rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(3), EGF(1), EGFR(1), GRB2(1), MET(22), PDGFRA(1), PRKCA(1), SH3KBP1(2) 8180436 32 28 24 2 2 8 8 11 3 0 0.00408 4.66e-05 0.0287 2 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(5), GLUD1(1), OAT(2) 2436277 10 10 10 0 0 0 6 1 3 0 0.0985 0.00251 0.505 3 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 213542 3 3 3 0 0 0 0 1 2 0 0.858 0.00308 0.505 4 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(4), NRG2(1), NRG3(3), PRKCA(1), PSEN1(1) 3787830 13 13 13 1 1 2 1 6 3 0 0.168 0.00328 0.505 5 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 757351 5 5 5 1 1 0 0 3 1 0 0.725 0.00436 0.537 6 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(4), PARK2(2), SNCAIP(3), UBE2L3(1) 2673213 10 10 10 1 0 1 1 6 2 0 0.284 0.00751 0.771 7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), AKT3(1), BPNT1(3), GRB2(1), MAPK1(1), PIK3CA(6), PIK3CD(1), PTEN(7), PTK2B(1), SOS1(2) 8543628 24 21 22 2 2 5 3 5 8 1 0.0310 0.00884 0.778 8 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), KEAP1(2), MAPK1(1), MAPK14(1), NFE2L2(6), PRKCA(1) 3800165 12 12 12 1 1 0 1 7 3 0 0.228 0.0190 1.000 9 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(4), CPS1(1), EPRS(1), GAD1(2), GAD2(2), GCLC(3), GCLM(1), GFPT1(2), GLS(5), GLUD1(1), GLUL(2), GMPS(1), GOT2(1), GPT(2), PPAT(1), QARS(3) 14031798 34 32 34 2 0 2 8 15 9 0 0.0135 0.0230 1.000 10 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(3), AGTR2(1), KNG1(3), NOS3(1) 4215483 12 12 12 0 2 0 2 7 1 0 0.0527 0.0253 1.000 11 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), GREB1(6), HSPB2(1), MTA1(4), MTA3(2), PDZK1(1), TUBA8(1) 4765391 16 14 16 2 1 4 3 4 4 0 0.161 0.0292 1.000 12 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(2), HADHA(2) 2302526 7 7 7 0 0 2 2 3 0 0 0.119 0.0386 1.000 13 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1), SHMT1(2), SHMT2(3) 1788627 6 6 6 0 1 0 2 2 1 0 0.186 0.0389 1.000 14 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(3) 7532575 19 19 19 2 1 3 5 6 4 0 0.0631 0.0398 1.000 15 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(1), ELK1(1), GRB2(1), HGF(1), ITGA1(3), ITGB1(1), MAP2K2(1), MAP4K1(1), MAPK1(1), MET(22), PAK1(2), PIK3CA(6), PIK3R1(2), PTEN(7), PTK2(1), PTK2B(1), PXN(1), RAF1(3), RASA1(2), SOS1(2), STAT3(1) 18739217 62 51 52 8 4 15 11 16 15 1 0.0101 0.0424 1.000 16 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(5), GLUD1(1) 1921945 6 6 6 0 0 0 4 1 1 0 0.184 0.0433 1.000 17 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(1), EIF4A2(3), EIF4G1(3), EIF4G2(1), EIF4G3(4), IRS1(2), MAPK1(1), MAPK14(1), PABPC1(1), PDK2(1), PIK3CA(6), PIK3R1(2), PRKCA(1), PTEN(7) 12040868 34 30 32 4 4 6 4 8 11 1 0.0887 0.0448 1.000 18 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), FDXR(3), SHMT1(2) 6762762 16 16 16 1 1 1 4 7 3 0 0.111 0.0449 1.000 19 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(1) 893891 4 4 4 1 0 0 1 1 2 0 0.870 0.0471 1.000 20 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB3A(2), RAB6A(2) 1776569 6 6 6 1 0 1 0 4 1 0 0.678 0.0495 1.000 21 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASNS(1), CAD(4), CRAT(1), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT2(1), GPT(2), PC(5) 11017816 28 25 28 2 0 5 2 11 10 0 0.0414 0.0645 1.000 22 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(1), ACOX3(3), ELOVL6(2), FADS1(1), FASN(4), HADHA(2) 6270892 17 14 17 1 1 4 0 9 3 0 0.0455 0.0707 1.000 23 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), SDHA(1), SDHD(1), UQCRC1(1) 2760417 6 6 6 1 1 2 2 0 1 0 0.365 0.0764 1.000 24 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(1), GLS(5), GLUD1(1) 3247694 8 8 8 0 0 0 4 1 3 0 0.151 0.0769 1.000 25 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 LDLR(2), LPL(4) 2241756 6 6 6 1 1 1 0 2 2 0 0.530 0.0860 1.000 26 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(2), ADORA3(1), P2RY1(2), P2RY2(1) 2424634 6 6 6 0 1 1 2 2 0 0 0.144 0.103 1.000 27 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(1), DPYS(1), ENPP1(2), ENPP3(1), ILVBL(3), PANK1(2), PANK2(1), PANK3(1), PPCDC(1), UPB1(1) 7326739 15 15 15 1 2 1 3 3 6 0 0.156 0.104 1.000 28 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(2), IL18(1), IL2(1) 1254329 4 4 4 0 0 0 0 2 2 0 0.623 0.109 1.000 29 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(1), SHMT1(2), SHMT2(3) 2366575 6 6 6 1 1 0 2 2 1 0 0.472 0.109 1.000 30 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(3), AASS(3), KARS(1) 2887466 7 7 7 1 0 2 2 3 0 0 0.338 0.112 1.000 31 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL10RA(3), IL10RB(1), JAK1(2), STAT1(2), STAT3(1), STAT5A(2), TNF(1) 5178247 13 13 13 2 2 1 0 6 4 0 0.538 0.113 1.000 32 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), RDH11(1), RDH12(3), RDH13(1) 2006027 6 6 6 1 0 1 0 4 1 0 0.556 0.119 1.000 33 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), UGDH(1) 3609475 8 8 8 1 2 0 3 2 1 0 0.306 0.120 1.000 34 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(1), PC(5), SLC25A11(3) 3908337 12 11 12 2 1 0 1 7 3 0 0.505 0.122 1.000 35 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), DPYD(1), DPYS(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), UPB1(1) 12244829 26 26 26 3 2 5 6 8 5 0 0.0467 0.144 1.000 36 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(1), IKBKB(1), JAK2(1), NFKBIA(1), RELA(2), TNF(1), TNFRSF1B(2), TP53(7), USH1C(1) 8101310 22 21 22 3 0 1 1 11 9 0 0.424 0.147 1.000 37 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(2), RANBP2(5) 3499668 9 9 9 2 1 1 1 5 1 0 0.522 0.147 1.000 38 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD86(2), GRB2(1), ICOS(1), IL2(1), ITK(1), PIK3CA(6), PIK3R1(2) 5352015 14 13 12 2 1 4 0 6 3 0 0.331 0.147 1.000 39 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2) 6354375 13 13 13 1 1 0 4 5 3 0 0.213 0.158 1.000 40 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2) 6354375 13 13 13 1 1 0 4 5 3 0 0.213 0.158 1.000 41 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), SHMT1(2) 6354375 13 13 13 1 1 0 4 5 3 0 0.213 0.158 1.000 42 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(1), DPYS(1), ENPP1(2), ENPP3(1), PANK1(2), PANK2(1), PANK3(1), UPB1(1) 5901772 11 11 11 0 2 1 2 2 4 0 0.0635 0.158 1.000 43 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AMD1(2), AOC2(2), ARG1(1), ARG2(1), CPS1(1), GATM(1), MAOA(1), MAOB(3), NAGS(1), ODC1(1), SAT2(1) 12415512 26 26 26 3 4 1 4 9 8 0 0.0935 0.173 1.000 44 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CRY1(1), CSNK1E(3), PER1(4) 3595871 9 9 9 2 2 0 1 5 1 0 0.545 0.176 1.000 45 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3) 3369494 7 7 7 0 2 0 2 2 1 0 0.122 0.176 1.000 46 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3) 3369494 7 7 7 0 2 0 2 2 1 0 0.122 0.176 1.000 47 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), FH(2), IDH2(1), OGDH(5), SDHA(1), SUCLA2(1) 3979992 11 10 11 2 0 2 0 4 5 0 0.425 0.179 1.000 48 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(1), CAD(4), CPS1(1), EPRS(1), GAD1(2), GAD2(2), GCLC(3), GCLM(1), GFPT1(2), GFPT2(2), GLS(5), GLUD1(1), GLUL(2), GMPS(1), GNPNAT1(1), GOT2(1), GPT(2), GSR(1), NAGK(1), PPAT(1), QARS(3) 16668961 39 37 39 4 0 2 11 17 9 0 0.0290 0.180 1.000 49 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(1), PLA2G6(2), PTGES(1), PTGS2(1), TBXAS1(1) 6572016 14 13 14 1 1 1 2 6 4 0 0.185 0.182 1.000 50 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), PTPRU(2), STAT1(2) 4807806 12 12 12 2 1 0 0 8 3 0 0.646 0.191 1.000 51 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), HADHA(2) 5139811 10 10 10 1 2 0 3 4 1 0 0.177 0.196 1.000 52 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CDK4(1), CDKN2A(1), E2F2(1), NXT1(1), TP53(7) 3494096 12 12 12 3 0 0 2 7 3 0 0.567 0.198 1.000 53 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(2), ATM(5), BAX(1), CDK4(1), TP53(7) 7599839 16 16 16 2 0 1 3 6 6 0 0.274 0.205 1.000 54 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(3), CBS(1), CTH(1), GGT1(1), MARS(1), MAT1A(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(1) 5243911 13 12 13 2 0 3 2 4 4 0 0.418 0.216 1.000 55 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(8), HMGB2(2) 4479170 10 10 10 2 1 2 4 2 1 0 0.271 0.222 1.000 56 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(2), MBTPS1(1), MBTPS2(1), SCAP(1), SREBF1(2), SREBF2(5) 5207942 14 14 14 3 1 0 3 6 4 0 0.490 0.223 1.000 57 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ACADM(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), DPYD(1), DPYS(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), UPB1(1) 11394131 22 22 22 2 2 3 4 8 5 0 0.0518 0.225 1.000 58 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2) 4449110 8 8 8 0 0 5 0 2 1 0 0.0493 0.226 1.000 59 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(1), HADHA(2), HSD17B4(1), NTAN1(1), SIRT7(3) 5008608 9 9 9 1 1 1 3 4 0 0 0.203 0.237 1.000 60 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(1), IL18(1), ITGB1(1), KLRC3(1), PAK1(2), PIK3CA(6), PIK3R1(2), PTK2B(1), VAV1(3) 7923065 19 17 17 3 2 5 1 5 5 1 0.315 0.245 1.000 61 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 NFKBIA(1), RELA(2), TP53(7) 4174476 10 10 10 2 0 0 1 5 4 0 0.639 0.247 1.000 62 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP3(1), TP53(7) 3015499 8 8 8 2 0 0 2 4 2 0 0.567 0.250 1.000 63 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), ELK1(1), GRB2(1), INS(1), IRS1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RASA1(2), SLC2A4(2), SOS1(2) 10713694 24 22 22 3 4 6 2 8 4 0 0.0701 0.256 1.000 64 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(5), CDC25A(1), CDC25C(1), CDK4(1), CHEK1(1), MYT1(6), TP53(7) 7448439 22 21 22 4 1 6 4 7 4 0 0.175 0.264 1.000 65 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), HADHA(2) 2052238 4 4 4 1 0 0 2 2 0 0 0.593 0.267 1.000 66 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 PON1(1), PON2(2), RDH11(1), RDH12(3), RDH13(1) 3766454 8 8 8 1 0 1 0 6 1 0 0.439 0.270 1.000 67 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), ELK1(1), GRB2(1), IGF1R(2), IRS1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RASA1(2), SOS1(2) 10400555 23 21 21 3 3 6 2 7 5 0 0.105 0.273 1.000 68 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(3), ABAT(1), ACY3(1), ADSL(1), ADSSL1(2), AGXT(1), AGXT2(1), ASNS(1), CAD(4), CRAT(1), DARS(3), DDO(1), DLAT(1), DLD(2), GAD1(2), GAD2(2), GOT2(1), GPT(2), NARS2(1), PC(5) 16007712 38 33 38 4 2 6 3 14 12 1 0.0580 0.273 1.000 69 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), LPO(1), MPO(1), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(3) 4894459 11 11 11 2 1 0 3 4 3 0 0.463 0.277 1.000 70 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), EHHADH(1), HADHA(2) 3556745 7 7 7 1 0 0 1 5 1 0 0.510 0.278 1.000 71 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), LPO(1), MPO(1), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(3) 5006222 11 11 11 2 1 1 2 4 3 0 0.402 0.280 1.000 72 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 MAPK14(1), THBS1(5) 3033979 6 6 6 1 0 0 3 2 1 0 0.544 0.280 1.000 73 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(1) 1962369 4 4 4 1 0 1 1 2 0 0 0.622 0.282 1.000 74 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), CS(1), DLD(2), FH(2), IDH2(1), IDH3B(1), PC(5), PCK1(5), SDHA(1), SUCLA2(1), SUCLG1(1) 8691813 21 20 21 4 0 2 4 4 10 1 0.358 0.294 1.000 75 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(2), GAD2(2), GGT1(1) 2439448 7 7 7 2 0 1 2 2 2 0 0.647 0.295 1.000 76 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(4), CREB1(1), MAPK1(1), RAF1(3), SNX13(1), TERF2IP(1) 4794132 14 13 13 3 1 2 1 5 5 0 0.507 0.311 1.000 77 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1), TAT(1) 1111600 2 2 2 0 1 0 0 0 1 0 0.719 0.321 1.000 78 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(1), FTCD(1), GART(2), MTHFD1(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(3) 8055369 20 20 20 4 1 3 5 7 4 0 0.258 0.325 1.000 79 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(2), HMGCS1(2), HMGCS2(2) 3208910 6 6 6 0 0 0 0 2 4 0 0.303 0.328 1.000 80 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), ELK1(1), GRB2(1), NGFR(1), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2) 8022754 18 17 16 3 3 6 1 5 3 0 0.182 0.335 1.000 81 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(2), MTMR6(1), PHPT1(1), TPK1(1) 2672050 5 5 5 0 0 1 1 3 0 0 0.266 0.336 1.000 82 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(3), BHMT(3), CBS(1), CTH(1), DNMT1(1), DNMT3A(5), DNMT3B(2), MARS(1), MAT1A(1), MAT2B(1), MTR(1) 7364714 20 19 20 4 1 2 1 5 11 0 0.496 0.337 1.000 83 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), STAT1(2) 3422146 8 8 8 2 1 0 0 5 2 0 0.789 0.349 1.000 84 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(1), ITGAM(3), ITGB2(1), SELE(1), SELL(1) 4416966 8 8 8 1 0 2 0 5 1 0 0.423 0.358 1.000 85 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH4A1(1), AMD1(2), AOC2(2), ARG1(1), ARG2(1), CKB(1), CPS1(1), GATM(1), GLUD1(1), GOT2(1), MAOA(1), MAOB(3), NOS1(1), NOS3(1), OAT(2), ODC1(1), P4HA1(1), P4HA3(1), RARS(2) 19064227 33 31 33 2 5 1 6 10 11 0 0.0136 0.364 1.000 86 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), MTHFD2(1), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(2) 5376760 10 10 10 1 0 1 1 4 4 0 0.274 0.364 1.000 87 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2) 1649292 3 3 3 1 0 0 0 1 2 0 0.947 0.375 1.000 88 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(2), GNE(1), HEXA(1), HEXB(1), HK1(2), RENBP(3), UAP1(1) 7186249 13 12 13 1 0 2 3 7 1 0 0.130 0.375 1.000 89 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(3), PAPSS1(1), PAPSS2(2), SUOX(1) 3571801 7 6 7 0 0 1 1 2 3 0 0.261 0.375 1.000 90 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), RXRA(2) 2272079 4 4 4 1 0 2 0 1 1 0 0.662 0.375 1.000 91 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL4(1), ST6GALNAC2(1), ST6GALNAC4(1) 2380495 4 4 4 0 1 1 0 2 0 0 0.254 0.385 1.000 92 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA6(1), PSMA7(1), PSMB1(1), PSMB5(1), PSMC3(1), RPN1(2), RPN2(1), UBE3A(3) 5492992 11 11 11 2 1 1 1 6 2 0 0.489 0.385 1.000 93 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(2), RIPK1(1), TNF(1), TNFRSF1B(2) 3529516 6 6 6 1 0 1 1 3 1 0 0.608 0.385 1.000 94 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ARG1(1), ARG2(1), CKB(1), CPS1(1), GATM(1), GLUD1(1), NAGS(1), OAT(2), ODC1(1) 7819835 13 13 13 1 0 0 2 5 6 0 0.336 0.395 1.000 95 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 636973 1 1 1 0 0 0 0 0 1 0 1.000 0.399 1.000 96 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(2), HSD17B4(1), MECR(3) 3591561 6 6 6 1 1 1 0 4 0 0 0.520 0.409 1.000 97 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(2), GOT2(1), PAH(2), TAT(1), YARS2(1) 3669188 7 6 7 1 1 1 1 2 2 0 0.545 0.409 1.000 98 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(2), HDC(1), TPH1(1) 2532576 4 4 4 1 0 1 1 1 1 0 0.630 0.414 1.000 99 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), EGFR(1), ERBB3(2), NRG1(3) 4311395 7 7 7 1 0 1 1 3 2 0 0.330 0.415 1.000 100 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15B(2), ALOX5(2), CYP2C18(2), CYP2C8(1), CYP2J2(1), CYP4A11(2), CYP4F2(2), CYP4F3(3), DHRS4(1), EPHX2(1), GGT1(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PTGES(1), PTGS2(1), TBXAS1(1) 16819046 31 27 31 2 2 3 2 14 9 1 0.0627 0.420 1.000 101 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAX(1), BCL10(1), BCL2L11(1), BID(1), CASP9(1), CES1(1) 4751872 8 8 8 1 0 2 1 2 3 0 0.420 0.429 1.000 102 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(3), CYP2A7(1), XDH(1) 3374553 7 7 7 2 0 1 0 5 1 0 0.783 0.431 1.000 103 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(3), ITPKA(1), ITPKB(1) 2545891 6 5 6 4 0 0 2 0 4 0 0.994 0.434 1.000 104 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), CES1(1), ESD(1) 2618986 4 4 4 1 0 2 1 1 0 0 0.517 0.440 1.000 105 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DOT1L(5), EHHADH(1), EHMT1(1), EHMT2(3), GCDH(2), HADHA(2), HSD17B4(1), NSD1(4), OGDH(5), OGDHL(1), PIPOX(3), PLOD1(1), PLOD2(3), PLOD3(1), RDH11(1), RDH12(3), RDH13(1), SETD1A(4), SETDB1(4), SHMT1(2), SHMT2(3), SPCS3(1), SUV39H1(1), SUV39H2(1) 24470018 64 53 64 9 5 10 7 25 16 1 0.0234 0.445 1.000 106 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ARG2(1), CKB(1), CPS1(1), EPRS(1), GATM(1), GLUD1(1), GOT2(1), LAP3(2), NOS1(1), NOS3(1), OAT(2), P4HA1(1), P4HA3(1), PARS2(1), PYCR2(2), PYCRL(2), RARS(2), RARS2(2) 15623692 26 24 26 1 1 2 5 8 10 0 0.0248 0.449 1.000 107 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 EHHADH(1), GCDH(2), HADHA(2) 3289306 5 5 5 1 1 1 1 2 0 0 0.456 0.451 1.000 108 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(1), AKT3(1), GRB2(1), IL4R(2), IRS1(2), IRS2(3), JAK1(2), JAK3(1), MAP4K1(1), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PPP1R13B(2), RAF1(3), SOCS1(1), SOS1(2), SOS2(1) 15413510 33 30 31 4 4 8 3 12 6 0 0.0241 0.455 1.000 109 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(1), GRB2(1), IL2(1), JAK1(2), JAK3(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1) 9976485 16 15 16 0 2 2 2 5 5 0 0.0180 0.459 1.000 110 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(1), ITGA1(3), ITGB1(1), LYN(3) 6558287 11 10 11 1 1 1 0 5 4 0 0.400 0.460 1.000 111 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), SELL(1), TNF(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2) 5743595 11 9 11 1 0 2 2 5 2 0 0.281 0.468 1.000 112 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(4), ACADM(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), BCKDHA(1), DBT(1), DLD(2), EHHADH(1), HADHA(2), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), MCCC1(1), MCCC2(1), PCCA(1), PCCB(1) 18437493 33 31 33 3 2 2 5 15 8 1 0.0452 0.483 1.000 113 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(2), CYP1A2(2), CYP2C18(2), CYP2C8(1), CYP2J2(1), CYP3A43(2), CYP3A7(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), RDH11(1), RDH12(3), RDH13(1) 10225652 20 18 20 2 0 4 0 10 5 1 0.206 0.487 1.000 114 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), IFNG(2), IFNGR1(1), IL12RB2(1), IL18(1), IL2(1), IL4R(2) 5304213 10 10 10 2 0 0 1 4 5 0 0.684 0.491 1.000 115 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ALPI(1), ALPL(1), ALPPL2(1), CMBL(3), CYP3A43(2), CYP3A7(1), PON1(1), PON2(2) 7725604 13 13 13 2 1 2 0 4 6 0 0.578 0.496 1.000 116 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(1), GOT2(1), PAH(2), TAT(1) 3488541 6 5 6 1 1 1 1 1 2 0 0.543 0.499 1.000 117 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(2), BMPR2(1) 2624596 4 4 4 0 0 1 0 2 1 0 0.280 0.505 1.000 118 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP17A1(1), HSD11B1(1) 2913236 4 4 4 1 1 0 0 2 1 0 0.682 0.509 1.000 119 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(2), PTPRU(2), STAT1(2), STAT2(1) 5274834 8 8 8 1 1 0 0 4 3 0 0.291 0.514 1.000 120 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 708436 1 1 1 0 0 0 0 1 0 0 0.838 0.526 1.000 121 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ENPP1(2), ENPP3(1), FLAD1(2) 4080194 6 6 6 0 0 1 0 3 2 0 0.375 0.531 1.000 122 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK4(1), MAPK1(1), NFKBIA(1), PAK1(2), PIK3CA(6), PIK3R1(2), RAF1(3), RELA(2) 8506020 18 16 16 3 2 4 2 5 5 0 0.341 0.543 1.000 123 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT2(1), GALNT4(2), GALNT6(3), GALNT7(3), ST3GAL4(1) 6190496 11 11 11 2 0 1 0 6 4 0 0.518 0.544 1.000 124 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1), SPCS3(1) 1311142 2 2 2 0 0 0 0 1 1 0 0.833 0.551 1.000 125 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS2(1) 2228210 3 3 3 0 0 1 0 2 0 0 0.397 0.555 1.000 126 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1) 5263556 9 9 9 2 0 3 1 5 0 0 0.490 0.558 1.000 127 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFLAR(2) 1616937 2 2 2 0 0 0 1 1 0 0 0.622 0.559 1.000 128 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(3), CHST13(1), PAPSS1(1), PAPSS2(2), SUOX(1) 4897485 8 7 8 0 0 1 2 2 3 0 0.195 0.561 1.000 129 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), ANAPC5(3), ANAPC7(1), BTRC(2), CDC16(1), CDC20(2), CDC23(1), CDC27(2), CUL1(2), CUL2(1), CUL3(11), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), TCEB1(1), UBA1(1), VHL(3), WWP1(5), WWP2(1) 17344240 42 38 41 6 2 0 7 19 12 2 0.161 0.567 1.000 130 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(1), B4GALT5(1), ST3GAL4(1) 3277078 6 5 6 1 0 0 0 3 3 0 0.862 0.572 1.000 131 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ENPP1(2), ENPP3(1), FLAD1(2), MTMR2(2), MTMR6(1), PHPT1(1) 6327633 10 9 10 0 0 2 1 5 2 0 0.120 0.575 1.000 132 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(5), GCLC(3), GCLM(1), GGT1(1), GSTA1(2), GSTA2(1), GSTM1(1), GSTM4(1), GSTT1(1), IDH2(1), PGD(1) 8079424 18 15 18 3 0 0 9 7 2 0 0.191 0.576 1.000 133 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(1), CTH(1) 2066227 3 3 3 1 0 0 0 1 2 0 0.880 0.581 1.000 134 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(2), STAT1(2), STAT2(1) 4583583 6 6 6 1 1 0 0 2 3 0 0.395 0.586 1.000 135 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX5(2), CYP4F2(2), CYP4F3(3), GGT1(1), LPO(1), MPO(1), PLA2G4A(1), PLA2G6(2), PRDX5(1), PRDX6(2), PTGS2(1), TBXAS1(1) 11962719 23 21 23 3 1 2 2 12 6 0 0.222 0.588 1.000 136 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(1), IL4R(2), IRS1(2), JAK1(2), JAK3(1) 6214245 8 8 8 1 2 0 2 3 1 0 0.336 0.588 1.000 137 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(2) 1426382 2 2 2 0 0 0 0 1 1 0 0.524 0.589 1.000 138 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(2) 1492159 2 2 2 0 0 0 0 1 1 0 0.462 0.592 1.000 139 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 698255 1 1 1 0 0 0 0 1 0 0 0.819 0.594 1.000 140 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(1), CA1(1), CA12(1), CA14(1), CA6(1), CPS1(1), CTH(1), GLS(5), GLUD1(1), GLUL(2) 7964104 16 16 16 3 0 1 4 6 5 0 0.482 0.603 1.000 141 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CMAS(1), GFPT1(2), GFPT2(2), GNE(1), GNPNAT1(1), HEXA(1), HEXB(1), HK1(2), MTMR2(2), MTMR6(1), NAGK(1), NANS(1), NPL(1), PHPT1(1), RENBP(3), UAP1(1) 12120719 23 22 23 3 0 3 7 12 1 0 0.0943 0.606 1.000 142 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD33(1), CD5(1), CD7(2), IFNG(2), ITGAX(6), TLR2(1), TLR7(1) 7809328 19 16 19 4 2 2 5 4 6 0 0.193 0.608 1.000 143 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA6(1), PSMA7(1), PSMB1(1), PSMB10(1), PSMB5(1) 3696156 5 5 5 1 0 0 0 4 1 0 0.724 0.608 1.000 144 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), KHK(2), LCT(1), MPI(1), PGM1(1), PYGM(1) 5719237 8 8 8 1 0 1 1 3 3 0 0.496 0.609 1.000 145 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), HLA-A(1), ICAM1(1), ITGAL(1), ITGB2(1) 3651810 5 5 5 1 0 1 0 3 1 0 0.683 0.612 1.000 146 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 CFLAR(2), GRB2(1), IRS1(2), JAK1(2), JAK3(1), MAPK1(1), PIK3CA(6), PIK3R1(2), PPIA(1), RAF1(3), SOCS1(1), SOCS3(1), SOS1(2), STAT5A(2), STAT5B(1) 15280907 28 24 26 3 4 6 3 9 6 0 0.0418 0.617 1.000 147 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 HMGB1(2), HMGB2(2), TOP2A(1), TOP2B(1) 4099910 6 5 6 1 1 1 1 1 2 0 0.570 0.620 1.000 148 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXA(1), HEXB(1), LCT(1), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA5(2) 6938159 10 9 10 0 0 3 0 5 2 0 0.0686 0.620 1.000 149 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), JUNB(1), MAP2K3(1), MAPK14(1), NFATC2(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2) 5164669 9 8 9 2 0 1 2 3 3 0 0.563 0.623 1.000 150 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1), RAF1(3) 3505685 7 7 7 2 2 0 0 4 1 0 0.671 0.623 1.000 151 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(2), PRKCA(1) 2113467 3 3 3 0 0 0 0 0 3 0 1.000 0.627 1.000 152 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BAX(1), BID(1), BIK(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1) 5685902 10 10 10 2 0 1 1 6 2 0 0.575 0.636 1.000 153 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RXRA(2), TNF(1) 2421261 11 10 11 4 1 4 0 2 4 0 0.784 0.638 1.000 154 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMKK1(3), CREB1(1) 4946231 11 11 11 3 2 1 2 3 3 0 0.534 0.638 1.000 155 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(2), DHCR24(1), GGCX(1), HMGCR(1), IDI2(1), LSS(2), TM7SF2(2) 8159862 11 11 11 1 1 1 1 6 2 0 0.229 0.638 1.000 156 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(2), ATM(5), BAX(1), CPB2(1), HIF1A(2), HSPA1A(1), TP53(7) 9123599 19 19 19 4 0 2 3 8 5 1 0.514 0.638 1.000 157 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25C(1), GRB2(1), PRKCA(1), PTPRA(1) 3934790 5 5 5 1 1 1 0 2 1 0 0.550 0.639 1.000 158 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT2(1), TAT(1) 1976215 2 2 2 1 1 0 0 0 1 0 0.915 0.640 1.000 159 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(1), PTK2B(1), SOS1(2) 3684463 5 5 5 0 0 1 0 2 2 0 0.191 0.642 1.000 160 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), BCKDHA(1), EHHADH(1), HADHA(2), HMGCL(2), MCCC1(1), MCCC2(1), PCCA(1), PCCB(1) 15234550 28 27 28 4 2 3 6 12 5 0 0.116 0.651 1.000 161 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IFNG(2), IL2(1), TGFBR1(1), TOB1(2) 4487039 6 6 6 1 0 0 1 4 1 0 0.545 0.655 1.000 162 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), HMGCR(1), HMGCS1(2), LSS(2) 5531951 7 7 7 1 0 1 1 3 2 0 0.456 0.659 1.000 163 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(1), IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2) 7931845 19 17 17 4 3 5 0 7 4 0 0.306 0.660 1.000 164 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2) 1344997 2 1 2 0 0 1 0 1 0 0 0.470 0.669 1.000 165 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 RECK(2), TIMP1(1), TIMP2(1) 3222203 4 4 4 1 0 0 0 3 1 0 0.875 0.679 1.000 166 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(1), ALPPL2(1), FPGS(1), GGH(1) 2929678 5 5 5 2 1 2 0 0 2 0 0.761 0.679 1.000 167 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1) 1245173 1 1 1 0 0 0 1 0 0 0 0.746 0.680 1.000 168 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2I(1), UBE2L3(1), UBE3A(3) 4426773 5 5 5 1 1 0 1 3 0 0 0.607 0.680 1.000 169 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(3), AXIN1(3), BTRC(2), CTNNB1(2), FZD1(1), NOTCH1(2), PSEN1(1) 9100119 17 17 17 3 1 2 0 12 2 0 0.313 0.682 1.000 170 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3) 5595886 9 9 9 2 2 0 2 4 1 0 0.470 0.685 1.000 171 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(3), CBS(1), CTH(1), GGT1(1), MARS(1), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), SCLY(1) 10556326 21 18 21 3 0 3 4 7 7 0 0.270 0.685 1.000 172 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(3), AMD1(2), BHMT(3), CBS(1), CTH(1), DNMT1(1), DNMT3A(5), DNMT3B(2), MARS(1), MAT1A(1), MAT2B(1), MTR(1), TAT(1) 8773642 23 22 23 6 3 2 2 5 11 0 0.620 0.686 1.000 173 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(2), F2R(1), F5(3), PROS1(1) 6902048 8 8 8 1 2 0 1 3 2 0 0.452 0.686 1.000 174 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), GCNT2(2) 2588553 3 3 3 0 0 0 0 2 1 0 0.576 0.687 1.000 175 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3) 7087152 11 11 11 2 0 3 2 3 3 0 0.349 0.692 1.000 176 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), FH(2), IDH2(1), SUCLA2(1) 3759767 5 5 5 2 0 0 0 1 4 0 0.807 0.692 1.000 177 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYC(1), SP3(1) 2821383 5 5 5 2 0 2 1 2 0 0 0.724 0.693 1.000 178 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(3), AASS(3), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DOT1L(5), EHHADH(1), EHMT1(1), EHMT2(3), GCDH(2), HADHA(2), PLOD1(1), PLOD2(3), PLOD3(1), SHMT1(2), SHMT2(3) 15586489 37 31 37 5 5 6 6 13 7 0 0.0205 0.695 1.000 179 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(1), CDKN2A(1), PIK3CA(6), PIK3R1(2), POLR1A(5), POLR1B(2), TP53(7) 8558328 24 20 22 5 2 6 1 8 7 0 0.284 0.705 1.000 180 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLG2(1), POLI(1), POLK(2), POLL(1), POLM(3), POLQ(3), REV1(2), REV3L(3), RFC5(1) 17221311 26 25 26 2 0 5 3 12 6 0 0.0536 0.708 1.000 181 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKBIA(1), PLCB1(1), PRKCA(1), RELA(2) 3458019 5 5 5 3 0 0 0 1 4 0 0.991 0.708 1.000 182 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), ESCO1(2), HADHA(2), PNPLA3(1), YOD1(1) 12981038 16 16 16 1 2 2 3 5 4 0 0.0835 0.711 1.000 183 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), GRB2(1), JAK2(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1) 7548306 13 12 13 2 0 1 1 6 5 0 0.485 0.721 1.000 184 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PRKCA(1), PTK2B(1) 2832700 3 3 3 0 1 0 0 1 1 0 0.584 0.721 1.000 185 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(1) 1552318 1 1 1 0 0 0 0 0 1 0 0.830 0.723 1.000 186 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 ENPP1(2), ENPP3(1), NMNAT2(1), NNT(3), NT5C(1), NT5M(1) 6144505 9 9 9 2 1 2 0 5 1 0 0.554 0.724 1.000 187 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 GRB2(1), ITGB1(1), MAPK1(1), PDK2(1), PIK3CA(6), PIK3R1(2), PTEN(7), PTK2(1), SOS1(2) 8319429 22 20 20 6 2 5 2 3 9 1 0.576 0.725 1.000 188 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFS1(1), NDUFV1(1) 2949207 6 6 6 3 0 0 1 2 3 0 0.925 0.733 1.000 189 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), COPS5(1), CREB1(1), EP300(5), HIF1A(2), NOS3(1), VHL(3) 7130600 14 12 14 5 1 0 1 4 7 1 0.943 0.740 1.000 190 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(2), EXTL1(1), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), NDST1(1), NDST4(2) 8879971 13 13 13 2 1 5 1 2 4 0 0.208 0.744 1.000 191 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), IL5RA(1) 2227903 2 2 2 0 0 0 1 0 1 0 0.734 0.744 1.000 192 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), GOT2(1), SULT1B1(1), SULT1C4(4) 5300168 7 7 7 2 0 1 3 1 2 0 0.680 0.745 1.000 193 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(4) 4183403 4 4 4 1 1 0 1 0 2 0 0.766 0.746 1.000 194 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), IGF1R(2), PIK3CA(6), PIK3R1(2) 5551174 11 10 9 3 1 4 0 4 2 0 0.635 0.754 1.000 195 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CHEK1(1), NEK1(1) 3063667 3 3 3 0 1 0 0 2 0 0 0.532 0.754 1.000 196 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(1), ACSS1(1), ACSS2(1), FH(2), IDH2(1), SUCLA2(1) 5614980 10 9 10 5 1 0 0 3 6 0 0.937 0.754 1.000 197 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1) 2942367 5 5 5 2 2 0 0 2 1 0 0.760 0.754 1.000 198 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1) 2942367 5 5 5 2 2 0 0 2 1 0 0.760 0.754 1.000 199 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT1(2), B4GALT2(1), B4GALT5(1), DPAGT1(2), MAN1B1(1), MGAT4B(1), MGAT5(1), RPN1(2), RPN2(1), ST6GAL1(1) 8449245 13 12 13 2 0 3 0 3 7 0 0.521 0.758 1.000 200 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(2), CPT1A(1), EHHADH(1), HADHA(2), SCP2(1) 7084853 10 10 10 2 0 3 3 4 0 0 0.310 0.759 1.000 201 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS2(4), ILVBL(3), LARS(4), VARS(1), VARS2(3) 7792424 15 14 15 3 2 0 5 4 4 0 0.519 0.759 1.000 202 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), HDC(1), MAOA(1), MAOB(3), PRPS2(1) 10296754 15 14 15 2 3 2 2 6 2 0 0.158 0.760 1.000 203 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ALPI(1), ALPL(1), ALPPL2(1), CYP1A2(2), CYP2A13(3), CYP2A7(1), CYP2C18(2), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP2J2(1), CYP3A7(1), CYP51A1(2), PON1(1) 12447440 20 18 20 3 2 3 0 9 5 1 0.383 0.763 1.000 204 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(1), EIF4A2(3), EIF4B(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), PDK2(1), PIK3CA(6), PIK3R1(2), PTEN(7), TSC1(2), TSC2(6) 11897016 37 34 35 8 3 7 5 9 12 1 0.385 0.765 1.000 205 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(1), GALNT10(1), GALNT11(1), GALNT2(1), GALNT4(2), GALNT5(1), GALNT6(3), GALNT7(3), GCNT3(2), OGT(2) 13649419 19 18 19 2 1 2 3 7 6 0 0.135 0.765 1.000 206 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 RPE(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2) 7392982 15 15 15 4 0 2 6 4 3 0 0.554 0.765 1.000 207 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(5), GCLC(3), GCLM(1), GGT1(1), GSR(1), GSTA1(2), GSTA2(1), GSTK1(2), GSTM1(1), GSTM4(1), GSTT1(1), IDH2(1), TXNDC12(1) 9769147 21 17 21 4 0 1 9 9 2 0 0.184 0.766 1.000 208 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1) 1656194 1 1 1 1 0 0 1 0 0 0 0.910 0.766 1.000 209 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(1) 1797382 1 1 1 1 1 0 0 0 0 0 0.889 0.767 1.000 210 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(3), ITGB1(1), ITGB2(1), SELE(1), SELL(1) 6715243 10 10 10 2 0 2 1 5 2 0 0.566 0.771 1.000 211 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 ENPP1(2), ENPP3(1), NADK(1), NMNAT2(1), NNT(3), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1) 9058758 12 12 12 2 2 2 0 7 1 0 0.373 0.771 1.000 212 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), GBGT1(1), HEXA(1), HEXB(1), ST3GAL4(1) 4227049 5 5 5 0 0 0 0 4 1 0 0.479 0.775 1.000 213 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), AMT(1), AOC2(2), BHMT(3), CBS(1), CHDH(1), CPT1B(1), CTH(1), DLD(2), GATM(1), MAOA(1), MAOB(3), PLCB2(3), PLCG2(1), SHMT1(2), SHMT2(3), TARS(1) 17905481 29 29 29 4 3 3 6 9 7 1 0.123 0.778 1.000 214 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS3(1), PTPRU(2), STAT3(1) 6484112 10 9 10 2 1 2 1 5 1 0 0.488 0.796 1.000 215 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(1), CDC25C(1), SHH(1), XPO1(2) 3701017 5 5 5 2 2 1 2 0 0 0 0.587 0.796 1.000 216 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(1), ITGAL(1), ITGB1(1), ITGB2(1), SELE(1), SELL(1) 5088470 7 7 7 2 0 2 1 2 2 0 0.728 0.799 1.000 217 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), AKT3(1), ELK1(1), GRB2(1), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(6), PIK3CD(1), SOS1(2) 6877524 16 15 14 4 2 6 0 5 3 0 0.189 0.808 1.000 218 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT5(1), FUT6(1) 2144272 2 2 2 0 0 1 0 1 0 0 0.446 0.809 1.000 219 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(1), PLCB1(1), TUB(1) 2975997 5 4 5 2 0 1 0 3 1 0 0.807 0.810 1.000 220 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLAT(1), DLD(2), FH(2), IDH2(1), IDH3B(1), OGDH(5), PC(5), PDK2(1), PDK4(2), SDHA(1), SDHD(1), SUCLA2(1), SUCLG1(1) 11993651 25 23 25 5 0 2 4 6 12 1 0.373 0.816 1.000 221 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(2), FBXW7(1) 3513457 3 3 3 0 1 0 0 1 1 0 0.569 0.816 1.000 222 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(1), CLYBL(1), CS(1), DLD(2), FH(2), IDH2(1), IDH3B(1), OGDH(5), OGDHL(1), PC(5), PCK1(5), PCK2(1), SDHA(1), SDHD(1), SUCLA2(1), SUCLG1(1) 12557410 33 29 33 7 2 3 5 9 13 1 0.356 0.818 1.000 223 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 IL2(1), IL9(1) 2606000 2 2 2 0 0 0 1 1 0 0 0.613 0.818 1.000 224 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), GBGT1(1), HEXA(1), HEXB(1) 4477720 5 5 5 0 0 0 0 4 1 0 0.486 0.818 1.000 225 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(1), CA1(1), CA12(1), CA13(2), CA14(1), CA6(1), CPS1(1), CTH(1), GLS(5), GLUD1(1), GLUL(2) 8897092 18 18 18 4 0 2 4 7 5 0 0.544 0.820 1.000 226 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(4), ABCG2(1), CES1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2) 9684980 22 22 22 5 1 4 7 6 4 0 0.352 0.824 1.000 227 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(8), EP300(5), NCOA3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RXRA(2) 8710774 22 22 22 8 0 5 4 3 10 0 0.771 0.825 1.000 228 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), JAK1(2), JAK2(1), JAK3(1), SOCS3(1), STAT1(2), STAT3(1), STAT5A(2), STAT5B(1) 7923615 14 14 14 3 2 1 2 5 4 0 0.628 0.828 1.000 229 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL16(1), IL18(1), IL2(1), IL9(1), TNF(1) 4170267 7 6 7 2 0 0 1 3 3 0 0.858 0.832 1.000 230 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 RDH5(1) 1610580 1 1 1 0 0 0 0 1 0 0 0.829 0.832 1.000 231 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA6(1), PSMA7(1), PSMB1(1), PSMB5(1), PSMC2(2), PSMC3(1), PSMD1(2), PSMD12(1), PSMD13(1), PSMD2(3), PSMD6(1) 6742547 15 14 15 4 0 0 1 9 5 0 0.819 0.833 1.000 232 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), CS(1), HAO1(2), HAO2(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 5364802 10 10 10 3 1 1 2 3 3 0 0.713 0.835 1.000 233 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), NOX1(1), RELA(2), TNF(1), XDH(1) 4208926 6 6 6 2 0 0 2 0 4 0 0.947 0.838 1.000 234 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CUL1(2), SKP2(1) 3618986 3 3 3 0 1 0 0 2 0 0 0.480 0.841 1.000 235 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CUL1(2), SKP2(1) 3631878 3 3 3 0 1 0 0 2 0 0 0.473 0.841 1.000 236 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 HMGCR(1), LSS(2), NQO2(1) 4646807 4 4 4 1 0 1 2 0 1 0 0.529 0.843 1.000 237 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), HMGCL(2) 10912064 17 17 17 3 2 1 3 7 4 0 0.247 0.845 1.000 238 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 IL2(1) 1657614 1 1 1 0 0 0 0 1 0 0 0.836 0.847 1.000 239 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(5), CDC25A(1), CDC25C(1), CHEK1(1), MYT1(6) 5824087 14 13 14 4 1 6 2 3 2 0 0.430 0.848 1.000 240 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(1), BIRC3(2), CASP10(1), CASP9(1), SCAP(1), SREBF1(2), SREBF2(5) 7841016 15 14 15 3 1 1 2 6 5 0 0.428 0.849 1.000 241 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1) 1364155 1 1 1 0 0 0 0 1 0 0 0.834 0.849 1.000 242 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), BAAT(1), CEL(1), CYP27A1(1), CYP7A1(1), SRD5A1(1) 9808640 18 18 18 4 2 0 2 11 3 0 0.518 0.849 1.000 243 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(2), CES1(1), DDHD1(1), ESCO1(2), LIPA(1), PLA1A(1), PNPLA3(1), PRDX6(2) 10690549 11 11 11 0 0 4 1 4 2 0 0.0570 0.852 1.000 244 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), NOTCH1(2), PSEN1(1) 4010060 6 6 6 2 0 1 0 4 1 0 0.729 0.853 1.000 245 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(1) 2093168 1 1 1 1 0 0 1 0 0 0 0.902 0.858 1.000 246 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGT(3), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2) 10719413 15 15 15 3 1 5 0 6 3 0 0.424 0.864 1.000 247 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), CS(1), HAO1(2), HAO2(1), MTHFD1(3), MTHFD1L(1), MTHFD2(1) 5626210 10 10 10 3 1 1 2 3 3 0 0.717 0.865 1.000 248 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 COMT(1), GAD1(2), GAD2(2), HDC(1), MAOA(1), PAH(2), SLC18A3(1), TPH1(1) 6051726 11 10 11 3 0 2 2 5 2 0 0.578 0.865 1.000 249 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2) 5690160 11 11 11 4 0 0 1 5 5 0 0.892 0.866 1.000 250 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(2), JAK2(1), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), SOAT1(1) 5844477 11 10 11 3 1 1 2 6 1 0 0.661 0.874 1.000 251 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 PSAT1(1) 2026272 1 1 1 1 0 0 0 0 1 0 1.000 0.874 1.000 252 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), CHST2(3), ST3GAL4(1) 5162524 9 7 9 2 0 1 0 2 6 0 0.870 0.877 1.000 253 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(2), ABCB11(1), ABCB4(2), ABCC1(3), ABCC3(2) 6032348 10 10 10 3 1 4 1 3 1 0 0.475 0.879 1.000 254 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(3), CALCRL(2), CD97(3), CRHR2(1), ELTD1(2), GIPR(1), GLP2R(2), LPHN1(2), LPHN2(1), LPHN3(2) 11479233 19 19 18 4 0 2 4 8 4 1 0.406 0.881 1.000 255 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(2), EHHADH(1), ESCO1(2), GCDH(2), HADHA(2), PNPLA3(1), YOD1(1) 10884336 11 11 11 1 1 3 1 3 3 0 0.225 0.881 1.000 256 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2) 6314317 8 6 8 1 0 0 2 3 3 0 0.419 0.883 1.000 257 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAD8(1), ACAD9(1), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), BAAT(1), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SOAT1(1), SRD5A1(1) 13438700 27 27 27 5 2 2 2 17 4 0 0.325 0.884 1.000 258 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 PCYT1A(1), SLC18A3(1) 2907571 2 2 2 1 1 0 0 1 0 0 0.775 0.885 1.000 259 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(5), MAPK1(1) 6317038 14 14 14 7 1 2 3 2 6 0 0.933 0.888 1.000 260 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(1), LRP8(2), RELN(3), VLDLR(1) 5847438 7 7 7 2 0 2 1 3 1 0 0.685 0.891 1.000 261 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT2(1) 2860139 2 2 2 1 0 0 0 1 1 0 0.952 0.895 1.000 262 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), ELK1(1), GRB2(1), IL6ST(2), JAK1(2), JAK2(1), JAK3(1), RAF1(3), SOS1(2), STAT3(1) 10106356 16 15 16 3 2 3 2 7 2 0 0.280 0.896 1.000 263 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(1), JAK3(1), MAPK1(1), STAT3(1) 5018977 6 6 6 2 2 1 1 2 0 0 0.675 0.896 1.000 264 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(1) 3098032 4 4 4 2 0 0 3 1 0 0 0.830 0.898 1.000 265 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(1), GRB2(1), JAK2(1), RAF1(3), SOS1(2), STAT5A(2), STAT5B(1) 9205902 13 11 13 2 1 2 1 4 5 0 0.379 0.900 1.000 266 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), HK1(2), PFKL(1) 3851963 6 6 6 3 1 1 0 1 3 0 0.864 0.900 1.000 267 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), EIF2S3(1), IGF1R(2), INPPL1(2), PDK2(1), PIK3CA(6), PIK3R1(2), PTEN(7) 8538863 22 20 20 5 4 4 2 4 7 1 0.529 0.900 1.000 268 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(1), CASP10(1), CASP9(1) 5341862 5 5 5 0 0 1 0 0 4 0 0.552 0.902 1.000 269 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(4), CLTA(2), CLTB(1), GBF1(8), GPLD1(1), KDELR3(3) 6840426 20 19 20 7 1 1 4 8 6 0 0.759 0.907 1.000 270 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(2), ATM(5), BAX(1), BID(1), CASP6(1), CASP9(1), PRKCA(1), PTK2(1), PXN(1), STAT1(2), TLN1(6), TP53(7) 11436364 29 26 29 9 0 2 4 11 12 0 0.777 0.910 1.000 271 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACMSD(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), CAT(1), CYP1A2(2), CYP2A13(3), CYP2A7(1), CYP2C18(2), CYP2C8(1), CYP2D6(1), CYP2F1(1), CYP2J2(1), CYP3A7(1), CYP51A1(2), EHHADH(1), GCDH(2), HAAO(1), HADHA(2), KYNU(1), MAOA(1), MAOB(3), TDO2(1), TPH1(1) 23132971 40 35 40 5 6 3 4 19 7 1 0.0628 0.911 1.000 272 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(2), ELK1(1), GRB2(1), LYN(3), MAP3K1(3), MAPK1(1), PAPPA(4), RPS6KA3(1), SOS1(2), VAV1(3), VAV3(1) 13492461 23 21 23 4 2 4 1 14 2 0 0.221 0.912 1.000 273 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 METTL2B(1), PCYT1A(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2) 5902006 9 7 9 2 1 0 2 3 3 0 0.515 0.915 1.000 274 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(2), F2R(1) 5606927 6 6 6 2 2 0 1 2 1 0 0.770 0.918 1.000 275 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 LPO(1), MPO(1), PRDX5(1), PRDX6(2) 4095748 5 5 5 2 0 1 1 1 2 0 0.825 0.923 1.000 276 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACMSD(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AOC2(2), CAT(1), CYP1A2(2), CYP1B1(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(2), HSD17B4(1), INMT(1), KYNU(1), LNX1(2), MAOA(1), MAOB(3), METTL2B(1), NFX1(3), OGDH(5), OGDHL(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), TDO2(1), TPH1(1), TPH2(1) 25475869 50 42 50 8 5 7 7 22 9 0 0.0539 0.927 1.000 277 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(1), AMT(1), AOC2(2), BHMT(3), CBS(1), CHDH(1), CTH(1), DLD(2), GATM(1), MAOA(1), MAOB(3), PIPOX(3), PSAT1(1), RDH11(1), RDH12(3), RDH13(1), SHMT1(2), SHMT2(3), TARS(1) 18194804 33 32 33 5 2 4 4 13 9 1 0.171 0.928 1.000 278 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL9(1) 3562906 2 2 2 1 0 0 1 1 0 0 0.901 0.932 1.000 279 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1) 2631811 1 1 1 0 0 0 1 0 0 0 0.709 0.933 1.000 280 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1), THY1(1) 4462002 5 5 5 2 0 1 0 2 2 0 0.904 0.936 1.000 281 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), ITPKA(1), PDE1B(1), PLCB1(1), PLCB2(3) 4671953 8 8 8 4 1 0 1 3 3 0 0.913 0.937 1.000 282 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), RELA(2), TNFRSF11A(2) 4625022 5 5 5 4 0 0 1 1 3 0 0.978 0.939 1.000 283 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 LPO(1), MPO(1), PRDX6(2) 3552250 4 4 4 2 0 0 1 1 2 0 0.931 0.941 1.000 284 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA2(1), CCNE2(1), CDK4(1), CDKN2A(1), E2F2(1) 3752358 5 5 5 3 0 1 1 1 2 0 0.843 0.944 1.000 285 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ABAT(1), ACSM1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DDHD1(1), EHHADH(1), GAD1(2), GAD2(2), HADHA(2), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), ILVBL(3), PLA1A(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(1) 17360886 35 34 35 6 2 3 5 16 9 0 0.171 0.946 1.000 286 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(1), ELK1(1), GNB1(1), GRB2(1), IGF1R(2), ITGB1(1), MAP2K2(1), MAPK1(1), MKNK2(1), NGFR(1), PDGFRA(1), PTPRR(3), RAF1(3), RPS6KA5(1), SOS1(2), STAT3(1) 14106066 22 21 22 4 3 7 1 6 5 0 0.174 0.946 1.000 287 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(6), PIK3R1(2), PLCB1(1), PRKCA(1), VAV1(3) 5403064 13 12 11 4 2 5 0 3 3 0 0.615 0.947 1.000 288 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1), THY1(1) 4691866 5 5 5 2 0 1 0 2 2 0 0.905 0.948 1.000 289 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), FBL(1), GPT(2), MAPK14(1), NCL(2) 3756147 11 10 11 5 0 0 4 5 2 0 0.804 0.950 1.000 290 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(4), CREB1(1), DUSP6(2), EEF2K(1), GRB2(1), MAP2K2(1), MAP3K8(1), MAPK1(1), MKNK2(1), RPS6KA3(1), SOS1(2), SOS2(1) 12556673 17 17 16 3 1 4 2 5 5 0 0.179 0.952 1.000 291 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), AOC2(2), GOT2(1), HPD(1), LPO(1), MAOA(1), MAOB(3), MPO(1), PRDX5(1), PRDX6(2), TAT(1) 9321186 15 15 15 4 2 2 2 4 5 0 0.570 0.953 1.000 292 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(2), RPL11(1), RPL13(1), RPL18A(1), RPL24(1), RPL26(1), RPL28(1), RPL3(1), RPL35(1), RPL36A(1), RPL37A(1), RPL3L(1), RPL6(1), RPS16(1), RPS2(1), RPS20(1), RPS8(1), RPSA(1) 9174315 20 20 20 5 2 1 1 8 8 0 0.730 0.953 1.000 293 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), CYP17A1(1), HSD11B1(1) 3795312 4 4 4 2 1 0 0 1 2 0 0.839 0.954 1.000 294 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(1), CYP17A1(1), HSD11B1(1) 3795312 4 4 4 2 1 0 0 1 2 0 0.839 0.954 1.000 295 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(3), RELA(2), TNF(1) 6483453 10 9 10 3 1 0 0 3 6 0 0.918 0.954 1.000 296 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 TNF(1) 2749234 1 1 1 0 0 0 0 0 1 0 1.000 0.955 1.000 297 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(1), NTRK1(1), PIK3CA(6), PIK3R1(2), PRKCA(1), SOS1(2) 6549249 13 12 11 4 1 5 0 3 4 0 0.509 0.958 1.000 298 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(1), IGF1R(2), POLR2A(1), PRKCA(1), TEP1(5), TERF1(1), TERT(3), TNKS(1), TP53(7), XRCC5(2) 11822950 24 24 24 5 1 2 3 12 6 0 0.417 0.958 1.000 299 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), DNMT1(1), PTGDR(1), PTGFR(2) 4761797 5 4 5 2 0 0 2 2 1 0 0.833 0.959 1.000 300 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(3), AGTR2(1), EGF(1), EGFR(1), PRKCA(1), RELA(2) 8592363 9 9 9 2 1 0 1 3 4 0 0.665 0.963 1.000 301 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT3(1), CHST13(1), CHST3(1), CHSY1(1), XYLT1(1) 5998351 6 6 6 2 1 1 1 2 1 0 0.721 0.965 1.000 302 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(5), ATR(2), CDC25C(1), CHEK1(1), CHEK2(1), TP53(7) 6657322 17 17 17 6 0 3 2 8 4 0 0.794 0.966 1.000 303 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 IFNG(2), IL2(1), TNF(1) 5687118 4 4 4 1 0 0 0 2 2 0 0.873 0.966 1.000 304 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 HIF1A(2), JAK2(1), NFKBIA(1), RELA(2) 5418738 6 5 6 4 0 0 1 2 2 1 0.993 0.967 1.000 305 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(1), EGFR(1), GRB2(1), MAPK1(1), PTPRB(4), RAF1(3), RASA1(2), SOS1(2), SPRY1(1), SPRY2(1) 10508049 17 17 17 4 1 2 3 7 4 0 0.416 0.967 1.000 306 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CREBBP(8), EP300(5), IKBKB(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2) 9688449 21 20 21 6 0 3 4 5 9 0 0.759 0.968 1.000 307 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(2), PGM1(1) 4351106 4 4 4 2 0 1 0 2 1 0 0.873 0.968 1.000 308 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), CASP9(1), DAXX(1), FASLG(2), HSPB2(1), MAPKAPK2(1), TNF(1) 4716370 10 8 10 4 0 3 3 0 4 0 0.820 0.969 1.000 309 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), AKT3(1), CDKN2A(1), DAPP1(1), GRB2(1), IGFBP1(1), PIK3CA(6), PPP1R13B(2), PTEN(7), RPS6KA3(1), SFN(1), SOS1(2), SOS2(1) 15069186 26 25 24 5 1 6 4 6 8 1 0.206 0.970 1.000 310 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(16), ESR2(2), HNF4A(3), NPM1(2), NR1D2(1), NR2E1(2), NR2F1(2), NR2F2(5), NR2F6(1), NR3C1(2), PPARG(1), RARG(1), ROR1(1), RORA(2), RORC(1), RXRA(2), RXRB(1), THRA(1) 17836749 49 44 42 10 3 8 8 26 4 0 0.230 0.971 1.000 311 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(8), EP300(5), IKBKB(1), MAP2K3(1), MAP3K7(1), MAPK14(1), NFKBIA(1), NR3C1(2), RELA(2), TGFBR1(1), TLR2(1), TNF(1) 12451981 25 24 25 8 0 3 3 7 12 0 0.926 0.972 1.000 312 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(1), EGFR(1), HGS(1), TF(1), TFRC(2) 5366844 7 7 7 3 0 0 1 3 3 0 0.903 0.973 1.000 313 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ACTR3(1), WASF1(1), WASL(2) 3445473 6 6 6 3 0 2 2 2 0 0 0.824 0.974 1.000 314 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1), MASP1(2), MASP2(1), MBL2(1) 14575805 14 14 14 2 0 4 2 8 0 0 0.199 0.975 1.000 315 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CDH1(2), CREBBP(8), EP300(5), MAP3K7(1), SKIL(2), TGFBR1(1) 10788868 22 21 22 6 0 2 4 7 9 0 0.740 0.976 1.000 316 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(8), EP300(5), IL7R(1), JAK1(2), JAK3(1), PIK3CA(6), PIK3R1(2), PTK2B(1), STAT5A(2), STAT5B(1) 11835018 29 27 27 7 2 6 4 7 10 0 0.504 0.977 1.000 317 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), SHH(1), SMO(1), SUFU(2) 7090514 12 12 12 4 0 3 3 5 1 0 0.555 0.977 1.000 318 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACADL(3), ACADM(2), ACADSB(1), ACOX1(1), ACOX3(3), ACSL6(1), ADH6(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CPT1A(1), CPT1B(1), CPT1C(1), CYP4A11(2), EHHADH(1), GCDH(2), HADHA(2), HSD17B4(1) 20639447 35 31 35 6 3 8 7 15 2 0 0.0790 0.978 1.000 319 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1) 9820864 20 19 20 5 2 3 1 7 7 0 0.505 0.978 1.000 320 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 CREB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), PIK3CA(6), PIK3R1(2), RELA(2) 8193979 18 15 16 6 2 4 0 6 6 0 0.838 0.979 1.000 321 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSE(3), CYP11B1(1), HSD11B1(1), HSD17B8(1), SRD5A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2) 11471269 20 20 20 7 1 1 5 4 9 0 0.812 0.979 1.000 322 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 PTPRC(1), ZAP70(1) 3789564 2 2 2 2 0 0 0 1 1 0 0.980 0.980 1.000 323 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), CPT1A(1), LEPR(1), PRKAA1(1), PRKAG1(1), PRKAG2(3) 6043609 9 9 9 3 0 0 3 5 1 0 0.717 0.980 1.000 324 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2), SLC23A1(2), SLC23A2(1) 10739948 13 12 13 3 0 6 0 4 3 0 0.640 0.980 1.000 325 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), GOT2(1), GPT(2), ME2(1), RPE(1), RPIA(2), TKT(2) 7627295 11 10 11 3 1 3 0 2 5 0 0.692 0.981 1.000 326 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), HSD17B1(1), HSD17B4(1) 3380470 3 3 3 2 1 1 0 0 1 0 0.922 0.981 1.000 327 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CAPN2(1), EP300(5), NFATC2(1), PPP3CB(1), PRKCA(1) 10249593 12 12 12 9 1 0 1 2 8 0 1.000 0.982 1.000 328 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GABBR1(2), GPRC5C(1), GPRC5D(1), GRM1(1), GRM2(1), GRM3(2), GRM4(2), GRM5(1) 8754061 12 11 12 3 2 3 1 6 0 0 0.332 0.982 1.000 329 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(8), DAXX(1), PML(1), SP100(1), TNF(1), TNFRSF1B(2), TP53(7) 7958139 21 20 21 6 0 3 4 8 6 0 0.546 0.982 1.000 330 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(1), CCR3(1), CCR5(1), CCR7(1), IFNG(2), IFNGR1(1), IL12RB2(1), IL2(1), IL4R(2) 8425104 11 11 11 3 0 0 2 6 3 0 0.719 0.983 1.000 331 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(3), EIF2B5(1), EIF2S3(1), EIF5(1) 4844715 7 6 7 3 2 1 2 0 2 0 0.769 0.983 1.000 332 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 IFNG(2), IL18(1), IL1R1(1) 4552908 4 4 4 2 0 0 0 2 2 0 0.955 0.984 1.000 333 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), GNA13(2), GNB1(1), MYLK(1), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2) 8643722 10 10 10 3 0 1 0 3 6 0 0.919 0.985 1.000 334 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), CYP7A1(1), HMGCR(1), LCAT(2), LDLR(2), LPL(4), LRP1(4), SOAT1(1) 11515774 17 17 17 4 2 2 2 8 3 0 0.469 0.986 1.000 335 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK14(1), RELA(2), TRAF5(1) 6070088 4 4 4 2 0 0 0 1 3 0 0.992 0.986 1.000 336 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ST3GAL4(1) 3017936 1 1 1 0 0 0 0 1 0 0 0.832 0.986 1.000 337 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), FUT4(2), FUT5(1), FUT6(1), GCNT2(2) 6764071 11 10 11 4 0 2 0 4 5 0 0.906 0.986 1.000 338 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1) 4135590 7 7 7 3 0 1 1 3 2 0 0.891 0.987 1.000 339 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), GRB2(1), JAK2(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2), STAT5B(1), THPO(1) 12648591 27 25 25 6 2 6 2 8 9 0 0.515 0.989 1.000 340 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), AKT3(1), BCR(2), CDKN2A(1), DAPP1(1), FLOT1(1), ITPR1(6), ITPR2(5), ITPR3(3), LYN(3), PIK3CA(6), PLCG2(1), PPP1R13B(2), PREX1(2), PTEN(7), PTPRC(1), RPS6KA3(1), VAV1(3) 23201854 47 40 45 9 3 8 5 18 12 1 0.183 0.989 1.000 341 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GRB2(1), INS(1), IRS1(2), JAK2(1), MAPK1(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), SLC2A4(2), SOCS1(1), SOS1(2), STAT5A(2), STAT5B(1) 14057623 26 23 24 5 4 6 0 9 7 0 0.306 0.989 1.000 342 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(1), GNAI1(1), GNB1(1), ITGA1(3), ITGB1(1), MAPK1(1), PLA2G4A(1), PLCB1(1), PRKCA(1), PTK2(1), RAF1(3), TBXAS1(1) 10205931 18 18 18 6 3 1 1 6 7 0 0.743 0.989 1.000 343 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 PPOX(1) 3256503 1 1 1 3 0 0 0 0 1 0 1.000 0.989 1.000 344 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C8B(1), C9(1), MASP1(2) 14319678 13 13 13 2 0 4 1 8 0 0 0.245 0.990 1.000 345 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), HEXA(1), HEXB(1), LCT(1), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(1) 8730691 8 8 8 2 1 0 0 4 3 0 0.562 0.990 1.000 346 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP29(1), STX11(1), STX17(1), STX18(3), TSNARE1(1), VAMP1(1), VTI1B(1) 7031491 9 9 9 3 0 3 0 4 2 0 0.637 0.990 1.000 347 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(2), ACADL(3), ACADM(2), ACADSB(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), EHHADH(1), HADHA(2), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(1) 13955083 24 23 24 5 2 3 5 10 4 0 0.313 0.990 1.000 348 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(1), NFKBIA(1), PIK3CA(6), PIK3R1(2), RELA(2) 6144997 12 11 10 6 1 5 0 3 3 0 0.907 0.991 1.000 349 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), HEXA(1), HEXB(1), LCT(1), MAN2C1(1), MANBA(1) 7073422 6 6 6 2 0 0 0 3 3 0 0.740 0.991 1.000 350 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), MAPT(1) 3972386 2 2 2 6 0 0 0 1 1 0 1.000 0.992 1.000 351 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), GOT2(1), GPT(2), PGK2(1), RPE(1), RPIA(2), TKT(2) 8522981 11 10 11 3 1 3 0 2 5 0 0.690 0.992 1.000 352 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(2), GAPDH(1), INS(1), MAGI1(2), RERE(6), WWP1(5), WWP2(1) 10045952 21 21 21 7 2 0 3 10 5 1 0.936 0.992 1.000 353 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 GATA1(2) 3507070 2 2 2 4 1 0 0 0 1 0 0.997 0.992 1.000 354 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(1), ALG11(1), ALG14(1), ALG2(1), ALG6(1), ALG9(2), B4GALT1(2), B4GALT2(1), DHDDS(1), DPAGT1(2), MAN1B1(1), MAN1C1(2), MAN2A1(2), MGAT4B(1), MGAT5(1), MGAT5B(1), RPN1(2), RPN2(1), ST6GAL1(1) 17957001 25 23 25 4 0 3 4 8 10 0 0.377 0.993 1.000 355 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG7(2), IFNA2(2), IFNG(2), INS(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(1), ULK2(1), ULK3(1) 8945177 13 13 13 4 1 1 1 7 3 0 0.760 0.993 1.000 356 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO1(2), PNPLA3(1) 6879195 3 3 3 0 0 2 0 1 0 0 0.358 0.993 1.000 357 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH6(2), AKR1C1(1), AKR1C2(1), AKR1C3(2), ALDH1A3(1), CYP1A2(2), CYP1B1(1), CYP2C18(2), CYP2C8(1), CYP2F1(1), CYP3A43(2), CYP3A7(1), DHDH(2), GSTA1(2), GSTA2(1), GSTK1(2), GSTM1(1), GSTM4(1), GSTT1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1) 24168481 43 40 43 8 1 3 7 23 8 1 0.367 0.993 1.000 358 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FHL5(1), XPO1(2) 4047018 3 3 3 4 1 0 1 0 1 0 0.995 0.993 1.000 359 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), PAK1(2), PDGFRA(1), PIK3CA(6), PIK3R1(2), WASL(2) 5639771 15 14 13 5 2 5 3 3 2 0 0.665 0.995 1.000 360 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), BIRC2(1), BIRC3(2), CASP10(1), CASP4(1), CASP6(1), CASP9(1), LMNA(2), LMNB1(1), LMNB2(1) 8124111 13 13 13 4 0 2 2 5 4 0 0.687 0.995 1.000 361 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 GNB1(1), NOS3(1), NR3C1(2), PIK3CA(6), PIK3R1(2), RELA(2) 7604377 14 13 12 6 2 4 0 4 4 0 0.926 0.995 1.000 362 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 CFTR(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), SLC9A3R1(1) 5568417 6 6 6 5 0 1 1 2 2 0 0.981 0.996 1.000 363 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 F2(2), F2R(1), GNA13(2), GNAI1(1), GNB1(1), MAP3K7(1), PIK3CA(6), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(1), ROCK1(2) 10806720 22 20 20 8 2 4 1 8 7 0 0.895 0.996 1.000 364 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(1), FASN(4), MCAT(2), OLAH(1), OXSM(2) 6810274 12 12 12 5 1 3 0 5 3 0 0.779 0.996 1.000 365 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6AP1(1), ATP6V0A1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1H(1), ATP7A(2), ATP7B(4), COX10(3), COX5A(1), COX7A1(1), COX7C(1), COX8A(1), NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFS1(1), NDUFV1(1), SDHA(1), SHMT1(2), UQCRC1(1) 16120443 35 32 35 8 1 3 6 14 11 0 0.548 0.996 1.000 366 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), AOC2(2), ESCO1(2), GOT2(1), HPD(1), LPO(1), MAOA(1), MAOB(3), MPO(1), PNPLA3(1), PRDX6(2), TAT(1) 14388552 17 17 17 4 2 3 2 5 5 0 0.446 0.996 1.000 367 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSE(3), ASAH1(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2B(1), SMPD1(4), SMPD2(1), SPTLC1(2), SPTLC2(1) 10228649 16 16 15 8 3 2 0 5 6 0 0.929 0.996 1.000 368 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(2), JAK1(2), JAK2(1) 4391912 5 5 5 3 1 0 1 2 1 0 0.918 0.996 1.000 369 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(2), JAK1(2), JAK2(1) 4391912 5 5 5 3 1 0 1 2 1 0 0.918 0.996 1.000 370 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), POLR2A(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2) 5423744 6 6 6 3 0 1 1 2 2 0 0.763 0.997 1.000 371 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 CTNNA1(5), CTNNA2(1), CTNNB1(2), PTK2(1), PXN(1), VCL(1) 8083387 11 11 11 7 0 1 2 4 4 0 0.968 0.997 1.000 372 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), PRKACG(1), PRKAG1(1), PRKAR2B(2) 4248454 7 7 7 4 0 1 2 3 1 0 0.879 0.997 1.000 373 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C2(1), C3(2), C5(1), C6(2), C7(1), C8A(2), C9(1) 12947139 10 10 10 2 0 3 1 6 0 0 0.403 0.997 1.000 374 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ASAH1(1), GNAI1(1), GNB1(1), ITGAV(1), ITGB3(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(2), PLCB1(1), PRKCA(1), PTK2(1), SMPD1(4), SMPD2(1), SPHK1(1) 11494201 26 25 23 9 5 6 0 8 7 0 0.727 0.997 1.000 375 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 IKBKAP(1), IKBKB(1), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2) 7933738 10 9 10 5 0 1 0 5 4 0 0.988 0.997 1.000 376 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2D(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), NFAT5(2), PDE6A(1), PDE6B(2), SLC6A13(4), TF(1) 15120160 33 30 33 9 2 4 7 12 8 0 0.592 0.997 1.000 377 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(3), AXIN1(3), CCND3(1), CSNK1E(3), CTNNB1(2), DVL3(1), FBXW2(1), FZD1(1), FZD2(1), FZD5(2), FZD7(3), FZD8(2), LDLR(2), MAPK10(1), PAFAH1B1(1), PPP2R5C(2), PPP2R5E(3), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1) 24908717 48 43 48 9 6 5 2 21 14 0 0.172 0.997 1.000 378 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 HEXA(1), HEXB(1), IDUA(1), LCT(1), NAGLU(1) 6243845 5 5 5 4 0 1 0 2 2 0 0.969 0.997 1.000 379 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CRY1(1), CSNK1E(3), PER1(4), PER2(2), PER3(2) 7217419 13 13 13 9 3 0 1 6 3 0 0.988 0.997 1.000 380 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IFNG(2), IKBKB(1), IL2(1), MAP3K1(3), MAPK14(1), NFKBIA(1), RELA(2) 8201375 12 9 12 5 0 0 0 8 4 0 0.972 0.997 1.000 381 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), IFNG(2), IL12RB2(1), JAK2(1) 6205716 5 5 5 3 0 0 0 3 2 0 0.968 0.998 1.000 382 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), H6PD(1), PFKP(1), PGD(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(2), TAL1(1), TKT(2) 8545294 14 13 14 5 1 4 2 3 4 0 0.788 0.998 1.000 383 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(2), PGM1(1) 4961998 4 4 4 3 0 1 0 2 1 0 0.961 0.998 1.000 384 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), EGFR(1), ERBB2(3), ERBB4(4), ETS1(2), FMN2(1), GRB2(1), KRAS(5), MAPK1(1), NOTCH1(2), NOTCH2(1), NOTCH3(4), NOTCH4(1), PIWIL3(1), PIWIL4(2), RAF1(3), SOS1(2), SOS2(1), SPIRE2(2) 22277392 41 40 35 9 3 8 5 15 10 0 0.229 0.998 1.000 385 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNB1(1), LIMK1(1), MAPK1(1), NOX1(1), PIK3C2G(3), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2(1), RAF1(3), ROCK2(1) 10612980 16 16 16 9 2 2 2 4 6 0 0.964 0.998 1.000 386 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(1), ATM(5), BRCA1(3), CHEK1(1), CHEK2(1), MRE11A(2), NFKBIA(1), RBBP8(2), RELA(2), TP53(7) 12457303 25 24 25 9 0 2 2 14 7 0 0.879 0.998 1.000 387 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(1), AKT3(1), CDKN2A(1), CREB1(1), ERBB4(4), F2RL2(1), GRB2(1), IGFBP1(1), INPPL1(2), IRS1(2), IRS2(3), MET(22), NOLC1(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PARD3(2), PIK3CA(6), PIK3CD(1), PPP1R13B(2), PREX1(2), PTEN(7), PTK2(1), PTPN1(1), RPS6KA3(1), SFN(1), SLC2A4(2), SOS1(2), SOS2(1), TSC1(2), TSC2(6) 32398549 87 71 77 16 6 21 15 25 19 1 0.0120 0.998 1.000 388 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B5(1), EIF2S3(1), FLT1(1), FLT4(4), HIF1A(2), KDR(1), NOS3(1), PIK3CA(6), PIK3R1(2), PRKCA(1), PTK2(1), PXN(1), VHL(3) 14452438 25 24 23 9 5 5 1 5 8 1 0.810 0.998 1.000 389 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), DIAPH1(2), GSN(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(1), PFN1(1), PIK3CA(6), PIK3R1(2), PTK2(1), PXN(1), RAF1(3), ROCK1(2), TLN1(6) 15768831 32 26 30 8 3 5 1 12 11 0 0.604 0.998 1.000 390 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), AMDHD1(1), AOC2(2), FTCD(1), HDC(1), MAOA(1), MAOB(3), METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), PRPS2(1) 16819000 26 22 26 5 4 2 4 11 5 0 0.236 0.998 1.000 391 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), ETV5(2), IFNG(2), IL12RB2(1), IL18(1), JAK2(1), MAPK14(1) 7826288 9 8 9 3 0 1 0 5 3 0 0.867 0.999 1.000 392 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), MAP3K1(3), MAPK1(1), NSMAF(1), RAF1(3), RELA(2), RIPK1(1), SMPD1(4) 8596933 16 13 15 8 3 1 1 6 5 0 0.980 0.999 1.000 393 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH6(2), ESCO1(2), PNPLA3(1) 10394276 7 7 7 2 0 3 0 4 0 0 0.623 0.999 1.000 394 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(1), ICAM1(1), ITGAL(1), ITGB2(1), PTPRC(1) 7118068 8 7 8 3 0 2 0 3 3 0 0.911 0.999 1.000 395 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 NFATC2(1), NFATC3(3), PPP3CB(1), PRKCA(1), SP3(1) 8782821 7 7 7 4 0 0 2 1 4 0 0.977 0.999 1.000 396 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 IKBKB(1), MAP2K3(1), MAP3K1(3), MAP4K2(2), MAPK14(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1) 10419138 13 12 13 8 0 1 2 5 5 0 0.995 0.999 1.000 397 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(1), ELK1(1), PIK3CA(6), PIK3R1(2), RAF1(3), RALA(1), RALBP1(2), RELA(2) 8105105 18 16 16 8 2 7 0 5 4 0 0.888 0.999 1.000 398 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNB1(1), PRKAA1(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR2B(2) 6532754 10 10 10 4 0 1 3 4 2 0 0.765 0.999 1.000 399 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 CREB1(1), GRB2(1), MAPK1(1), MEF2C(1), NTRK1(1), PIK3CA(6), PIK3R1(2) 8198895 13 11 11 6 2 4 0 4 3 0 0.717 0.999 1.000 400 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 IKBKB(1), IL1R1(1), MAP3K1(3), MAP3K7(1), NFKBIA(1), RELA(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(2) 10476520 15 14 15 6 0 2 1 7 5 0 0.965 0.999 1.000 401 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNB1(2), PIK3CA(6), PIK3R1(2), PTK2(1), PTK2B(1), TERT(3) 6992141 15 14 13 6 1 4 1 7 2 0 0.669 0.999 1.000 402 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), ASAH1(1), CERK(1), CREB1(1), DAG1(3), EPHB2(1), ITPKA(1), ITPKB(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1) 12058795 17 16 17 7 2 0 3 6 6 0 0.909 0.999 1.000 403 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), GCK(1), GMDS(1), GMPPA(1), HK1(2), KHK(2), MPI(1), PFKFB3(2), PFKFB4(1), PFKP(1) 10150439 14 13 14 6 0 3 2 5 4 0 0.905 1.000 1.000 404 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), F2(2), GNAI1(1), GNB1(1), GRB2(1), JAK2(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPT(1), MYLK(1), PRKCA(1), PTK2B(1), RAF1(3), SOS1(2), STAT1(2), STAT3(1), STAT5A(2) 17711931 31 28 31 7 4 4 0 15 8 0 0.423 1.000 1.000 405 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(3), COL4A3(2), COL4A5(1), COL4A6(2), F10(1), F12(6), F2(2), F2R(1), F5(3), F8(1), F9(1), PROS1(1) 18773061 26 24 26 6 2 6 3 7 8 0 0.474 1.000 1.000 406 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 GRB2(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), PAK1(2), PRKCA(1), PTK2B(1), RAF1(3), SOS1(2) 11994967 17 16 17 8 1 1 1 8 6 0 0.977 1.000 1.000 407 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ACTR3(1), NCKAP1(1), NTRK1(1), PSMA7(1), WASF1(1), WASL(2) 6431404 9 9 9 6 0 3 2 3 1 0 0.896 1.000 1.000 408 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(1), MAP2(1), PRKACG(1), PRKAG1(1), PRKAR2B(2), PRKCE(2) 7304465 8 7 8 5 0 2 1 3 2 0 0.927 1.000 1.000 409 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDT1(1), DIAPH2(1), MCM10(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), NACA(1), POLD1(2), POLD2(1), POLE(1), RFC4(1), RFC5(1), RPA2(1), RPA4(1), UBA52(1), UBC(2) 21391245 23 22 23 4 2 6 4 9 2 0 0.115 1.000 1.000 410 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 IKBKAP(1), IKBKB(1), MAP3K1(3), NFKBIA(1), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(2) 9722679 13 12 13 7 0 2 1 6 4 0 0.988 1.000 1.000 411 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(1), MAPK14(1), PRKCA(1), PTK2B(1) 5735990 4 4 4 3 0 0 0 3 1 0 0.987 1.000 1.000 412 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), H6PD(1), PFKL(1), PFKP(1), PGD(1), PGM1(1), PRPS2(1), RBKS(1), RPE(1), RPIA(2), TKT(2) 10246833 14 13 14 6 2 4 2 2 4 0 0.839 1.000 1.000 413 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCND3(1), CDC25A(1), CDK4(1), CDKN2A(1) 6773795 4 4 4 3 1 0 1 1 1 0 0.897 1.000 1.000 414 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IKBKB(1), IL1R1(1), IL1RN(1), MAP2K3(1), MAP3K1(3), MAP3K7(1), MAPK14(1), NFKBIA(1), RELA(2), TNF(1) 12411204 13 12 13 6 0 1 0 6 6 0 0.994 1.000 1.000 415 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 RPE(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1), XYLB(2) 10951920 20 19 20 6 0 3 7 7 3 0 0.609 1.000 1.000 416 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CANX(2), CIITA(2), CREB1(1), CTSB(1), HLA-A(1), HLA-B(1), HLA-C(3), HLA-DOB(1), HLA-DPB1(1), HLA-DQA2(1), HSP90AA1(1), IFI30(1), IFNA2(2), KIR3DL3(1), KLRC3(1), NFYA(3), NFYC(1), PSME2(1), RFX5(2) 20022746 29 27 29 7 1 4 4 10 9 1 0.590 1.000 1.000 417 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(3), CYP11B1(1), HSD11B1(1), HSD17B1(1), HSD17B8(1), METTL2B(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), SRD5A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1) 20577620 32 29 32 8 1 1 8 9 13 0 0.584 1.000 1.000 418 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(1), ATM(5), ATR(2), CDC25A(1), CDK4(1), CDKN2A(1), SKP2(1), TP53(7) 12720112 19 18 19 8 1 2 3 8 5 0 0.838 1.000 1.000 419 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(3), AR(16), ASAH1(1), BRAF(4), DAG1(3), EGFR(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(2), RAF1(3) 22506157 63 57 53 14 3 9 8 31 12 0 0.265 1.000 1.000 420 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), ELK1(1), GRB2(1), JAK1(2), MAP3K1(3), PDGFRA(1), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2) 14720099 31 25 29 8 4 7 2 9 9 0 0.527 1.000 1.000 421 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 BAX(1), CSF2RB(3), IGF1R(2), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2) 9197946 18 17 16 9 1 5 2 7 3 0 0.891 1.000 1.000 422 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), AKT3(1), CISH(2), GRB2(1), IL4R(2), JAK1(2), JAK2(1), JAK3(1), PI3(1), PIK3CA(6), PPP1R13B(2), SOS1(2), SOS2(1) 15480556 23 20 21 5 2 6 2 9 4 0 0.239 1.000 1.000 423 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), DCK(1), DPYD(1), DPYS(1), DUT(1), NT5C(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2), RRM1(2), TK2(1), TXNRD1(1), UMPS(2), UNG(1), UPB1(1), UPP1(1) 24416329 42 39 42 9 2 4 6 14 16 0 0.396 1.000 1.000 424 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), ELK1(1), GNB1(1), MAP2K2(1), MAP2K3(1), MAP3K1(3), MAPK1(1), MAPK14(1), NCF2(1), NFATC2(1), NFATC3(3), NFKBIA(1), PAK1(2), PIK3C2G(3), PLCB1(1), PPP3CB(1), RAF1(3), RELA(2) 16331465 30 27 30 9 2 3 3 12 10 0 0.845 1.000 1.000 425 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), DARS(3), EPRS(1), KARS(1), LARS(4), MARS(1), QARS(3), RARS(2), TARS(1) 13420837 18 17 18 5 1 0 4 7 6 0 0.787 1.000 1.000 426 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), AGT(3), AGTR2(1), ANPEP(5), CMA1(1), CTSA(1), ENPEP(2), LNPEP(2), MAS1(1), MME(1) 8844682 21 17 21 7 2 1 6 11 1 0 0.573 1.000 1.000 427 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 PRKACG(1), PRKAR1A(1), PRKAR2B(2) 6272754 4 4 4 4 0 1 1 1 1 0 0.974 1.000 1.000 428 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 ELK1(1), GRB2(1), LYN(3), MAP3K1(3), MAPK14(1), NFATC2(1), NFATC3(3), PPP3CB(1), PRKCA(1), RAF1(3), SOS1(2), VAV1(3) 16023855 23 21 23 5 1 3 1 11 7 0 0.602 1.000 1.000 429 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 DAG1(3), EPHB2(1), FBXW7(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(1), LCP2(1), MAPK1(1), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PTPRC(1), RAF1(3), RASGRP1(1), RASGRP3(1), RASGRP4(1), SOS1(2), SOS2(1), VAV1(3), ZAP70(1) 23842032 39 37 39 9 4 6 5 14 10 0 0.333 1.000 1.000 430 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CREBBP(8), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTPRC(1), ZAP70(1) 9722945 15 14 15 8 0 3 4 5 3 0 0.901 1.000 1.000 431 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CREBBP(8), GNB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTPRC(1), ZAP70(1) 9722945 15 14 15 8 0 3 4 5 3 0 0.901 1.000 1.000 432 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 MAP3K1(3), NFATC2(1), NFKBIA(1), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RELA(2) 11716299 12 11 12 9 0 1 2 4 5 0 0.997 1.000 1.000 433 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DLAT(1), DLD(2), HAGH(1), ME2(1), PC(5), PCK1(5) 15534483 24 23 24 8 2 1 6 8 6 1 0.821 1.000 1.000 434 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HEXA(1), HEXB(1), HGSNAT(1), HPSE(1), HYAL1(1), HYAL2(1), IDUA(1), LCT(1), NAGLU(1), SPAM1(1) 8859011 10 10 10 7 1 1 1 5 2 0 0.959 1.000 1.000 435 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(1), EGFR(1), ELK1(1), GRB2(1), JAK1(2), MAP3K1(3), PIK3CA(6), PIK3R1(2), PRKCA(1), RAF1(3), RASA1(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(2) 15780425 32 27 30 9 3 7 3 10 9 0 0.606 1.000 1.000 436 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA3(1), ANXA4(1), CYP11A1(1), HSD11B1(1), PLA2G4A(1), PTGDR(1), PTGFR(2), PTGS2(1), TBXAS1(1) 9219276 10 8 10 5 1 1 2 4 2 0 0.834 1.000 1.000 437 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP4A(1), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5L(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), COX10(3), COX15(2), COX5A(1), COX7A1(1), COX7C(1), COX8A(1), NDUFB10(1), NDUFB4(2), NDUFB5(1), NDUFB7(1), NDUFB9(1), NDUFS1(1), NDUFS3(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), PPA1(2), SDHA(1), SDHD(1), TCIRG1(1), UQCRC1(1), UQCRC2(2) 23761375 55 52 55 12 2 3 12 21 17 0 0.346 1.000 1.000 438 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), GRB2(1), MAPK1(1), MAPK14(1), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), RPS6KA5(1), SOS1(2) 12343499 24 22 22 7 3 8 1 7 5 0 0.441 1.000 1.000 439 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(3), ASAH1(1), CERK(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2B(1), SGMS1(1), SGPP1(1), SMPD1(4), SMPD2(1), SMPD3(2), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1) 15076420 25 24 24 8 4 4 1 9 7 0 0.580 1.000 1.000 440 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(3), ATF2(1), AXIN1(3), BMP4(1), BMP7(1), BMPR1A(2), BMPR2(1), CHRD(1), CTNNB1(2), FZD1(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFBR1(1) 15368413 20 19 20 5 1 2 2 13 2 0 0.495 1.000 1.000 441 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PGAP1(4), PIGK(1), PIGM(1), PIGU(1) 10228833 8 8 8 3 0 2 0 3 3 0 0.775 1.000 1.000 442 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), EGFR(1), MAP3K1(3), MAPK14(1), NCOR2(1), RXRA(2), THRA(1) 7349352 10 8 10 7 0 2 2 5 1 0 0.978 1.000 1.000 443 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(1), AP2A1(2), AP2M1(1), BIN1(1), PICALM(2), PPP3CB(1), SYNJ2(1) 9352756 9 9 9 7 0 0 5 2 2 0 0.985 1.000 1.000 444 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 94 ANK2(8), B3GALT4(1), IL6ST(2), PIGK(1), RPL10(1), RPL11(1), RPL13(1), RPL18A(1), RPL22(1), RPL24(1), RPL26(1), RPL28(1), RPL3(1), RPL35(1), RPL3L(1), RPL6(1), RPL7A(1), RPS14(1), RPS16(1), RPS2(1), RPS20(1), RPS6KA3(1), RPS6KB2(1), RPS8(1), RPSA(1), SLC36A2(2), UBA52(1), UBC(2) 21912168 38 37 38 8 2 2 4 20 10 0 0.449 1.000 1.000 445 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 CREB1(1), ELK1(1), GNAI1(1), GNB1(1), NFATC2(1), NFATC3(3), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), RAF1(3), RPS6KA3(1) 14740330 18 18 18 7 0 2 3 6 7 0 0.905 1.000 1.000 446 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), CHRM1(2), FLT1(1), FLT4(4), KDR(1), NOS3(1), PDE3A(2), PDE3B(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKG1(2), PRKG2(2), RYR2(5), SLC7A1(1) 17299609 28 24 28 8 2 6 2 13 5 0 0.533 1.000 1.000 447 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(2), B4GALT2(1), GAA(2), GCK(1), HK1(2), LCT(1), MGAM(3), PFKP(1), PGM1(1) 13655636 14 11 14 7 0 2 0 5 7 0 0.991 1.000 1.000 448 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA2A(1), CHRM1(2), CHRM2(1), CHRM3(1), DRD2(1), DRD4(1), DRD5(1), HTR1A(1), HTR1B(1), HTR2B(2) 10828382 12 11 12 5 2 2 0 5 3 0 0.716 1.000 1.000 449 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 EPHB2(1), F2(2), F2RL2(1), MAP2K5(2), MAPK1(1), PLD1(1), PLD3(1), PTK2(1), RAF1(3), RASAL1(1), VAV1(3) 11636431 17 17 17 5 3 1 2 9 2 0 0.515 1.000 1.000 450 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), CDC25C(1), GNAI1(1), GNB1(1), MAPK1(1), MYT1(6), PRKACG(1), PRKAR1A(1), PRKAR2B(2) 8764490 15 13 15 5 1 7 2 4 1 0 0.467 1.000 1.000 451 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(1), AGPAT2(1), AGPS(1), CPT1B(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GPD1(2), GPD2(1), LCAT(2), PAFAH1B1(1), PCYT1A(1), PLA2G4A(1), PLA2G6(2), PLCB2(3), PLCG2(1), PPAP2B(1) 21393378 30 29 30 7 4 4 5 9 8 0 0.301 1.000 1.000 452 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH6(2), AGPAT1(1), AGPAT2(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CEL(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GK(1), LCT(1), LPL(4), PPAP2B(1) 20567654 31 29 31 8 3 3 5 12 8 0 0.455 1.000 1.000 453 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT2(1), AKT3(1), FCER1A(1), GRB2(1), KRAS(5), LCP2(1), LYN(3), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK14(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCA(1), PRKCD(2), PRKCE(2), RAC2(1), RAF1(3), SOS1(2), SOS2(1), TNF(1), VAV1(3), VAV3(1) 30285322 61 51 55 11 7 13 4 25 12 0 0.0656 1.000 1.000 454 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP5(1), ARHGAP6(1), ARHGEF11(1), ARHGEF5(2), BAIAP2(2), DIAPH1(2), GSN(1), LIMK1(1), MYLK(1), PFN1(1), PPP1R12B(1), ROCK1(2), TLN1(6), VCL(1) 19988739 25 23 25 7 1 3 2 9 10 0 0.688 1.000 1.000 455 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), AGPS(1), PAFAH1B1(1), PAFAH1B2(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLD1(1), PPAP2B(1) 9927654 11 11 11 6 2 2 1 4 2 0 0.877 1.000 1.000 456 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(3), AXIN1(3), BTRC(2), CREBBP(8), CSNK2A1(2), CTBP1(1), CTNNB1(2), FZD1(1), MAP3K7(1), WIF1(1) 12529904 24 23 24 9 2 3 4 11 4 0 0.776 1.000 1.000 457 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT2(1), AKT3(1), APC(3), AXIN1(3), AXIN2(2), CER1(1), CTNNB1(2), LRP1(4), NKD1(2), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), WIF1(1) 17055103 24 24 24 6 3 2 1 16 2 0 0.405 1.000 1.000 458 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(2), ACACB(1), ACADM(2), ACSS1(1), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDH6A1(1), EHHADH(1), HADHA(2), PCCA(1), PCCB(1), SUCLA2(1), SUCLG1(1) 16739208 23 22 23 6 2 1 3 10 7 0 0.614 1.000 1.000 459 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CREB1(1), EEF2K(1), ELK1(1), IL1R1(1), MAP2K3(1), MAP3K10(1), MAP3K4(3), MAP3K7(1), MAPK1(1), MAPK14(1), MAPKAPK2(1), MKNK2(1) 14256462 14 14 14 7 1 3 1 4 5 0 0.959 1.000 1.000 460 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BIRC2(1), BIRC3(2), CFLAR(2), MAP3K3(1), MAP3K7(1), NFKB2(2), NFKBIA(1), NFKBIL1(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1B(2) 11936711 19 19 19 7 2 3 2 9 3 0 0.723 1.000 1.000 461 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(2), AP2M1(1), EEA1(1), GRASP(1), LYN(3), PFKL(1), PFKP(1), PRKCE(2) 10542377 12 11 12 8 1 1 2 6 2 0 0.979 1.000 1.000 462 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 ELK1(1), IKBKB(1), MAP2K3(1), MAP3K1(3), MAP3K7(1), MAPK14(1), NFKBIA(1), RELA(2), TLR10(1), TLR2(1), TLR3(2), TLR6(1), TLR7(1) 15522847 17 15 17 8 0 2 1 9 5 0 0.978 1.000 1.000 463 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GCK(1), HK1(2), PFKP(1), PGM1(1) 20477333 23 23 23 8 2 3 4 6 7 1 0.844 1.000 1.000 464 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GCK(1), HK1(2), PFKP(1), PGM1(1) 20477333 23 23 23 8 2 3 4 6 7 1 0.844 1.000 1.000 465 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(2), GTF2A2(1), GTF2B(2), GTF2F1(1), GTF2H4(1), GTF2IRD1(1), TAF1(1), TAF12(1), TAF2(2), TAF4B(2), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1), TBPL2(1) 15742156 20 20 20 7 3 4 4 4 5 0 0.599 1.000 1.000 466 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(2), C5(1), C6(2), C7(1), ICAM1(1), ITGA4(1), ITGAL(1), ITGB1(1), ITGB2(1), TNF(1), VCAM1(1) 10330878 13 12 13 5 0 2 1 8 2 0 0.890 1.000 1.000 467 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(5), ATR(2), BRCA1(3), BRCA2(3), CHEK1(1), CHEK2(1), FANCA(2), MRE11A(2), TP53(7), TREX1(1) 18463318 27 26 27 9 0 3 4 14 6 0 0.805 1.000 1.000 468 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH6(2), ALDH1A3(1), AOC2(2), COMT(1), DCT(1), GOT2(1), HPD(1), MAOA(1), MAOB(3), TAT(1) 13378552 14 14 14 7 2 2 1 6 3 0 0.877 1.000 1.000 469 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(3), AXIN1(3), CTNNB1(2), FZD1(1), GNAI1(1), LEF1(1), PIK3CA(6), PIK3R1(2), RELA(2) 13080858 21 19 19 7 2 5 0 11 3 0 0.730 1.000 1.000 470 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(2), B4GALT2(1), GAA(2), GANC(1), GCK(1), HK1(2), LCT(1), MGAM(3), PFKL(1), PFKP(1), PGM1(1), RDH11(1), RDH12(3), RDH13(1) 16192342 21 18 21 7 1 3 0 10 7 0 0.877 1.000 1.000 471 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(3), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1R(2), INS(1), MAPK14(1), MEF2C(1), NFATC2(1), PIK3CA(6), PIK3R1(2), PPP3CB(1) 14748409 24 23 22 9 4 4 2 10 4 0 0.738 1.000 1.000 472 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN2A(4), GRIN2B(1), GRIN2D(2), NOS1(1), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1) 10899913 14 14 14 6 0 1 5 6 2 0 0.811 1.000 1.000 473 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), HEXA(1), HEXB(1), HGSNAT(1), HPSE(1), HYAL1(1), HYAL2(1), IDUA(1), LCT(1), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(1), NAGLU(1), SPAM1(1) 14906286 15 15 15 9 2 1 1 7 4 0 0.924 1.000 1.000 474 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(1), AGT(3), CALR(1), CAMK1(2), CAMK1G(1), CREBBP(8), F2(2), HAND2(1), LIF(1), MAPK1(1), MAPK14(1), MEF2C(1), NFATC2(1), NFATC3(3), NKX2-5(1), PIK3CA(6), PIK3R1(2), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RAF1(3) 21395683 44 40 42 11 6 8 7 15 8 0 0.265 1.000 1.000 475 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(3), AMY1A(2), AMY1B(2), AMY1C(2), AMY2B(1), ENPP1(2), ENPP3(1), GAA(2), GBE1(1), GCK(1), GYS2(1), HK1(2), MGAM(3), PGM1(1), PYGB(1), PYGM(1), SI(2), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2) 28161509 42 32 42 9 4 2 6 15 15 0 0.563 1.000 1.000 476 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(3), DARS(3), EPRS(1), FARSA(2), IARS2(4), KARS(1), LARS(4), MARS(1), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(2), TARS(1), VARS(1), VARS2(3), YARS2(1) 22791849 36 32 36 9 2 3 7 15 9 0 0.612 1.000 1.000 477 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(2), GMDS(1), GMPPA(1), HK1(2), KHK(2), MPI(1), MTMR2(2), MTMR6(1), PFKFB3(2), PFKFB4(1), PFKL(1), PFKP(1), PHPT1(1), RDH11(1), RDH12(3), RDH13(1) 15806092 23 22 23 8 1 5 3 10 4 0 0.725 1.000 1.000 478 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), DAG1(3), DGKA(1), GCA(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), MAPK1(1), PAK1(2), PDE3A(2), PDE3B(2), PI3(1), PIK3C2G(3), PIK3CA(6), PIK3CD(1), PIK3R1(2), RIPK3(1) 20586960 44 42 42 11 3 10 5 18 8 0 0.359 1.000 1.000 479 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT2(1), AKT3(1), BCL10(1), CARD11(1), CD81(1), CR2(1), IFITM1(1), IKBKB(1), KRAS(5), LYN(3), MALT1(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NFKBIA(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PPP3CB(1), RAC2(1), RASGRP3(1), VAV1(3), VAV3(1) 31853024 53 47 47 10 5 9 6 25 8 0 0.123 1.000 1.000 480 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 MAP2K7(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK8IP1(1), NFKB2(2), NFKBIA(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), TRAF5(1) 14859966 20 17 18 9 4 5 1 7 3 0 0.846 1.000 1.000 481 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(2), ATM(5), ATR(2), BAI1(1), BAX(1), BID(1), CASP9(1), CCNB2(1), CCND3(1), CCNE2(1), CCNG2(1), CDK4(1), CDKN2A(1), CHEK1(1), CHEK2(1), GADD45B(2), GTSE1(2), PPM1D(2), PTEN(7), RCHY1(2), RFWD2(2), SESN1(2), SFN(1), THBS1(5), TP53(7), TSC2(6), ZMAT3(1) 27634097 60 56 60 14 3 7 12 17 20 1 0.316 1.000 1.000 482 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT2(1), AKT3(1), BCL10(1), CARD11(1), CBLB(2), CBLC(1), CDK4(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(1), IL2(1), ITK(1), KRAS(5), LCP2(1), MALT1(1), MAP3K8(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NFKBIA(1), NRAS(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP3CB(1), PTPRC(1), RASGRP1(1), SOS1(2), SOS2(1), TNF(1), VAV1(3), VAV3(1), ZAP70(1) 43062776 71 60 65 12 6 13 9 29 14 0 0.0407 1.000 1.000 483 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT4(1), B3GNT1(1), B3GNT2(1), B4GALT1(2), B4GALT2(1), FUT4(2), FUT5(1), FUT6(1), GBGT1(1), GCNT2(2), PIGK(1), PIGM(1), PIGU(1), ST3GAL4(1), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA5(2) 20613005 25 20 25 7 0 6 0 11 8 0 0.702 1.000 1.000 484 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), AKT3(1), BCR(2), CD81(1), CR2(1), DAG1(3), FLOT1(1), GRB2(1), ITPR1(6), ITPR2(5), ITPR3(3), LYN(3), MAP4K1(1), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(2), PPP3CB(1), PTPRC(1), RAF1(3), SOS1(2), SOS2(1), VAV1(3) 30981930 54 49 52 12 4 10 5 24 11 0 0.220 1.000 1.000 485 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CLCA1(1), CNGA3(1), CNGB1(2), GUCA1B(1), PDE1C(2), PRKACG(1), PRKG1(2), PRKG2(2), PRKX(1) 12962075 19 19 19 9 1 6 0 11 1 0 0.821 1.000 1.000 486 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK2(1), CLK3(1), CLK4(5), COL2A1(1), CPSF2(1), CPSF3(1), CSTF1(1), CSTF2T(1), DDX20(4), DHX15(1), DHX16(2), DHX38(3), DHX8(3), DHX9(4), DICER1(2), METTL3(2), NCBP2(1), NUDT21(1), NXF1(4), PABPN1(1), POLR2A(1), PPM1G(1), PRPF18(3), PRPF4B(2), PRPF8(4), PTBP2(1), RBM17(1), RBM5(2), RNGTT(1), RNMT(1), SF3A1(2), SF3A3(1), SF3B1(7), SF3B2(2), SNRPA1(1), SNRPE(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(3), U2AF2(2), XRN2(1) 44592287 83 71 83 15 4 11 13 36 19 0 0.106 1.000 1.000 487 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), AKT3(1), BCR(2), DAG1(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), LYN(3), MAP2K2(1), MAPK1(1), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(2), RAF1(3), SOS1(2), SOS2(1), VAV1(3) 22375624 44 38 42 11 4 8 3 21 8 0 0.365 1.000 1.000 488 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), AKT3(1), ASAH1(1), BRAF(4), DAG1(3), DRD2(1), EGFR(1), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), RAF1(3), RGS20(1), SOS1(2), SOS2(1), STAT3(1), TERF2IP(1) 24651714 51 49 50 13 4 8 9 13 17 0 0.286 1.000 1.000 489 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH6(2), ALDH1A3(1), AOC2(2), COMT(1), DCT(1), ECH1(1), ESCO1(2), GOT2(1), HPD(1), MAOA(1), MAOB(3), METTL2B(1), PNPLA3(1), PRMT2(1), PRMT5(3), PRMT6(1), PRMT7(2), TAT(1), TYRP1(2) 25003055 28 26 28 8 2 4 3 13 6 0 0.522 1.000 1.000 490 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(1), BRAF(4), FASLG(2), GRB2(1), HLA-A(1), HLA-B(1), HLA-C(3), ICAM1(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), ITGAL(1), ITGB2(1), KLRC3(1), KLRK1(3), KRAS(5), LCP2(1), MAP2K2(1), MAPK1(1), MICA(1), NFAT5(2), NFATC2(1), NFATC3(3), NRAS(2), PAK1(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(1), RAC2(1), RAF1(3), SH3BP2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), TNF(1), TNFRSF10D(1), TNFSF10(3), ULBP1(1), VAV1(3), VAV3(1), ZAP70(1) 48098920 89 70 82 16 6 16 12 33 21 1 0.0479 1.000 1.000 491 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), BMPR1A(2), BMPR2(1), CDKL2(3), CLK1(1), CLK2(1), CLK4(5), COL4A3BP(2), CSNK2A1(2), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), INPP4A(1), INPP4B(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(1), NEK1(1), NEK3(1), OCRL(1), PAK4(3), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3CA(6), PIK3CB(2), PIK3CG(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLK3(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKG1(2), RAF1(3), RPS6KA3(1), RPS6KA4(1), STK11(2), TGFBR1(1), VRK1(1) 48033757 94 80 92 18 5 15 14 31 29 0 0.0716 1.000 1.000 492 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(4), CTCFL(5), DOT1L(5), EHMT1(1), EHMT2(3), EZH1(3), FBXO11(3), HCFC1(2), JMJD6(1), KDM6A(10), NSD1(4), OGT(2), PAXIP1(3), PPP1CC(1), PRDM2(6), PRDM6(1), PRDM7(1), PRMT1(1), PRMT5(3), PRMT6(1), PRMT7(2), SATB1(1), SETD1A(4), SETD2(17), SETDB1(4), SETDB2(1), SETMAR(1), SUV39H1(1), SUV39H2(1), SUZ12(1), WHSC1(1) 51978140 94 80 94 18 5 8 13 28 37 3 0.171 1.000 1.000 493 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(4), DCK(1), DPYD(1), DPYS(1), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1), NUDT2(1), PNPT1(4), POLA1(2), POLD1(2), POLD2(1), POLE(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), UMPS(2), UPB1(1), UPP1(1), UPP2(1), UPRT(1) 34343580 61 54 61 13 4 6 10 20 21 0 0.315 1.000 1.000 494 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(4), CACNA1A(5), CRH(1), GNA13(2), GNAI1(1), GNAI2(2), GNAZ(2), GRIA1(3), GRIA2(1), GRID2(2), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), IGF1R(2), ITPR1(6), ITPR2(5), ITPR3(3), KRAS(5), LYN(3), MAP2K2(1), MAPK1(1), NOS1(1), NOS3(1), NPR1(1), NPR2(3), NRAS(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PRKCA(1), PRKCG(2), PRKG1(2), PRKG2(2), RAF1(3), RYR1(7) 47003647 98 81 93 20 11 13 11 40 23 0 0.0909 1.000 1.000 495 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), ABL2(1), AKT2(1), AKT3(1), BRAF(4), CAMK2A(1), CAMK2B(2), CAMK2D(1), CBLB(2), CBLC(1), EGF(1), EGFR(1), ELK1(1), ERBB2(3), ERBB3(2), ERBB4(4), GRB2(1), KRAS(5), MAP2K2(1), MAP2K7(2), MAPK1(1), MAPK10(1), NRAS(2), NRG1(3), NRG2(1), NRG3(3), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PRKCA(1), PRKCG(2), PTK2(1), RAF1(3), RPS6KB2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), STAT5A(2), STAT5B(1) 43801577 89 71 81 18 6 17 10 37 19 0 0.0546 1.000 1.000 496 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR10(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CXCR6(2), GRPR(1), LHCGR(1), NPY1R(1), NPY2R(2), OPRM1(1), SSTR1(2), TAC4(1), TACR2(1), TSHR(1) 21737294 26 24 26 9 1 4 3 14 4 0 0.766 1.000 1.000 497 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG10B(1), ALG11(1), ALG14(1), ALG2(1), ALG6(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT6(2), B4GALT1(2), B4GALT2(1), B4GALT5(1), CHST13(1), CHST2(3), CHST3(1), CHSY1(1), DPAGT1(2), EXT2(2), EXTL1(1), FUT11(1), GALNT10(1), GALNT11(1), GALNT2(1), GALNT4(2), GALNT5(1), GALNT6(3), GALNT7(3), GCNT3(2), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), MAN1B1(1), MAN1C1(2), MAN2A1(2), MGAT4B(1), MGAT5(1), MGAT5B(1), NDST1(1), NDST4(2), OGT(2), RPN1(2), RPN2(1), ST3GAL4(1), ST6GAL1(1), XYLT1(1) 46819146 65 56 65 12 3 11 8 19 24 0 0.163 1.000 1.000 498 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(1), BAX(1), BFAR(2), CAD(4), CASP10(1), CD7(2), DAXX(1), DEDD(1), EGFR(1), EPHB2(1), MAP2K7(2), MAP3K1(3), MAPK1(1), MAPK10(1), MAPK8IP1(1), MET(22), NFAT5(2), NFKB2(2), NFKBIA(1), NFKBIL1(1), PFN1(1), PTPN13(2), RALBP1(2), RIPK1(1), ROCK1(2), SMPD1(4), TP53(7), TPX2(1) 31135058 71 58 62 18 6 12 13 29 11 0 0.298 1.000 1.000 499 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 ELK1(1), FCER1A(1), GRB2(1), LYN(3), MAP2K7(2), MAP3K1(3), MAPK1(1), NFATC2(1), NFATC3(3), PIK3CA(6), PIK3R1(2), PLA2G4A(1), PPP3CB(1), RAF1(3), SOS1(2), VAV1(3) 18030994 34 30 32 10 4 8 1 13 8 0 0.652 1.000 1.000 500 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), EGFR(1), IKBKB(1), JAM3(1), LYN(3), MAPK10(1), MAPK14(1), MET(22), NFKB2(2), NFKBIA(1), NOD1(2), PAK1(2), PLCG2(1), PTPRZ1(5), RELA(2), TCIRG1(1), TJP1(2) 30026690 65 58 57 17 1 8 15 30 11 0 0.383 1.000 1.000 501 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(1), INPPL1(2), ITPKA(1), ITPKB(1), OCRL(1), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3CA(6), PIK3CB(2), PIK3CG(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1) 18958427 36 34 34 10 3 8 5 10 10 0 0.493 1.000 1.000 502 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(4), ACADL(3), ACADM(2), ACOX1(1), ACOX2(3), ACOX3(3), ACSL6(1), ANGPTL4(1), AQP7(1), CPT1A(1), CPT1B(1), CPT1C(1), CYP27A1(1), CYP4A11(2), CYP7A1(1), EHHADH(1), GK(1), HMGCS2(2), LPL(4), PCK1(5), PCK2(1), PPARG(1), RXRA(2), RXRB(1), SCP2(1), SORBS1(1), UBC(2) 27725096 48 40 48 13 2 13 8 16 9 0 0.410 1.000 1.000 503 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 85 ANPEP(5), CD1A(1), CD1C(2), CD1D(1), CD33(1), CD5(1), CD7(2), CD9(1), CR1(3), CR2(1), CSF1R(3), CSF2RA(1), CSF3R(1), FCER2(1), FCGR1A(1), FLT3(1), IL1R1(1), IL1R2(1), IL4R(2), IL5RA(1), IL7R(1), IL9R(1), ITGA1(3), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGAM(3), ITGB3(3), MME(1), TFRC(2), THPO(1), TNF(1) 35359469 56 47 56 15 5 6 7 21 17 0 0.552 1.000 1.000 504 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH6(2), AGK(2), AGPAT1(1), AGPAT2(1), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), CEL(1), DAK(1), DGAT2(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), GK(1), GPAM(2), LCT(1), LIPA(1), LPL(4), PNPLA3(1), PPAP2B(1) 25005034 39 37 39 12 3 4 6 14 12 0 0.627 1.000 1.000 505 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(1), ACSL6(1), AKT2(1), AKT3(1), CAMKK1(3), CPT1A(1), CPT1B(1), CPT1C(1), IKBKB(1), IRS1(2), IRS2(3), JAK1(2), JAK2(1), JAK3(1), LEPR(1), MAPK10(1), NFKB2(2), NFKBIA(1), PCK1(5), PCK2(1), POMC(1), PRKAA1(1), PRKAG1(1), PRKAG2(3), RELA(2), RXRA(2), RXRB(1), SLC2A4(2), SOCS3(1), STAT3(1), STK11(2), TNF(1), TNFRSF1B(2) 35467157 51 46 51 13 6 7 11 15 12 0 0.350 1.000 1.000 506 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT2(1), AKT3(1), CD40(1), CD86(2), IFNA2(2), IFNAR1(1), IKBKB(1), IKBKE(1), IRF5(1), IRF7(1), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAP3K7(1), MAP3K8(1), MAPK1(1), MAPK10(1), MAPK14(1), NFKB2(2), NFKBIA(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), RELA(2), RIPK1(1), STAT1(2), TBK1(1), TLR1(2), TLR2(1), TLR3(2), TLR5(3), TLR6(1), TLR7(1), TNF(1) 37932952 58 51 56 14 6 8 7 20 17 0 0.384 1.000 1.000 507 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(1), AKT3(1), CASP9(1), KDR(1), KRAS(5), MAP2K2(1), MAPK1(1), MAPK14(1), MAPKAPK2(1), NFAT5(2), NFATC2(1), NFATC3(3), NOS3(1), NRAS(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PTK2(1), PXN(1), RAC2(1), RAF1(3), SHC2(1), SPHK1(1), SPHK2(1) 30702457 58 50 52 16 5 11 7 19 16 0 0.499 1.000 1.000 508 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 252 ACVR1B(1), ACVR2A(4), AMH(2), AMHR2(2), BMP7(1), BMPR1A(2), BMPR2(1), CCL27(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CCR9(2), CD27(1), CD40(1), CNTF(2), CSF1R(3), CSF2RA(1), CSF2RB(3), CSF3R(1), CX3CL1(2), CXCR6(2), EGF(1), EGFR(1), FASLG(2), FLT1(1), FLT3(1), FLT4(4), HGF(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), IFNK(1), IL10RA(3), IL10RB(1), IL12RB2(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18(1), IL1R1(1), IL1R2(1), IL2(1), IL21R(3), IL4R(2), IL5RA(1), IL6ST(2), IL7R(1), IL9(1), IL9R(1), INHBB(1), INHBE(1), KDR(1), LEPR(1), LIF(1), LIFR(2), LTBR(1), MET(22), NGFR(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(1), TGFBR1(1), TNF(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF14(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(1), TNFRSF8(1), TNFSF10(3), TNFSF15(1), TNFSF8(2) 75116070 130 103 122 27 10 21 23 52 24 0 0.0655 1.000 1.000 509 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(1), CFL2(1), INPPL1(2), ITPR1(6), ITPR2(5), ITPR3(3), LIMK1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(1), PIK3R1(2), PPP1R13B(2), PTEN(7), RACGAP1(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2) 29510862 58 55 56 16 5 11 7 19 15 1 0.488 1.000 1.000 510 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(1), ACVR2A(4), AMH(2), AMHR2(2), BMP4(1), BMP7(1), BMP8A(1), BMPR1A(2), BMPR2(1), CHRD(1), CREBBP(8), CUL1(2), E2F5(1), EP300(5), IFNG(2), INHBB(1), INHBE(1), LTBP1(5), MAPK1(1), NODAL(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), ROCK1(2), ROCK2(1), RPS6KB2(1), SMAD1(1), SMAD2(1), SMAD4(3), SMAD7(1), SMAD9(1), SMURF2(1), TGFBR1(1), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNF(1), ZFYVE16(2), ZFYVE9(2) 41966205 76 64 76 19 6 8 16 25 21 0 0.357 1.000 1.000 511 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(5), CCND3(1), CCNE2(1), CCNG2(1), CDC25A(1), CDK4(1), CDKN1C(1), CDKN2A(1), CREB3L1(2), CREB3L3(1), E2F2(1), E2F3(1), E2F5(1), GBA2(3), MCM2(1), MCM3(2), MCM5(1), MCM6(2), MYT1(6), NACA(1), POLE(1), RPA2(1), TNXB(5), TP53(7) 32727373 48 47 48 13 6 10 8 15 9 0 0.178 1.000 1.000 512 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(1), CCKBR(2), CCR2(1), CCR3(1), CCR5(1), CELSR1(3), CELSR2(3), CELSR3(3), CHRM2(1), CHRM3(1), CIDEB(1), DRD4(1), F2R(1), GPR116(2), GPR133(3), GPR18(2), GRM1(1), GRPR(1), LPHN2(1), LPHN3(2), LTB4R2(1), OR2M4(1), PTGFR(2), SMO(1), TSHR(1), VN1R1(1) 27973261 40 34 40 12 2 4 10 18 6 0 0.509 1.000 1.000 513 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(1), BIRC2(1), BIRC3(2), BRAF(4), CAPN2(1), CAV2(1), CCND3(1), CHAD(3), COL11A1(3), COL11A2(1), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), CTNNB1(2), DIAPH1(2), DOCK1(1), EGF(1), EGFR(1), ELK1(1), ERBB2(3), FARP2(1), FIGF(1), FLNB(2), FLNC(1), FLT1(1), FN1(4), GRB2(1), HGF(1), IGF1R(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAV(1), ITGB1(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), KDR(1), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), MAPK1(1), MAPK10(1), MET(22), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PARVG(1), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PPP1R12A(2), PRKCA(1), PRKCG(2), PTEN(7), PTK2(1), PXN(1), RAC2(1), RAF1(3), RAPGEF1(2), RELN(3), ROCK1(2), ROCK2(1), SHC2(1), SHC4(1), SOS1(2), SOS2(1), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TLN1(6), TLN2(4), TNC(1), TNN(1), TNR(1), TNXB(5), VAV1(3), VAV3(1), VCL(1), VWF(2) 157808074 262 160 250 70 18 48 37 96 60 3 0.191 1.000 1.000 514 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN4(1), APC(3), APC2(1), ARHGEF12(2), ARHGEF4(2), ARHGEF6(1), ARHGEF7(2), BAIAP2(2), BRAF(4), CFL2(1), CHRM1(2), CHRM2(1), CHRM3(1), CYFIP1(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(1), EGFR(1), EZR(1), F2(2), F2R(1), FGD3(1), FGF1(1), FGF12(1), FGF19(1), FGF3(1), FGF4(1), FGF5(1), FGF6(1), FGF7(1), FGFR1(1), FGFR3(6), FGFR4(2), FN1(4), GNA13(2), GNG12(1), GSN(1), INS(1), IQGAP1(1), IQGAP2(3), IQGAP3(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAD(2), ITGAE(2), ITGAL(1), ITGAM(3), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), KRAS(5), LIMK1(1), LIMK2(1), MAP2K2(1), MAPK1(1), MSN(1), MYH10(4), MYH14(3), MYH9(4), MYLK(1), NCKAP1(1), NCKAP1L(3), NRAS(2), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PDGFRA(1), PDGFRB(2), PFN1(1), PFN3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP4K2A(1), PIP5K1C(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC2(1), RAF1(3), RDX(1), ROCK1(2), ROCK2(1), SCIN(3), SOS1(2), SOS2(1), SSH1(2), SSH2(5), TIAM1(1), TIAM2(1), VAV1(3), VAV3(1), VCL(1), WASF1(1), WASL(2) 117558519 217 147 209 53 18 31 28 95 45 0 0.0969 1.000 1.000 515 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY2(1), ADCY3(2), ADCY4(1), ADCY7(1), ADCY8(3), ADCY9(3), ADORA2A(2), ATP2A1(1), ATP2A2(1), ATP2B1(1), ATP2B2(1), ATP2B3(2), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1G(4), CACNA1H(5), CACNA1I(1), CACNA1S(5), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(1), CHRM3(1), EGFR(1), ERBB2(3), ERBB3(2), ERBB4(4), F2R(1), GNA14(1), GRIN2A(4), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HTR2B(2), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), LHCGR(1), LTB4R2(1), MYLK(1), NOS1(1), NOS3(1), P2RX1(1), P2RX2(1), P2RX7(1), PDE1B(1), PDE1C(2), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), PPID(1), PPP3CB(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(7), RYR2(5), RYR3(6), SLC25A5(1), SLC8A1(3), SLC8A2(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(1), TRPC1(1), VDAC2(1), VDAC3(2) 115532110 183 131 181 56 16 33 26 62 46 0 0.374 1.000 1.000 516 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(1), AKT2(1), AKT3(1), ARRB1(1), ATF2(1), BDNF(1), BRAF(4), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1G(4), CACNA1H(5), CACNA1I(1), CACNA1S(5), CACNA2D1(1), CACNA2D2(1), CACNA2D3(1), CACNA2D4(3), CACNB1(2), CACNG2(3), CACNG7(1), CACNG8(1), DAXX(1), DUSP6(2), DUSP7(1), ECSIT(1), EGF(1), EGFR(1), ELK1(1), FASLG(2), FGF1(1), FGF12(1), FGF19(1), FGF3(1), FGF4(1), FGF5(1), FGF6(1), FGF7(1), FGFR1(1), FGFR3(6), FGFR4(2), FLNB(2), FLNC(1), GADD45B(2), GNG12(1), GRB2(1), IKBKB(1), IL1R1(1), IL1R2(1), KRAS(5), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K6(3), MAP3K7(1), MAP3K8(1), MAP4K1(1), MAP4K2(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK8IP1(1), MAPKAPK2(1), MAPT(1), MEF2C(1), MKNK2(1), NF1(5), NFATC2(1), NFKB2(2), NRAS(2), NTRK1(1), NTRK2(2), PAK1(2), PDGFRA(1), PDGFRB(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PPM1A(1), PPP3CB(1), PPP5C(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAC2(1), RAF1(3), RASA1(2), RASGRF1(6), RASGRP1(1), RASGRP3(1), RASGRP4(1), RPS6KA3(1), RPS6KA4(1), RPS6KA5(1), SOS1(2), SOS2(1), STMN1(1), TAOK2(1), TAOK3(2), TGFBR1(1), TNF(1), TP53(7), ZAK(1) 123003962 200 130 193 50 19 22 33 76 49 1 0.223 1.000 1.000 517 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTB(3), CHAD(3), COL11A1(3), COL11A2(1), COL17A1(2), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), DES(1), DSC2(2), DSC3(1), DSG1(1), DSG3(1), DSG4(1), FN1(4), GJA3(1), GJA4(1), GJB3(2), GJB7(1), GJC1(1), GJC3(1), GJD3(1), ITGA6(3), ITGB4(4), KRT10(3), KRT13(3), KRT15(1), KRT17(1), KRT19(1), KRT2(5), KRT23(2), KRT24(1), KRT25(1), KRT27(3), KRT3(5), KRT32(1), KRT33A(1), KRT33B(1), KRT37(1), KRT38(1), KRT4(1), KRT5(1), KRT6A(1), KRT72(2), KRT73(1), KRT76(1), KRT82(1), KRT83(1), KRT84(1), KRT85(2), KRT86(2), KRT9(2), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), LMNA(2), LMNB1(1), LMNB2(1), PRPH(1), RELN(3), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNR(1), TNXB(5), VIM(1), VWF(2) 106277079 170 124 165 61 16 30 21 63 38 2 0.879 1.000 1.000 518 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ARRB1(1), ATP1A4(1), ATP1B1(7), ATP2A2(1), ATP2B1(1), ATP2B2(1), ATP2B3(2), CACNA1A(5), CACNA1B(4), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1S(5), CACNB1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CHRM1(2), CHRM2(1), CHRM3(1), GJA4(1), GJB3(2), GNAI2(2), GNAZ(2), GNB1(1), GNB5(1), GNG12(1), GNG13(1), GRK5(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNB1(2), KCNJ3(1), MIB1(1), NME7(1), PLCB3(2), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), RGS1(1), RGS14(2), RGS20(1), RGS3(2), RGS6(1), RGS7(2), RYR1(7), RYR2(5), RYR3(6), SFN(1), SLC8A1(3), SLC8A3(1), USP5(2) 79899945 144 116 143 51 16 15 21 52 40 0 0.835 1.000 1.000 519 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), ABLIM1(1), ARHGEF12(2), CFL2(1), DCC(3), DPYSL2(1), EFNA1(3), EFNA2(1), EFNA5(1), EPHA2(1), EPHA3(4), EPHA4(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(2), EPHB6(2), FES(1), GNAI1(1), GNAI2(2), ITGB1(1), KRAS(5), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK1(1), MET(22), NFAT5(2), NFATC2(1), NFATC3(3), NGEF(1), NRAS(2), NTN1(1), NTNG1(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PLXNA2(6), PLXNA3(2), PLXNB1(3), PLXNB2(4), PLXNB3(1), PLXNC1(1), PPP3CB(1), PTK2(1), RAC2(1), RASA1(2), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA3A(1), SEMA3D(1), SEMA3E(2), SEMA3F(3), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5A(1), SEMA6A(2), SEMA7A(1), SLIT2(1), SLIT3(2), SRGAP1(4), SRGAP3(1), UNC5A(2), UNC5B(1), UNC5C(2) 83407915 152 116 140 49 8 21 20 69 34 0 0.823 1.000 1.000 520 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(3), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDK4(1), CGN(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CRB3(1), CSNK2A1(2), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EPB41L1(3), EPB41L2(1), EPB41L3(4), EXOC4(2), GNAI1(1), GNAI2(2), INADL(3), JAM3(1), KRAS(5), LLGL1(1), MAGI1(2), MAGI3(1), MLLT4(4), MYH1(2), MYH10(4), MYH11(1), MYH13(3), MYH14(3), MYH15(3), MYH3(2), MYH4(5), MYH6(3), MYH7(6), MYH7B(2), MYH8(3), MYH9(4), NRAS(2), PARD3(2), PARD6B(7), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), PTEN(7), SPTAN1(3), SYMPK(2), TJAP1(2), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(1) 81621009 150 111 145 47 7 14 37 53 38 1 0.822 1.000 1.000 521 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 86 AGRN(2), CHAD(3), COL11A1(3), COL11A2(1), COL1A2(3), COL2A1(1), COL4A1(2), COL4A2(3), COL4A6(2), COL5A1(4), COL5A2(1), COL5A3(3), COL6A1(1), COL6A2(4), COL6A3(5), COL6A6(4), DAG1(3), FN1(4), HSPG2(4), ITGA1(3), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAV(1), ITGB1(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), LAMA3(5), LAMA4(1), LAMA5(1), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(2), LAMC3(2), RELN(3), SDC4(2), SV2A(1), SV2B(2), SV2C(2), THBS1(5), THBS2(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNR(1), TNXB(5), VWF(2) 95705615 140 110 140 45 8 26 16 57 31 2 0.671 1.000 1.000 522 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 145 APC(3), APC2(1), AXIN1(3), AXIN2(2), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCND3(1), CER1(1), CHD8(5), CREBBP(8), CSNK1E(3), CSNK2A1(2), CTBP1(1), CTNNB1(2), CUL1(2), DAAM1(1), DAAM2(2), DVL3(1), EP300(5), FZD1(1), FZD2(1), FZD4(1), FZD5(2), FZD7(3), FZD8(2), LEF1(1), LRP5(3), LRP6(6), MAP3K7(1), MAPK10(1), NFAT5(2), NFATC2(1), NFATC3(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PORCN(1), PPP2R1A(2), PPP2R2A(2), PPP2R2C(1), PPP3CB(1), PRICKLE1(2), PRICKLE2(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), RAC2(1), ROCK1(2), ROCK2(1), RUVBL1(1), SENP2(1), SMAD2(1), SMAD4(3), SOX17(1), TBL1X(2), TBL1XR1(1), TCF7L1(2), TP53(7), VANGL1(1), WIF1(1), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2) 68206570 138 106 138 36 14 18 21 49 36 0 0.307 1.000 1.000 523 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(2), ACACB(1), AKT2(1), AKT3(1), BRAF(4), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(4), FLOT1(1), FOXO1(1), GCK(1), GRB2(1), GYS2(1), IKBKB(1), INS(1), IRS1(2), IRS2(3), KRAS(5), MAP2K2(1), MAPK1(1), MAPK10(1), MKNK2(1), NRAS(2), PCK1(5), PCK2(1), PDE3A(2), PDE3B(2), PFKL(1), PFKP(1), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP1CC(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAG1(1), PRKAG2(3), PRKAR1A(1), PRKAR2B(2), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(1), PYGB(1), PYGM(1), RAF1(3), RAPGEF1(2), RHEB(1), RHOQ(1), RPS6KB2(1), SHC2(1), SHC4(1), SLC2A4(2), SOCS1(1), SOCS3(1), SORBS1(1), SOS1(2), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(6) 68489870 130 99 123 32 11 26 21 50 22 0 0.0767 1.000 1.000 524 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADORA2A(2), ADORA3(1), ADRA2A(1), AGTR2(1), C3AR1(3), CALCR(3), CALCRL(2), CCKAR(1), CCKBR(2), CHRM1(2), CHRM2(1), CHRM3(1), CRHR2(1), DRD2(1), DRD4(1), DRD5(1), F2(2), F2R(1), F2RL2(1), GABBR1(2), GABRA3(1), GABRB2(2), GABRB3(2), GABRD(1), GABRG1(1), GABRG2(3), GABRG3(3), GABRP(1), GABRQ(2), GIPR(1), GLP2R(2), GLRA1(2), GLRB(1), GPR50(1), GPR83(1), GRIA1(3), GRIA2(1), GRID1(1), GRID2(2), GRIK3(1), GRIK4(1), GRIK5(1), GRIN2A(4), GRIN2B(1), GRIN2D(2), GRIN3A(2), GRM1(1), GRM2(1), GRM3(2), GRM4(2), GRM5(1), GRM6(1), GRPR(1), HCRTR1(1), HCRTR2(4), HTR1A(1), HTR1B(1), HTR2B(2), LEPR(1), LHCGR(1), LTB4R2(1), MAS1(1), MCHR1(1), NPBWR2(1), NPY1R(1), NPY2R(2), NR3C1(2), OPRM1(1), P2RX1(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY2(1), P2RY4(1), P2RY8(1), PARD3(2), PRLR(1), PRSS3(3), PTGDR(1), PTGER3(2), PTGFR(2), RXFP1(2), SSTR1(2), TACR2(1), THRA(1), TRPV1(2), TSHR(1) 93144676 131 98 130 33 13 22 23 49 23 1 0.0859 1.000 1.000 525 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(3), ACTN4(1), ACVR1B(1), BAIAP2(2), CDH1(2), CREBBP(8), CSNK2A1(2), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EGFR(1), EP300(5), ERBB2(3), FARP2(1), FGFR1(1), IGF1R(2), IQGAP1(1), LEF1(1), LMO7(5), MAP3K7(1), MAPK1(1), MET(22), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(4), PTPRF(1), PTPRJ(4), PTPRM(6), PVRL3(2), RAC2(1), SMAD2(1), SMAD4(3), SNAI2(2), SORBS1(1), SSX2IP(2), TCF7L1(2), TGFBR1(1), TJP1(2), VCL(1), WASF1(1), WASL(2), YES1(1) 50569022 116 93 107 31 3 21 30 39 23 0 0.238 1.000 1.000 526 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ARRB1(1), ATF2(1), ATP2A2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CRH(1), GABPB2(1), GBA2(3), GNB1(1), GNB5(1), GNG12(1), GNG13(1), GRK5(1), GUCA2A(1), IGFBP1(1), IGFBP2(1), IGFBP6(1), ITPR1(6), ITPR2(5), ITPR3(3), MIB1(1), MYL4(1), NOS1(1), NOS3(1), OXT(1), PLCB3(2), PLCD1(2), PLCG2(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), RGS1(1), RGS14(2), RGS20(1), RGS3(2), RGS6(1), RGS7(2), RYR1(7), RYR2(5), RYR3(6), SFN(1), SLC8A1(3), TNXB(5), USP5(2) 73754844 106 89 106 40 11 17 15 37 26 0 0.859 1.000 1.000 527 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ADK(2), ADSL(1), ADSSL1(2), AK7(2), AMPD2(1), ATIC(1), DCK(1), ENPP1(2), ENPP3(1), ENTPD4(2), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(2), GDA(1), GMPR(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), NME7(1), NPR1(1), NPR2(3), NT5C(1), NT5C1A(1), NT5C1B(1), NT5M(1), NUDT2(1), NUDT5(1), PAPSS1(1), PAPSS2(2), PDE11A(1), PDE1C(2), PDE3B(2), PDE4A(1), PDE7B(1), PDE8B(1), PDE9A(2), PFAS(2), PNPT1(4), POLA1(2), POLD1(2), POLD2(1), POLE(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLR3A(3), POLR3G(1), POLR3GL(1), POLR3H(1), PPAT(1), PRPS2(1), PRUNE(1), RFC5(1), RRM1(2), XDH(1) 69293580 108 88 108 30 11 17 10 41 29 0 0.545 1.000 1.000 528 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 AKT2(1), AKT3(1), CBLB(2), CBLC(1), CCND3(1), CISH(2), CNTF(2), CREBBP(8), CSF2RA(1), CSF2RB(3), CSF3R(1), EP300(5), GRB2(1), IFNA2(2), IFNAR1(1), IFNG(2), IFNGR1(1), IFNK(1), IL10RA(3), IL10RB(1), IL12RB2(1), IL15RA(1), IL2(1), IL21R(3), IL4R(2), IL5RA(1), IL6ST(2), IL7R(1), IL9(1), IL9R(1), IRF9(1), JAK1(2), JAK2(1), JAK3(1), LEPR(1), LIF(1), LIFR(2), PIAS1(1), PIAS2(2), PIAS3(1), PIAS4(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PRLR(1), SOCS1(1), SOCS3(1), SOCS5(1), SOS1(2), SOS2(1), SPRED2(1), SPRY1(1), SPRY2(1), STAM(2), STAT1(2), STAT2(1), STAT3(1), STAT5A(2), STAT5B(1) 61485967 104 85 102 26 7 17 19 33 28 0 0.310 1.000 1.000 529 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), ASIP(2), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3L1(2), CREB3L3(1), CREBBP(8), CTNNB1(2), DCT(1), DVL3(1), EP300(5), FZD1(1), FZD2(1), FZD4(1), FZD5(2), FZD7(3), FZD8(2), GNAI1(1), GNAI2(2), KRAS(5), LEF1(1), MAP2K2(1), MAPK1(1), MITF(2), NRAS(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), POMC(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(3), TCF7L1(2), TYRP1(2), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2) 46226369 95 81 90 37 11 21 7 29 27 0 0.826 1.000 1.000 530 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), INPP4A(1), INPP4B(1), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(2), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), OCRL(1), PI4KA(2), PIK3C2A(5), PIK3C2B(2), PIK3C2G(3), PIK3C3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PIP4K2A(1), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), PRKCA(1), PRKCG(2), PTEN(7), SYNJ2(1) 53065294 92 79 90 27 6 14 14 30 27 1 0.565 1.000 1.000 531 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADK(2), ADSL(1), AMPD2(1), ATIC(1), ATP1B1(7), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), DCK(1), ENPP1(2), ENPP3(1), GART(2), GDA(1), GMPS(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), NPR1(1), NPR2(3), NT5C(1), NT5M(1), NUDT2(1), PAPSS1(1), PAPSS2(2), PDE4A(1), PDE6B(2), PDE7B(1), PDE9A(2), PFAS(2), POLB(1), POLD1(2), POLD2(1), POLE(1), POLG(2), POLL(1), POLQ(3), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2D(1), POLR2F(1), POLR2K(1), POLRMT(2), PPAT(1), PRPS2(1), PRUNE(1), RRM1(2) 54475602 93 78 93 24 6 14 13 32 28 0 0.489 1.000 1.000 532 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM3(1), CD226(1), CD40(1), CD58(1), CD6(2), CD86(2), CDH1(2), CDH3(1), CDH4(1), CDH5(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CNTN1(4), CNTN2(1), GLG1(3), HLA-A(1), HLA-B(1), HLA-C(3), HLA-DOB(1), HLA-DPB1(1), HLA-DQA2(1), ICAM1(1), ICOS(1), ITGA4(1), ITGA6(3), ITGA8(1), ITGAL(1), ITGAM(3), ITGAV(1), ITGB1(1), ITGB2(1), ITGB7(1), ITGB8(2), JAM3(1), MADCAM1(1), MAG(3), MPZL1(1), NCAM1(2), NCAM2(4), NEO1(4), NFASC(3), NLGN1(1), NLGN2(1), NRCAM(1), NRXN1(2), NRXN2(1), NRXN3(1), PTPRC(1), PTPRF(1), PTPRM(6), PVRL3(2), SDC4(2), SELE(1), SELL(1), VCAM1(1), VCAN(5) 62185657 97 77 97 31 5 10 11 45 26 0 0.717 1.000 1.000 533 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), DRD2(1), EGF(1), EGFR(1), GNAI1(1), GNAI2(2), GRB2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1B3(2), GUCY2C(2), GUCY2D(1), HTR2B(2), ITPR1(6), ITPR2(5), ITPR3(3), KRAS(5), MAP2K2(1), MAP2K5(2), MAPK1(1), NPR1(1), NPR2(3), NRAS(2), PDGFRA(1), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKG1(2), PRKG2(2), PRKX(1), RAF1(3), SOS1(2), SOS2(1), TJP1(2), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1) 56262924 92 76 88 38 9 18 9 37 19 0 0.906 1.000 1.000 534 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), CAPN1(1), CAPN11(2), CAPN2(1), CAPN3(1), CAPN7(3), CAV2(1), DOCK1(1), GIT2(1), GRB2(1), ITGA10(3), ITGA11(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGAD(2), ITGAE(2), ITGAL(1), ITGAM(3), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(1), ITGB3(3), ITGB4(4), ITGB5(4), ITGB7(1), ITGB8(2), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK6(2), PAK1(2), PAK3(2), PAK4(3), PIK3R2(1), PTK2(1), PXN(1), RAC2(1), RAPGEF1(2), ROCK1(2), ROCK2(1), SORBS1(1), SOS1(2), TLN1(6), TNS1(5), VAV3(1), VCL(1) 57317312 96 76 96 30 3 12 10 42 29 0 0.673 1.000 1.000 535 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY8(3), BRAF(4), CACNA1C(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREBBP(8), EP300(5), GRIA1(3), GRIA2(1), GRIN2A(4), GRIN2B(1), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(6), ITPR2(5), ITPR3(3), KRAS(5), MAP2K2(1), MAPK1(1), NRAS(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PRKACG(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(3), RAPGEF3(1), RPS6KA3(1) 42449010 84 75 79 27 5 15 11 32 21 0 0.603 1.000 1.000 536 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), CACNA1C(3), CACNA1D(5), CACNA1S(5), CAMK2A(1), CAMK2B(2), CAMK2D(1), EGFR(1), ELK1(1), GRB2(1), ITPR1(6), ITPR2(5), ITPR3(3), KRAS(5), MAP2K2(1), MAP2K3(1), MAP2K7(2), MAP3K1(3), MAP3K3(1), MAP3K4(3), MAPK1(1), MAPK10(1), MAPK14(1), NRAS(2), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLD1(1), PRKACG(1), PRKCA(1), PRKCD(2), PRKX(1), PTK2B(1), RAF1(3), SOS1(2), SOS2(1) 54380867 93 75 89 38 8 21 8 31 25 0 0.907 1.000 1.000 537 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(1), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(2), BRAF(4), CDKN2A(1), CSE1L(3), DOCK1(1), EPHB2(1), GRB2(1), GRB7(2), ITGA1(3), ITGA10(3), ITGA11(1), ITGA3(1), ITGA4(1), ITGA5(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGB3BP(1), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PIK3CA(6), PIK3CB(2), PLCG2(1), PTEN(7), PTK2(1), RAF1(3), RALA(1), ROCK1(2), ROCK2(1), SOS1(2), SOS2(1), TERF2IP(1), TLN1(6), TLN2(4) 51860496 90 71 87 24 4 14 11 35 25 1 0.429 1.000 1.000 538 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(1), ANAPC10(1), ANAPC5(3), ANAPC7(1), ATM(5), ATR(2), BUB1B(1), CCNA2(1), CCNB2(1), CCND3(1), CCNE2(1), CDC14A(1), CDC16(1), CDC20(2), CDC23(1), CDC25A(1), CDC25C(1), CDC27(2), CDC6(2), CDK4(1), CDKN1C(1), CDKN2A(1), CHEK1(1), CHEK2(1), CREBBP(8), CUL1(2), DBF4(2), E2F2(1), E2F3(1), EP300(5), ESPL1(2), FZR1(1), GADD45B(2), MAD1L1(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), PKMYT1(1), PLK1(1), SFN(1), SKP2(1), SMAD2(1), SMAD4(3), SMC1A(1), SMC1B(2), TP53(7) 57716674 83 70 83 27 3 12 16 34 18 0 0.669 1.000 1.000 539 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(3), ABCA12(4), ABCA13(4), ABCA3(1), ABCA4(3), ABCA5(3), ABCA6(1), ABCA7(8), ABCA8(3), ABCB1(2), ABCB10(1), ABCB11(1), ABCB4(2), ABCB5(2), ABCB6(3), ABCB8(1), ABCB9(1), ABCC1(3), ABCC10(1), ABCC11(1), ABCC12(2), ABCC2(4), ABCC3(2), ABCC4(2), ABCC5(3), ABCC6(3), ABCC9(1), ABCD2(1), ABCD3(1), ABCD4(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG8(1), CFTR(1) 49963868 77 68 77 30 6 7 10 35 19 0 0.940 1.000 1.000 540 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN4(1), ARHGAP5(1), CDH5(1), CLDN11(2), CLDN16(1), CLDN18(1), CLDN3(1), CTNNA1(5), CTNNA2(1), CTNNA3(1), CTNNB1(2), EZR(1), GNAI1(1), GNAI2(2), ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(3), ITGB1(1), ITGB2(1), ITK(1), JAM3(1), MAPK14(1), MLLT4(4), MSN(1), NCF2(1), NCF4(1), NOX1(1), NOX3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PLCG2(1), PRKCA(1), PRKCG(2), PTK2(1), PTK2B(1), PXN(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), ROCK1(2), ROCK2(1), SIPA1(1), THY1(1), VAV1(3), VAV3(1), VCAM1(1), VCL(1) 52852549 80 67 78 27 7 11 10 35 17 0 0.835 1.000 1.000 541 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN4(1), DES(1), DMD(5), MYBPC1(2), MYBPC3(1), MYH3(2), MYH6(3), MYH7(6), MYH8(3), MYL4(1), MYOM1(1), NEB(5), TCAP(1), TMOD1(1), TNNT1(1), TPM4(1), TTN(37), VIM(1) 57074839 74 66 73 25 4 9 13 33 15 0 0.842 1.000 1.000 542 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY2(1), ADCY3(2), ADCY4(1), ADCY5(1), ADCY6(2), ADCY7(1), ADCY8(3), ADCY9(3), AKAP1(1), AKAP10(1), AKAP11(1), AKAP12(3), AKAP3(2), AKAP4(1), AKAP6(2), AKAP9(1), CHMP1B(1), GNA13(2), GNA14(1), GNAI2(2), GNAZ(2), GNB1(1), GNB5(1), GNG10(1), GNG12(1), GNG13(1), ITPR1(6), KCNJ3(1), KRAS(5), NRAS(2), PALM2(1), PDE1B(1), PDE1C(2), PDE4A(1), PDE7B(1), PDE8B(1), PLCB3(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCI(3), USP5(2) 49175169 78 65 74 27 3 15 8 32 20 0 0.782 1.000 1.000 543 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(3), AMY1A(2), AMY1B(2), AMY1C(2), AMY2B(1), ASCC3(2), ATP13A2(3), DDX18(1), DDX23(1), DDX4(2), DDX41(2), DDX47(2), DDX50(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENPP1(2), ENPP3(1), ENTPD7(3), EP400(5), ERCC3(2), GAA(2), GANC(1), GBE1(1), GCK(1), GYS2(1), HK1(2), IFIH1(1), MGAM(3), MOV10L1(2), NUDT5(1), PGM1(1), PYGB(1), PYGM(1), RAD54B(1), SETX(4), SI(2), SKIV2L2(1), SMARCA2(1), SMARCA5(1), UGDH(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1) 55864054 87 63 86 21 5 9 14 38 21 0 0.434 1.000 1.000 544 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(3), CABIN1(3), CAMK2B(2), CREBBP(8), CSNK2A1(2), EP300(5), FCER1A(1), FKBP1B(1), GATA3(1), ICOS(1), IFNG(2), IL2(1), ITK(1), JUNB(1), KPNA5(2), MAP2K7(2), MAPK14(1), NFAT5(2), NFATC2(1), NFATC3(3), NFKB2(2), NUP214(5), P2RX7(1), PAK1(2), PPIA(1), PPP3CB(1), PTPRC(1), RELA(2), SFN(1), SP3(1), TNF(1), TRPV6(1), VAV1(3), VAV3(1), XPO5(2) 38608381 68 59 68 20 6 4 14 23 21 0 0.728 1.000 1.000 545 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CITED2(2), CPT1B(1), CREBBP(8), DUT(1), EHHADH(1), EP300(5), HSD17B4(1), HSPA1A(1), INS(1), LPL(4), MAPK1(1), MRPL11(1), NCOA1(3), NCOR1(7), NCOR2(1), NFKBIA(1), NR2F1(2), NRIP1(1), PIK3CA(6), PIK3R1(2), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PRKCA(1), PTGS2(1), RELA(2), RXRA(2), STAT5A(2), STAT5B(1), TNF(1) 27113395 65 58 63 23 4 14 8 19 20 0 0.873 1.000 1.000 546 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA2A(2), ADORA3(1), ADRA2A(1), AGTR2(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR10(1), CCR2(1), CCR3(1), CCR5(1), CCR7(1), CCR9(2), CHRM1(2), CHRM2(1), CHRM3(1), DRD2(1), DRD4(1), DRD5(1), F2R(1), F2RL2(1), GPR173(1), GPR174(2), GPR3(1), GPR37(4), GPR37L1(1), GPR50(1), GPR83(1), GPR85(1), GPR87(2), GRPR(1), HCRTR1(1), HCRTR2(4), HTR1A(1), HTR1B(1), HTR2B(2), LHCGR(1), MAS1(1), NPY1R(1), NPY2R(2), OPRM1(1), OR11A1(1), OR5V1(1), OR8B8(1), P2RY1(2), P2RY2(1), PTGDR(1), PTGFR(2), SSTR1(2) 50750072 68 57 68 24 5 8 11 32 12 0 0.730 1.000 1.000 547 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AKT2(1), AKT3(1), APAF1(2), ATM(5), BAX(1), BID(1), BIRC2(1), BIRC3(2), CAPN1(1), CAPN2(1), CASP10(1), CASP6(1), CASP9(1), CFLAR(2), CSF2RB(3), FASLG(2), IKBKB(1), IL1R1(1), NFKB2(2), NFKBIA(1), NTRK1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), RELA(2), RIPK1(1), TNF(1), TNFRSF10D(1), TNFSF10(3), TP53(7) 35583338 69 57 67 19 4 9 13 27 16 0 0.458 1.000 1.000 548 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(1), ATM(5), BUB1B(1), CCNA2(1), CCNB2(1), CCND3(1), CCNE2(1), CDAN1(3), CDC14A(1), CDC20(2), CDC25A(1), CDC25C(1), CDC6(2), CDH1(2), CDK4(1), CDKN2A(1), CHEK1(1), CHEK2(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(2), HDAC5(3), HDAC6(2), HDAC8(1), MAD1L1(1), MCM2(1), MCM3(2), MCM5(1), MCM6(2), MPEG1(1), PLK1(1), PTPRA(1), SKP2(1), SMAD4(3), TP53(7) 46539337 64 53 64 20 4 9 12 21 18 0 0.554 1.000 1.000 549 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 69 A2M(4), C2(1), C3(2), C3AR1(3), C4BPB(1), C5(1), C6(2), C7(1), C8A(2), C8B(1), C9(1), CD46(1), CFH(1), CPB2(1), CR1(3), CR2(1), F10(1), F12(6), F13A1(2), F2(2), F2R(1), F5(3), F8(1), F9(1), KNG1(3), MASP1(2), MASP2(1), MBL2(1), PROS1(1), SERPINA1(1), SERPIND1(1), VWF(2) 44405967 55 50 55 18 4 8 5 27 11 0 0.830 1.000 1.000 550 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(4), CEBPA(1), CREB1(1), DAXX(1), ELK1(1), GRB2(1), IKBKB(1), MAP2K2(1), MAP2K3(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K6(3), MAP3K7(1), MAP3K8(1), MAP4K1(1), MAP4K2(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK6(2), MAPKAPK2(1), MEF2C(1), MKNK2(1), NFKBIA(1), PAK1(2), RAF1(3), RELA(2), RIPK1(1), RPS6KA3(1), RPS6KA4(1), RPS6KA5(1), RPS6KB2(1), STAT1(2), TGFBR1(1) 40936972 58 49 57 21 2 5 8 23 20 0 0.954 1.000 1.000 551 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(1), INPP5B(2), INPP5E(1), INPPL1(2), ITPK1(2), ITPKA(1), ITPKB(1), MINPP1(1), OCRL(1), PI4KA(2), PIK3C3(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIP4K2A(1), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(1), PLCD1(2), PLCG2(1), PLCZ1(2), PTEN(7), SYNJ2(1) 31542399 48 45 46 17 3 5 8 15 16 1 0.856 1.000 1.000 552 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(5), CACNA1B(4), GNB1(1), GNG13(1), GRM4(2), ITPR3(3), KCNB1(2), PLCB2(3), PRKACG(1), PRKX(1), SCNN1A(2), SCNN1B(3), TAS1R1(1), TAS1R2(2), TAS1R3(3), TAS2R13(1), TAS2R39(1), TAS2R41(1), TAS2R43(1), TAS2R50(2), TRPM5(1) 24304045 47 44 46 17 9 8 4 14 12 0 0.669 1.000 1.000 553 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), AKT3(1), BRAF(4), CAB39(1), EIF4B(1), FIGF(1), HIF1A(2), INS(1), MAPK1(1), PIK3CA(6), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(2), PIK3R2(1), PIK3R3(1), PIK3R5(3), PRKAA1(1), RHEB(1), RICTOR(1), RPS6KA3(1), RPS6KB2(1), STK11(2), TSC1(2), TSC2(6), ULK1(1), ULK2(1), ULK3(1) 22740312 48 43 45 15 7 7 7 15 11 1 0.584 1.000 1.000 554 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(1), AKT3(1), BRD4(2), CDKN2A(1), F2RL2(1), FLOT1(1), GRB2(1), IGFBP1(1), INPPL1(2), IRS1(2), IRS2(3), LNPEP(2), MAPK1(1), PARD3(2), PIK3CA(6), PIK3CD(1), PIK3R1(2), PTEN(7), PTPN1(1), RAF1(3), RPS6KA3(1), SFN(1), SLC2A4(2), SORBS1(1), SOS1(2), SOS2(1) 24941622 49 43 47 16 6 8 6 16 12 1 0.608 1.000 1.000 555 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(1), ALPPL2(1), ASCC3(2), ATP13A2(3), DDX18(1), DDX23(1), DDX4(2), DDX41(2), DDX47(2), DDX50(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(5), ERCC3(2), FPGS(1), GGH(1), IFIH1(1), MOV10L1(2), NUDT5(1), RAD54B(1), SETX(4), SKIV2L2(1), SMARCA2(1), SMARCA5(1) 26693809 46 42 45 14 2 9 7 20 8 0 0.554 1.000 1.000 556 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), APH1A(1), CREBBP(8), CTBP1(1), DTX3L(1), DVL3(1), EP300(5), JAG1(4), MAML1(3), MAML2(3), MAML3(2), NCOR2(1), NCSTN(1), NOTCH1(2), NOTCH2(1), NOTCH3(4), NOTCH4(1), NUMB(1), NUMBL(1), PSEN1(1), SNW1(1) 30012141 46 42 46 26 0 5 5 17 19 0 0.999 1.000 1.000 557 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BMP7(1), BMP8A(1), BTRC(2), CSNK1E(3), GLI1(4), GLI3(2), IHH(1), LRP2(11), PRKACG(1), PRKX(1), PTCH1(1), PTCH2(1), SHH(1), SMO(1), SUFU(2), WNT10A(2), WNT2(1), WNT2B(1), WNT7A(1), WNT7B(1), WNT8B(1), WNT9B(2), ZIC2(2) 25858401 45 41 45 14 5 10 5 15 10 0 0.562 1.000 1.000 558 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(2), BAX(1), BCL2L11(1), BID(1), BIRC2(1), BIRC3(2), BIRC5(1), CASP10(1), CASP4(1), CASP6(1), CASP9(1), FASLG(2), IKBKB(1), IRF2(1), IRF4(1), IRF5(1), IRF6(1), IRF7(1), MAP3K1(3), MAPK10(1), NFKBIA(1), PLEKHG5(1), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2), TNFRSF21(1), TNFSF10(3), TP53(7) 24538883 44 39 44 15 2 7 6 18 11 0 0.779 1.000 1.000 559 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(1), BRAF(4), CREB1(1), CREBBP(8), DAG1(3), EGR1(1), EGR4(1), ELK1(1), FRS2(1), MAP1B(3), MAP2K7(2), MAPK1(1), MAPK10(1), MAPK8IP1(1), NTRK1(1), PIK3C2G(3), PIK3CA(6), PIK3CD(1), PIK3R1(2), RPS6KA3(1), TERF2IP(1) 21958250 44 39 41 15 4 10 7 14 9 0 0.530 1.000 1.000 560 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(2), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1), CFLAR(2), DAXX(1), GSN(1), LMNA(2), LMNB1(1), LMNB2(1), MAP2K7(2), MAP3K1(3), NFKBIA(1), NUMA1(2), PRKCD(2), PSEN1(1), PTK2(1), RASA1(2), RELA(2), RIPK1(1), SPTAN1(3), TNF(1), TNFRSF1B(2) 29197838 39 36 39 18 0 3 7 14 15 0 0.988 1.000 1.000 561 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(3), CREBBP(8), EP300(5), ERCC3(2), GRIP1(4), GTF2A1(2), GTF2F1(1), HDAC5(3), HDAC6(2), MEF2C(1), NCOR2(1), NRIP1(1), POLR2A(1), TBP(1) 19887436 35 34 35 22 3 3 6 13 10 0 0.996 1.000 1.000 562 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(2), BAX(1), BID(1), BIRC2(1), BIRC3(2), CASP6(1), CASP9(1), FASLG(2), MAP3K1(3), MAPK10(1), MCL1(1), NFKBIA(1), PARP1(3), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2), TNFSF10(3), TP53(7) 15926355 36 33 36 11 1 3 6 17 9 0 0.794 1.000 1.000 563 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(3), ASAH1(1), DAG1(3), EPHB2(1), GNAI1(1), ITPR1(6), ITPR2(5), ITPR3(3), KCNJ3(1), MAPK1(1), RYR1(7) 19367225 32 32 32 10 4 3 5 14 6 0 0.669 1.000 1.000 564 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(5), ATR(2), BRCA1(3), CDC25A(1), CDC25C(1), CHEK1(1), CHEK2(1), EP300(5), MYT1(6), TP53(7) 17778876 32 31 32 10 1 8 3 10 10 0 0.711 1.000 1.000 565 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(1), AGPAT2(1), DGKA(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), ESCO1(2), ETNK2(2), GPAM(2), GPD1(2), GPD1L(1), GPD2(1), LCAT(2), PCYT1A(1), PLA2G2D(1), PLA2G4A(1), PLA2G6(2), PLD1(1), PNPLA3(1), PPAP2B(1), PTDSS2(1) 28001652 34 31 34 10 1 7 5 11 10 0 0.471 1.000 1.000 566 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 AKT2(1), AKT3(1), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(6), ITPR2(5), ITPR3(3), NFKB2(2), NFKBIA(1), NFKBIL1(1), PHKA2(2), PIK3CB(2), PLD1(1), PLD3(1), VN1R1(1) 19365337 32 31 32 10 2 4 8 10 8 0 0.546 1.000 1.000 567 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(1), DLD(2), GCK(1), IL1R1(1), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K3(1), MAP3K4(3), MAP3K7(1), MAPK10(1), NFATC3(3), PAPPA(4), TP53(7), ZAK(1) 21126623 35 31 35 14 0 1 4 19 10 1 0.970 1.000 1.000 568 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(1), DAXX(1), EGF(1), EGFR(1), ETS1(2), HOXA7(2), IKBKB(1), MAP2K3(1), MAP2K7(2), MAP3K1(3), MAPK1(1), MAPK14(1), NFKBIA(1), PRKCA(1), PRKCD(2), PRKCE(2), PRKCG(2), RAF1(3), RELA(2), RIPK1(1), TNF(1), TNFRSF1B(2) 20407881 34 30 34 15 2 1 3 15 13 0 0.992 1.000 1.000 569 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(2), EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(1), EIF1AX(1), EIF2AK1(3), EIF2AK3(1), EIF2B5(1), EIF2S3(1), EIF4A1(1), EIF4A2(3), EIF4G1(3), EIF4G3(4), EIF5(1), GSPT2(1), PABPC1(1), PABPC3(1), PAIP1(1), SLC35A4(1) 18578059 34 30 34 12 3 5 2 13 10 1 0.895 1.000 1.000 570 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ADH6(2), AKR1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GAPDHS(1), GCK(1), HK1(2), PFKL(1), PFKP(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(1) 24437858 30 29 30 10 4 3 4 8 10 1 0.831 1.000 1.000 571 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 ELK1(1), GRB2(1), MAP3K1(3), NFATC2(1), NFATC3(3), NFKBIA(1), PIK3CA(6), PIK3R1(2), PPP3CB(1), PRKCA(1), RAF1(3), RASA1(2), RELA(2), SOS1(2), VAV1(3), ZAP70(1) 20103595 33 29 31 12 2 7 2 11 11 0 0.895 1.000 1.000 572 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 COX10(3), COX15(2), CP(3), EPRS(1), FTH1(1), FTMT(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(2), UGT2B7(1) 17235292 30 28 30 14 1 1 8 15 5 0 0.972 1.000 1.000 573 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(5), CDK4(1), DMC1(1), EGR1(1), ESR2(2), GJA4(1), LHCGR(1), MLH1(3), NCOR1(7), NRIP1(1), PRLR(1), SMPD1(4), ZP2(2) 14650348 30 28 29 10 2 4 2 18 4 0 0.772 1.000 1.000 574 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), LIMK1(1), MAP3K1(3), MYLK(1), NCF2(1), PAK1(2), PDGFRA(1), PIK3CA(6), PIK3R1(2), PLD1(1), PPP1R12B(1), RALBP1(2), TRIO(5), VAV1(3), WASF1(1) 14691042 31 28 29 11 5 7 2 12 5 0 0.731 1.000 1.000 575 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(1), ACSS1(1), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(2), ALDH3A2(3), DLAT(1), DLD(2), HAGH(1), ME2(1), PC(5), PCK1(5), PCK2(1) 19672542 28 27 28 10 2 1 6 8 10 1 0.902 1.000 1.000 576 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(5), LPL(4), NCOA1(3), NCOA2(4), PPARG(1), RXRA(2) 7685324 27 27 27 11 2 7 3 4 11 0 0.909 1.000 1.000 577 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(3), CDH1(2), CTNNB1(2), EZR(1), ITGB1(1), NCL(2), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(3), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1), WASL(2) 22224358 26 26 26 14 0 2 6 11 7 0 0.989 1.000 1.000 578 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(3), CDH1(2), CTNNB1(2), EZR(1), ITGB1(1), NCL(2), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(3), TUBA3D(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB1(1), WASL(2) 22224358 26 26 26 14 0 2 6 11 7 0 0.989 1.000 1.000 579 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), BTG1(1), CBX3(1), CRY1(1), EIF4G2(1), HERPUD1(1), HSPA8(2), MYF6(2), NCKAP1(1), NCOA4(1), NR1D2(1), PER1(4), PER2(2), SF3A3(1), SUMO3(1), TOB1(2), ZFR(2) 15408395 25 25 25 11 1 2 4 14 4 0 0.950 1.000 1.000 580 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(1), DLD(2), ENO1(1), ENO2(1), GAPDH(1), GAPDHS(1), GCK(1), GOT2(1), HK1(2), PC(5), PCK1(5), PFKL(1), PFKP(1), PGAM2(1), PGK2(1) 17758926 27 25 27 11 1 4 4 6 11 1 0.958 1.000 1.000 581 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), BCR(2), CAPN1(1), GRB2(1), ITGA1(3), ITGB1(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(3), ROCK1(2), SOS1(2), TLN1(6), VCL(1) 19861543 28 25 28 10 2 2 1 13 10 0 0.858 1.000 1.000 582 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 ERCC3(2), GTF2A2(1), GTF2B(2), GTF2H4(1), POLR1A(5), POLR1B(2), POLR2A(1), POLR2B(2), POLR2C(1), POLR2F(1), POLR2K(1), POLR3E(1), POLR3H(1), TAF12(1), TAF6(1), TAF7(1), TAF9(1), TBP(1) 15046131 26 25 26 15 1 3 3 10 9 0 0.979 1.000 1.000 583 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BID(1), BIRC2(1), BIRC3(2), CASP10(1), CASP6(1), CASP9(1), CFLAR(2), GAS2(1), LMNA(2), NFKBIA(1), RELA(2), RIPK1(1), SPTAN1(3), TNFSF10(3) 14096545 24 24 24 10 0 2 6 9 7 0 0.913 1.000 1.000 584 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(3), CREBBP(8), CTNNB1(2), EP300(5), FZD1(1), LDB1(1), LEF1(1), TRRAP(1) 13923838 25 24 25 10 1 3 4 11 6 0 0.888 1.000 1.000 585 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT2(1), AKT3(1), ARHGEF11(1), GNA13(2), LPA(3), MAP3K1(3), NFKB2(2), NFKBIA(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(2), PLD1(1), PLD3(1), PTK2(1), RDX(1), ROCK1(2), ROCK2(1) 21448809 27 23 27 17 2 1 4 12 8 0 0.994 1.000 1.000 586 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAX(1), CASP10(1), CASP4(1), CASP6(1), CASP9(1), CD40(1), DAXX(1), FASLG(2), IKBKE(1), MCL1(1), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(1), PTPN13(2), RIPK1(1), TNF(1), TNFRSF1B(2) 18286505 24 22 24 10 1 4 4 7 8 0 0.918 1.000 1.000 587 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), ATF2(1), EGFR(1), ELK1(1), GRB2(1), MAP2K2(1), MAP3K1(3), MAPK1(1), MEF2C(1), PAK1(2), PRKCA(1), PTK2(1), PTK2B(1), RAF1(3), SOS1(2) 14235107 23 22 23 12 2 2 2 10 7 0 0.957 1.000 1.000 588 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(2), GRB2(1), JAK2(1), MAP3K1(3), PIK3CA(6), PIK3R1(2), RAF1(3), SOS1(2), STAT1(2), STAT5A(2), STAT5B(1) 11736578 25 22 23 10 1 5 0 11 8 0 0.935 1.000 1.000 589 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(1), ACTR2(1), ACTR3(1), CFL2(1), FLNC(1), LIMK1(1), MYLK(1), PAK1(2), PAK3(2), PAK4(3), PAK7(1), PFN1(1), ROCK1(2), ROCK2(1), WASF1(1), WASL(2) 20282546 22 22 22 10 3 5 3 8 3 0 0.816 1.000 1.000 590 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 GNAI1(1), GNB1(1), MAPK1(1), PIK3C2G(3), PIK3CA(6), PIK3R1(2), PRKCA(1), PTK2(1), PTK2B(1), PXN(1), RAF1(3), RELA(2) 11709092 23 21 21 11 2 6 0 8 7 0 0.957 1.000 1.000 591 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(1), ADCY3(2), ADCY9(3), ARF3(1), ARF5(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(1), ATP6V1E2(2), ATP6V1H(1), PDIA4(1), PLCG2(1), PRKCA(1) 15701413 21 21 21 10 1 2 3 8 7 0 0.954 1.000 1.000 592 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), CAPN2(1), EGF(1), EGFR(1), ITGA1(3), ITGB1(1), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2), PTK2(1), PXN(1), TLN1(6) 13899188 23 20 23 10 2 3 3 8 7 0 0.849 1.000 1.000 593 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2A1(2), GTF2B(2), GTF2F1(1), NCOA1(3), NCOA2(4), NCOA3(2), NCOR2(1), POLR2A(1), RXRA(2), TBP(1) 10551839 21 20 21 14 2 3 2 7 7 0 0.983 1.000 1.000 594 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP6(1), CFLAR(2), DAXX(1), LMNA(2), LMNB1(1), LMNB2(1), MAP3K1(3), MAP3K7(1), PAK1(2), PTPN13(2), SPTAN1(3) 17404519 20 19 20 14 0 0 6 6 8 0 0.999 1.000 1.000 595 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(3), EPRS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A6(2), UGT1A7(1), UGT1A9(2) 11532644 20 19 20 10 0 1 7 7 5 0 0.968 1.000 1.000 596 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPN1(1), ITGA1(3), ITGB1(1), ITGB3(3), PTK2(1), PXN(1), SPTAN1(3), TLN1(6) 12038924 20 19 20 10 1 2 2 7 8 0 0.960 1.000 1.000 597 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 21 F10(1), F12(6), F2(2), F5(3), F8(1), F9(1), LPA(3), VWF(2) 15295394 19 18 19 11 3 1 3 5 7 0 0.991 1.000 1.000 598 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 LMNA(2), LMNB1(1), LMNB2(1), MADD(4), MAP3K1(3), MAP3K7(1), PAK1(2), RIPK1(1), SPTAN1(3), TNF(1) 16469039 19 18 19 12 0 0 5 8 6 0 0.997 1.000 1.000 599 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CREB1(1), DAXX(1), ELK1(1), GRB2(1), HSPB2(1), MAP3K1(3), MAP3K7(1), MAPK14(1), MAPKAPK2(1), MEF2C(1), PLA2G4A(1), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(1) 15580736 19 16 19 13 0 3 3 8 5 0 0.997 1.000 1.000 600 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), DDX20(4), ETS1(2), HDAC5(3), NCOR2(1), SIN3A(2), SIN3B(2) 11243536 17 15 17 10 2 3 1 9 2 0 0.909 1.000 1.000 601 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), HDAC5(3), MEF2C(1), PPP3CB(1), SLC2A4(2) 8731904 14 14 14 7 4 1 2 7 0 0 0.789 1.000 1.000 602 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(1), PLCB1(1), PRKACG(1), PRKAR1A(1), PRKAR2B(2) 6735888 7 7 7 11 1 1 2 1 2 0 0.998 1.000 1.000 603 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA3(1), GPHN(4) 5315406 5 5 5 4 2 0 0 3 0 0 0.947 1.000 1.000 604 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR18(2), GPR34(1), GPR39(1), GPR65(1) 4123324 5 5 5 4 1 1 0 3 0 0 0.969 1.000 1.000 605 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), MEF2C(1) 3418490 4 4 4 5 1 0 1 2 0 0 0.970 1.000 1.000 606 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(1), PRKCE(2) 2999407 3 3 3 4 1 0 0 2 0 0 0.986 1.000 1.000 607 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH6(2) 2340952 2 2 2 2 0 0 0 2 0 0 0.968 1.000 1.000 608 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNB1(1), PRKAR1A(1) 2813075 2 2 2 2 0 0 1 1 0 0 0.981 1.000 1.000 609 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1) 1756852 1 1 1 4 0 0 0 1 0 0 0.999 1.000 1.000 610 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 991302 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 303179 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 935102 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 839458 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 3162488 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 615 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 487291 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 1347964 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000