Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.127 0.191 -9999.0 0.0 -0.513 10.0 10.0 IHH -0.08 0.138 -9999.0 0.0 -0.298 17.0 17.0 SHH Np/Cholesterol/GAS1 0.029 0.046 -9999.0 0.0 -0.151 3.0 3.0 LRPAP1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.028 0.045 0.151 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.051 0.169 -9999.0 0.0 -0.445 5.0 5.0 SMO -0.079 0.16 -9999.0 0.0 -0.455 6.0 6.0 AKT1 -0.031 0.171 -9999.0 0.0 -0.593 5.0 5.0 ARRB2 0.041 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.079 -9999.0 0.0 -0.43 2.0 2.0 ADRBK1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.078 0.158 -9999.0 0.0 -0.448 6.0 6.0 STIL -0.042 0.106 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.047 0.064 -9999.0 0.0 -0.304 2.0 2.0 DHH N/PTCH1 -0.069 0.123 -9999.0 0.0 -0.342 1.0 1.0 PIK3CA 0.043 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.03 0.079 -9999.0 0.0 -0.43 2.0 2.0 PTHLH -0.209 0.34 -9999.0 0.0 -0.938 11.0 11.0 determination of left/right symmetry -0.078 0.158 -9999.0 0.0 -0.448 6.0 6.0 PIK3R1 0.009 0.116 -9999.0 0.0 -0.404 5.0 5.0 skeletal system development -0.206 0.336 -9999.0 0.0 -0.925 11.0 11.0 IHH N/Hhip -0.057 0.138 -9999.0 0.0 -0.275 15.0 15.0 DHH N/Hhip 0.01 0.13 -9999.0 0.0 -0.269 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.078 0.158 -9999.0 0.0 -0.448 6.0 6.0 pancreas development -0.014 0.135 -9999.0 0.0 -0.324 11.0 11.0 HHAT 0.039 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.091 -9999.0 0.0 -0.284 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.028 0.07 -9999.0 0.0 -0.301 3.0 3.0 somite specification -0.078 0.158 -9999.0 0.0 -0.448 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.055 0.099 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.037 0.025 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.004 0.09 -9999.0 0.0 -0.231 8.0 8.0 SHH 0.02 0.026 -9999.0 0.0 -0.175 1.0 1.0 catabolic process -0.083 0.124 -9999.0 0.0 -0.302 10.0 10.0 SMO/Vitamin D3 -0.064 0.13 -9999.0 0.0 -0.371 3.0 3.0 SHH Np/Cholesterol/Hhip 0.011 0.075 -9999.0 0.0 -0.169 9.0 9.0 LRP2 -0.027 0.165 -9999.0 0.0 -0.43 10.0 10.0 receptor-mediated endocytosis -0.081 0.159 -9999.0 0.0 -0.386 9.0 9.0 SHH Np/Cholesterol/BOC 0.029 0.052 -9999.0 0.0 -0.231 2.0 2.0 SHH Np/Cholesterol/CDO 0.016 0.081 -9999.0 0.0 -0.233 6.0 6.0 mesenchymal cell differentiation -0.01 0.074 0.168 9.0 -9999.0 0.0 9.0 mol:Vitamin D3 -0.043 0.116 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 -0.015 0.092 -9999.0 0.0 -0.19 5.0 5.0 CDON -0.009 0.146 -9999.0 0.0 -0.413 8.0 8.0 IHH N/PTCH1 -0.081 0.13 -9999.0 0.0 -0.303 10.0 10.0 Megalin/LRPAP1 0.007 0.128 -9999.0 0.0 -0.304 10.0 10.0 PTCH2 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.083 0.124 -9999.0 0.0 -0.303 10.0 10.0 HHIP -0.014 0.135 -9999.0 0.0 -0.324 11.0 11.0