Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.022 0.072 -9999.0 0.0 -0.359 5.0 5.0 IHH 0.034 0.037 -9999.0 0.0 -0.148 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.058 -9999.0 0.0 -0.177 15.0 15.0 LRPAP1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.058 0.176 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.007 0.13 -9999.0 0.0 -0.312 15.0 15.0 SMO -0.015 0.121 -9999.0 0.0 -0.279 24.0 24.0 AKT1 0.017 0.068 -9999.0 0.0 -0.34 2.0 2.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.029 -9999.0 0.0 -0.339 1.0 1.0 ADRBK1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.014 0.12 -9999.0 0.0 -0.275 24.0 24.0 STIL 0.008 0.067 0.185 2.0 -0.255 8.0 10.0 DHH N/PTCH2 0.04 0.033 -9999.0 0.0 -0.238 2.0 2.0 DHH N/PTCH1 0.033 0.071 -9999.0 0.0 -0.364 5.0 5.0 PIK3CA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.017 0.086 -9999.0 0.0 -0.448 5.0 5.0 determination of left/right symmetry -0.014 0.12 -9999.0 0.0 -0.275 24.0 24.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.017 0.085 -9999.0 0.0 -0.445 5.0 5.0 IHH N/Hhip 0.019 0.079 -9999.0 0.0 -0.261 11.0 11.0 DHH N/Hhip 0.02 0.07 -9999.0 0.0 -0.238 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.014 0.12 -9999.0 0.0 -0.275 24.0 24.0 pancreas development 0.0 0.091 -9999.0 0.0 -0.338 11.0 11.0 HHAT 0.025 0.05 -9999.0 0.0 -0.339 3.0 3.0 PI3K 0.046 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.095 -9999.0 0.0 -0.339 12.0 12.0 somite specification -0.014 0.12 -9999.0 0.0 -0.275 24.0 24.0 SHH Np/Cholesterol/PTCH1 0.014 0.064 -9999.0 0.0 -0.299 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.02 0.036 -9999.0 0.0 -0.176 5.0 5.0 SHH Np/Cholesterol/Megalin 0.019 0.028 -9999.0 0.0 -0.166 3.0 3.0 SHH -0.001 0.03 -9999.0 0.0 -0.238 2.0 2.0 catabolic process 0.013 0.075 -9999.0 0.0 -0.405 5.0 5.0 SMO/Vitamin D3 -0.006 0.09 0.201 1.0 -0.435 5.0 6.0 SHH Np/Cholesterol/Hhip 0.003 0.056 -9999.0 0.0 -0.177 14.0 14.0 LRP2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.002 0.093 -9999.0 0.0 -0.476 5.0 5.0 SHH Np/Cholesterol/BOC 0.02 0.032 -9999.0 0.0 -0.168 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.042 -9999.0 0.0 -0.176 7.0 7.0 mesenchymal cell differentiation -0.003 0.056 0.176 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.015 0.07 0.197 4.0 -0.3 6.0 10.0 IHH N/PTCH2 0.041 0.043 -9999.0 0.0 -0.131 7.0 7.0 CDON 0.018 0.057 -9999.0 0.0 -0.339 4.0 4.0 IHH N/PTCH1 0.024 0.078 -9999.0 0.0 -0.406 5.0 5.0 Megalin/LRPAP1 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.041 -9999.0 0.0 -0.339 2.0 2.0 SHH Np/Cholesterol 0.016 0.027 -9999.0 0.0 -0.169 3.0 3.0 PTCH1 0.013 0.075 -9999.0 0.0 -0.406 5.0 5.0 HHIP 0.0 0.091 -9999.0 0.0 -0.339 11.0 11.0