06 4 BCL2|BCL-2 0.00406616468219451 0.161087155929331 0.00992900678210287 4 MAP2K1|MEK1 0.000115396846063214 0.157852197675754 0.000457232786288206 4 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.000140962523716788 0.156836753539641 0.000538220545100463 4 PRKAA1|AMPK_ALPHA 3.01983424796931e-06 0.150497050579503 2.11388397357852e-05 4 AKT1 AKT2 AKT3|AKT 0.000404534722675237 0.146444015074709 0.00134844907558412 4 EIF4EBP1|4E-BP1_PT37_T46 0.0160508589070963 0.139781212768126 0.0343946976580635 4 AR|AR 0.00090353969045752 0.135446359848045 0.00263532409716777 4 PDK1|PDK1_PS241 1.12935652877714e-07 0.135425390861242 1.185824355216e-06 4 MAPK1|ERK2 0.0023911792946918 0.135390194192798 0.00604997170946118 4 RAB11A RAB11B|RAB11 0.00245119407582752 0.128151153905435 0.0061279851895688 4 FRAP1|MTOR_PS2448 9.05139638276801e-05 0.122819425236495 0.000380158648076256 4 TSC2|TUBERIN_PT1462 0.000767224726782705 0.115930370116435 0.00230167418034811 4 ERBB2|HER2_PY1248 0.000665518819466904 0.109755775243003 0.0020552787071772 4 RAF1|C-RAF_PS338 3.17492805462502e-05 0.0868083757893719 0.000170957664479809 4 EIF4EBP1|4E-BP1_PS65 0.001687853699454 0.0805703235626535 0.00443061596106675 4 ERBB3|HER3_PY1289 0.000238618783442033 0.0786923594264113 0.000849321093607236 4 MAP2K1|MEK1_PS217_S221 0.00535662575448025 0.0755393483443816 0.0124987934271206 4 NOTCH1|NOTCH1 0.00225102741738582 0.071272024272619 0.00576482631281734 4 JUN|C-JUN_PS73 0.0182807011398071 0.066490600458635 0.0387772448420151 4 PDK1|PDK1 0.00224439377205717 0.0662874918295572 0.00576482631281734 4 MAPK9|JNK2 0.014530828039476 0.0657668916311948 0.0317861863363538 4 RICTOR|RICTOR_PT1135 0.0125142027528953 0.0451313140392318 0.0282578771839571 4 STK11|LKB1 0.0402290289755047 -0.0296892291113392 0.0782231118968147 4 MET|C-MET_PY1235 0.0366669999273495 -0.0340367352039054 0.073333999854699 4 NRAS|N-RAS 0.0491821192765845 -0.0372433941427655 0.0938931368007522 4 XRCC1|XRCC1 0.0134360897386863 -0.0381462131467087 0.0300167962247247 4 FOXO3|FOXO3A_PS318_S321 0.0119827318651145 -0.0403226416541855 0.0273518879529787 4 SCD|SCD 0.0374712545308867 -0.0461901036921043 0.0742355042593038 4 MSH6|MSH6 0.0290275447336712 -0.0557581396800959 0.0603543009313956 4 C12ORF5|TIGAR 0.00450750930000817 -0.0561253308906863 0.0107565562841104 4 SFRS1|SF2 0.0076580220533162 -0.0581370433267238 0.0176723585845758 4 CHEK1|CHK1_PS345 0.000871140259907452 -0.0581371448361506 0.00257661203634598 4 MS4A1|CD20 0.000208848935987904 -0.0625944568135154 0.00075617718202517 4 IRS1|IRS1 0.0136552259764401 -0.0629246440004794 0.0301852363689729 4 PCNA|PCNA 0.00138454346291184 -0.0654930478802037 0.00368043199001881 4 BAK1|BAK 9.24252328667624e-05 -0.071389008582229 0.000380574488274904 4 CCNE2|CYCLIN_E2 0.0009243250358229 -0.0736091264076008 0.00265901722633985 4 YWHAB|14-3-3_BETA 7.69268071187914e-05 -0.0748700283761635 0.000351187597716222 4 FOXO3|FOXO3A 0.000152210957390656 -0.0774757794107897 0.00057079109021496 4 BAX|BAX 0.003898124469172 -0.0775207603448449 0.00963066045324847 4 ESR1|ER-ALPHA_PS118 0.000446262400058594 -0.0814998246746337 0.00146429850019226 4 EEF2|EEF2 0.00118375700490629 -0.081580774541225 0.00327090751355685 4 PRKCD|PKC-DELTA_PS664 1.55101330040197e-05 -0.0817843325981846 8.5713892916951e-05 4 CASP8|CASPASE-8 0.000940149474125024 -0.0829785725311092 0.00266799175089534 4 ATP5A1|OXPHOS-COMPLEX-V_SUBUNITB 0.000531973442522455 -0.0838471824513889 0.00166737944671217 4 ETS1|ETS-1 0.000125017665750841 -0.0838895488128474 0.000486179811253271 4 YBX1|YB-1_PS102 0.0152498081358345 -0.0869138042254417 0.0330150485414974 4 TP53BP1|53BP1 0.0481459404706095 -0.0909524193061032 0.0927582339342018 4 CCNE1|CYCLIN_E1 9.75088329495392e-05 -0.0971283738006411 0.000393785671526985 4 PRKCA |PKC-ALPHA 0.033622103681134 -0.100761346221251 0.0679878834486016 4 CHEK2|CHK2 0.000369848436940149 -0.102074924641807 0.00127324871733494 4 RPTOR|RAPTOR 0.000738009274450752 -0.1034347389757 0.00224611518311098 4 SDHB|COMPLEX-II_SUBUNIT30 0.0267960885494014 -0.103983831227335 0.0562717859537429 4 CHEK1|CHK1 2.44385637789417e-06 -0.108679465602882 1.76968910123371e-05 4 NRG1|HEREGULIN 0.000177703253835356 -0.116050813901966 0.000654696198340785 4 FOXM1|FOXM1 1.84798880661715e-06 -0.117785577009066 1.43732462736889e-05 4 MYC|C-MYC 3.13287380032933e-06 -0.120163504233296 2.12226934861019e-05 4 BCL2L1|BCL-XL 2.37477965982318e-08 -0.123318182074677 2.77057626979371e-07 4 RICTOR|RICTOR 0.0336701898983551 -0.127694886823007 0.0679878834486016 4 MET|C-MET 1.94318766081658e-06 -0.127775199388738 1.45739074561244e-05 4 ACACA ACACB|ACC_PS79 0.000299524928464231 -0.129461824886474 0.00104833724962481 4 ARHI|ARHI 6.61724113950384e-06 -0.131089523104462 4.08711952734061e-05 4 ACACA|ACC1 0.00122923963667155 -0.136102949674289 0.00335247173637695 4 PEA15|PEA15_PS116 8.92219090928499e-05 -0.137590136302645 0.000380158648076256 4 GYG1|GYG-GLYCOGENIN1 3.93744604238755e-07 -0.140237118256639 3.59505943000602e-06 4 BECN1|BECLIN 5.52601044265271e-06 -0.14345540654951 3.51655209986991e-05 4 PGR|PR 0.000527551369065778 -0.145741522956653 0.00166737944671217 4 FN1|FIBRONECTIN 0.032372071510577 -0.147981246308452 0.0666483825217762 4 GATA3|GATA3 4.81780763985782e-05 -0.164814317034825 0.000229940819175032 4 SQSTM1|P62-LCK-LIGAND 0.000957510017018878 -0.16877204036219 0.00268102804765286 4 INPP4B|INPP4B 1.80454214234573e-06 -0.171090797848098 1.43732462736889e-05 4 ASNS|ASNS 4.65883682061382e-05 -0.17278115903879 0.000227524588913698 4 FASN|FASN 1.0548145089366e-08 -0.173501748449003 1.47674031251124e-07 4 CDH3|P-CADHERIN 2.25512844836927e-10 -0.184916017692464 5.2619663795283e-09 4 TP53|P53 4.77843436535093e-10 -0.195731932737961 9.12246560657905e-09 4 XBP1|XBP1 2.88027535949292e-11 -0.202233891354455 8.64082607847876e-10 4 HIF1A|HIF-1_ALPHA 0.00439860918123272 -0.208680984789301 0.0106173325064238 4 MTCO2|MITOCHONDRIA 3.69740841333577e-05 -0.234042286164759 0.000189379455317198 4 TFRC|TFRC 5.92212327306999e-05 -0.241546527615735 0.000276365752743266 4 CCNB1|CYCLIN_B1 8.543796982462e-11 -0.265644480792895 2.24274670789627e-09 4 DIABLO|SMAC 1.9515979697348e-07 -0.282776760893015 1.9515979697348e-06 4 YBX1|YB-1 2.7949936556417e-10 -0.28636167962403 5.86948667684757e-09 4 G6PD|G6PD 1.92871488220272e-12 -0.349488271116575 8.10060250525142e-11 4 SERPINE1|PAI-1 1.22663133407436e-05 -0.364887438241602 7.13346284247263e-05 4 VHL|VHL 1.42964641074915e-05 1.04781808660136 0.00100075248752441 5 SERPINE1|PAI-1 2.92066257701692e-05 0.870408809619599 0.00142622687862617 5 TGM2|TRANSGLUTAMINASE 0.000279181320440905 0.820807727418004 0.00344871042897589 5 SQSTM1|P62-LCK-LIGAND 0.00804788174014531 0.716010004353801 0.034464009949926 5 GAPDH|GAPDH 0.000183353233917361 0.711303935217141 0.00295781271715687 5 GYS1|GYS_PS641 0.000228905119475344 0.665901750097179 0.00320467167265482 5 GYS1|GYS 0.000819815609321158 0.541916627256851 0.00688645111829773 5 G6PD|G6PD 0.00155672875456809 0.423015510525136 0.0108971012819766 5 ACACA|ACC1 7.23496989326133e-05 0.419804627577276 0.0018991795969811 5 EIF4EBP1|4E-BP1_PT37_T46 0.00167343722543053 0.386770472803099 0.0113361876561423 5 ACACA ACACB|ACC_PS79 4.39827277828826e-05 0.361513498733621 0.00153939547240089 5 STAT5A|STAT5-ALPHA 0.00127109679732617 0.326197343080557 0.00953322597994627 5 YBX1|YB-1_PS102 0.00286729854788119 0.285866237938017 0.0172037912872871 5 PKC|PKC-PAN_BETAII_PS660 0.000394727631084973 0.277349879463709 0.00436277908041286 5 DIABLO|SMAC 0.00320979007045676 0.275299315785548 0.0187237754109978 5 HIF1A|HIF-1_ALPHA 0.0162789831065327 0.268240720613524 0.0542632770217757 5 MTCO2|MITOCHONDRIA 0.000658810327600088 0.262675786430548 0.00688645111829773 5 PRKCA |PKC-ALPHA_PS657 0.00393537502781742 0.2554112286011 0.0211904809190169 5 BAD|BAD_PS112 1.29188258760265e-05 0.244130479918509 0.00100075248752441 5 PRKCA |PKC-ALPHA 0.00404199601951222 0.228227661389209 0.0212204791024392 5 ANXA1|ANNEXIN-1 0.0148457651653827 0.223915440198139 0.0511083718808257 5 ASNS|ASNS 0.0316349562527551 0.218596348828538 0.0885778775077143 5 RBM15|RBM15 0.00202201885954222 0.213018725518171 0.0128673927425414 5 CCNB1|CYCLIN_B1 0.00965468099010758 0.212051127883757 0.0389900578446652 5 EIF4EBP1|4E-BP1 0.00610485425452028 0.208268609480618 0.0285139849597652 5 RPTOR|RAPTOR 0.0103550741735679 0.208152922892287 0.0400341864521939 5 RB1|RB_PS807_S811 0.0281961698032433 0.197016837580608 0.0811122692970013 5 YBX1|YB-1 0.0009244893885463 0.195853627750151 0.00719047302202678 5 EEF2|EEF2 0.000780562300328677 0.18352468319304 0.00688645111829773 5 CDH3|P-CADHERIN 0.00387720464334557 0.175661777550601 0.0211904809190169 5 FASN|FASN 0.0127358485699804 0.172634229453841 0.0445754699949314 5 EIF4G1|EIF4G 0.0291413077210512 0.161647169755249 0.082698305694875 5 CASP8|CASPASE-8 0.00072913500113945 0.155225854896416 0.00688645111829773 5 MAP2K1|MEK1_PS217_S221 0.00836983098783918 0.129145109358823 0.034464009949926 5 LCK|LCK 0.0462800828059654 0.124466182446118 0.122838813202148 5 IRS1|IRS1 0.0174021346256096 0.114047689615738 0.0553704283542124 5 RPS6KB1|P70S6K 0.00827754703240828 0.114047018523092 0.034464009949926 5 CHEK2|CHK2 0.00460662109452098 0.11335516635529 0.0230331054726049 5 BAX|BAX 0.00611013963423541 0.11323105602549 0.0285139849597652 5 PIK3R1|PI3K-P85 0.0215394428268976 0.105237550277887 0.0655548259949058 5 MAPK9|JNK2 0.0125110040695599 0.0982819963289673 0.0445754699949314 5 CDKN1B|P27_PT157 0.0226401528847016 -0.046356022821598 0.0679204586541048 5 ARID1A|ARID1A 0.01730169440543 -0.0560015844142033 0.0553704283542124 5 BAK1|BAK 0.0048908027966375 -0.0630221379407682 0.0238853159835785 5 RAF1|C-RAF_PS338 0.0324716892647828 -0.0631355904595195 0.0897244045474262 5 YWHAB|14-3-3_BETA 0.0104851440708127 -0.0646182009618917 0.0400341864521939 5 STK11|LKB1 0.0109032084857587 -0.065000814228826 0.0408870318215951 5 YWHAE|14-3-3_EPSILON 0.0467957383627231 -0.067509965576065 0.122838813202148 5 PARP1|PARP_CLEAVED 0.0246167401908377 -0.0679870059587704 0.0728100766207876 5 STMN1|STATHMIN 0.0042484276735089 -0.0753401217137846 0.0217602393033383 5 FOXO3|FOXO3A_PS318_S321 3.39577828244327e-05 -0.0807323791805219 0.00142622687862617 5 ESR1|ER-ALPHA_PS118 0.000807726491921797 -0.0839283459637089 0.00688645111829773 5 MRE11A|MRE11 0.000119718958983171 -0.0937616192096709 0.00267498207948768 5 SNAI1|SNAIL 0.00279886655819417 -0.0947228483259033 0.0172037912872871 5 BID|BID 0.000907853193143863 -0.0952622721597517 0.00719047302202678 5 RAD51|RAD51 0.037300826238164 -0.10013160299306 0.101729526104084 5 SMAD4|SMAD4 0.00142413786171216 -0.103269674046235 0.0103127224468812 5 SDHB|COMPLEX-II_SUBUNIT30 0.046520190614991 -0.106169542980931 0.122838813202148 5 PEA15|PEA15 0.0157783648481298 -0.107862107463204 0.0534428486791493 5 ITGA2|CD49B 0.000296219329509603 -0.114823679661872 0.00345589217761203 5 SHC1|SHC_PY317 0.0499946129307651 -0.116800129096709 0.129615663153835 5 STAT3|STAT3_PY705 0.0126158612737733 -0.119419603842091 0.0445754699949314 5 CDC2|CDK1 0.00197981452252988 -0.127207774544847 0.0128673927425414 5 BCL2L11|BIM 0.0181268752948334 -0.12960976568461 0.0568155792823136 5 CDH2|N-CADHERIN 0.000250060675449676 -0.135292502130552 0.003282046365277 5 NOTCH1|NOTCH1 0.000158567729651878 -0.138293340976757 0.00295781271715687 5 RAB11A RAB11B|RAB11 0.0197300280121058 -0.148385640788133 0.060930968860915 5 PECAM1|CD31 0.000811843019083515 -0.14999571836006 0.00688645111829773 5 ERBB2|HER2_PY1248 0.0167412405851492 -0.151642160756183 0.0549321956700208 5 ESR1|ER-ALPHA 0.00392006421942464 -0.1632496648165 0.0211904809190169 5 LDHB|LDHB 0.0104396533642379 -0.164046796386476 0.0400341864521939 5 ERBB2|HER2 0.00792670928736583 -0.171392592042298 0.034464009949926 5 PARK7|DJ-1 0.000127380099023223 -0.171789420968024 0.00267498207948768 5 YAP1|YAP 6.52900688969121e-05 -0.189107093774253 0.0018991795969811 5 CDKN1B|P27 0.000174821159727512 -0.202243364050575 0.00295781271715687 5 BCL2|BCL-2 0.0111823308759199 -0.233895276581996 0.0411980611218102 5 COL6A1|COLLAGEN_VI 0.000197187514477125 -0.259927280581617 0.00295781271715687 5 KIT|C-KIT 6.37907147528597e-06 -0.264800653951519 0.00100075248752441 5 PKM2|PKM2 0.0258577421553613 -0.272395037898937 0.0754184146198038 5 SRC|SRC_PY527 0.00826802618474669 -0.287391246498031 0.034464009949926 5 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.00773841973026021 -0.348510107717494 0.034464009949926 5 HSPA1A|HSP70 2.87981921671446e-10 0.819172266446032 1.23832226318722e-08 6 FN1|FIBRONECTIN 1.94318779770269e-06 0.560958122931976 1.09943520133179e-05 6 SERPINE1|PAI-1 0.000921466823439106 0.530513365459323 0.00220128185599342 6 NDRG1|NDRG1_PT346 0.00729464118129359 0.496105893234054 0.0134046825126335 6 RAD51|RAD51 9.43577902018304e-09 0.458285518226778 1.69057707444946e-07 6 HIF1A|HIF-1_ALPHA 0.000176699393059692 0.452251564950213 0.000493381422179659 6 RB1|RB 1.1118962874472e-07 0.391716525264152 1.19528850900574e-06 6 ERRFI1|MIG-6 0.000605932188394966 0.378728788128084 0.00148850348197641 6 COL6A1|COLLAGEN_VI 1.98238362934365e-07 0.352816771321977 2.02958323956612e-06 6 MAPK1 MAPK3|MAPK_PT202_Y204 0.00021001110350814 0.346787492610782 0.000571549205750001 6 RAB11A RAB11B|RAB11 1.76926328462834e-08 0.344473007896112 2.53594404130062e-07 6 SRC|SRC_PY527 7.7805849642762e-05 0.336154450777213 0.000229154214701285 6 ERBB3|HER3 0.0217135374472517 0.324229359574765 0.0359108503935317 6 SETD2|SETD2 5.14042863892149e-07 0.313444913939073 4.14418680284082e-06 6 STMN1|STATHMIN 5.6385523363713e-10 0.302562742213028 2.02048125386638e-08 6 MRE11A|MRE11 1.68893318796976e-10 0.277830173888492 9.07801588533746e-09 6 BID|BID 7.77789744450148e-08 0.27669091391328 9.83675265039893e-07 6 KIT|C-KIT 1.81379330683105e-05 0.273391149709304 6.5792533340055e-05 6 CHEK2|CHK2_PT68 1.11075522068025e-06 0.249408397885112 7.23673855897739e-06 6 STAT3|STAT3_PY705 0.00337819471505582 0.241139145596555 0.00654335012375677 6 RPS6KB1|P70S6K_PT389 0.00178337411245534 0.235566230934879 0.00368678302094133 6 MYC|C-MYC 9.96212286793198e-07 0.234586115162134 6.6933013018918e-06 6 EGFR|EGFR_PY1173 1.43693850722306e-08 0.22682701396637 2.20672699323541e-07 6 RAF1|C-RAF_PS338 3.80783712980213e-09 0.220686594516901 8.18684982907458e-08 6 SNAI1|SNAIL 0.000267228217262032 0.214925790861097 0.00070930946557206 6 RICTOR|RICTOR_PT1135 3.02834444523023e-07 0.203283033707165 2.62192543951295e-06 6 IGFBP2|IGFBP2 0.0198517639927713 0.197116532126174 0.0330862733212855 6 CCND1|CYCLIN_D1 0.00619509783249856 0.189605655930334 0.0114822933964413 6 STK11|LKB1 4.71388853714803e-06 0.183010943246085 2.35694426857402e-05 6 ERBB2|HER2_PY1248 0.00163761834137763 0.181491896640249 0.00348000282069213 6 BAK1|BAK 3.4781578977428e-06 0.174931820418016 1.86950987003676e-05 6 PARP1|PARP_CLEAVED 0.00128506894248097 0.17226737132216 0.00281928390442254 6 XBP1|XBP1 0.000609247936808951 0.169525565607899 0.00148850348197641 6 CDKN1A|P21 0.0264023823160293 0.161934223924356 0.043003880287472 6 YAP1|YAP 0.0016810419431934 0.160041269502311 0.00350897104647166 6 CDH2|N-CADHERIN 0.000197128756670377 0.159943164510904 0.000543367726719629 6 ETS1|ETS-1 0.000437261988540612 0.159841634370178 0.00110601561807331 6 ERBB3|HER3_PY1289 3.68077250175202e-08 0.159606259041173 4.94603804922928e-07 6 CDC2|CDK1 0.00211035472692566 0.15875375497525 0.00424043239522446 6 MET|C-MET_PY1235 6.98283573816183e-06 0.155156155686712 3.12772850771832e-05 6 MS4A1|CD20 4.55415471275271e-05 0.151376620399568 0.000148355039885126 6 BRCA2|BRCA2 9.09656835022233e-05 0.146563046669698 0.000260768292706373 6 TP53|P53 0.00107099715595476 0.144125102527443 0.00247596116699219 6 FOXO3|FOXO3A 1.22600785077801e-06 0.141141879845734 7.54233371198687e-06 6 PECAM1|CD31 1.836070697862e-05 0.138118966696757 6.5792533340055e-05 6 NRAS|N-RAS 1.39652295234177e-06 0.137090968849133 8.3403454098189e-06 6 WWTR1|TAZ 1.66238018786984e-05 0.136045456224104 6.27038141038624e-05 6 FOXM1|FOXM1 0.00122627017121404 0.135132739052612 0.00271802151351566 6 JUN|C-JUN_PS73 0.0031883058074492 0.134871300447044 0.00623168862365071 6 YWHAB|14-3-3_BETA 3.8150517740482e-05 0.133924417337216 0.000130196211336566 6 CASP7|CASPASE-7_CLEAVEDD198 0.0124403368685783 0.130984817383871 0.02210473079954 6 C12ORF5|TIGAR 0.00103594407495673 0.125919932569189 0.00242095626212714 6 NOTCH1|NOTCH1 0.000523042337259602 0.119561170196547 0.001307605843149 6 IRS1|IRS1 0.0010356275114796 0.117232267835689 0.00242095626212714 6 SMAD4|SMAD4 0.00467579332199184 0.103814248839489 0.00884803883582766 6 CDKN1B|P27_PT198 0.00194627534858972 0.101604745688183 0.00394763396176217 6 ITGA2|CD49B 0.00039870796520504 0.0923385638476816 0.00102050252998909 6 CDKN1B|P27_PT157 0.0014040731691447 0.0860918174536323 0.00304924981177889 6 YWHAE|14-3-3_EPSILON 0.00116090843811673 0.0860017079249102 0.00259995118953226 6 CCNE2|CYCLIN_E2 0.0355453744421047 0.0644878233321557 0.0557828868981935 6 XRCC1|XRCC1 0.0297676104235255 0.0626570288854175 0.0474076758596888 6 ESR1|ER-ALPHA_PS118 0.0192086429626293 0.0601009410867581 0.0322645174762914 6 PDK1|PDK1 0.0340989824621672 -0.0634034457402032 0.0539064796276908 6 PYGB|PYGB-AB2 0.0169016771564891 -0.0751699145970908 0.0288977982648054 6 PIK3CA |PI3K-P110-ALPHA 0.0240004518959725 -0.0884636475398938 0.0393900546384282 6 FRAP1|MTOR_PS2448 0.00154612982278853 -0.145177869187973 0.00332417911899534 6 GYG1|GYG-GLYCOGENIN1 9.48653396841585e-06 -0.145633046694063 3.77704593186927e-05 6 PEA15|PEA15 0.0153209690582467 -0.147012883016156 0.0265645834477665 6 FASN|FASN 0.0149142380327653 -0.147549920130872 0.0260696030654028 6 PRKCD|PKC-DELTA_PS664 8.55592431779487e-07 -0.148333922097338 5.93493493650386e-06 6 NF2|NF2 0.00234477927764493 -0.15284803917936 0.00466784763605241 6 PEA15|PEA15_PS116 0.0272823784395349 -0.153504819204778 0.0437739654067165 6 EIF4EBP1|4E-BP1_PS65 5.20432761286987e-07 -0.154220956226205 4.14418680284082e-06 6 CHEK2|CHK2 0.00738597543884168 -0.15608759563685 0.0134574976216183 6 PYGM|PYGM 0.00615929714493786 -0.157726817358917 0.0114822933964413 6 EGFR|EGFR 6.47936781312828e-05 -0.157852384099496 0.000201893344901823 6 PIK3R1|PI3K-P85 0.00112898913368785 -0.159783396757983 0.00258226238024349 6 ERBB2|HER2 0.00469151826643885 -0.16648789767577 0.00884803883582766 6 RICTOR|RICTOR 0.0363450731344164 -0.170746115670212 0.05662457046304 6 BAD|BAD_PS112 2.03763650405687e-05 -0.171524674646322 7.06599755439076e-05 6 ERCC1|ERCC1 0.0113773074198887 -0.173023917540276 0.0203843424606339 6 PDK1|PDK1_PS241 0.00075258533305541 -0.174415560406042 0.00181804322030239 6 G6PD|G6PD 0.00190625945468079 -0.175116762516385 0.00390329316910828 6 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00380887557888089 -0.176936198642541 0.00731168079874457 6 AKT1S1|PRAS40_PT246 8.98101847429461e-05 -0.177997479128695 0.000260768292706373 6 MSH2|MSH2 2.44917910736804e-07 -0.178834134026469 2.39351594583695e-06 6 MSH6|MSH6 7.98516885798552e-06 -0.18214848735469 3.36629667542527e-05 6 KDR|VEGFR2 0.0107200032475553 -0.183303174215587 0.0193680730943226 6 YBX1|YB-1 0.0148733931830866 -0.195615519403254 0.0260696030654028 6 DVL3|DVL3 3.04875051106157e-07 -0.197832543707948 2.62192543951295e-06 6 PDCD4|PDCD4 0.0169354538668162 -0.202484954927737 0.0288977982648054 6 MAPK9|JNK2 6.11754592695066e-06 -0.207065269912917 2.8592877702052e-05 6 PRKAA1|AMPK_ALPHA 7.70544718369613e-05 -0.211002250203308 0.000229154214701285 6 ACACA|ACC1 0.0187552023987865 -0.213421751390364 0.031750933194796 6 ACACA ACACB|ACC_PS79 0.00277538709937073 -0.228349704166679 0.00547438739784135 6 PRKCA |PKC-ALPHA 5.29190172326029e-06 -0.228692371845275 2.54518176264973e-05 6 RB1|RB_PS807_S811 7.50290095489378e-06 -0.242308525001299 3.29208919449421e-05 6 RPS6KB1|P70S6K 8.24926203572277e-07 -0.244424687916584 5.93493493650386e-06 6 TGM2|TRANSGLUTAMINASE 0.0269870539910815 -0.248415628591475 0.0436256887825754 6 TSC1|TSC1 0.00165097808237487 -0.254932467647181 0.00348000282069213 6 SDHB|COMPLEX-II_SUBUNIT30 4.504102767875e-05 -0.285633024683893 0.000148355039885126 6 EEF2|EEF2 2.77989418309723e-09 -0.289812914220514 6.64085832628783e-08 6 RPS6KA1|P90RSK 2.45695690625746e-06 -0.296667620369319 1.35447624319322e-05 6 PRKCA |PKC-ALPHA_PS657 7.09237605275158e-05 -0.320504160265984 0.000214769133991773 6 PYGB|PYGB 4.55537157947311e-06 -0.323551155794111 2.3319164037779e-05 6 MAPK1|ERK2 8.91794197682739e-06 -0.323772866401115 3.62905433245954e-05 6 XRCC5|KU80 4.77151496099611e-05 -0.327468358429761 0.000153115778599129 6 GSK3A GSK3B|GSK3_PS9 0.000106017959865048 -0.336467639739287 0.000299919228565596 6 PTEN|PTEN 1.26026229808452e-05 -0.340358726402051 4.92647989251221e-05 6 MAPK14|P38_MAPK 0.000368563440653331 -0.341069575627122 0.000954712526993568 6 TFRC|TFRC 4.06596498676121e-05 -0.351832642067947 0.000136591011274009 6 AKT1 AKT2 AKT3|AKT 1.98966335096143e-05 -0.353907458169162 7.01274787633947e-05 6 PXN|PAXILLIN 5.32712461949944e-06 -0.35675428194248 2.54518176264973e-05 6 ATM|ATM 5.90298820105953e-05 -0.357079921440436 0.0001866385975335 6 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 4.27948297111052e-06 -0.362981265048392 2.24411911899698e-05 6 CTNNB2|BETA-CATENIN 0.000352836738412666 -0.365299512985467 0.000925120716569795 6 SQSTM1|P62-LCK-LIGAND 9.33493772023256e-10 -0.375207979734188 2.5087645123125e-08 6 FRAP1|MTOR 7.29487341957277e-07 -0.381257428782637 5.60142066145766e-06 6 EEF2K|EEF2K 1.45909310952907e-10 -0.3833763881747 9.07801588533746e-09 6 GYS1|GYS_PS641 0.000224168814780474 -0.391718915056646 0.000602453689722524 6 RPS6|S6 1.81673527825871e-05 -0.396738866384539 6.5792533340055e-05 6 TSC2|TUBERIN 1.53280995753148e-06 -0.401907588776984 8.90686867214238e-06 6 CDH1|E-CADHERIN 7.78727553351595e-06 -0.402133886795413 3.34852847941186e-05 6 LDHB|LDHB 8.94604091257469e-06 -0.402822975998699 3.62905433245954e-05 6 RBM15|RBM15 1.28076332511141e-08 -0.427737640753552 2.11818549922272e-07 6 TP53BP1|53BP1 1.61735569520297e-10 -0.432892945890917 9.07801588533746e-09 6 BRAF|B-RAF 4.61518766129701e-09 -0.447636293442308 9.02059406526234e-08 6 EIF4G1|EIF4G 8.76881758944116e-08 -0.460548050144489 9.92260937752552e-07 6 MTCO2|MITOCHONDRIA 8.55734804798231e-07 -0.482438250894868 5.93493493650386e-06 6 VHL|VHL 0.00115483313402166 -0.486872998104706 0.00259995118953226 6 GYS1|GYS 1.22782176706763e-06 -0.505306344369087 7.54233371198687e-06 6 TUBA1B|ACETYL-A-TUBULIN-LYS40 1.29471910315622e-05 -0.552152151475962 4.97079655676049e-05 6 LDHA|LDHA 2.88026329459393e-07 -0.557679382755085 2.62192543951295e-06 6 PKM2|PKM2 6.75378754680608e-05 -0.562689874384697 0.000207437760366187 6 PKC|PKC-PAN_BETAII_PS660 7.57561649931914e-10 -0.564776548181995 2.32679649621945e-08 6 STAT5A|STAT5-ALPHA 8.59670323924655e-08 -0.59122190301375 9.92260937752552e-07 6 GAPDH|GAPDH 6.43282653860416e-06 -0.651684939115805 2.94267596978701e-05 6 DIABLO|SMAC 4.71459692992451e-12 -0.679234346203999 1.01363833993377e-09 6 MYH11|MYH11 3.09978125767416e-28 2.3575528863255 6.60253407884596e-26 7 RICTOR|RICTOR 6.89781642666048e-20 0.978153485323334 7.34617449439341e-18 7 CAV1|CAVEOLIN-1 7.4360004916259e-09 0.633698352590819 1.21836008055101e-07 7 FN1|FIBRONECTIN 1.68824986964358e-10 0.616830028184122 4.49496527792603e-09 7 HIF1A|HIF-1_ALPHA 3.64545733794678e-08 0.560790430313567 4.85301508114165e-07 7 YBX1|YB-1 2.4740912341264e-12 0.406082771619632 1.31745358217231e-10 7 COL6A1|COLLAGEN_VI 2.22727580401391e-06 0.351144102137781 1.58136582084988e-05 7 YAP1|YAP_PS127 5.94598406362682e-08 0.339430981008034 7.0360811419584e-07 7 SYK|SYK 4.44532458605202e-07 0.331188395221403 4.11675711664818e-06 7 G6PD|G6PD 0.000398423930830175 0.289787132435943 0.00146317753908323 7 LCK|LCK 6.13083984330953e-07 0.26314235409852 5.44112036093721e-06 7 INPP4B|INPP4B 4.25836546434836e-09 0.242972947958297 7.55859869921834e-08 7 PXN|PAXILLIN 6.44276664716018e-06 0.237795236092581 4.15851301771248e-05 7 GATA3|GATA3 0.0156836480689541 0.233261474421493 0.0371179670965247 7 HSPA1A|HSP70 0.0109786334193872 0.232861443946636 0.0266403774274628 7 PGR|PR 6.91044013414304e-05 0.230482746816138 0.000342307848505225 7 ANXA1|ANNEXIN-1 0.000186695699018058 0.228800850373796 0.000779729095898948 7 STAT3|STAT3_PY705 0.000240326294694106 0.227854170925004 0.000965839637166879 7 XBP1|XBP1 5.80684497626947e-10 0.220700311442431 1.37428664438377e-08 7 RPTOR|RAPTOR 2.72717668477906e-05 0.20968670757001 0.000152865429962616 7 PEA15|PEA15_PS116 0.00153502553983636 0.203264414206751 0.00510875687476789 7 AKT1 AKT2 AKT3|AKT 0.000201710186618154 0.202686115112956 0.000826235956724362 7 TSC1|TSC1 8.04501739646954e-07 0.202108709281776 6.34662483499264e-06 7 KDR|VEGFR2 0.00156643894776291 0.188792982639197 0.00513309993651538 7 PDCD4|PDCD4 0.00362697509666528 0.17367989784066 0.0105828177478042 7 RB1|RB 9.34891596830779e-06 0.17227851192931 5.53144194791544e-05 7 PTEN|PTEN 4.75514777140831e-05 0.169797159033712 0.000252777689694449 7 KIT|C-KIT 0.00274148568956922 0.164087319383822 0.00834194931254634 7 ETS1|ETS-1 3.98351052390594e-07 0.157443587989423 3.85676246178166e-06 7 DVL3|DVL3 7.70085076098668e-07 0.150473227044694 6.33126786777813e-06 7 MAP2K1|MEK1 0.0059504367399137 0.147691240606193 0.0156474447605138 7 IGFBP2|IGFBP2 0.0356577946909058 0.1335685705565 0.0696799107262655 7 XRCC5|KU80 0.00369686970672395 0.13200923385865 0.0106409898315162 7 CASP7|CASPASE-7_CLEAVEDD198 0.00801161467677737 0.122183369573478 0.0198427200715533 7 CDKN1A|P21 0.0266302547960936 0.120231953396119 0.0561608343719598 7 MSH6|MSH6 0.0346831175678084 0.115802251756026 0.0684028152031777 7 PEA15|PEA15 0.0035090952068627 0.107513150738498 0.0103810733203022 7 PREX1|PREX1 0.0199585896586022 0.0951489181605688 0.0462084738835029 7 SNAI1|SNAIL 0.00120751633552434 0.0935441169852675 0.00408255522962991 7 FOXO3|FOXO3A_PS318_S321 0.000375001269453462 0.0894459601435466 0.00140290643705854 7 C12ORF5|TIGAR 0.000171471701965851 0.0894020624826455 0.000745376990178087 7 CCND1|CYCLIN_D1 0.00570325278805887 0.0827401569397145 0.0151849105482067 7 BECN1|BECLIN 0.00185334282959067 0.0779513319395988 0.00589197048810168 7 MYC|C-MYC 0.0410724472047865 0.0729330559337755 0.0795311932238139 7 SMAD1|SMAD1 0.0207622159799271 0.0587211399366655 0.0470462979119625 7 RAF1|C-RAF 0.0302005383806163 0.0543078925954136 0.0606859875006724 7 ARID1A|ARID1A 0.0201866644361429 0.0521084827120493 0.0462339733860047 7 MS4A1|CD20 0.0227497292818819 0.0511043517325588 0.0499555911035139 7 RAD50|RAD50 0.0476707900788117 0.0495031054591642 0.0890691077788324 7 CDKN1B|P27_PT157 0.000930509205874698 -0.0477950826649616 0.00319674936856953 7 YWHAB|14-3-3_BETA 0.00383946093584641 -0.0529591836723166 0.0109040690578038 7 FOXO3|FOXO3A 0.0283815096975039 -0.0573435515124559 0.0581275150535416 7 ESR1|ER-ALPHA_PS118 0.0062641781931951 -0.058250320897188 0.0162715848189092 7 EIF4EBP1|4E-BP1_PT70 0.0342085982735643 -0.0623723610989827 0.0680974900212074 7 MSH2|MSH2 0.046229814604845 -0.0656533785482775 0.0871411549631149 7 XRCC1|XRCC1 0.000125857139853446 -0.0708230172294231 0.000582773278017043 7 JUN|C-JUN_PS73 0.00721394812093152 -0.0715820904707676 0.0182925113066478 7 BIRC2 |CIAP 0.000251887286594399 -0.0728369106290966 0.000993555408233463 7 PECAM1|CD31 0.021315183668203 -0.0729771112097856 0.0473226770299344 7 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00486538182085224 -0.0759233509897694 0.0131194272915199 7 SHC1|SHC_PY317 0.0420982301854515 -0.0815871688481736 0.0807830903558664 7 YWHAE|14-3-3_EPSILON 0.000756886259717428 -0.0891100012440466 0.00264289792327561 7 FOXM1|FOXM1 0.000681407098673267 -0.0918087128608172 0.0024189952002901 7 RAB11A RAB11B|RAB11 0.0243379853056581 -0.0928510244042252 0.0523635441424765 7 ARAF|A-RAF_PS299 0.0213285304923648 -0.0949374513517571 0.0473226770299344 7 BAX|BAX 0.0143325964896262 -0.0967717584830212 0.0343016073291054 7 SCD|SCD 2.03285133814318e-05 -0.104918081907211 0.000117026306763378 7 PCNA|PCNA 7.72830819540992e-07 -0.106117780067164 6.33126786777813e-06 7 ATP5A1|OXPHOS-COMPLEX-V_SUBUNITB 4.86567383918892e-05 -0.108375425803658 0.000252777689694449 7 ARHI|ARHI 0.000258437869029273 -0.110166002288886 0.00100085938369518 7 NF2|NF2 0.0236263868744525 -0.110854114331686 0.0513512286148815 7 RPS6KB1|P70S6K_PT389 0.00785221333120916 -0.112403236673213 0.0196767228182065 7 EEF2K|EEF2K 0.0270272292657623 -0.113193164657476 0.0564392140549742 7 NRAS|N-RAS 1.69524095966327e-07 -0.113274184070805 1.80543162204138e-06 7 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.0276804482837739 -0.116417158383128 0.057242092081979 7 PDK1|PDK1_PS241 0.000183528752182397 -0.117687455921753 0.000779729095898948 7 PRDX1|PRDX1 0.000513262007610579 -0.119818470406075 0.0018529628410348 7 PDK1|PDK1 2.44406621366556e-09 -0.125700343853607 4.73260094100695e-08 7 EGFR|EGFR 0.00235904356737582 -0.128357709791717 0.00738935705663308 7 AKT1S1|PRAS40_PT246 0.00458855614662085 -0.130557646816615 0.0126930189510421 7 SMAD4|SMAD4 3.06355469945384e-07 -0.130936767790142 3.10731976658889e-06 7 PYGB|PYGB-AB2 2.71024498365872e-08 -0.13924371313425 3.84854787679538e-07 7 NRG1|HEREGULIN 3.0018832858789e-06 -0.144142865250853 1.99812856216314e-05 7 ACACA|ACC1 0.0110063531155715 -0.144198209794853 0.0266403774274628 7 EIF4EBP1|4E-BP1_PT37_T46 0.0293430402647734 -0.144752842425308 0.0595244531085403 7 PARK7|DJ-1 7.40378972688221e-06 -0.147138406446708 4.50573489093117e-05 7 TSC2|TUBERIN_PT1462 7.36151427388891e-06 -0.147269216150251 4.50573489093117e-05 7 AKT1 AKT2 AKT3|AKT_PT308 0.0192484010136113 -0.14727556013099 0.045053949625266 7 MAPK1|ERK2 0.00259170109210246 -0.147291306354401 0.00800046858866412 7 EIF4EBP1|4E-BP1 0.00486589087338063 -0.149070388189888 0.0131194272915199 7 DIABLO|SMAC 0.0252401573581046 -0.151909829072079 0.0537615351727628 7 EGFR|EGFR_PY1068 0.0426148799403134 -0.157174064240015 0.0810443698864889 7 AR|AR 0.00324101326734904 -0.157409803407043 0.00972303980204712 7 ACVRL1|ACVRL1 1.82968834997906e-08 -0.161680251270649 2.78374013246814e-07 7 ACACA ACACB|ACC_PS79 0.000375425666255102 -0.176831942440957 0.00140290643705854 7 PRKAA1|AMPK_ALPHA 1.56525627914494e-06 -0.195031872282961 1.19071281234954e-05 7 BRAF|B-RAF 8.4406581283103e-05 -0.195227353534261 0.00040860458666593 7 RPS6KA1|P90RSK 5.57226294967533e-05 -0.203619058468123 0.000282593335304963 7 RPS6|S6_PS240_S244 0.00415258177178884 -0.21906953127062 0.0116381568077766 7 SDHB|COMPLEX-II_SUBUNIT30 2.40418379976891e-06 -0.22789754856246 1.65190693338961e-05 7 TFRC|TFRC 0.006469204742032 -0.231546456394833 0.0166016940970219 7 CTNNB1|ALPHA-CATENIN 3.29248112643033e-05 -0.245752044403322 0.000179820123058887 7 PYGB|PYGB 0.000157514016577976 -0.262809728713631 0.000713840117683168 7 MTCO2|MITOCHONDRIA 2.18086362932308e-06 -0.288277580444181 1.58136582084988e-05 7 ERBB3|HER3 9.33811897712602e-05 -0.334209078157765 0.000442004298250632 7 TGM2|TRANSGLUTAMINASE 0.000166969135687417 -0.39238621714476 0.000740925539612913 7 LDHB|LDHB 1.46780156549501e-11 -0.436401003551286 6.25283466900874e-10 7 VHL|VHL 0.00174956592060252 -0.456375791638552 0.00564632638012631 7 PYGL|PYGL 1.09227525647562e-07 -0.597785213012387 1.22449805068056e-06 7 GYS1|GYS_PS641 4.25690097555608e-08 -0.600182127789321 5.33364651643203e-07 7 GYS1|GYS 1.44124032254665e-09 -0.616757515718691 3.06984188702436e-08 7 LDHA|LDHA 3.68202891066714e-13 -0.78092874789727 2.61424052657367e-11 7 GAPDH|GAPDH 3.02068804796387e-11 -0.782271706911349 1.07234425702717e-09 7 PKM2|PKM2 1.1542463586889e-10 -0.809735469335178 3.51220677715337e-09 7