Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.004 0.092 -9999.0 0.0 -0.742 8.0 8.0 ENAH 0.078 0.065 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.001 0.112 -9999.0 0.0 -0.849 9.0 9.0 EPHA2 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 MYO6 0.032 0.096 -9999.0 0.0 -0.775 2.0 2.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.057 -9999.0 0.0 -0.472 8.0 8.0 AQP5 -0.167 0.242 -9999.0 0.0 -0.522 161.0 161.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.034 0.083 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.122 -9999.0 0.0 -0.487 15.0 15.0 EGF -0.666 0.227 -9999.0 0.0 -0.742 480.0 480.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.16 -9999.0 0.0 -0.578 39.0 39.0 cortical microtubule organization -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.034 0.079 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.017 0.08 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.014 0.062 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.034 -9999.0 0.0 -0.521 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.05 0.084 -9999.0 0.0 -0.575 1.0 1.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.034 0.084 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.002 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.016 0.151 -9999.0 0.0 -0.742 22.0 22.0 EGFR/EGFR/EGF/EGF -0.343 0.144 -9999.0 0.0 -0.768 28.0 28.0 RhoA/GDP -0.015 0.073 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.042 0.092 -9999.0 0.0 -0.71 2.0 2.0 IGF-1R heterotetramer 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.006 0.093 -9999.0 0.0 -0.863 6.0 6.0 DIAPH1 -0.01 0.085 -9999.0 0.0 -0.693 8.0 8.0 Wnt receptor signaling pathway 0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.063 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.042 0.094 -9999.0 0.0 -0.738 2.0 2.0 EFNA1 0.014 0.038 -9999.0 0.0 -0.863 1.0 1.0 LPP 0.043 0.089 -9999.0 0.0 -0.802 1.0 1.0 Ephrin A1/EPHA2 -0.016 0.074 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.013 0.062 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.018 0.124 -9999.0 0.0 -0.862 1.0 1.0 HGF/MET -0.036 0.129 -9999.0 0.0 -0.951 4.0 4.0 HGF -0.019 0.166 -9999.0 0.0 -0.799 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.099 0.07 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.036 0.124 -9999.0 0.0 -0.85 6.0 6.0 KIFC3 0.034 0.086 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.033 0.093 -9999.0 0.0 -0.862 1.0 1.0 NCK1/GIT1 -0.001 0.024 -9999.0 0.0 -0.556 1.0 1.0 mol:GDP -0.016 0.079 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.034 0.084 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.084 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.054 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.058 0.123 -9999.0 0.0 -0.786 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.019 0.083 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.085 -9999.0 0.0 -0.863 5.0 5.0 PLEKHA7 0.031 0.102 -9999.0 0.0 -0.775 3.0 3.0 mol:GTP -0.003 0.034 -9999.0 0.0 -0.517 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.07 0.076 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.042 0.092 -9999.0 0.0 -0.71 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0