Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.245 0.257 -9999.0 0.0 -0.741 32.0 32.0 IHH -0.096 0.229 -9999.0 0.0 -0.817 47.0 47.0 SHH Np/Cholesterol/GAS1 -0.036 0.124 -9999.0 0.0 -0.449 43.0 43.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.123 0.446 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 -0.145 0.15 -9999.0 0.0 -0.599 33.0 33.0 SMO -0.13 0.19 -9999.0 0.0 -0.634 33.0 33.0 AKT1 -0.04 0.092 -9999.0 0.0 -0.464 1.0 1.0 ARRB2 0.014 0.038 -9999.0 0.0 -0.863 1.0 1.0 BOC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.187 -9999.0 0.0 -0.623 33.0 33.0 STIL -0.093 0.165 -9999.0 0.0 -0.67 10.0 10.0 DHH N/PTCH2 -0.044 0.161 -9999.0 0.0 -0.63 37.0 37.0 DHH N/PTCH1 -0.159 0.161 -9999.0 0.0 -0.616 37.0 37.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 DHH -0.002 0.112 -9999.0 0.0 -0.742 12.0 12.0 PTHLH -0.436 0.407 -9999.0 0.0 -0.74 328.0 328.0 determination of left/right symmetry -0.128 0.187 -9999.0 0.0 -0.623 33.0 33.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 skeletal system development -0.431 0.402 -9999.0 0.0 -0.732 328.0 328.0 IHH N/Hhip -0.2 0.307 -9999.0 0.0 -0.648 164.0 164.0 DHH N/Hhip -0.153 0.256 -9999.0 0.0 -0.574 142.0 142.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.187 -9999.0 0.0 -0.623 33.0 33.0 pancreas development -0.176 0.331 -9999.0 0.0 -0.749 133.0 133.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.034 -9999.0 0.0 -0.556 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.031 0.183 -9999.0 0.0 -0.745 33.0 33.0 somite specification -0.128 0.187 -9999.0 0.0 -0.623 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.132 0.142 -9999.0 0.0 -0.551 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.034 0.127 -9999.0 0.0 -0.505 36.0 36.0 SHH Np/Cholesterol/Megalin -0.047 0.148 -9999.0 0.0 -0.48 52.0 52.0 SHH 0.018 0.085 -9999.0 0.0 -0.567 11.0 11.0 catabolic process -0.153 0.193 -9999.0 0.0 -0.65 32.0 32.0 SMO/Vitamin D3 -0.109 0.177 -9999.0 0.0 -0.577 36.0 36.0 SHH Np/Cholesterol/Hhip -0.119 0.205 -9999.0 0.0 -0.457 139.0 139.0 LRP2 -0.05 0.213 -9999.0 0.0 -0.744 46.0 46.0 receptor-mediated endocytosis -0.151 0.176 -9999.0 0.0 -0.764 19.0 19.0 SHH Np/Cholesterol/BOC -0.009 0.063 -9999.0 0.0 -0.442 11.0 11.0 SHH Np/Cholesterol/CDO -0.069 0.179 -9999.0 0.0 -0.525 70.0 70.0 mesenchymal cell differentiation 0.118 0.204 0.454 139.0 -9999.0 0.0 139.0 mol:Vitamin D3 -0.106 0.17 -9999.0 0.0 -0.557 36.0 36.0 IHH N/PTCH2 -0.081 0.214 -9999.0 0.0 -0.616 70.0 70.0 CDON -0.083 0.278 -9999.0 0.0 -0.863 60.0 60.0 IHH N/PTCH1 -0.155 0.194 -9999.0 0.0 -0.66 32.0 32.0 Megalin/LRPAP1 -0.048 0.157 -9999.0 0.0 -0.558 46.0 46.0 PTCH2 -0.026 0.186 -9999.0 0.0 -0.863 25.0 25.0 SHH Np/Cholesterol -0.009 0.065 -9999.0 0.0 -0.454 11.0 11.0 PTCH1 -0.154 0.193 -9999.0 0.0 -0.652 32.0 32.0 HHIP -0.177 0.331 -9999.0 0.0 -0.751 133.0 133.0