Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
FLT3	52 (27%)	141	0.68104	0.805	4e-05	0.000552	9.9999e-06	0.000197	0.00081999	0.00742	0.080519	0.258	0.00070999	0.007
DNMT3A	48 (25%)	145	0.34056	0.601	2e-05	0.000307	0.050739	0.189	0.00218	0.0147	0.00085999	0.00742	0.00203	0.0147
NPM1	33 (17%)	160	0.27765	0.547	9.9999e-06	0.000197	9.9999e-06	0.000197	9.9999e-06	0.000197	2e-05	0.000307	9.9999e-06	0.000197
IDH2	20 (10%)	173	0.39075	0.627	0.21492	0.511	0.64642	0.783	0.34443	0.601	0.75348	0.839	0.18211	0.46
IDH1	18 (9%)	175	0.02339	0.104	0.00095999	0.00779	0.098319	0.302	0.26227	0.525	0.44746	0.667	0.80444	0.881
TET2	17 (9%)	176	0.69892	0.817	0.51296	0.699	0.35029	0.601	0.58155	0.746	0.36563	0.601	0.75294	0.839
NRAS	15 (8%)	178	0.14942	0.404	0.35253	0.601	0.51504	0.699	0.93135	0.953	0.92762	0.953	0.58797	0.746
WT1	12 (6%)	181	0.8224	0.894	0.00275	0.0165	0.059759	0.201	0.37153	0.603	0.055289	0.195	0.25168	0.525
U2AF1	8 (4%)	185	0.24231	0.525	0.12938	0.365	0.26238	0.525	0.2627	0.525	0.0487	0.188	0.47144	0.677
RUNX1	16 (8%)	177	0.45936	0.667	0.0087099	0.0462	0.0099199	0.0507	3e-04	0.00318	0.056469	0.195	0.00224	0.0147
CEBPA	13 (7%)	180	1	1	0.03477	0.145	0.22604	0.518	0.00021	0.00241	0.01236	0.0609	0.01326	0.0631
TP53	15 (8%)	178	0.01737	0.0799	9.9999e-06	0.000197	0.00105	0.00805	0.00237	0.0149	9.9999e-06	0.000197	8.9999e-05	0.00113
KRAS	8 (4%)	185	0.86423	0.91	0.57647	0.746	0.32428	0.601	0.63739	0.778	0.30064	0.584	0.68285	0.805
PHF6	6 (3%)	187	0.51684	0.699	0.4224	0.648	0.72653	0.836	0.47604	0.677	0.89735	0.938	0.35038	0.601
STAG2	6 (3%)	187	1	1	0.3367	0.601	0.12965	0.365	0.02728	0.118	0.078839	0.258	0.04901	0.188
KIT	8 (4%)	185	0.74382	0.839	0.00361	0.0208	0.32485	0.601	0.0060399	0.0333	0.67642	0.805	0.22188	0.518
RAD21	5 (3%)	188	0.932	0.953	0.43703	0.663	0.60546	0.746	0.18195	0.46	0.36302	0.601	0.60304	0.746
EZH2	3 (2%)	190	0.090319	0.283	NA	NA	0.25617	0.525	0.59336	0.746	0.19	0.46	0.42002	0.648
SMC3	7 (4%)	186	0.83882	0.899	0.41779	0.648	0.48508	0.683	0.45348	0.667	0.74422	0.839	0.3621	0.601
ASXL1	5 (3%)	188	0.72391	0.836	0.18732	0.46	0.25506	0.525	0.59348	0.746	0.11021	0.331	0.41606	0.648
SMC1A	6 (3%)	187	0.85191	0.904	0.054439	0.195	0.56841	0.746	0.22886	0.518	0.33529	0.601	0.57568	0.746
PTPN11	9 (5%)	184	0.12802	0.365	0.16418	0.436	0.04774	0.188	0.51343	0.699	0.45949	0.667	0.18548	0.46
SUZ12	3 (2%)	190	0.79117	0.873	0.84005	0.899	0.25671	0.525	0.59591	0.746	0.326	0.601	0.13943	0.385