E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.428 31.0 31.0 KLHL20 -0.022 0.098 0.167 1.0 -0.217 21.0 22.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.339 2.0 2.0 Rac1/GDP -0.039 0.117 -9999.0 0.0 -0.247 29.0 29.0 ENAH -0.063 0.173 -9999.0 0.0 -0.401 31.0 31.0 AP1M1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.095 0.14 1.0 -0.19 28.0 29.0 ABI1/Sra1/Nap1 -0.039 0.06 -9999.0 0.0 -0.162 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.178 28.0 28.0 RAPGEF1 -0.066 0.146 -9999.0 0.0 -0.345 31.0 31.0 CTNND1 0.024 0.05 -9999.0 0.0 -0.339 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.382 32.0 32.0 CRK -0.065 0.155 0.186 1.0 -0.369 30.0 31.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.124 -9999.0 0.0 -0.223 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.229 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.339 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.339 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.056 -9999.0 0.0 -0.179 9.0 9.0 DLG1 -0.053 0.161 -9999.0 0.0 -0.387 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.146 28.0 28.0 MLLT4 0.008 0.084 -9999.0 0.0 -0.339 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.179 11.0 11.0 PI3K -0.032 0.083 -9999.0 0.0 -0.185 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.131 -9999.0 0.0 -0.268 36.0 36.0 TIAM1 0.003 0.092 -9999.0 0.0 -0.339 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.097 -9999.0 0.0 -0.175 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.148 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.133 -9999.0 0.0 -0.339 26.0 26.0 RhoA/GDP -0.04 0.118 -9999.0 0.0 -0.245 31.0 31.0 actin cytoskeleton organization -0.014 0.075 0.166 2.0 -0.162 19.0 21.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.244 32.0 33.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.214 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.339 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.104 -9999.0 0.0 -0.188 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.173 28.0 28.0 mol:GDP -0.06 0.126 -9999.0 0.0 -0.275 33.0 33.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.196 1.0 1.0 JUP -0.008 0.112 -9999.0 0.0 -0.339 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.249 32.0 32.0 RAC1/GTP/IQGAP1 0.037 0.022 -9999.0 0.0 -0.17 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.339 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.012 0.053 -9999.0 0.0 -0.14 13.0 13.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.389 31.0 31.0 regulation of cell-cell adhesion -0.024 0.08 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.082 1.0 -0.095 16.0 17.0 Rap1/GTP -0.023 0.104 0.176 2.0 -0.209 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.124 -9999.0 0.0 -0.192 41.0 41.0 CCND1 -0.015 0.064 -9999.0 0.0 -0.172 13.0 13.0 VAV2 -0.093 0.217 -9999.0 0.0 -0.595 17.0 17.0 RAP1/GDP -0.028 0.111 0.194 1.0 -0.224 25.0 26.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.378 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.111 -9999.0 0.0 -0.187 40.0 40.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.275 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.388 32.0 32.0 PIK3CA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.132 -9999.0 0.0 -0.343 22.0 22.0 E-cadherin/beta catenin/alpha catenin 0.01 0.1 -9999.0 0.0 -0.206 28.0 28.0 ITGAE 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.39 32.0 32.0