rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(3) 1555735 7 7 7 0 3 2 0 1 1 0 0.127 0.00310 1.000 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), MDM2(3), PRB1(1) 5804677 22 17 22 3 5 1 4 4 8 0 0.0867 0.00340 1.000 3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCND1(4), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(3), CDKN2A(4), E2F1(1), E2F2(1), PRB1(1) 6835457 20 16 20 0 4 1 5 2 8 0 0.00260 0.00940 1.000 4 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(3), HGD(5) 1707352 10 6 10 2 4 0 1 2 3 0 0.309 0.0303 1.000 5 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), TYR(4) 7436313 17 14 17 1 6 2 2 5 2 0 0.0379 0.0395 1.000 6 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), E2F1(1), RB1(7), RBL1(4) 12315604 38 25 38 4 7 4 9 5 13 0 0.0113 0.0427 1.000 7 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), FBXW7(4), RB1(7) 6347312 17 13 17 1 4 2 3 2 6 0 0.0627 0.0459 1.000 8 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), RB1(7), SKP2(2) 6559026 17 13 17 1 2 2 5 1 7 0 0.0730 0.0501 1.000 9 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(1), CSF1R(4), EGF(7), MET(10), PRKCA(5), SH3GLB1(3), SH3KBP1(5) 11129068 35 19 35 7 13 3 4 9 5 1 0.0659 0.0553 1.000 10 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(5), ALPPL2(2), DHFR(1), FPGS(2), GGH(1), SPR(1) 4986272 13 12 13 2 5 2 3 1 2 0 0.161 0.0699 1.000 11 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFB11(1) 3077711 9 7 9 0 1 4 0 2 2 0 0.0791 0.0779 1.000 12 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), MTMR1(4), MTMR2(3), MTMR6(1), TYR(4) 11528162 25 19 25 2 6 4 4 7 4 0 0.0235 0.0885 1.000 13 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(1), CDKN1B(3), CUL1(1), E2F1(1), RB1(7), RBX1(1), SKP2(2), UBE2M(1) 6571866 18 14 18 2 1 3 5 1 8 0 0.149 0.0927 1.000 14 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), ENPP1(4), ENPP3(2), NADSYN1(4), NMNAT1(1), NNMT(1), NNT(5), NT5C(3), NT5E(1), NT5M(1) 11163287 27 18 27 2 4 9 4 7 3 0 0.00451 0.0940 1.000 15 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(12) 6470917 13 11 13 2 2 2 3 4 2 0 0.169 0.108 1.000 16 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(7), SP3(4) 5114449 12 9 12 1 1 0 3 1 7 0 0.304 0.118 1.000 17 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(8), BAX(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), E2F1(1), MDM2(3), RB1(7), TIMP3(1) 13286988 32 20 32 5 5 3 7 9 8 0 0.119 0.145 1.000 18 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), CYP2A7(1), NAT1(1), NAT2(3), XDH(8) 6114871 16 11 16 1 4 3 1 6 2 0 0.0312 0.157 1.000 19 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(5), IL12B(2), IL18(3) 2286577 10 6 10 2 2 1 1 6 0 0 0.430 0.157 1.000 20 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), CAT(3), GH1(1), GHR(4), IGF1(1), IGF1R(7), SHC1(1), SOD2(1) 7315753 19 13 19 1 4 3 4 5 3 0 0.00940 0.161 1.000 21 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2B(3), ENPP1(4), ENPP3(2), G6PC(7), GAA(5), GANAB(4), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), MGAM(8), PGM3(1), PYGB(1), PYGL(5), PYGM(1), SI(10), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5), UXS1(2) 43653770 105 64 104 15 36 18 14 24 13 0 2.28e-05 0.203 1.000 22 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), PANK2(1), PANK4(4) 10666449 22 17 21 4 5 5 0 7 5 0 0.250 0.209 1.000 23 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 7746586 20 11 20 4 4 3 4 6 3 0 0.218 0.217 1.000 24 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(5), PANK2(1), PANK4(4), VNN1(2) 13235696 29 22 28 4 7 6 1 9 6 0 0.0719 0.229 1.000 25 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(4), DBH(3), DDC(3), GAD1(2), GAD2(1), HDC(2), MAOA(2), PAH(2), TH(3), TPH1(4) 11020178 29 18 29 6 12 8 0 7 2 0 0.0390 0.229 1.000 26 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(2), IL6(1) 4104039 14 9 14 2 2 4 0 7 1 0 0.115 0.229 1.000 27 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 1624242 5 4 5 0 2 1 0 2 0 0 0.207 0.245 1.000 28 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(1), IGF1R(7), POLR2A(7), PPP2CA(4), PRKCA(5), RB1(7), TEP1(8), TERF1(1), TERT(3), TNKS(1), XRCC5(3) 18961508 47 29 47 8 17 2 9 11 7 1 0.0181 0.260 1.000 29 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(7), ZAP70(5) 6947285 20 13 20 4 5 5 1 8 1 0 0.195 0.263 1.000 30 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(7), ERBB3(4), NRG1(3) 5885404 14 10 14 2 7 2 0 1 4 0 0.196 0.267 1.000 31 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(4), PFKL(5), PGK1(2), PKLR(2), TPI1(1) 7108176 19 12 19 0 8 6 0 1 4 0 0.000189 0.267 1.000 32 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(1), GALNT2(2), GALNT3(1), GALNT4(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), WBSCR17(5) 11078056 29 18 29 5 10 4 4 8 3 0 0.0762 0.281 1.000 33 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), F10(1), F12(1), F2(3), F2R(2), F5(7), F8(20), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), PROS1(1), SERPINC1(1), SERPING1(3) 34041840 81 50 81 16 20 14 14 21 11 1 0.00412 0.282 1.000 34 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 2431617 5 4 5 0 0 0 3 0 2 0 0.337 0.293 1.000 35 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), GGPS1(1), IDI1(2), SQLE(1) 3261825 6 5 6 0 0 0 4 0 2 0 0.227 0.295 1.000 36 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(2), HDC(2), TH(3), TPH1(4) 4613301 14 9 14 2 7 3 0 3 1 0 0.0601 0.308 1.000 37 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(4), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(5), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1) 16500726 36 22 36 6 7 11 5 8 5 0 0.0262 0.315 1.000 38 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1) 1822679 6 4 6 1 1 1 0 3 1 0 0.359 0.316 1.000 39 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 6036845 14 13 14 3 5 2 3 2 2 0 0.264 0.328 1.000 40 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), TAT(1), TYR(4) 3613786 10 7 10 3 5 0 1 4 0 0 0.603 0.331 1.000 41 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCL5(1), CCR3(1), HLA-DRA(3), HLA-DRB1(1), IL3(1), IL5(1) 2335625 10 6 10 3 2 2 0 4 2 0 0.491 0.331 1.000 42 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4) 6064241 22 16 22 6 5 5 2 7 3 0 0.299 0.343 1.000 43 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), LPO(5), MPO(2), PRDX1(1), TPO(6), TYR(4) 7401127 23 13 23 5 9 7 1 5 0 1 0.0660 0.358 1.000 44 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), HTR2C(3), PLCB1(3), TUB(4) 5487240 12 9 12 3 4 2 0 5 1 0 0.371 0.358 1.000 45 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(2), HBEGF(1), IFRD1(3), IL18(3), IL1R1(2), NR4A3(1), WDR1(1) 8243333 17 12 17 2 5 1 2 5 4 0 0.143 0.409 1.000 46 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL10(1), IL12B(2), IL15(2), IL16(8), IL18(3), IL3(1), IL5(1), IL6(1), IL9(1), TNF(1) 7618258 22 15 22 5 3 2 4 9 4 0 0.329 0.409 1.000 47 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(2), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(2) 6847415 15 9 15 3 3 4 1 4 3 0 0.240 0.422 1.000 48 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), GAD1(2), GAD2(1), GGT1(2) 4410044 7 6 7 0 2 1 2 2 0 0 0.0978 0.426 1.000 49 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(2), ARHGDIB(1), CASP1(5), CASP8(2), CYCS(2), GZMB(1), PRF1(3) 9878151 19 13 19 4 5 5 2 7 0 0 0.219 0.428 1.000 50 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 1265612 5 2 5 0 0 3 0 2 0 0 0.195 0.429 1.000 51 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(4), PDHA1(5), PDHA2(4) 5341985 15 10 14 4 2 7 1 3 2 0 0.181 0.432 1.000 52 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(4), MYL2(2), MYLK(5), NCF2(3), PAK1(2), PLD1(7), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(5), VAV1(5), WASF1(1) 22139671 46 27 46 5 14 4 8 11 9 0 0.00161 0.437 1.000 53 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(4), SP3(4), WT1(1) 4780132 9 7 7 0 4 1 1 2 1 0 0.0521 0.441 1.000 54 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(3), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5) 13491856 28 20 27 5 7 3 7 10 1 0 0.0660 0.443 1.000 55 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(8), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(7), RB1(7), WEE1(1), YWHAH(1) 12876889 31 18 31 6 4 2 5 4 16 0 0.410 0.445 1.000 56 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT1(1), FUT2(2), ST3GAL3(2), ST3GAL4(3) 5530723 16 10 16 3 7 0 1 5 3 0 0.208 0.455 1.000 57 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFL1(1), CFLAR(1) 2977582 4 4 4 0 0 1 1 1 1 0 0.228 0.468 1.000 58 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(3), GLS(2), GLUD1(5), GOT1(2) 5986993 14 7 14 2 2 1 0 5 6 0 0.331 0.471 1.000 59 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(3), EPRS(3), FECH(1), GUSB(3), HCCS(4), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5), UROD(1), UROS(1) 20995792 44 30 43 8 11 5 12 15 1 0 0.0305 0.483 1.000 60 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(2), IDS(2), LCT(10), NAGLU(3), SPAM1(3) 15716131 37 23 37 6 17 2 6 6 6 0 0.0322 0.483 1.000 61 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 1395557 3 3 3 1 2 0 0 1 0 0 0.732 0.493 1.000 62 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PDXK(1), PSAT1(2) 3724214 8 6 8 3 3 3 0 2 0 0 0.560 0.500 1.000 63 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), ALAS2(1), CPO(2), FECH(1), HBA2(1), HBB(1), UROD(1), UROS(1) 6021833 11 7 11 2 4 2 1 3 1 0 0.215 0.513 1.000 64 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(4), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2) 4915592 13 6 13 2 1 3 2 5 2 0 0.308 0.520 1.000 65 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), E2F1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PAK1(2), RAC1(1), RAF1(1), RB1(7), RELA(1) 12605547 32 19 32 6 6 2 6 3 14 1 0.137 0.530 1.000 66 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(2), ELK1(3), FOS(1), IGF1(1), IGF1R(7), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2) 16140365 40 30 38 9 8 9 5 10 7 1 0.0743 0.532 1.000 67 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7) 8056469 17 10 17 2 5 0 3 5 4 0 0.103 0.533 1.000 68 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7) 8056469 17 10 17 2 5 0 3 5 4 0 0.103 0.533 1.000 69 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F12(1), F13B(4), F2(3), F5(7), F7(2), F8(20), F9(3), FGA(6), FGB(1), FGG(1), LPA(7), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2), SERPINF2(1), VWF(7) 27079747 73 42 73 16 18 12 10 21 12 0 0.0207 0.537 1.000 70 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(6), CREB1(1), MAPK1(2), RAF1(1), SNX13(1), TERF2IP(1) 8552402 14 9 13 1 1 0 4 5 4 0 0.0834 0.554 1.000 71 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(2), GFPT1(4), GNPDA1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), PGM3(1), RENBP(3), UAP1(2) 13000975 28 19 28 4 8 7 4 6 3 0 0.0273 0.566 1.000 72 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(2), FUT5(3), FUT6(2), ST3GAL3(2) 3901442 10 6 10 2 6 1 0 1 2 0 0.303 0.569 1.000 73 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(8), ATR(6), CCNA1(2), CCND1(4), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), DHFR(1), E2F1(1), RB1(7), SKP2(2), TGFB2(2), TGFB3(1) 22545243 51 28 51 8 10 6 9 10 16 0 0.0301 0.569 1.000 74 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), NR1H3(5), RXRA(1) 4175693 7 6 6 2 3 2 2 0 0 0 0.339 0.576 1.000 75 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 9 ACLY(3), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(1) 8949329 18 10 18 1 6 4 2 3 3 0 0.00792 0.593 1.000 76 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF2S2(1), EIF4E(2), IGF1(1), IGF1R(7), INPPL1(5), PPP2CA(4), RPS6KB1(2) 11555038 23 13 23 3 5 3 5 7 3 0 0.0444 0.611 1.000 77 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(9), DFFA(2), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1) 8112658 20 12 20 3 9 1 2 5 3 0 0.117 0.612 1.000 78 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), LCT(10), MPI(2), PYGL(5), PYGM(1), TPI1(1) 10283177 23 14 23 4 6 4 3 4 6 0 0.0500 0.613 1.000 79 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(2), SHMT1(2) 3195549 5 4 5 1 2 1 2 0 0 0 0.351 0.621 1.000 80 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL10(1) 3051417 7 5 7 3 1 1 1 3 1 0 0.637 0.642 1.000 81 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 2360464 5 3 5 2 1 1 0 2 1 0 0.649 0.648 1.000 82 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(4), FOS(1), FYN(1), THBS1(4) 5676993 10 7 10 3 3 4 2 0 1 0 0.295 0.650 1.000 83 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(2), CMAS(2), GFPT1(4), GFPT2(3), GNPDA1(2), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), MTMR1(4), MTMR2(3), MTMR6(1), NANS(1), PGM3(1), RENBP(3), UAP1(2) 22000028 42 29 42 7 9 9 7 10 7 0 0.0302 0.654 1.000 84 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPAT6(1), AGPS(3), ENPP2(3), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PPAP2A(2), PPAP2C(1) 17753159 40 22 40 8 8 6 8 13 5 0 0.0717 0.654 1.000 85 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(1), CD3D(1), CD86(1), CTLA4(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1), PTPN11(7) 6925185 18 15 16 5 2 4 2 8 2 0 0.420 0.655 1.000 86 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(3), EGF(7), HGS(3), TF(2), TFRC(2) 7830351 17 12 17 5 6 3 2 4 2 0 0.390 0.678 1.000 87 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP3A4(3), CYP3A7(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(2), PON3(1) 13793896 26 21 25 5 13 1 2 4 6 0 0.0943 0.692 1.000 88 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 2018992 3 2 3 1 1 0 1 1 0 0 0.729 0.696 1.000 89 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(2), SDHA(4), SDHC(2), UQCRC1(3) 5070356 11 7 10 2 2 2 4 3 0 0 0.228 0.696 1.000 90 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(5), AGT(2), AGTR2(3), ANPEP(3), CMA1(2), CTSA(1), CTSG(2), ENPEP(6), LNPEP(2), MME(2), NLN(1), REN(2), THOP1(5) 16249989 40 25 39 10 11 6 6 11 6 0 0.157 0.696 1.000 91 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), PTGS1(2), PTGS2(2) 4103759 7 6 7 2 4 0 0 2 1 0 0.690 0.698 1.000 92 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(1), ALDOB(1), TPI1(1) 3004731 7 3 7 0 0 4 0 2 1 0 0.101 0.703 1.000 93 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 7 ACO1(5), ACO2(4), FH(1) 5576639 10 6 10 0 3 2 2 2 1 0 0.0346 0.707 1.000 94 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP8(2), CYCS(2), DFFA(2), DIABLO(1) 10285959 15 11 15 3 4 4 2 4 1 0 0.191 0.714 1.000 95 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(2), ELK1(3), FOS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(4), JAK3(3), MAPK3(1), PTPN11(7), RAF1(1), SHC1(1), SOS1(4), SRF(2), STAT3(2) 18321791 38 25 36 8 6 8 2 14 7 1 0.102 0.726 1.000 96 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(5) 3779974 8 5 8 3 3 0 1 3 0 1 0.602 0.729 1.000 97 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 873576 1 1 1 1 0 1 0 0 0 0 0.898 0.731 1.000 98 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(2), TYK2(7) 9013253 20 10 20 3 6 0 2 6 5 1 0.164 0.732 1.000 99 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), BCAR1(3), CDKN1B(3), ILK(1), ITGB1(2), MAPK1(2), MAPK3(1), PTK2(2), SHC1(1), SOS1(4) 11274599 20 12 20 3 5 1 3 3 7 1 0.167 0.734 1.000 100 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(1), CDC25B(1), CHEK1(3), MYT1(7), WEE1(1), YWHAH(1) 10571537 22 13 22 6 3 2 2 4 11 0 0.688 0.737 1.000 101 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(2), AKT1(1), BAX(1), CSF2RB(2), IGF1(1), IGF1R(7), IL3(1), IL3RA(2), KIT(6), KITLG(2), PRKACG(1), PRKAR1A(2), YWHAH(1) 13930778 29 20 29 6 7 1 7 8 6 0 0.127 0.738 1.000 102 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2) 11498575 26 12 25 5 7 3 6 6 4 0 0.0957 0.746 1.000 103 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(2), GLUD1(5), OAT(1) 4222368 10 6 10 3 2 1 0 4 3 0 0.540 0.746 1.000 104 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(4), AFMID(1), HAO1(2), HAO2(2), HYI(2), MTHFD1(2), MTHFD1L(1) 10271683 19 11 19 3 3 5 2 3 6 0 0.136 0.751 1.000 105 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(3), ARSE(3), ASAH1(1), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(6), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(3), SPTLC2(2), UGCG(2) 18565041 45 24 45 10 14 4 9 13 4 1 0.107 0.751 1.000 106 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4) 2496561 6 6 6 3 2 1 1 1 1 0 0.706 0.753 1.000 107 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(2) 2931676 4 3 4 0 0 1 2 0 1 0 0.317 0.763 1.000 108 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GAPDHS(1), GCK(2), GOT1(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGK1(2), PKLR(2), TNFAIP1(2), TPI1(1) 32565460 68 40 67 8 27 19 3 10 9 0 1.42e-05 0.777 1.000 109 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2), SHMT1(2) 4212834 4 4 4 1 1 1 2 0 0 0 0.463 0.785 1.000 110 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(3), CBS(4), CTH(1), MUT(1) 3767512 10 4 10 0 2 5 0 2 1 0 0.0264 0.788 1.000 111 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), ALAS2(1), FECH(1), PPOX(1), UROD(1), UROS(1) 5806910 8 5 8 1 2 2 1 3 0 0 0.243 0.789 1.000 112 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM3(1), CDKN1A(1), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), SP3(4), SYT1(2) 16106333 35 21 34 8 9 5 6 9 5 1 0.119 0.791 1.000 113 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(7), ATP4B(2), ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(10), ATP7B(4), COX10(3), COX6B1(1), COX7A1(1), NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(4), SHMT1(2), UQCRC1(3), UQCRH(2) 29154375 59 33 58 9 11 10 12 17 8 1 0.00326 0.791 1.000 114 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), PAK1(2), RAC1(1), WASL(2) 5655150 12 6 12 2 0 2 0 7 3 0 0.360 0.797 1.000 115 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 2596524 2 2 2 0 0 1 0 1 0 0 0.592 0.800 1.000 116 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2C1(2), MANBA(1), NEU1(1), NEU2(6), NEU3(2) 12662054 32 23 32 8 8 3 6 10 5 0 0.312 0.800 1.000 117 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(4), HAO1(2), HAO2(2), HYI(2), MTHFD1(2), MTHFD1L(1) 9809602 18 10 18 3 3 5 2 3 5 0 0.139 0.800 1.000 118 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), LPO(5), MPO(2), TPO(6) 6410429 18 11 18 5 8 7 1 2 0 0 0.142 0.804 1.000 119 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(4), HK2(3), HK3(3), PGM3(1), TGDS(1) 7833826 14 9 14 2 6 4 2 1 1 0 0.0618 0.804 1.000 120 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(1), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1) 4946758 8 8 8 3 5 1 0 1 1 0 0.481 0.805 1.000 121 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), GH1(1), GHR(4), NFKB1(1), NFKBIA(2), PPP2CA(4), RELA(1), YWHAH(1) 7891392 15 8 15 4 3 3 1 6 2 0 0.438 0.805 1.000 122 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), MBTPS1(2), MBTPS2(3), SCAP(2), SREBF1(6), SREBF2(3) 9188088 18 12 18 5 4 3 3 5 3 0 0.383 0.809 1.000 123 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(3), EPX(5), LPO(5), MPO(2), MTHFR(6), SHMT1(2), TPO(6) 8894149 30 13 30 8 11 9 3 5 2 0 0.101 0.814 1.000 124 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), RDH5(1) 2995139 2 2 2 1 0 2 0 0 0 0 0.705 0.815 1.000 125 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(4), CTH(1), GGT1(2), MARS(5), MARS2(2), SCLY(2), SEPHS1(1) 9489964 17 9 17 1 3 6 3 3 2 0 0.0123 0.823 1.000 126 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2) 10762568 22 10 22 5 4 3 5 6 4 0 0.210 0.825 1.000 127 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(4), CYP11B2(1), HSD3B1(2), HSD3B2(1) 5293806 8 8 8 3 4 0 1 1 2 0 0.522 0.830 1.000 128 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(10), MAP2(7), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1) 13962992 24 12 24 4 4 4 2 8 6 0 0.224 0.833 1.000 129 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), GALNTL5(1), GCNT3(1), GCNT4(2), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5) 24810260 55 33 54 11 16 11 5 16 7 0 0.0423 0.837 1.000 130 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(12), CPT1A(1), LEPR(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1) 11110749 22 10 22 2 6 3 1 7 5 0 0.0364 0.837 1.000 131 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(3), PLCG1(6), PRKCA(5), VAV1(5) 6948733 20 16 19 6 5 3 2 8 1 1 0.472 0.838 1.000 132 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 18 ACO1(5), ACO2(4), DLD(1), FH(1), IDH3B(1), PC(2), PCK1(3), SDHA(4), SUCLG2(1) 14543340 22 15 21 3 6 5 5 3 3 0 0.0337 0.840 1.000 133 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL5(1), MAF(3), MAP2K3(3), NFATC1(2), NFATC2(5), PRKACG(1), PRKAR1A(2) 9358111 20 13 20 6 8 1 3 6 2 0 0.311 0.840 1.000 134 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(2), ACADS(2), ECHS1(2), HADHA(2) 4142921 9 6 9 4 2 1 1 2 3 0 0.655 0.843 1.000 135 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(4), HK2(3), HK3(3), ISYNA1(2), PGM3(1), TGDS(1) 8942240 16 10 16 2 6 5 2 2 1 0 0.0330 0.844 1.000 136 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(1), G6PC(7), GAA(5), GANAB(4), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), LCT(10), MGAM(8), PFKP(1), PGM3(1) 24926337 53 30 53 10 30 6 4 9 4 0 0.00767 0.848 1.000 137 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1) 5487350 9 4 9 0 1 3 0 4 1 0 0.0803 0.851 1.000 138 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(9), DAXX(2), PAX3(1), PML(3), RB1(7), SIRT1(1), SP100(4), TNF(1), TNFRSF1B(2) 13964936 30 15 30 5 6 3 4 8 9 0 0.144 0.854 1.000 139 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(2), LDHA(1), LDHB(2), LDHC(1) 5256692 7 4 7 1 1 4 0 2 0 0 0.259 0.855 1.000 140 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(2), RAB3A(1), RAB9A(1) 3252783 4 3 4 1 2 1 0 1 0 0 0.493 0.856 1.000 141 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(10), NAGLU(3) 11032768 22 13 22 5 9 2 4 3 4 0 0.182 0.857 1.000 142 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), LCT(10), MGAM(8), PFKL(5), PFKP(1), PGM3(1), UGP2(1) 29566659 63 35 63 12 34 6 5 13 5 0 0.00447 0.860 1.000 143 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(1), ULK2(5) 16176760 30 13 30 3 6 2 8 9 5 0 0.0124 0.862 1.000 144 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1) 7079674 10 9 10 3 4 0 2 1 3 0 0.401 0.862 1.000 145 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1) 7079674 10 9 10 3 4 0 2 1 3 0 0.401 0.862 1.000 146 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(1), CSK(1), PRKCA(5), PTPRA(4) 7060597 14 7 14 4 6 2 3 2 0 1 0.340 0.864 1.000 147 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(3), FCGR3A(1), IL1B(2), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10008896 21 13 21 5 9 6 2 2 2 0 0.0957 0.865 1.000 148 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(7) 8325437 15 8 15 4 4 0 1 7 2 1 0.498 0.866 1.000 149 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(1), PC(2), PDHA1(5), SLC25A1(1) 7109855 12 11 11 4 1 3 0 4 4 0 0.502 0.867 1.000 150 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(8), ATR(6), BRCA1(2), BRCA2(9), CHEK1(3), CHEK2(3), FANCA(4), FANCC(1), FANCD2(8), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(5), RAD9A(3), TREX1(2) 33267544 63 34 62 11 14 15 11 14 9 0 0.0166 0.868 1.000 151 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(2) 3740112 5 3 5 0 0 1 2 1 1 0 0.259 0.871 1.000 152 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(4), PRKACG(1), PRKAR1A(2), PRKCA(5) 7375801 14 11 14 4 6 0 1 5 1 1 0.629 0.872 1.000 153 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(2), RECK(3), TIMP1(1), TIMP3(1), TIMP4(2) 5775647 9 6 9 2 3 2 1 1 2 0 0.354 0.877 1.000 154 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1) 3630153 2 2 2 0 0 0 0 1 1 0 0.606 0.882 1.000 155 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELE(6) 9284705 21 17 20 8 8 4 6 1 2 0 0.412 0.886 1.000 156 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(3), SRPR(5) 5799384 10 5 10 2 4 0 2 2 2 0 0.475 0.887 1.000 157 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(1) 6698395 12 5 12 3 3 3 2 3 1 0 0.415 0.888 1.000 158 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ARSE(3), ASAH1(1), B4GALT6(1), DEGS1(2), DEGS2(2), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(6), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(2), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(3), SPTLC2(2), UGCG(2), UGT8(1) 27354238 58 29 58 12 17 5 12 18 5 1 0.0475 0.889 1.000 159 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2) 20950367 51 35 50 12 12 5 11 21 2 0 0.117 0.889 1.000 160 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(1), ABCB4(6), ABCC1(5), ABCC3(6) 11003494 23 12 23 7 5 3 3 8 3 1 0.434 0.894 1.000 161 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(1) 5351407 5 4 5 1 0 0 1 2 2 0 0.604 0.897 1.000 162 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM3(1), CD3D(1), ELK1(3), FOS(1), FYN(1), LAT(2), LCK(1), MAP3K1(4), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), PTPN7(2), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5), ZAP70(5) 33816769 72 38 71 15 20 13 7 19 11 2 0.0105 0.897 1.000 163 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), SHH(1), XPO1(1) 6658622 8 6 8 3 3 4 1 0 0 0 0.496 0.897 1.000 164 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(1), PRKCA(5) 6924105 11 7 11 3 3 1 2 3 1 1 0.458 0.899 1.000 165 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(2), PON3(1) 6871905 11 7 10 4 5 0 1 3 2 0 0.671 0.902 1.000 166 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(4), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(5), MARS2(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(2), SEPHS1(1), WBSCR22(2) 19114057 38 18 38 7 6 9 8 9 6 0 0.0350 0.904 1.000 167 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CDO1(1), CTH(1), GOT1(2), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), SDS(1), SULT1B1(2), SULT1C2(3) 9619319 15 8 15 4 3 5 1 4 2 0 0.388 0.905 1.000 168 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), MAPK1(2), MAPK8(2), NFE2L2(1), PRKCA(5) 6796384 12 8 12 3 2 2 3 1 3 1 0.230 0.906 1.000 169 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(2), BAX(1), BCL2L11(1), CES1(1) 8308418 8 6 8 1 3 1 1 2 1 0 0.225 0.907 1.000 170 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(6), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(1), MKNK1(2), NFKB1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(4), SOS2(5), TRAF3(2) 22652756 49 26 48 11 13 3 6 17 9 1 0.133 0.907 1.000 171 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(2), GREB1(7), MTA3(2), PDZK1(1), TUBA8(1) 8344839 15 8 15 3 6 3 1 3 2 0 0.181 0.912 1.000 172 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(1), RPN1(1), RPN2(1), UBE3A(1) 9890647 15 7 15 4 4 4 2 3 2 0 0.419 0.915 1.000 173 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4) 6131033 14 8 14 5 6 2 2 2 2 0 0.470 0.915 1.000 174 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4) 6131033 14 8 14 5 6 2 2 2 2 0 0.470 0.915 1.000 175 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP8(2), CFLAR(1), DAXX(2), DFFA(2), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(4), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), PTPN13(3), RB1(7), RIPK2(1), SPTAN1(5) 31072941 52 29 52 9 10 10 9 12 10 1 0.0360 0.916 1.000 176 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(2), CREB1(1), SYT1(2) 8865394 16 7 16 4 4 5 4 0 3 0 0.170 0.916 1.000 177 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT2(1), AGPAT3(1), AGPS(3), CDS2(2), CHAT(4), CHKB(1), CLC(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), ETNK1(1), GNPAT(1), LGALS13(3), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(4), PLCG1(6), PLCG2(9), PPAP2A(2), PPAP2C(1) 38189756 81 49 80 17 25 18 10 17 11 0 0.00766 0.917 1.000 178 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(2), EGF(7), ELK1(3), FOS(1), JAK1(1), MAP3K1(4), MAPK3(1), MAPK8(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1) 23849655 49 32 48 11 14 9 4 12 7 3 0.0758 0.920 1.000 179 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD4(1) 2467483 3 2 3 2 1 1 0 1 0 0 0.810 0.926 1.000 180 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), CISH(1), IARS(1), IL13RA1(3), IL4R(2), INPP5D(2), JAK1(1), JAK2(4), JAK3(3), PI3(2), PPP1R13B(2), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), STAT6(4), TYK2(7) 26627012 47 27 47 7 12 4 7 15 9 0 0.0202 0.928 1.000 181 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 3699675 8 5 8 6 3 0 2 1 2 0 0.883 0.928 1.000 182 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(3), F2R(2), F5(7), F7(2), FGA(6), FGB(1), FGG(1), PROS1(1), SERPINC1(1) 12573981 25 20 25 8 9 1 6 7 2 0 0.404 0.929 1.000 183 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(7), MAPK1(2), MAPK3(1), PTPRB(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3) 17108465 36 24 36 8 11 2 4 7 11 1 0.195 0.933 1.000 184 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), UGDH(1) 6537836 16 8 16 4 8 2 2 2 2 0 0.236 0.935 1.000 185 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(2), AGTR2(3), CMA1(2), COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), REN(2) 19293319 40 22 39 12 10 10 5 9 5 1 0.238 0.938 1.000 186 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(2) 4092143 3 3 3 0 0 0 0 3 0 0 0.585 0.939 1.000 187 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11552717 13 9 13 3 3 5 3 1 0 1 0.198 0.939 1.000 188 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11552717 13 9 13 3 3 5 3 1 0 1 0.198 0.939 1.000 189 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11552717 13 9 13 3 3 5 3 1 0 1 0.198 0.939 1.000 190 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), DRD3(2), DRD5(3), HRH1(3), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1) 19720937 46 29 46 11 21 8 4 7 6 0 0.0119 0.940 1.000 191 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), AXIN1(1), BTRC(1), CCND1(4), CREBBP(9), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(5), CTNNB1(3), FZD1(2), NLK(1), PPP2CA(4), WIF1(3) 22507040 40 20 40 6 10 5 5 12 8 0 0.0354 0.941 1.000 192 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(9), EP300(5), ESR1(2), MAPK1(2), MAPK3(1), PELP1(2) 11325441 21 10 20 4 9 1 2 5 3 1 0.161 0.944 1.000 193 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(3), BLNK(2), ELK1(3), FOS(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(4), VAV1(5), VAV2(2), VAV3(2) 24556801 48 26 48 11 10 8 2 16 10 2 0.101 0.945 1.000 194 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), CASP8(2), DFFA(2), GZMB(1), PRF1(3), SCAP(2), SREBF1(6), SREBF2(3) 14000346 24 18 24 6 9 6 4 4 1 0 0.196 0.946 1.000 195 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5) 17651067 38 24 38 9 12 6 2 13 5 0 0.218 0.946 1.000 196 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5) 17651067 38 24 38 9 12 6 2 13 5 0 0.218 0.946 1.000 197 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), RAC1(1), WASF1(1), WASL(2) 6241477 11 5 11 3 0 2 1 7 1 0 0.524 0.950 1.000 198 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(2) 2884526 3 2 3 0 1 0 0 2 0 0 0.422 0.950 1.000 199 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(12), ACACB(11), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), ECHS1(2), EHHADH(1), HADHA(2), HIBCH(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SUCLG2(1) 30434175 71 37 71 17 22 16 6 16 11 0 0.0395 0.950 1.000 200 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(2), MST1R(2), TNF(1) 5022309 5 3 5 2 1 3 0 1 0 0 0.538 0.952 1.000 201 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(1), PSMD1(1), PSMD11(2), PSMD2(3) 12284178 19 9 19 3 3 8 2 4 2 0 0.108 0.953 1.000 202 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(2), CSNK1E(1), PER1(5) 6537677 9 5 9 3 2 2 1 3 1 0 0.630 0.954 1.000 203 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), IFNGR2(1), IKBKB(1), JAK2(4), NFKB1(1), NFKBIA(2), RB1(7), RELA(1), TNF(1), TNFRSF1B(2), USH1C(2), WT1(1) 13269091 26 14 26 8 4 3 3 6 10 0 0.509 0.954 1.000 204 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GLS(2), GLS2(1), GLUD1(5), GLUL(1), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3) 25419296 44 24 44 7 10 7 6 12 9 0 0.0286 0.957 1.000 205 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(4), STAT4(2), TYK2(7) 11280059 21 8 21 6 7 2 3 7 2 0 0.397 0.957 1.000 206 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(1) 4692995 5 2 5 5 0 1 0 2 2 0 0.980 0.959 1.000 207 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1), CD58(1), IL3(1), IL6(1), KITLG(2) 4730197 7 3 7 2 0 1 1 5 0 0 0.603 0.961 1.000 208 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK1(1), JAK2(4), STAT1(2) 6282386 8 3 8 4 1 0 1 3 2 1 0.840 0.961 1.000 209 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(4), CDKN2A(4), E2F1(1), MDM2(3), POLR1A(5), POLR1B(2), RAC1(1), RB1(7), TBX2(1) 12054745 28 14 28 9 5 2 4 6 11 0 0.532 0.961 1.000 210 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2) 12288400 14 9 14 3 4 5 3 1 0 1 0.160 0.963 1.000 211 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(2), ELK1(3), FOS(1), JAK1(1), MAP3K1(4), MAPK3(1), MAPK8(2), PDGFA(1), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1) 22180629 43 28 42 10 11 8 4 11 6 3 0.102 0.963 1.000 212 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), NCKAP1(4), NTRK1(2), RAC1(1), WASF1(1), WASF2(1), WASF3(3), WASL(2) 11123070 21 11 21 6 3 4 3 9 2 0 0.406 0.965 1.000 213 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(4), JAK3(3), PIAS3(2), PTPRU(2), REG1A(2), STAT3(2) 11667939 19 14 19 5 4 1 2 6 6 0 0.364 0.966 1.000 214 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(2), FOS(1), JAK2(4), MAPK3(1), MPL(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), THPO(1) 20106368 39 25 38 9 9 6 4 11 6 3 0.132 0.968 1.000 215 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(2), ELK1(3), FOS(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(4) 11754235 22 16 21 6 3 7 2 5 4 1 0.242 0.969 1.000 216 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(3), DCN(2), FMOD(2), KERA(4), LUM(2) 2782871 13 11 13 6 1 2 3 6 1 0 0.756 0.970 1.000 217 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(3), EPX(5), LPO(5), MPO(2), PRDX1(1), SHMT1(2), TPO(6) 9053766 26 12 26 8 10 9 2 3 1 1 0.146 0.970 1.000 218 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), NTRK1(2), PLCG1(6), PRKCA(5), SHC1(1), SOS1(4) 9033693 19 15 18 5 4 3 3 5 3 1 0.397 0.971 1.000 219 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), G6PC2(1), GALM(1), GAPDHS(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1) 44598644 98 53 97 21 38 19 8 21 12 0 0.00147 0.972 1.000 220 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(2), FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1) 6371064 14 6 14 3 7 3 1 1 2 0 0.243 0.973 1.000 221 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1), TOB2(1) 8084133 14 7 14 4 5 4 1 3 1 0 0.320 0.974 1.000 222 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(8), PRKACG(1), PRKAG1(1) 7747858 10 6 10 4 2 0 1 5 2 0 0.791 0.974 1.000 223 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(2), AGTR2(3), KNG1(2), NOS3(7), REN(2) 7572529 20 15 19 8 9 2 2 4 3 0 0.674 0.974 1.000 224 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), IKBKB(1), MAP3K1(4), MAP3K5(3), MAP4K5(1), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TNFRSF9(3), TNFSF9(2), TRAF2(2) 14842600 24 19 23 8 6 3 3 3 9 0 0.592 0.975 1.000 225 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(2), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), GZMB(1), LMNA(2), LMNB2(2), PRF1(3) 14811367 27 16 27 7 8 7 3 8 1 0 0.262 0.978 1.000 226 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(6), EIF4A2(2), EIF4B(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(3) 17636298 37 25 37 9 10 8 6 9 4 0 0.165 0.980 1.000 227 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(1), ABCG2(1), CES1(1), CES2(2), CYP3A4(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2) 17545908 29 19 28 8 8 3 7 7 4 0 0.250 0.980 1.000 228 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(3), EPO(1), EPOR(1), FOS(1), JAK2(4), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 16495935 30 20 29 8 4 7 4 9 5 1 0.205 0.981 1.000 229 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), HSD3B7(1) 3659485 5 5 5 3 2 0 0 3 0 0 0.876 0.981 1.000 230 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1) 6683013 9 6 9 3 3 3 1 1 1 0 0.552 0.981 1.000 231 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), HLA-DRA(3), HLA-DRB1(1), IFNB1(1), IL10(1), IL12B(2), IL15(2), IL3(1), IL5(1), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1) 10076046 19 12 19 6 4 2 4 7 2 0 0.468 0.981 1.000 232 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), IL4R(2) 9713698 20 15 20 9 2 2 2 10 4 0 0.826 0.982 1.000 233 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(12), ACACB(11), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DLD(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(2) 35881897 71 46 70 16 24 16 6 14 11 0 0.0181 0.982 1.000 234 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(1), FDPS(1), HMGCS1(2), IDI1(2), LSS(1), MVD(3), NSDHL(2), SQLE(1) 10097400 18 10 18 6 6 1 3 5 3 0 0.595 0.982 1.000 235 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(7), MAP3K1(4), NCOR2(8), RXRA(1), THRA(2), THRB(2) 11195903 24 18 23 8 9 4 1 5 5 0 0.452 0.982 1.000 236 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), FHL5(3), FSHR(2), GNAS(4), XPO1(1) 7359434 12 11 12 4 3 1 3 3 2 0 0.663 0.983 1.000 237 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(1), JAK2(4), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(2) 10505884 18 13 18 9 2 1 3 6 6 0 0.867 0.983 1.000 238 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(4), ESR1(2), ESR2(3), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(5), NR1I2(1), NR2C2(2), NR2E1(2), NR2F1(1), NR2F2(3), NR3C1(3), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(1), PGR(4), PPARA(3), PPARG(2), RARB(1), ROR1(3), RORA(1), RORC(1), RXRA(1), RXRG(3), THRA(2), THRB(2), VDR(2) 32251692 69 39 67 16 29 10 11 14 5 0 0.0217 0.983 1.000 239 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(7), IRS1(4), MAPK1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), YWHAH(1) 11660001 22 16 22 5 5 4 3 3 6 1 0.151 0.984 1.000 240 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(7), EPHB1(2), FYN(1), ITGA1(2), ITGB1(2), L1CAM(7), SELP(2) 12110214 23 11 23 8 6 5 3 8 1 0 0.460 0.985 1.000 241 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(2), REG1A(2), STAT1(2), STAT2(1), TYK2(7) 9574957 18 11 18 6 4 1 1 6 5 1 0.517 0.985 1.000 242 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1) 37455873 80 45 79 19 29 18 7 17 9 0 0.0109 0.986 1.000 243 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(2), TPI1(1) 37455873 80 45 79 19 29 18 7 17 9 0 0.0109 0.986 1.000 244 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(3), PLCB2(4), PRL(1), VIP(2) 8536635 18 15 18 6 6 4 0 5 3 0 0.497 0.986 1.000 245 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1) 5333746 9 4 9 4 0 0 2 4 3 0 0.857 0.987 1.000 246 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(5), COL4A4(4), COL4A5(9), COL4A6(6), SLC23A1(1), SLC23A2(3), SLC2A1(2), SLC2A3(4) 19140819 36 20 36 10 12 7 5 8 3 1 0.100 0.987 1.000 247 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(2), HADHA(2), HSD17B4(2), MECR(1), PPT2(2) 6494079 12 8 12 6 2 1 2 3 4 0 0.824 0.988 1.000 248 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(5), CPT1A(1), CPT2(1), EHHADH(1), HADHA(2), PECR(2), SCP2(1), SLC25A20(1) 12897180 26 15 26 7 2 6 2 7 9 0 0.306 0.988 1.000 249 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(2), ELK1(3), FOS(1), INSR(4), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2) 16666362 37 24 35 10 9 10 2 10 5 1 0.184 0.988 1.000 250 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(1), RAF1(1) 6311360 8 4 8 3 1 3 1 0 2 1 0.357 0.988 1.000 251 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHPF(1), CHST11(3), CHST13(2), CHST3(3), CHSY1(2), DSE(3), XYLT1(2), XYLT2(2) 10766638 18 12 18 5 7 2 1 6 2 0 0.354 0.988 1.000 252 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(2), ST8SIA1(1) 4708422 4 2 4 4 1 0 0 1 2 0 0.991 0.989 1.000 253 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK1(1), JAK2(4), PTPRU(2), REG1A(2), STAT1(2) 8754459 12 6 12 6 2 1 1 3 4 1 0.733 0.989 1.000 254 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), NFKB1(1), RB1(7), RELA(1) 12003539 22 10 22 8 6 2 4 2 7 1 0.655 0.990 1.000 255 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(4), BMPR1A(1), BMPR1B(1) 4827084 6 5 6 4 3 0 1 1 1 0 0.955 0.990 1.000 256 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), ABAT(1), ACADS(2), ACAT2(1), ACSM1(6), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCS1(2), HMGCS2(3), HSD17B4(2), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), PLA1A(3) 31061083 68 38 67 18 19 10 6 21 12 0 0.0782 0.990 1.000 257 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(9), EP300(5), LPL(2), NCOA1(2), NCOA2(2), PPARG(2), RXRA(1) 14174654 23 14 22 7 6 5 1 9 2 0 0.443 0.991 1.000 258 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(2), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 6426744 12 11 12 5 4 3 1 1 3 0 0.638 0.991 1.000 259 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST13(2), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(2), SUOX(1) 7044200 13 9 13 6 2 1 0 7 3 0 0.840 0.991 1.000 260 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), SDS(1) 5971869 8 6 8 7 2 1 1 2 2 0 0.949 0.991 1.000 261 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(6), CPEB1(3), ERBB2(2), ERBB4(5), ETS1(4), ETV6(4), ETV7(1), FMN2(3), KRAS(3), MAPK1(2), MAPK3(1), NOTCH2(11), NOTCH3(6), NOTCH4(8), PIWIL2(3), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(4), SOS2(5), SPIRE1(1), SPIRE2(2) 34976923 79 44 78 18 20 13 12 20 12 2 0.0545 0.991 1.000 262 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), ABAT(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(3), ASPA(1), ASS1(3), CAD(5), CRAT(1), DARS2(2), DLD(1), GAD1(2), GAD2(1), GOT1(2), NARS(2), NARS2(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1) 28997037 50 27 49 10 15 11 3 12 9 0 0.0342 0.992 1.000 263 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), FDPS(1), IDI1(2), LSS(1), MVD(3), NQO1(1), NQO2(1), SQLE(1) 8462946 14 7 14 5 4 1 3 3 3 0 0.614 0.992 1.000 264 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(2) 5035249 6 5 6 3 3 2 0 1 0 0 0.581 0.992 1.000 265 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(2) 5035249 6 5 6 3 3 2 0 1 0 0 0.581 0.992 1.000 266 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 25 ACLY(3), ACO1(5), ACO2(4), CLYBL(1), DLD(1), FH(1), IDH3B(1), OGDH(1), OGDHL(4), PC(2), PCK1(3), SDHA(4), SDHC(2), SUCLG2(1) 21641832 33 22 32 9 10 6 7 6 4 0 0.149 0.992 1.000 267 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), HSD17B4(2), SIRT1(1), SIRT5(2), SIRT7(1) 9069287 13 9 13 9 3 0 2 4 4 0 0.957 0.992 1.000 268 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2) 13722087 26 9 26 8 6 7 5 3 4 1 0.227 0.992 1.000 269 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), FOS(1), IL3(1), IL3RA(2), JAK2(4), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 13577246 20 11 20 5 3 2 3 7 4 1 0.312 0.993 1.000 270 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(1), ASAH1(1), ATF1(1), BRAF(6), CREB1(1), CREBBP(9), CRKL(1), DAG1(1), EGR1(2), EGR2(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(8), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3C2G(1), PIK3CD(3), PTPN11(7), RPS6KA3(3), SHC1(1), TERF2IP(1), TH(3) 36530391 74 44 71 18 15 11 12 23 12 1 0.0588 0.993 1.000 271 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EARS2(1), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GFPT2(3), GLS(2), GLS2(1), GLUD1(5), GLUD2(1), GLUL(1), GNPNAT1(2), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3) 30252374 51 28 51 11 10 9 7 14 11 0 0.0885 0.993 1.000 272 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(3), ACAT2(1), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 6411457 10 8 10 9 2 1 2 2 3 0 0.970 0.993 1.000 273 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1) 5276157 9 7 9 4 4 2 2 0 1 0 0.817 0.993 1.000 274 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(2), JAK2(4), NFKB1(1), NFKBIA(2), RELA(1), SOD2(1) 9705450 15 9 15 5 4 1 1 6 3 0 0.589 0.993 1.000 275 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), AP2M1(1), BIN1(2), CALM3(1), DNM1(1), EPN1(1), EPS15(1), PICALM(2), PPP3CA(1), PPP3CC(1), SYNJ1(6), SYNJ2(8), SYT1(2) 16487989 28 13 28 8 7 5 6 4 6 0 0.273 0.993 1.000 276 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(6), BCAR1(3), CSK(1), CTNNA2(3), CTNNB1(3), PTK2(2), VCL(1) 14709559 20 11 20 5 9 3 2 2 4 0 0.272 0.993 1.000 277 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RELA(1) 6316116 12 9 12 7 3 0 1 6 1 1 0.889 0.993 1.000 278 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(12), ACAT2(1), ADH5(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), DLD(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(2) 28371080 54 35 53 13 15 14 5 11 9 0 0.0641 0.993 1.000 279 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), GLB1(2), HEXA(1), HEXB(1), LCT(10), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3) 12649081 29 18 29 9 11 1 4 5 8 0 0.581 0.994 1.000 280 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), MPI(2), PFKFB1(4), PFKFB3(2), PFKP(1), SORD(1), TPI1(1) 18328412 32 15 32 8 12 9 1 6 4 0 0.0674 0.994 1.000 281 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(3), EPHB2(2), F2(3), F2RL1(4), F2RL3(1), MAP2K5(2), MAPK1(2), MAPK7(5), MAPK8(2), MYEF2(3), PLD1(7), PLD3(1), PTK2(2), RAF1(1), RASAL1(4), TEC(3), VAV1(5) 21051988 53 32 52 14 16 8 6 15 8 0 0.120 0.994 1.000 282 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(1), BRAF(6), CAB39(2), EIF4B(2), IGF1(1), MAPK1(2), MAPK3(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(3), ULK1(1), ULK2(5), VEGFA(2), VEGFB(2), VEGFC(2) 37859685 72 40 70 16 18 7 13 22 11 1 0.0557 0.994 1.000 283 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(8), ATR(6), CHEK1(3), CHEK2(3), YWHAH(1) 11670702 21 10 21 5 4 4 3 5 5 0 0.423 0.994 1.000 284 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(3), ASPA(1), CAD(5), CRAT(1), GAD1(2), GAD2(1), GOT1(2), NARS(2), PC(2) 19972600 32 14 32 5 9 7 1 9 6 0 0.0399 0.995 1.000 285 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1) 4329563 7 7 7 4 3 0 1 2 1 0 0.892 0.995 1.000 286 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX10(3), COX15(1), CP(3), EARS2(1), EPRS(3), FECH(1), FTH1(3), GUSB(3), HCCS(4), MMAB(2), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), UROD(1), UROS(1) 32362879 79 51 78 20 20 10 17 30 2 0 0.0833 0.996 1.000 287 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT2(1), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CEL(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), GK(1), GLA(2), GLB1(2), LCT(10), LIPC(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(4), PPAP2A(2), PPAP2C(1) 36849046 78 36 78 20 28 10 13 20 7 0 0.0374 0.996 1.000 288 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(4), PRKAR1A(2) 5069121 8 8 8 4 4 0 0 2 2 0 0.866 0.996 1.000 289 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), CDKN1A(1), ELK1(3), MAP2K2(1), NGFR(1), NTRK1(2), PIK3CD(3), SHC1(1), SOS1(4) 10689433 17 10 17 5 6 2 1 5 3 0 0.423 0.996 1.000 290 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(5), OAT(1), ODC1(3), SMS(1) 13415477 24 12 24 6 5 4 0 6 9 0 0.329 0.997 1.000 291 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2) 12311457 17 10 17 6 4 2 1 9 1 0 0.717 0.997 1.000 292 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(12), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ECHS1(2), EHHADH(1), HADHA(2), LDHA(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SDS(1), SUCLG2(1) 25406954 54 26 54 14 14 14 4 13 9 0 0.128 0.997 1.000 293 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(3), CALM3(1), ELK1(3), FCER1A(2), FOS(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PAK2(2), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5) 30153159 59 31 58 14 12 12 9 18 7 1 0.0506 0.997 1.000 294 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(4), CREBBP(9), EP300(5), MAPK3(1), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3) 19708504 32 13 32 7 9 4 3 12 3 1 0.220 0.997 1.000 295 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM3(1), CRKL(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PRKCA(5), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2) 21880324 42 26 41 11 9 9 7 7 8 2 0.107 0.997 1.000 296 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(2), RPL10L(2), RPL13A(1), RPL18A(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(2), RPS2(1), RPS24(1), RPS3(3) 17273282 24 12 24 3 9 1 3 7 4 0 0.156 0.997 1.000 297 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1) 7752310 15 9 15 6 5 1 1 4 4 0 0.793 0.998 1.000 298 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), CYP4B1(1), CYP51A1(2), PON1(2) 22412447 43 35 43 10 17 3 4 9 10 0 0.149 0.998 1.000 299 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(3), APOBEC3B(1), APOBEC3C(1), APOBEC3F(2), APOBEC3G(1), APOBEC4(1) 5628441 13 12 13 5 4 3 0 5 1 0 0.612 0.998 1.000 300 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 12719180 12 5 11 1 5 3 1 2 1 0 0.0852 0.998 1.000 301 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(2), RALGDS(2), RELA(1) 11709872 16 6 16 8 3 1 1 4 6 1 0.816 0.998 1.000 302 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), APAF1(3), ATM(8), BAX(1), CYCS(2), PRKCA(5), PTK2(2), STAT1(2), TLN1(5) 20370666 29 17 29 7 6 2 4 11 4 2 0.285 0.998 1.000 303 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(6), BAIAP2(3), CASP1(5), CASP8(2), INSR(4), MAGI1(4), MAGI2(4), RERE(7), WWP1(3), WWP2(1) 18383027 39 23 39 11 13 8 3 11 4 0 0.280 0.998 1.000 304 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), IARS2(3), ILVBL(5), LARS(4), PDHA1(5), PDHA2(4), PDHB(1), VARS(3), VARS2(2) 14233841 29 17 28 8 5 7 2 10 5 0 0.367 0.998 1.000 305 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(1), FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1) 8229760 13 6 13 8 4 1 1 3 4 0 0.950 0.999 1.000 306 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), MPI(2), MTMR1(4), MTMR2(3), MTMR6(1), PFKFB1(4), PFKFB2(2), PFKFB3(2), PFKL(5), PFKP(1), PGM2(4), SORD(1), TPI1(1), TSTA3(1) 28474586 53 26 53 13 20 10 4 11 8 0 0.0572 0.999 1.000 307 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(4), HSD17B4(2), HSD17B7(2), HSD3B1(2), HSD3B2(1) 6213529 11 11 10 6 2 3 3 2 1 0 0.758 0.999 1.000 308 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(1), GLUD1(5), GLUD2(1) 3498124 9 7 9 4 1 2 0 4 2 0 0.768 0.999 1.000 309 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(3), CALM3(1), CD79A(1), ELK1(3), FOS(1), MAP3K1(4), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2), VAV1(5) 29338010 58 29 57 15 14 11 6 16 9 2 0.0883 0.999 1.000 310 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), NTRK1(2), PLCG1(6), RPS6KA1(4), SHC1(1) 11608558 26 17 25 9 3 5 3 7 7 1 0.583 0.999 1.000 311 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(3) 6704208 11 8 11 7 8 2 0 0 1 0 0.731 0.999 1.000 312 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 HLA-A(1), IL18(3), ITGB1(2), KLRC1(2), KLRC2(1), KLRC4(1), LAT(2), MAPK3(1), PAK1(2), PTK2B(2), RAC1(1), VAV1(5) 11395557 23 12 23 7 5 3 3 5 6 1 0.349 0.999 1.000 313 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGG(2), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGW(2), PIGX(1), PIGZ(1) 18249902 27 9 27 8 10 2 5 6 4 0 0.316 0.999 1.000 314 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(2), GZMB(1), HMGB2(1), TOP2A(4), TOP2B(3) 6803177 11 6 11 5 5 1 1 3 1 0 0.797 0.999 1.000 315 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), LARS(4), PDHA1(5), PDHA2(4), PDHB(1) 7685277 16 11 15 6 1 5 2 4 4 0 0.627 0.999 1.000 316 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(1), GNAI1(4), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(3), PRKCA(5), PTGS1(2), PTK2(2), RAF1(1), TBXAS1(2) 18702912 36 25 36 10 5 1 9 14 5 2 0.333 0.999 1.000 317 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1) 5904113 7 3 7 4 1 2 1 0 3 0 0.869 0.999 1.000 318 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), HADHA(2), PNPLA3(1), SH3GLB1(3) 23702376 42 22 41 11 18 7 5 6 6 0 0.125 0.999 1.000 319 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(2), EIF2S2(1), NFKB1(1), NFKBIA(2), RELA(1) 6855660 7 4 7 4 1 2 0 3 1 0 0.846 0.999 1.000 320 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GPHN(1), NSF(2), UBQLN1(2) 9183009 28 19 28 10 5 8 3 7 5 0 0.551 0.999 1.000 321 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), GLI2(3), GLI3(7), PRKACG(1), PRKAR1A(2), SHH(1), SMO(2), SUFU(3) 12777072 22 12 22 9 5 6 2 6 3 0 0.594 0.999 1.000 322 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(3), CYSLTR2(2), GPR161(1), GPR171(1), GPR18(2), GPR34(2), GPR45(1), GPR75(1) 7553131 13 7 13 9 4 2 2 2 3 0 0.881 0.999 1.000 323 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(3), ACADM(2), ACADS(2), ACAT2(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), DBT(2), DLD(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), HIBCH(1), HMGCS1(2), HMGCS2(3), HSD17B4(2), MCCC1(2), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3) 32956682 66 33 65 17 20 14 6 14 12 0 0.100 0.999 1.000 324 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT6(1), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CEL(2), DAK(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), GK(1), GK2(4), GLA(2), GLB1(2), GPAM(1), LCT(10), LIPA(2), LIPC(1), LIPG(3), LPL(2), MGLL(1), PNLIP(2), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1) 44894032 93 41 93 24 34 10 16 25 8 0 0.0348 0.999 1.000 325 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFA(2), LMNA(2), LMNB2(2), MADD(2), MAP3K1(4), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), RB1(7), RIPK1(3), SPTAN1(5), TNF(1), TRADD(1), TRAF2(2) 29620524 54 37 54 12 13 10 9 10 11 1 0.0999 0.999 1.000 326 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), DPAGT1(2), DPM1(2), FUT8(6), MAN1A1(2), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1) 15248910 31 18 31 9 6 10 5 3 7 0 0.203 0.999 1.000 327 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(2), ITGAM(2), ITGB2(1), SELE(6) 7957469 16 13 15 8 8 4 3 0 1 0 0.567 0.999 1.000 328 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(2), IRS1(4), JAK1(1), JAK3(3), RPS6KB1(2), SHC1(1), STAT6(4) 11338598 18 13 18 6 3 3 1 7 4 0 0.556 0.999 1.000 329 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(1), ANXA1(2), CALM3(1), GNAS(4), NFKB1(1), NOS3(7), NR3C1(3), RELA(1), SYT1(2) 10828575 23 16 23 8 10 3 4 4 2 0 0.538 0.999 1.000 330 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(7), PRKACG(1), PRKAR1A(2) 9893889 14 11 14 5 4 1 2 5 1 1 0.561 1.000 1.000 331 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(2), ATF2(2), AXIN1(1), BMP10(2), BMP4(2), BMP5(4), BMPR1A(1), CHRD(1), CTNNB1(3), FZD1(2), GATA4(1), MYL2(2), RFC1(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2) 27899952 37 21 37 9 13 5 4 5 10 0 0.210 1.000 1.000 332 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(2), CYCS(2), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(2), TRADD(1), TRAF2(2) 15737317 26 18 26 9 6 5 4 4 6 1 0.449 1.000 1.000 333 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(1), CDK2(1), CDKN1B(3), CDKN2A(4), CREB1(1), ERBB4(5), IGF1(1), INPPL1(5), IRS1(4), IRS2(1), IRS4(6), MET(10), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(2), PREX1(5), PTK2(2), PTPN1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(5), TSC1(2), TSC2(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 56919534 114 58 114 26 23 16 21 34 20 0 0.0163 1.000 1.000 334 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(4), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2) 11779304 20 11 20 6 8 1 0 8 3 0 0.591 1.000 1.000 335 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCR(3), CRKL(1), FOS(1), JAK2(4), MAP3K1(4), MAPK3(1), MAPK8(2), RAF1(1), SOS1(4), STAT1(2), STAT5A(1), STAT5B(2) 18669601 27 13 27 8 6 6 3 7 3 2 0.239 1.000 1.000 336 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), ASAH1(1), BRAF(6), DAG1(1), EPHB2(2), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PI3(2), PIK3CB(3), PITX2(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT3(2), TERF2IP(1) 42845391 85 46 84 21 22 8 19 28 7 1 0.0664 1.000 1.000 337 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NFKB1(1), NOX1(1), RELA(1), TNF(1), XDH(8) 7598377 13 6 13 7 3 4 0 5 1 0 0.782 1.000 1.000 338 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(4) 7096862 12 4 12 5 3 1 3 4 1 0 0.746 1.000 1.000 339 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 FURIN(1) 3992696 1 1 1 1 1 0 0 0 0 0 0.944 1.000 1.000 340 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(1), GNAS(4), PLCE1(8), PRKACG(1), PRKAR1A(2), RAP2B(2) 11343965 20 15 20 7 9 4 1 3 3 0 0.540 1.000 1.000 341 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(1) 8497832 13 8 13 8 1 3 2 6 1 0 0.904 1.000 1.000 342 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), EPO(1), IL3(1), IL5(1), IL6(1), IL9(1) 4572621 6 4 6 5 1 0 0 4 1 0 0.961 1.000 1.000 343 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(5), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(1), MAPK8(2), MDM2(3), NQO1(1) 15317147 26 15 26 9 5 2 3 11 5 0 0.694 1.000 1.000 344 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 48 AGT(2), AKT1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(9), CSNK1A1(2), F2(3), GATA4(1), IGF1(1), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RAF1(1), RPS6KB1(2), SYT1(2) 33018267 54 26 54 14 14 7 9 14 9 1 0.0779 1.000 1.000 345 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(4), GRAP2(1), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(2), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PLCG1(6), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), SOS1(4), SOS2(5), VAV1(5), ZAP70(5) 42085046 86 49 85 20 24 18 10 21 13 0 0.0311 1.000 1.000 346 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2) 14514574 30 13 30 10 8 7 5 4 5 1 0.303 1.000 1.000 347 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PIK3CD(3), SYT1(2), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1) 22868155 40 25 40 11 14 5 7 8 5 1 0.124 1.000 1.000 348 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(1), CFTR(4), GNAS(4), PRKACG(1), PRKAR1A(2), SLC9A3R1(1) 10042842 15 13 15 5 7 2 1 3 2 0 0.550 1.000 1.000 349 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 CES1(1) 4633326 1 1 1 1 0 1 0 0 0 0 0.829 1.000 1.000 350 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), EPRS(3), FARS2(3), GARS(3), HARS(2), IARS(1), LARS(4), MARS(5), MARS2(2), NARS(2), QARS(3), RARS(2), SARS(1), WARS2(2), YARS(1) 24580717 36 17 36 9 6 10 3 11 6 0 0.294 1.000 1.000 351 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNB1(2), CHRNG(2), MUSK(4), PTK2(2), PTK2B(2), RAPSN(1), TERT(3), YWHAH(1) 9609315 18 13 18 8 6 1 2 6 3 0 0.751 1.000 1.000 352 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(3), ALG6(3), DAD1(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(2), FUT8(6), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), RPN1(1), RPN2(1), ST6GAL1(1), STT3B(2) 32433571 60 32 60 15 12 16 10 8 14 0 0.0964 1.000 1.000 353 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1) 10369583 16 11 16 6 5 2 2 6 1 0 0.626 1.000 1.000 354 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RAF1(1), RELA(1), TNF(1) 11915064 18 13 18 9 3 2 2 6 3 2 0.708 1.000 1.000 355 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(8), ATR(6), BAI1(5), BAX(1), CASP8(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), CYCS(2), DDB2(2), EI24(4), FAS(1), GTSE1(4), IGF1(1), MDM2(3), MDM4(1), PPM1D(3), RCHY1(1), RFWD2(4), RRM2B(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN2(1), SESN3(1), SFN(2), SIAH1(3), STEAP3(2), THBS1(4), TP53I3(1), TSC2(3), ZMAT3(3) 48795177 105 61 104 27 21 15 20 28 21 0 0.0615 1.000 1.000 356 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(2), AKT1(1), ASAH1(1), GNAI1(4), ITGAV(3), ITGB3(2), MAPK1(2), MAPK3(1), PDGFA(1), PLCB1(3), PRKCA(5), PTK2(2), RAC1(1), SMPD1(2), SMPD2(1) 16421367 31 19 31 10 6 1 8 6 8 2 0.403 1.000 1.000 357 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 11 CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTR(2) 11948653 21 8 21 9 5 6 0 6 2 2 0.618 1.000 1.000 358 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), SDS(1) 19786610 42 26 41 14 13 7 4 9 9 0 0.233 1.000 1.000 359 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 18301934 40 30 40 12 14 5 5 8 8 0 0.305 1.000 1.000 360 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM3(1), CXCR4(2), FOS(1), MAPK8(2), PLCG1(6), PRKCA(5), PTK2B(2), SYT1(2) 10581180 21 18 20 9 3 6 6 4 1 1 0.530 1.000 1.000 361 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(3), GNAS(4), IGF1R(7), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(2), NGFR(1), PPP2CA(4), PTPRR(3), RAF1(1), RPS6KA1(4), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(2) 21611842 43 28 43 12 13 4 6 10 9 1 0.256 1.000 1.000 362 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CALM3(1), CAPNS1(1), CAPNS2(1), EP300(5), HDAC2(4), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CC(1), PRKCA(5), SYT1(2) 18701070 34 17 34 11 9 4 6 8 6 1 0.421 1.000 1.000 363 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(3), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), MAOA(2), TAT(1), TH(3), TPO(6), TYR(4) 24287774 60 33 60 20 22 7 6 19 6 0 0.253 1.000 1.000 364 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), BRD4(1), CBL(1), CDKN2A(4), FLOT2(3), INPPL1(5), IRS1(4), IRS2(1), IRS4(6), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PTPN1(1), RAF1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(4), SOS2(5), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 42125326 75 40 75 18 14 9 12 25 14 1 0.0735 1.000 1.000 365 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(2), ATF2(2), CALM3(1), ELK1(3), MAP2K2(1), MAP3K1(4), MAPK1(2), MAPK3(1), MAPK8(2), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(5), PTK2(2), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(2) 23677326 41 21 41 12 7 7 6 8 11 2 0.250 1.000 1.000 366 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CREB1(1), DAXX(2), DDIT3(2), ELK1(3), MAP3K1(4), MAP3K5(3), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), PLA2G4A(4), RAC1(1), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 28090078 52 31 50 14 14 8 8 12 9 1 0.218 1.000 1.000 367 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10(1), IL10RB(1), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(1), TNF(1) 9319196 12 7 12 6 3 1 2 5 0 1 0.784 1.000 1.000 368 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(2), AXIN1(1), BTRC(1), CTNNB1(3), FZD1(2) 13296887 9 6 9 5 2 1 1 2 3 0 0.920 1.000 1.000 369 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(4), INSR(4), IRS1(4), JAK2(4), MAPK1(2), MAPK3(1), PLCG1(6), PRKCA(5), RAF1(1), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2), STAT5A(1), STAT5B(2) 22492134 47 29 46 14 9 10 6 13 7 2 0.256 1.000 1.000 370 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM3(1), EGR2(1), EGR3(1), MAP3K1(4), NFATC1(2), NFATC2(5), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), SYT1(2), VIP(2), VIPR2(1) 21487235 34 23 33 11 7 5 3 14 5 0 0.471 1.000 1.000 371 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(2), BAX(1), BFAR(1), BTK(3), CAD(5), CASP8(2), CD7(1), CSNK1A1(2), DAXX(2), DEDD2(1), DFFA(2), DIABLO(1), EPHB2(2), FAF1(3), MAP3K1(4), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MET(10), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), RIPK1(3), ROCK1(2), SMPD1(2), TNFRSF6B(1), TPX2(5), TRAF2(2) 53092571 89 46 89 20 26 15 13 16 19 0 0.0172 1.000 1.000 372 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(3), FTCD(4), HAL(1), HARS(2), HARS2(1), HDC(2), HNMT(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(2) 30370803 64 35 64 20 25 9 9 14 7 0 0.169 1.000 1.000 373 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK8(2), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1) 11140174 15 10 15 7 6 4 2 2 1 0 0.713 1.000 1.000 374 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 EPO(1), FLT3(4), IGF1(1), IL3(1), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1) 6234686 14 7 14 6 3 1 3 5 2 0 0.728 1.000 1.000 375 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), ETV5(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), JAK2(4), MAPK8(2), STAT4(2), TYK2(7) 14316280 29 15 29 10 8 3 6 10 2 0 0.543 1.000 1.000 376 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(1) 13905406 16 11 16 9 8 1 1 4 2 0 0.846 1.000 1.000 377 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT2(1), AGPAT3(1), AGPAT6(1), CDS2(2), CHAT(4), CHKB(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), ESCO1(1), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(1), GPAM(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PHOSPHO1(1), PISD(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(2), SH3GLB1(3) 50146120 72 33 72 16 23 18 8 14 9 0 0.0121 1.000 1.000 378 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(6), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1(1), IGF1R(7), INSR(4), MAPK7(5), MEF2A(2), MEF2B(1), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CC(1), SYT1(2), YWHAH(1) 23782270 43 23 43 14 13 7 7 9 7 0 0.271 1.000 1.000 379 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(12), ACACB(11), FASN(3), MCAT(2), OXSM(2) 12091609 30 21 30 11 8 5 4 7 6 0 0.451 1.000 1.000 380 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(5), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 11659594 26 19 26 10 8 6 1 6 5 0 0.501 1.000 1.000 381 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), BCR(3), BTK(3), CD19(1), CDKN2A(4), FLOT2(3), ITPR1(4), ITPR2(13), ITPR3(13), PDK1(2), PHF11(1), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(5), PTPRC(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SAG(2), TEC(3), VAV1(5) 40008045 98 53 98 29 30 14 14 29 10 1 0.105 1.000 1.000 382 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM3(1), CREB1(1), ELK1(3), FOS(1), GNAI1(4), GNAS(4), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAF1(1), RPS6KA3(3), SYT1(2) 26832453 52 34 51 16 13 6 8 13 10 2 0.285 1.000 1.000 383 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(3), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR2(1), KDELR3(1) 12447578 14 8 14 7 2 4 3 2 3 0 0.772 1.000 1.000 384 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM3(1), DLG4(3), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), NOS1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), SYT1(2) 19576230 47 36 47 17 17 8 7 10 4 1 0.330 1.000 1.000 385 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(3), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNA11(1), GNAI1(4), JAK2(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), MYLK(5), PLCG1(6), PRKCA(5), PTK2B(2), RAF1(1), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), SYT1(2) 31956855 61 35 60 18 15 8 13 14 8 3 0.159 1.000 1.000 386 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(2), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), CFL1(1), CFL2(1), FLNA(13), FLNC(12), FSCN1(2), FSCN2(1), FSCN3(3), GDI1(3), GDI2(1), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), RHO(1), ROCK1(2), ROCK2(4), RPS4X(2), WASF1(1), WASL(2) 33679680 83 44 83 27 28 13 11 21 9 1 0.171 1.000 1.000 387 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 ACO2(4), FH(1), OGDH(1), SDHA(4) 6613532 10 8 9 5 4 0 4 1 1 0 0.722 1.000 1.000 388 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME2(1), ME3(1), PGK1(2), PKLR(2), RPIA(1), TKT(2), TPI1(1) 13838061 17 10 17 6 5 3 1 5 3 0 0.571 1.000 1.000 389 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CSK(1), F11R(1), GIT1(2), HBEGF(1), IKBKB(1), JAM2(4), JAM3(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(2), MAPK9(1), MET(10), NFKB1(1), NFKB2(2), NFKBIA(2), NOD1(1), PAK1(2), PLCG1(6), PLCG2(9), PTPN11(7), PTPRZ1(12), RAC1(1), RELA(1), TCIRG1(2), TJP1(5) 51857136 99 59 96 26 22 15 17 22 22 1 0.0605 1.000 1.000 390 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(3), STON1(2), TAF1(8), TAF10(1), TAF1L(6), TAF2(3), TAF4(3), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(2), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(1) 27646323 48 24 48 13 10 8 7 15 7 1 0.222 1.000 1.000 391 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 AKT1(1), APC(2), AR(4), ASAH1(1), BRAF(6), CCL16(1), DAG1(1), GNA11(1), GNA15(1), GNAI1(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(4), PTX3(2), RAF1(1) 36071505 75 43 74 23 18 7 22 19 7 2 0.271 1.000 1.000 392 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), MCCC1(2), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3), SDS(1) 27614201 55 28 54 18 15 15 5 11 9 0 0.276 1.000 1.000 393 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(2), SHC1(1), SOS1(4) 6770830 8 6 8 4 1 2 0 3 2 0 0.730 1.000 1.000 394 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 CES1(1), ESCO1(1), ESCO2(2), LIPA(2), PLA1A(3), PNPLA3(1), SH3GLB1(3) 19436703 13 4 13 3 2 4 1 4 2 0 0.342 1.000 1.000 395 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(2), AKT1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(4), MAPK1(2), MAPK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAC1(1), RPS6KA1(4), RPS6KA5(1), SOS1(4) 19449447 34 21 34 10 12 2 4 6 8 2 0.355 1.000 1.000 396 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), CYP19A1(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(1), SULT2A1(2), SULT2B1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), WBSCR22(2) 38494713 88 56 86 28 21 11 19 29 8 0 0.203 1.000 1.000 397 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME3(1), PGK1(2), PKLR(2), RPIA(1), TKT(2), TKTL2(2), TPI1(1) 15473083 18 11 18 8 5 3 1 5 4 0 0.770 1.000 1.000 398 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ACADM(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1), MLYCD(3), SMS(1), SRM(2) 20695116 43 19 42 15 14 6 4 11 8 0 0.415 1.000 1.000 399 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), ASAH1(1), CREB1(1), DAG1(1), EPHB2(2), FOS(1), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1) 21971132 22 14 22 7 5 4 5 4 4 0 0.332 1.000 1.000 400 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), GCDH(1), HADHA(2), PNPLA3(1), SH3GLB1(3) 19911387 22 11 21 8 7 5 3 4 3 0 0.497 1.000 1.000 401 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(2), AXIN1(1), CCND1(4), CD14(1), CTNNB1(3), FZD1(2), GJA1(5), GNAI1(4), IRAK1(1), LBP(2), LEF1(1), NFKB1(1), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1) 20667826 36 24 36 12 11 5 7 8 5 0 0.394 1.000 1.000 402 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(4), IRS1(4), MAPK1(2), MAPK3(1), MKNK1(2), PABPC1(4), PRKCA(5), RPS6KB1(2) 18060612 46 28 46 14 13 9 7 8 7 2 0.328 1.000 1.000 403 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(3), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(3), TAT(1), TH(3), TPO(6), TYR(4), TYRP1(4), WBSCR22(2) 45567111 94 45 93 28 27 14 12 28 13 0 0.141 1.000 1.000 404 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(5), PER2(3), PER3(1) 13091795 16 6 16 8 2 4 1 8 1 0 0.877 1.000 1.000 405 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(3), EPX(5), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PRDX1(1), TAT(1), TPO(6) 16843561 38 22 38 13 17 8 4 6 2 1 0.199 1.000 1.000 406 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), BPNT1(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PTK2B(2), RBL2(4), SHC1(1), SOS1(4) 13336249 22 14 22 9 4 4 1 10 2 1 0.668 1.000 1.000 407 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(8), ATR(6), BRCA1(2), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(1), CHEK1(3), CHEK2(3), EP300(5), MDM2(3), MYT1(7), PRKDC(11), RPS6KA1(4), WEE1(1), YWHAH(1), YWHAQ(1) 31368960 62 36 62 17 14 6 7 18 16 1 0.439 1.000 1.000 408 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(2), CCNB1(2), GNAI1(4), GNAS(4), MAPK1(2), MAPK3(1), MYT1(7), PRKACG(1), PRKAR1A(2), RPS6KA1(4) 15747333 29 24 29 10 7 0 4 5 12 1 0.715 1.000 1.000 409 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(2), IDS(2), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(1), NEU2(6), NEU3(2), SPAM1(3) 26414962 62 41 62 20 23 5 9 16 9 0 0.354 1.000 1.000 410 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(6), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(2), RAC1(1), SPTAN1(5), TLN1(5) 21879415 28 12 28 9 9 3 6 6 4 0 0.409 1.000 1.000 411 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(4), E2F1(1), ETS1(4), ETV3(1), FOS(1), HDAC2(4), HDAC5(1), NCOR2(8), RBL1(4), RBL2(4), SIN3A(3), SIN3B(1) 19892806 36 18 36 13 7 5 5 9 10 0 0.599 1.000 1.000 412 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKL(5), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TALDO1(2), TKT(2), TKTL2(2) 18631102 33 21 33 12 14 7 0 4 8 0 0.314 1.000 1.000 413 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(1), BTK(3), CDKN2A(4), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SOS1(4), SOS2(5), TEC(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 25270273 51 30 51 16 7 7 10 18 9 0 0.396 1.000 1.000 414 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(3), CYCS(2), DAXX(2), FAS(1), FASLG(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1) 8694596 12 6 12 6 0 3 3 5 1 0 0.851 1.000 1.000 415 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(2), ASAH1(1), DAG1(1), DLG4(3), EPHB2(2), GNAI1(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PITX2(4), PTX3(2), RAC1(1), RHO(1), RYR1(11) 35050698 70 39 70 22 19 8 17 16 9 1 0.235 1.000 1.000 416 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CDK4(1), CDKN1B(3), CEBPB(1), DMC1(2), EGR1(2), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(2), NCOR1(9), NR5A1(1), NRIP1(2), PGR(4), PRLR(2), SMPD1(2), VDR(2), ZP2(4) 26914895 56 31 56 18 11 10 7 14 13 1 0.584 1.000 1.000 417 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(2), CANX(1), CD4(1), CIITA(2), CREB1(1), CTSB(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(1), IFI30(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL3(2), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC4(1), LGMN(1), NFYA(1), PSME1(3), RFX5(1), RFXANK(1), TAP1(1), TAPBP(1) 35456910 59 33 59 19 9 10 10 19 11 0 0.311 1.000 1.000 418 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(3), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(2), YWHAH(1) 15514595 25 9 25 9 6 7 4 2 6 0 0.430 1.000 1.000 419 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(2), CBR3(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2U1(1), CYP4A11(1), CYP4A22(2), CYP4F3(5), DHRS4(1), EPHX2(2), GGT1(2), GPX2(2), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(2) 29827462 66 47 66 21 18 10 8 16 14 0 0.277 1.000 1.000 420 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(3), EPX(5), ESCO1(1), ESCO2(2), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(6) 26253253 44 24 44 14 18 11 4 8 3 0 0.185 1.000 1.000 421 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ASPA(1), CNDP1(2), DDC(3), HAL(1), HARS(2), HDC(2), HNMT(1), MAOA(2), PRPS1(1), PRPS2(3) 18746239 34 21 34 13 16 5 4 7 2 0 0.446 1.000 1.000 422 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GCK(2), IL1R1(2), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K9(3), MAPK10(1), MAPK7(5), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(2), PAPPA(4), SHC1(1), TRAF6(1), ZAK(2) 37997819 62 35 62 18 18 7 11 19 7 0 0.300 1.000 1.000 423 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(5) 20969314 39 28 38 15 13 4 10 9 3 0 0.420 1.000 1.000 424 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL6(1), IRAK1(1), IRAK2(2), IRAK3(6), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(1) 22717523 36 21 36 12 9 7 6 9 5 0 0.373 1.000 1.000 425 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(2), DIAPH1(5), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), TLN1(5) 25740474 34 18 34 11 10 1 8 9 5 1 0.357 1.000 1.000 426 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(1), EEF2K(2), EIF2AK1(1), EIF2AK3(2), EIF2B4(1), EIF2S2(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G3(6), EIF5A(1), GSPT2(4), PABPC1(4), PABPC3(2), PAIP1(1), SLC35A4(1) 33443963 49 30 49 15 12 6 4 17 10 0 0.484 1.000 1.000 427 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP2(1), CASP8(2), CYCS(2), FAS(1), FASLG(1), GZMB(1), MAP3K1(4), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 28017297 42 32 42 15 13 7 5 11 6 0 0.489 1.000 1.000 428 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), ARG2(2), ASL(2), ASS1(3), CPS1(3), MAOA(2), ODC1(3), SMS(1), SRM(2) 22576141 33 18 33 12 12 4 2 7 8 0 0.574 1.000 1.000 429 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(1), CRY1(2), DNAJA1(3), EIF4G2(1), ETV6(4), HERPUD1(1), HSPA8(3), IDI1(2), KLF9(2), MYF6(2), NCKAP1(4), NCOA4(3), NR1D2(1), PER1(5), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), UGP2(1), ZFR(1) 28077396 46 22 46 15 7 9 7 19 4 0 0.545 1.000 1.000 430 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(7), ATP4A(5), ATP4B(2), ATP5B(2), ATP5G2(1), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), COX10(3), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B2(1), NDUFA10(3), NDUFA3(1), NDUFA7(1), NDUFA9(3), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRH(2) 42556271 72 36 71 22 15 12 12 19 13 1 0.249 1.000 1.000 431 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), CREB1(1), EP300(5), EPO(1), LDHA(1), NOS3(7) 13022463 19 11 19 8 8 1 2 7 1 0 0.694 1.000 1.000 432 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), IL4R(2), IRS1(4), IRS2(1), JAK1(1), JAK3(3), MAP4K1(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PPP1R13B(2), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT6(4) 25062406 38 23 38 13 7 6 3 14 7 1 0.496 1.000 1.000 433 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 CRKL(1), DOCK1(1), ELK1(3), FOS(1), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAP4K1(1), MAPK1(2), MAPK3(1), MAPK8(2), MET(10), PAK1(2), PTK2(2), PTK2B(2), PTPN11(7), RAF1(1), RASA1(4), SOS1(4), STAT3(2) 30242672 54 32 52 19 12 7 7 15 12 1 0.409 1.000 1.000 434 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), AXIN1(1), CREBBP(9), CTNNB1(3), EP300(5), FZD1(2), LDB1(2), LEF1(1), PITX2(4), TRRAP(13) 25438161 42 23 42 16 14 4 6 12 6 0 0.602 1.000 1.000 435 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 DAXX(2), EGF(7), ETS1(4), FOS(1), HOXA7(2), IKBKB(1), MAP2K3(3), MAP3K1(4), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(2), PPP2CA(4), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRAF2(2) 35608485 62 37 62 22 20 12 8 9 10 3 0.217 1.000 1.000 436 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(2), AXIN1(1), CCND1(4), CSNK1E(1), CTNNB1(3), DVL2(1), DVL3(2), FZD1(2), FZD10(2), FZD2(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), MAPK10(1), MAPK9(1), PAFAH1B1(4), PPP2R5C(1), PPP2R5E(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT5B(1), WNT7A(2) 46081692 67 41 67 23 25 5 10 12 13 2 0.284 1.000 1.000 437 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(1), BCR(3), BLNK(2), BTK(3), CD19(1), CSK(1), DAG1(1), EPHB2(2), MAP2K2(1), MAPK1(2), NFAT5(4), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PI3(2), PIK3CD(3), PLCG2(9), PPP1R13B(2), RAF1(1), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), VAV1(5) 37472639 61 36 61 21 23 10 6 15 7 0 0.241 1.000 1.000 438 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(3), ARHGDIB(1), BAG4(1), BIRC2(2), CASP2(1), CASP8(2), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(2), GSN(1), LMNA(2), LMNB2(2), MAP3K1(4), MAP3K5(3), MAPK8(2), MDM2(3), NFKB1(1), NFKBIA(2), NUMA1(8), PAK2(2), PRKDC(11), PTK2(2), RASA1(4), RB1(7), RELA(1), RIPK1(3), SPTAN1(5), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 52916612 89 54 89 27 22 14 15 23 14 1 0.264 1.000 1.000 439 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(4), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), NT5C(3), NT5E(1), NT5M(1), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), RRM1(3), TK2(3), UCK1(3), UMPS(1), UPP1(1) 43920305 81 45 80 27 20 15 8 27 11 0 0.457 1.000 1.000 440 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), ARHGAP5(2), BCAR1(3), BIRC2(2), BRAF(6), CCND1(4), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), CRKL(1), CTNNB1(3), DIAPH1(5), DOCK1(1), EGF(7), ELK1(3), ERBB2(2), FARP2(2), FLNA(13), FLNB(9), FLNC(12), FLT1(5), FN1(6), FYN(1), HGF(3), IBSP(1), IGF1(1), IGF1R(7), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KDR(6), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PARVA(1), PARVB(2), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRB(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(5), PRKCG(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(4), RELN(13), ROCK1(2), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TLN1(5), TLN2(7), TNC(8), TNN(6), TNR(5), TNXB(11), VAV1(5), VAV2(2), VAV3(2), VCL(1), VEGFA(2), VEGFB(2), VEGFC(2), VWF(7) 276986969 525 222 521 169 161 96 68 125 69 6 0.00437 1.000 1.000 441 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(4), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), C5AR1(1), CALCR(1), CCKBR(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CNR1(1), CNR2(2), CRHR2(3), CTSG(2), CYSLTR1(3), CYSLTR2(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GABBR1(2), GABBR2(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GABRB1(5), GABRB2(4), GABRB3(1), GABRD(4), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(3), GABRQ(1), GABRR1(3), GALR1(1), GH1(1), GH2(2), GHR(4), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(1), GPR35(1), GPR50(3), GPR63(1), GPR83(2), GRIA1(5), GRIA2(2), GRIA3(6), GRIA4(4), GRID1(2), GRID2(3), GRIK1(4), GRIK2(3), GRIK3(2), GRIK4(5), GRIK5(3), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM6(3), GRM7(3), GRM8(2), GRPR(3), GZMA(1), HCRTR2(2), HRH1(3), HRH4(2), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(2), NPY1R(3), NPY2R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(3), PARD3(2), PRL(1), PRLR(2), PRSS1(1), PRSS3(2), PTAFR(1), PTGER3(2), PTGER4(1), PTGFR(6), PTH2R(2), RXFP1(2), RXFP2(5), SCTR(1), SSTR2(3), SSTR3(5), SSTR4(8), TAAR1(1), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(3), TBXA2R(1), THRA(2), THRB(2), TRHR(2), TRPV1(2), TSHR(4), UTS2R(1), VIPR1(1), VIPR2(1) 170192910 432 193 429 138 148 76 51 111 46 0 0.00169 1.000 1.000 442 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(2), ACTG1(2), CHAD(1), COL11A1(6), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), DSC1(3), DSC2(2), DSC3(6), DSG1(6), DSG2(8), DSG3(2), DSG4(2), FN1(6), GJA1(5), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB4(1), GJB6(2), GJC3(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(5), KRT1(3), KRT12(1), KRT13(3), KRT14(1), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(2), KRT20(3), KRT23(1), KRT24(2), KRT25(2), KRT27(2), KRT28(5), KRT3(4), KRT31(3), KRT33A(5), KRT33B(2), KRT34(2), KRT35(3), KRT36(4), KRT37(3), KRT39(2), KRT40(1), KRT5(4), KRT6A(2), KRT6B(4), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT75(4), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(4), KRT81(3), KRT82(2), KRT83(4), KRT84(3), KRT86(3), KRT9(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), LMNA(2), LMNB2(2), NES(2), PRPH(1), RELN(13), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VIM(3), VWF(7) 190061164 409 186 404 149 148 94 36 91 38 2 0.0761 1.000 1.000 443 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 241 ACVR1B(4), ACVR1C(1), AKT1(1), ARRB1(2), ARRB2(2), ATF2(2), ATF4(1), BDNF(1), BRAF(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CACNA2D1(6), CACNA2D2(2), CACNA2D3(2), CACNA2D4(2), CACNB2(3), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CRKL(1), DAXX(2), DDIT3(2), DUSP1(1), DUSP10(1), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(3), DUSP7(1), DUSP9(2), ECSIT(1), EGF(7), ELK1(3), ELK4(1), FAS(1), FASLG(1), FGF13(2), FGF14(1), FGF16(1), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(13), FLNB(9), FLNC(12), FOS(1), GNG12(1), IKBKB(1), IL1B(2), IL1R1(2), IL1R2(3), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MKNK1(2), MRAS(1), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(2), NLK(1), NR4A1(1), NTF3(1), NTRK1(2), PAK1(2), PAK2(2), PDGFA(1), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTPN5(1), PTPN7(2), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(4), RASA1(4), RASA2(3), RASGRF1(4), RASGRF2(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA5(1), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(5), SRF(2), STK3(2), STMN1(1), TAOK1(2), TAOK2(4), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TRAF2(2), TRAF6(1), ZAK(2) 209435931 414 185 411 148 126 66 52 91 75 4 0.168 1.000 1.000 444 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 165 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A1(1), ATP2A2(4), ATP2A3(2), ATP2B2(5), ATP2B3(6), AVPR1A(4), AVPR1B(1), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(2), CHRM1(2), CHRM3(3), CHRM5(4), CHRNA7(1), CYSLTR1(3), CYSLTR2(2), EDNRA(1), EDNRB(1), ERBB2(2), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(2), GRIN2A(8), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), GRPR(3), HRH1(3), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPR1(4), ITPR2(13), ITPR3(13), LTB4R2(1), MYLK(5), MYLK2(1), NOS1(6), NOS3(7), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRB(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PPID(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTAFR(1), PTGER3(2), PTGFR(6), PTK2B(2), RYR1(11), RYR3(12), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(3), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(3) 195952004 405 184 403 153 147 67 49 82 57 3 0.160 1.000 1.000 445 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(2), ACTN1(1), ACTN2(6), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(3), ARHGEF4(4), ARHGEF6(5), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), BCAR1(3), BRAF(6), CD14(1), CFL1(1), CFL2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(4), DIAPH1(5), DIAPH2(2), DIAPH3(2), DOCK1(1), EGF(7), F2(3), F2R(2), FGD1(1), FGD3(2), FGF13(2), FGF14(1), FGF16(1), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(3), FGFR3(2), FGFR4(3), FN1(6), GIT1(2), GNA13(2), GNG12(1), GSN(1), IQGAP1(9), IQGAP2(5), IQGAP3(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(3), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MRAS(1), MSN(1), MYH10(7), MYH14(4), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDGFA(1), PDGFRB(1), PFN4(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(4), RRAS(1), SCIN(2), SOS1(4), SOS2(5), SSH1(2), SSH2(1), SSH3(2), TIAM1(5), TIAM2(9), VAV1(5), VAV2(2), VAV3(2), VCL(1), WAS(2), WASF1(1), WASF2(1), WASL(2) 204712747 350 162 349 125 90 54 51 95 57 3 0.236 1.000 1.000 446 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(4), ABLIM1(4), ABLIM2(2), ABLIM3(5), ARHGEF12(3), CFL1(1), CFL2(1), CXCR4(2), DCC(6), DPYSL5(1), EFNA1(1), EFNA3(3), EFNA5(1), EFNB1(2), EFNB2(1), EFNB3(1), EPHA2(2), EPHA3(7), EPHA4(7), EPHA5(5), EPHA6(2), EPHA7(5), EPHA8(5), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(4), EPHB6(6), FES(5), FYN(1), GNAI1(4), GNAI2(1), GNAI3(2), ITGB1(2), KRAS(3), L1CAM(7), LIMK1(4), LRRC4C(4), MAPK1(2), MAPK3(1), MET(10), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NGEF(6), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PLXNA1(10), PLXNA2(6), PLXNA3(6), PLXNB1(6), PLXNB2(4), PLXNB3(8), PLXNC1(2), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(9), RHOD(1), RND1(1), ROBO1(4), ROBO2(9), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(5), SEMA3C(1), SEMA3D(3), SEMA3E(6), SEMA3F(2), SEMA4A(2), SEMA4B(1), SEMA4D(2), SEMA4F(3), SEMA4G(3), SEMA5B(1), SEMA6A(3), SEMA6B(4), SEMA6C(2), SEMA6D(5), SEMA7A(3), SLIT1(7), SLIT2(5), SLIT3(3), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(2), UNC5C(2), UNC5D(1) 150409358 339 152 337 104 100 54 48 86 50 1 0.0146 1.000 1.000 447 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), AMOTL1(4), ASH1L(5), CASK(2), CDK4(1), CGN(1), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTTN(1), EPB41L1(2), EPB41L2(7), EPB41L3(7), EXOC3(1), EXOC4(3), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(1), INADL(6), JAM2(4), JAM3(2), KRAS(3), LLGL1(3), LLGL2(3), MAGI1(4), MAGI2(4), MAGI3(6), MLLT4(7), MPDZ(10), MRAS(1), MYH1(12), MYH10(7), MYH11(10), MYH13(11), MYH14(4), MYH15(7), MYH3(9), MYH6(5), MYH7(11), MYH7B(9), MYL2(2), MYL5(1), OCLN(2), PARD3(2), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RAB3B(1), RRAS(1), SPTAN1(5), SYMPK(3), TJAP1(1), TJP1(5), TJP2(2), TJP3(3), YES1(2), ZAK(2) 138474372 289 146 288 90 102 41 39 69 36 2 0.0413 1.000 1.000 448 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(4), CD44(3), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(5), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), DAG1(1), FN1(6), FNDC1(4), FNDC3A(5), FNDC5(1), GP5(2), GP9(1), HMMR(1), HSPG2(17), IBSP(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(3), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), RELN(13), SDC1(1), SDC3(1), SPP1(2), SV2A(2), SV2B(3), SV2C(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VWF(7) 171246464 327 143 325 105 104 77 36 71 37 2 0.0126 1.000 1.000 449 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 246 ACVR1(3), ACVR1B(4), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(1), CCL1(1), CCL11(2), CCL16(1), CCL20(2), CCL26(2), CCL27(1), CCL5(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(4), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL13(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(6), EGF(7), EPO(1), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(2), GHR(4), HGF(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL17A(1), IL17B(1), IL17RA(1), IL17RB(1), IL18(3), IL18R1(2), IL18RAP(3), IL19(1), IL1B(2), IL1R1(2), IL1R2(3), IL1RAP(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(2), IL9(1), IL9R(2), INHBA(1), INHBB(1), INHBE(2), KDR(6), KIT(6), KITLG(2), LEPR(2), LIFR(2), LTB(1), LTBR(3), MET(10), MPL(2), NGFR(1), OSMR(3), PDGFC(2), PDGFRB(1), PLEKHO2(1), PPBP(1), PRL(1), PRLR(2), RELT(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TNFRSF6B(1), TNFRSF8(2), TNFRSF9(3), TNFSF13B(1), TNFSF15(3), TNFSF8(2), TNFSF9(2), TPO(6), VEGFA(2), VEGFB(2), VEGFC(2), XCL1(1) 130956489 288 141 286 108 69 55 52 72 40 0 0.281 1.000 1.000 450 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(2), ATP2B2(5), ATP2B3(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1S(7), CACNB3(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB4(1), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), ITPR1(4), ITPR2(13), ITPR3(13), KCNB1(3), KCNJ3(1), KCNJ5(3), MIB1(1), MYCBP(1), PEA15(1), PLCB3(4), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(2), RYR1(11), RYR3(12), SFN(2), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1) 136891849 265 119 264 103 93 42 36 49 42 3 0.359 1.000 1.000 451 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(3), CD22(3), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CD58(1), CD86(1), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(6), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(2), CNTN2(2), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(2), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ICOS(1), ICOSLG(2), ITGA4(5), ITGA6(3), ITGA8(5), ITGAL(2), ITGAM(2), ITGAV(3), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(4), JAM3(2), L1CAM(7), MAG(2), MPZ(1), NCAM1(2), NEGR1(3), NEO1(8), NFASC(1), NLGN1(3), NLGN2(4), NLGN3(4), NRCAM(5), NRXN1(5), NRXN3(5), OCLN(2), PDCD1LG2(1), PTPRC(7), PTPRF(5), PTPRM(7), PVR(2), PVRL1(1), PVRL3(2), SDC1(1), SDC3(1), SELE(6), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(1), VCAN(8) 113198311 227 114 225 91 63 47 23 55 39 0 0.472 1.000 1.000 452 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA2(2), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ARRB1(2), ARRB2(2), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(2), CACNB3(2), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(3), DGKZ(2), FOS(1), GABPA(2), GBA2(1), GJA1(5), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), GUCY1A3(2), IGFBP2(1), IGFBP6(1), IL1B(2), IL6(1), ITPR1(4), ITPR2(13), ITPR3(13), MIB1(1), MYL2(2), MYLK2(1), NFKB1(1), NOS1(6), NOS3(7), PDE4B(1), PDE4D(6), PLCB3(4), PLCD1(1), PLCG1(6), PLCG2(9), PRKAR1A(2), PRKCA(5), PRKCH(3), PRKCQ(2), RAMP3(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(2), RLN1(1), RYR1(11), RYR3(12), SFN(2), SLC8A1(3), TNXB(11), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1) 125794868 244 114 242 98 82 36 34 53 36 3 0.515 1.000 1.000 453 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADK(1), ADSL(4), ADSSL1(1), AK5(2), AK7(4), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), CANT1(4), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(4), GDA(1), GMPR(1), GMPR2(2), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(4), NPR1(1), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), PAICS(2), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE2A(4), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PDE9A(2), PFAS(6), PKLR(2), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3), RRM2B(1), XDH(8) 125158779 225 113 224 80 66 40 26 58 35 0 0.269 1.000 1.000 454 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA2(2), ACTN2(6), ACTN4(2), DMD(13), MYBPC1(4), MYBPC2(4), MYH3(9), MYH6(5), MYH7(11), MYL1(2), MYL2(2), MYOM1(3), NEB(20), TNNI1(1), TNNT1(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(2), TPM4(1), TTN(120), VIM(3) 101273842 222 109 221 70 66 39 27 68 20 2 0.153 1.000 1.000 455 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CHML(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GPR17(1), GPR173(1), GPR174(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(3), GPR6(2), GPR63(1), GPR83(2), GPR85(2), GPR87(1), GRPR(3), HCRTR2(2), HRH1(3), HTR1A(1), HTR1B(2), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LTB4R(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPY1R(3), NPY2R(1), NTSR1(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(3), OR7C1(1), P2RY1(1), P2RY12(2), P2RY13(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGER4(1), PTGFR(6), RHO(1), RRH(1), SSTR2(3), SSTR3(5), SSTR4(8), SUCNR1(2), TBXA2R(1), TRHR(2) 93357731 215 108 214 81 79 33 33 54 16 0 0.0967 1.000 1.000 456 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2B(3), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHX58(1), ENPP1(4), ENPP3(2), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), IFIH1(4), LYZL1(1), MGAM(8), MOV10L1(3), PGM3(1), PYGB(1), PYGL(5), PYGM(1), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SI(10), SKIV2L2(3), SMARCA2(2), SMARCA5(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2), UXS1(2) 94842560 199 107 198 48 61 33 26 53 26 0 0.00353 1.000 1.000 457 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(12), ACACB(11), AKT1(1), ARAF(1), BRAF(6), CALM3(1), CALML3(1), CALML6(1), CBL(1), CBLB(2), CBLC(2), CRKL(1), ELK1(3), EXOC7(1), FASN(3), FBP1(1), FBP2(1), FLOT2(3), G6PC(7), G6PC2(1), GCK(2), GYS1(1), GYS2(2), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS2(1), IRS4(6), KRAS(3), LIPE(4), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), PCK1(3), PDE3A(2), PFKL(5), PFKP(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(2), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2), PRKCI(2), PTPN1(1), PTPRF(5), PYGB(1), PYGL(5), PYGM(1), RAF1(1), RAPGEF1(4), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SLC2A4(1), SOCS4(2), SORBS1(1), SOS1(4), SOS2(5), SREBF1(6), TSC1(2), TSC2(3) 119655786 212 106 211 76 60 34 26 58 31 3 0.294 1.000 1.000 458 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(2), AXIN1(1), AXIN2(1), BTRC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CCND1(4), CHD8(2), CREBBP(9), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(1), CTBP1(5), CTBP2(1), CTNNB1(3), CUL1(1), CXXC4(1), DAAM1(1), DAAM2(2), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(2), EP300(5), FZD1(2), FZD10(2), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), LEF1(1), LRP5(7), LRP6(7), MAPK10(1), MAPK8(2), MAPK9(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NKD1(1), NLK(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PORCN(5), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(5), PRKCG(2), RAC1(1), RAC2(1), RBX1(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SOX17(3), TBL1XR1(3), TBL1Y(1), TCF7L2(4), VANGL1(1), VANGL2(2), WIF1(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1) 123081781 223 104 223 72 71 32 27 56 36 1 0.126 1.000 1.000 459 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 147 AKT1(1), CBL(1), CBLB(2), CBLC(2), CCND1(4), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(9), CRLF2(3), CSF2RB(2), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(4), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL19(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(2), IL9(1), IL9R(2), IRF9(3), JAK1(1), JAK2(4), JAK3(3), LEPR(2), LIFR(2), MPL(2), OSMR(3), PIAS1(1), PIAS3(2), PIAS4(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRL(1), PRLR(2), PTPN11(7), SOCS4(2), SOCS5(2), SOS1(4), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3), STAM(2), STAM2(1), STAT1(2), STAT2(1), STAT3(2), STAT4(2), STAT5A(1), STAT5B(2), STAT6(4), TPO(6), TYK2(7) 107722896 212 104 210 64 46 30 35 74 26 1 0.106 1.000 1.000 460 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), BRAF(6), CACNA1A(3), GNA11(1), GNA13(2), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(5), GRIA2(2), GRIA3(6), GRID2(3), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1(1), IGF1R(7), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(6), NOS3(7), NPR1(1), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), RYR1(11) 84162250 185 104 184 55 45 26 35 45 31 3 0.0777 1.000 1.000 461 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), CSNK1D(1), EGF(7), GJA1(5), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(1), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K5(2), MAPK1(2), MAPK3(1), MAPK7(5), NPR1(1), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRB(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), SOS1(4), SOS2(5), TJP1(5), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3) 97473371 185 102 185 70 63 24 26 39 30 3 0.449 1.000 1.000 462 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(4), ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), ATM(8), ATR(6), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC27(4), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CHEK1(3), CHEK2(3), CREBBP(9), CUL1(1), DBF4(5), E2F1(1), E2F2(1), E2F3(1), EP300(5), ESPL1(6), FZR1(3), HDAC2(4), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(11), RB1(7), RBL1(4), RBL2(4), RBX1(1), SFN(2), SKP2(2), SMAD2(3), SMAD3(3), SMC1A(5), SMC1B(7), TGFB2(2), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 103440163 210 100 210 56 35 37 37 56 42 3 0.0547 1.000 1.000 463 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), INPP4A(1), INPP4B(4), INPP5B(3), INPP5D(2), INPPL1(5), ITPK1(3), ITPR1(4), ITPR2(13), ITPR3(13), OCRL(5), PI4KA(7), PI4KB(2), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PRKCA(5), PRKCG(2), PTPMT1(1), SYNJ1(6), SYNJ2(8) 91958173 181 96 180 60 56 32 23 43 25 2 0.181 1.000 1.000 464 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(6), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C3AR1(3), C4BPA(6), C4BPB(1), C5(6), C5AR1(1), C6(3), C7(5), C8A(2), C8B(4), CD46(3), CD55(1), CFB(1), CFD(1), CFH(8), CPB2(1), CR1(5), CR2(5), F10(1), F12(1), F13A1(2), F13B(4), F2(3), F2R(2), F5(7), F7(2), F8(20), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), KNG1(2), MASP1(2), MBL2(3), PLAT(1), PLG(4), PROS1(1), SERPINA5(1), SERPINC1(1), SERPIND1(2), SERPINE1(2), SERPINF2(1), SERPING1(3), VWF(7) 69351045 175 96 175 52 54 30 21 47 23 0 0.0348 1.000 1.000 465 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(1), BRAF(6), CD244(1), FAS(1), FASLG(1), FCGR3A(1), FYN(1), GZMB(1), HLA-A(1), HLA-C(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL3(2), KIR3DL1(1), KLRC1(2), KLRC2(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(2), MAPK3(1), MICA(4), MICB(1), NCR1(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRF1(3), PRKCA(5), PRKCG(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAF1(1), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(5), VAV1(5), VAV2(2), VAV3(2), ZAP70(5) 83743298 170 96 166 56 41 27 20 51 28 3 0.144 1.000 1.000 466 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(1), ACTN2(6), ACTN4(2), ARHGAP5(2), BCAR1(3), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(1), ESAM(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(7), MMP9(2), MSN(1), MYL2(2), MYL5(1), NCF1(2), NCF2(3), NCF4(1), NOX1(1), NOX3(1), OCLN(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(4), SIPA1(2), TXK(2), VAV1(5), VAV2(2), VAV3(2), VCAM1(1), VCL(1) 92367794 172 94 169 76 54 26 23 43 24 2 0.768 1.000 1.000 467 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ASIP(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(9), CTNNB1(3), DVL2(1), DVL3(2), EDNRB(1), EP300(5), FZD1(2), FZD10(2), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), KIT(6), KITLG(2), KRAS(3), LEF1(1), MAP2K2(1), MAPK1(2), MAPK3(1), MC1R(3), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), TCF7L2(4), TYR(4), TYRP1(4), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1) 83365310 159 94 158 56 57 12 20 37 31 2 0.360 1.000 1.000 468 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTB(2), ACTG1(2), ACTN1(1), ACTN2(6), ACTN4(2), ACVR1B(4), ACVR1C(1), BAIAP2(3), CDH1(4), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), EP300(5), ERBB2(2), FARP2(2), FER(1), FGFR1(2), FYN(1), IGF1R(7), INSR(4), IQGAP1(9), LEF1(1), LMO7(6), MAPK1(2), MAPK3(1), MET(10), MLLT4(7), NLK(1), PARD3(2), PTPN1(1), PTPRB(7), PTPRF(5), PTPRJ(4), PTPRM(7), PVRL1(1), PVRL3(2), PVRL4(1), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SORBS1(1), SSX2IP(1), TCF7L2(4), TGFBR1(2), TGFBR2(3), TJP1(5), VCL(1), WAS(2), WASF1(1), WASF2(1), WASF3(3), WASL(2), YES1(2) 89799617 175 93 175 48 55 18 22 47 32 1 0.0295 1.000 1.000 469 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ATF4(1), CACNA1C(2), CACNA1D(7), CACNA1F(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(4), GNRHR(2), HBEGF(1), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAP3K3(2), MAP3K4(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK9(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLD1(7), PRKACG(1), PRKCA(5), PTK2B(2), RAF1(1), SOS1(4), SOS2(5) 95248589 181 93 181 68 65 23 27 37 26 3 0.302 1.000 1.000 470 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(2), ADCY8(1), ARAF(1), ATF4(1), BRAF(6), CACNA1C(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(9), EP300(5), GRIA1(5), GRIA2(2), GRIN1(2), GRIN2A(8), GRIN2B(7), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), ITPR1(4), ITPR2(13), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), RAPGEF3(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3) 76012608 157 91 156 43 47 15 21 47 24 3 0.0379 1.000 1.000 471 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), ATP1B1(1), ATP5B(2), ATP5G2(1), CANT1(4), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), GART(4), GDA(1), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(4), NPR1(1), NPR2(3), NT5C(3), NT5E(1), NT5M(1), PAICS(2), PDE1A(1), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE6B(3), PDE6C(7), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(6), PKLR(2), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3) 98341081 175 91 175 72 55 35 19 43 23 0 0.629 1.000 1.000 472 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), AKAP1(1), AKAP11(2), AKAP12(1), AKAP2(3), AKAP3(2), AKAP4(6), AKAP5(2), AKAP6(9), AKAP7(1), AKAP8(4), AKAP9(10), ARHGEF1(1), CALM3(1), GNA11(1), GNA13(2), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), ITPR1(4), KCNJ3(1), KRAS(3), PALM2(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RRAS(1), USP5(1) 89416452 149 88 149 68 42 23 16 35 31 2 0.874 1.000 1.000 473 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(3), B3GNT2(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(3), CHST13(2), CHST3(3), CHST4(1), CHSY1(2), DAD1(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), FUT11(1), FUT8(6), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT7(1), GALNT8(1), GALNT9(2), GALNTL5(1), GANAB(4), GCNT3(1), GCNT4(2), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2), OGT(8), RPN1(1), RPN2(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), WBSCR17(5), XYLT1(2), XYLT2(2) 84566367 160 88 159 48 52 29 21 36 22 0 0.0750 1.000 1.000 474 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(3), ACVR1B(4), ACVRL1(5), AKT1(1), BMPR1A(1), BUB1(4), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(2), INPP4A(1), INPP4B(4), INPPL1(5), MAP3K10(1), NEK1(2), NEK3(2), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PIM2(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9), PLK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(2), STK11(1), TGFBR1(2), VRK1(3) 84657018 151 87 150 58 46 23 18 36 25 3 0.658 1.000 1.000 475 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(4), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGEF6(5), BCAR1(3), BRAF(6), CDKN2A(4), DOCK1(1), EPHB2(2), FYN(1), GRB7(4), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PKLR(2), PLCG1(6), PLCG2(9), PTK2(2), RAF1(1), RALA(2), RHO(1), ROCK1(2), ROCK2(4), SHC1(1), SOS1(4), SOS2(5), TERF2IP(1), TLN1(5), TLN2(7), WAS(2) 91381994 161 85 159 45 46 22 22 46 25 0 0.0445 1.000 1.000 476 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(4), ABL2(1), AKT1(1), ARAF(1), AREG(2), BRAF(6), BTC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CDKN1B(3), CRKL(1), EGF(7), ELK1(3), ERBB2(2), ERBB3(4), ERBB4(5), EREG(1), HBEGF(1), KRAS(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), NRG1(3), NRG2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), RAF1(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(2) 73130984 145 80 143 37 39 20 20 34 30 2 0.0281 1.000 1.000 477 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(1), ABCA12(4), ABCA13(17), ABCA2(4), ABCA3(5), ABCA4(7), ABCA5(4), ABCA6(6), ABCA7(10), ABCA8(5), ABCA9(3), ABCB1(5), ABCB10(3), ABCB11(1), ABCB4(6), ABCB5(6), ABCB7(5), ABCB8(1), ABCB9(2), ABCC1(5), ABCC10(11), ABCC11(7), ABCC12(4), ABCC2(1), ABCC3(6), ABCC4(4), ABCC5(4), ABCC6(1), ABCC8(6), ABCC9(6), ABCD1(2), ABCD2(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG5(3), ABCG8(4), CFTR(4), TAP1(1) 90460006 176 79 176 67 47 29 27 52 18 3 0.439 1.000 1.000 478 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(1), CASP8(2), CCL5(1), CD14(1), CD40(1), CD86(1), CXCL9(1), FOS(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IKBKB(1), IKBKE(5), IL12B(2), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), IRF7(4), LBP(2), MAP2K2(1), MAP2K3(3), MAP3K8(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(3), SPP1(2), STAT1(2), TBK1(2), TICAM1(1), TLR1(4), TLR2(1), TLR3(5), TLR4(2), TLR5(2), TLR6(3), TLR7(6), TLR9(3), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(1) 65916165 123 75 122 47 32 22 20 32 15 2 0.375 1.000 1.000 479 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(3), CAPN10(4), CAPN11(4), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(5), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(3), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PIK3R2(1), PTK2(2), RAC1(1), RAC2(1), RAPGEF1(4), RHO(1), ROCK1(2), ROCK2(4), SDCCAG8(2), SHC1(1), SHC3(1), SORBS1(1), SOS1(4), TLN1(5), TNS1(3), VAV2(2), VAV3(2), VCL(1) 102578608 162 75 162 56 49 22 25 40 25 1 0.268 1.000 1.000 480 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(2), CPSF2(2), CPSF3(3), CSTF1(2), CSTF2(3), CSTF3(4), DDIT3(2), DHX15(1), DHX16(4), DHX38(4), DHX8(7), DHX9(2), DICER1(2), FUS(3), METTL3(4), NCBP1(1), NONO(2), PAPOLA(5), PHF5A(2), POLR2A(7), PRPF18(1), PRPF4(1), PRPF4B(3), PRPF8(10), PSKH1(1), PTBP1(2), RNGTT(4), SF3A3(1), SF3B1(7), SF3B2(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(5) 81017128 137 75 136 33 41 23 14 39 19 1 0.0687 1.000 1.000 481 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(5), ASH2L(2), CTCFL(5), DOT1L(3), EHMT1(6), EHMT2(3), EZH1(2), EZH2(2), FBXO11(2), HCFC1(7), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(3), MEN1(1), NSD1(4), OGT(8), PAXIP1(2), PPP1CA(1), PPP1CB(1), PRDM2(5), PRDM7(1), PRDM9(8), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(3), SETD1A(1), SETD2(13), SETD7(2), SETD8(1), SETDB1(7), SETDB2(1), SETMAR(3), STK38(1), SUV39H1(2), SUV420H1(2), SUZ12(1), WHSC1L1(4) 91004114 130 73 130 31 36 20 20 32 22 0 0.0275 1.000 1.000 482 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR1B(4), ACVR1C(1), ACVR2A(2), ACVRL1(5), AMHR2(1), BMP4(2), BMP5(4), BMP6(2), BMPR1A(1), BMPR1B(1), CHRD(1), COMP(1), CREBBP(9), CUL1(1), DCN(2), E2F5(1), EP300(5), FST(1), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBB(1), INHBE(2), LEFTY2(2), LTBP1(7), MAPK1(2), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), RBL1(4), RBL2(4), RBX1(1), ROCK1(2), ROCK2(4), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD5(1), SMAD6(1), SMAD7(2), SMAD9(3), SMURF1(2), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(1), ZFYVE9(1) 76135113 153 72 153 43 45 22 24 41 20 1 0.0438 1.000 1.000 483 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 88 AKT1(1), CARD11(3), CBL(1), CBLB(2), CBLC(2), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FOS(1), FYN(1), GRAP2(1), ICOS(1), IKBKB(1), IL10(1), IL5(1), ITK(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MALT1(2), MAP3K8(4), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPRC(7), RASGRP1(1), SOS1(4), SOS2(5), TEC(3), TNF(1), VAV1(5), VAV2(2), VAV3(2), ZAP70(5) 73976312 137 72 136 43 37 28 17 35 18 2 0.140 1.000 1.000 484 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(6), CREB1(1), DAXX(2), ELK1(3), FOS(1), IKBKB(1), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(3), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP3K9(3), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAP4K5(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(2), MAPK7(5), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), NFKB1(1), NFKBIA(2), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA5(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 72757665 129 70 126 43 32 14 22 31 28 2 0.341 1.000 1.000 485 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 ABL1(4), ATM(8), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), DTX4(2), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(6), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MPEG1(2), MPL(2), PLK1(2), PRKDC(11), PTPRA(4), RB1(7), RBL1(4), SKP2(2), TBC1D8(1), WEE1(1) 83413852 148 66 148 49 27 28 21 39 30 3 0.395 1.000 1.000 486 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(11), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(1), CAMKK1(1), CAMKK2(2), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), G6PC(7), G6PC2(1), IKBKB(1), IRS1(4), IRS2(1), IRS4(6), JAK1(1), JAK2(4), JAK3(3), LEPR(2), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), NPY(3), PCK1(3), PPARA(3), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(7), RELA(1), RXRA(1), RXRG(3), SLC2A1(2), SLC2A4(1), STAT3(2), STK11(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(7) 63579952 130 66 128 46 37 25 9 38 20 1 0.293 1.000 1.000 487 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), ALG6(3), CCKBR(2), CCR2(2), CCR3(1), CELSR1(9), CELSR2(12), CELSR3(13), CHRM3(3), EDNRA(1), EMR2(5), EMR3(1), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(6), GPR132(5), GPR133(4), GPR143(4), GPR17(1), GPR18(2), GPR61(3), GPR84(2), GRM1(4), GRPR(3), HRH4(2), LPHN2(7), LPHN3(5), LTB4R2(1), NTSR1(1), P2RY13(1), PTGFR(6), SMO(2), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(1) 51080574 130 65 129 41 41 28 19 31 11 0 0.0386 1.000 1.000 488 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), CYP1A2(2), CYP1B1(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2S1(1), CYP3A4(3), CYP3A7(2), EPHX1(3), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(5), UGT2B7(2) 43971362 112 65 111 35 32 14 19 35 12 0 0.209 1.000 1.000 489 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP4A(1), INPP4B(4), INPP5B(3), INPPL1(5), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), OCRL(5), PI4KA(7), PI4KB(2), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(5), PTPMT1(1), SYNJ1(6), SYNJ2(8) 54701985 114 64 113 36 30 22 13 32 17 0 0.247 1.000 1.000 490 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(3), CD14(1), CD19(1), CD1A(3), CD1B(4), CD1E(4), CD22(3), CD33(1), CD36(4), CD3D(1), CD4(1), CD44(3), CD55(1), CD7(1), CR1(5), CR2(5), CSF1R(4), CSF3R(2), DNTT(1), EPO(1), EPOR(1), FCGR1A(1), FLT3(4), GP5(2), GP9(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), IL1B(2), IL1R1(2), IL1R2(3), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL7R(2), IL9R(2), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGAM(2), ITGB3(2), KIT(6), KITLG(2), MME(2), MS4A1(3), TFRC(2), THPO(1), TNF(1), TPO(6) 61642197 128 64 128 44 30 28 19 35 16 0 0.162 1.000 1.000 491 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), CABIN1(6), CALM3(1), CAMK4(2), CDKN1A(1), CEBPB(1), CNR1(1), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(5), FCER1A(2), FCGR3A(1), FOS(1), GATA3(3), GATA4(1), ICOS(1), IFNB1(1), IL10(1), IL1B(2), IL3(1), IL6(1), ITK(1), KPNA5(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB2(2), NFKBIE(1), NUP214(2), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(7), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(4), TNF(1), TRAF2(2), TRPV6(7), VAV1(5), VAV2(2), VAV3(2), XPO5(1) 69732822 127 63 127 39 31 31 15 30 19 1 0.0752 1.000 1.000 492 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(5), CANT1(4), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(1), RRM1(3), RRM2B(1), TK2(3), TXNRD2(3), UCK1(3), UMPS(1), UPP1(1), UPP2(2), UPRT(2) 61991576 114 61 113 36 24 16 14 39 21 0 0.359 1.000 1.000 493 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(3), ATP8A1(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(2), CCR6(2), CCR7(1), CCR8(1), CX3CR1(1), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GNRHR(2), GRPR(3), MC1R(3), MC3R(2), MC4R(3), MC5R(3), NMBR(5), NPY1R(3), NPY2R(1), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), SSTR2(3), SSTR3(5), SSTR4(8), TACR2(2), TACR3(3), TRHR(2), TSHR(4) 40220137 100 61 100 48 32 12 24 26 6 0 0.771 1.000 1.000 494 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(5), ADCY8(1), CACNA1A(3), CACNA1B(9), GNAS(4), GNAT3(1), GNB3(1), GRM4(4), ITPR3(13), KCNB1(3), PDE1A(1), PLCB2(4), PRKACG(1), SCNN1B(3), SCNN1G(2), TAS1R2(3), TAS1R3(1), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R16(4), TAS2R3(1), TAS2R38(1), TAS2R4(2), TAS2R40(2), TAS2R41(3), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R7(1), TAS2R9(4), TRPM5(2) 43585423 88 60 88 32 34 15 9 21 9 0 0.395 1.000 1.000 495 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(1), BTK(3), FCER1A(2), FYN(1), GAB2(3), IL3(1), IL5(1), INPP5D(2), KRAS(3), LAT(2), LCP2(1), MAP2K2(1), MAP2K3(3), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PRKCA(5), RAC1(1), RAC2(1), RAF1(1), SOS1(4), SOS2(5), TNF(1), VAV1(5), VAV2(2), VAV3(2) 52094964 105 59 104 34 30 19 14 26 13 3 0.159 1.000 1.000 496 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(8), CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CREB3L1(1), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(1), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MYT1(7), NACA(5), POLA2(1), POLE(8), PRIM1(1), RB1(7), RBL1(4), RPA1(3), TFDP2(1), TNXB(11), WEE1(1) 58562644 107 58 107 34 19 10 16 26 36 0 0.480 1.000 1.000 497 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), BCR(3), BLNK(2), BTK(3), CD19(1), CD22(3), CD81(2), CR2(5), CSK(1), DAG1(1), FLOT2(3), INPP5D(2), ITPR1(4), ITPR2(13), ITPR3(13), MAP4K1(1), MAPK1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PLCG2(9), PPP1R13B(2), PPP3CA(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(1), SOS1(4), SOS2(5), VAV1(5) 53760119 109 58 109 36 35 18 12 31 11 2 0.143 1.000 1.000 498 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 CREBBP(9), CTBP1(5), CTBP2(1), DLL3(1), DTX1(4), DTX3L(1), DTX4(2), DVL2(1), DVL3(2), EP300(5), HDAC2(4), JAG1(4), JAG2(1), LFNG(2), MAML1(4), MAML2(2), MAML3(4), MFNG(1), NCOR2(8), NCSTN(4), NOTCH2(11), NOTCH3(6), NOTCH4(8), NUMB(1), NUMBL(2), RBPJL(2), SNW1(2) 49080954 97 55 97 36 30 13 9 20 24 1 0.599 1.000 1.000 499 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(2), ARHGEF11(2), BTK(3), CFL1(1), CFL2(1), GDI1(3), GDI2(1), INPPL1(5), ITPR1(4), ITPR2(13), ITPR3(13), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(4), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CD(3), PIK3CG(5), PITX2(4), PPP1R13B(2), RHO(1), ROCK1(2), ROCK2(4), RPS4X(2), SAG(2), WASF1(1), WASL(2) 50254520 111 55 111 31 29 22 21 29 9 1 0.0531 1.000 1.000 500 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(1), KDR(6), KRAS(3), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NOS3(7), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRKCA(5), PRKCG(2), PTGS2(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2) 51964879 105 54 104 34 31 16 18 22 16 2 0.133 1.000 1.000 501 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(2), ACOX1(2), ACOX2(3), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ANGPTL4(1), APOA1(1), AQP7(3), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP4(1), FABP6(1), FABP7(1), FADS2(2), GK(1), GK2(4), HMGCS2(3), ILK(1), LPL(2), ME1(1), MMP1(1), NR1H3(5), OLR1(1), PCK1(3), PPARA(3), PPARG(2), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(4), SORBS1(1), UBC(5) 50116493 97 52 96 35 23 21 12 27 14 0 0.336 1.000 1.000 502 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(5), AKT1(1), APAF1(3), ATM(8), BAX(1), BIRC2(2), CASP8(2), CFLAR(1), CSF2RB(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(1), IRAK2(2), IRAK3(6), IRAK4(2), NFKB1(1), NFKB2(2), NFKBIA(2), NTRK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), RIPK1(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1), TRAF2(2) 60507228 87 50 87 33 19 14 12 26 16 0 0.706 1.000 1.000 503 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), BMP5(4), BMP6(2), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(2), GLI1(3), GLI2(3), GLI3(7), HHIP(2), IHH(3), LRP2(22), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), STK36(2), SUFU(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1), ZIC2(1) 46743626 90 50 90 36 33 15 13 18 11 0 0.572 1.000 1.000 504 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(2), APOA1(1), CD36(4), CITED2(1), CREBBP(9), DUSP1(1), EHHADH(1), EP300(5), HSD17B4(2), LPL(2), MAPK1(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(9), NCOR2(8), NFKBIA(2), NR1H3(5), NR2F1(1), NRIP1(2), PDGFA(1), PPARA(3), PRKACG(1), PRKAR1A(2), PRKCA(5), PTGS2(2), RB1(7), RELA(1), RXRA(1), STAT5A(1), STAT5B(2), TNF(1) 45623274 88 49 86 30 22 12 11 21 19 3 0.491 1.000 1.000 505 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(1), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2), KMO(3), KYNU(1), LCMT1(2), LCMT2(1), LNX1(4), MAOA(2), METTL2B(3), METTL6(1), NFX1(2), OGDH(1), OGDHL(4), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(2), TPH1(4), TPH2(3), WARS2(2), WBSCR22(2) 46426041 92 48 92 31 30 12 12 24 14 0 0.295 1.000 1.000 506 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(5), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHFR(1), DHX58(1), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(4), MOV10L1(3), QDPR(2), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SKIV2L2(3), SMARCA2(2), SMARCA5(2), SPR(1) 48093737 83 48 83 29 26 15 10 17 15 0 0.483 1.000 1.000 507 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(1), BLNK(2), BTK(3), CARD11(3), CD19(1), CD22(3), CD72(3), CD79A(1), CD81(2), CR2(5), FOS(1), IFITM1(1), IKBKB(1), INPP5D(2), KRAS(3), LILRB3(2), MALT1(2), NFAT5(4), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(5), VAV2(2), VAV3(2) 53757176 97 48 97 37 33 22 5 21 15 1 0.312 1.000 1.000 508 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), AOX1(5), ASMT(1), CAT(3), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(2), CYP4B1(1), CYP51A1(2), DDC(3), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), KMO(3), KYNU(1), MAOA(2), SDS(1), TDO2(2), TPH1(4), WARS2(2) 42195996 78 47 78 27 28 11 6 20 13 0 0.396 1.000 1.000 509 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(3), BAK1(2), BAX(1), BCL2L11(1), BIRC2(2), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(1), HELLS(3), IKBKB(1), IRF1(4), IRF2(1), IRF3(1), IRF4(2), IRF5(1), IRF6(2), IRF7(4), MAP3K1(4), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), NFKBIE(1), PLEKHG5(3), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TRADD(1), TRAF2(2), TRAF3(2) 43208887 77 42 77 27 28 12 5 20 12 0 0.405 1.000 1.000 510 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(2), ADCY9(7), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(6), PLCG2(9), PRKCA(5), SEC61A1(1), TRIM23(2) 28366340 56 39 55 22 22 11 6 8 8 1 0.533 1.000 1.000 511 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP4A(1), INPP4B(4), INPPL1(5), OCRL(5), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9) 32645013 60 39 59 26 16 12 7 17 8 0 0.775 1.000 1.000 512 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1) 39734108 70 38 70 27 24 11 11 15 8 1 0.474 1.000 1.000 513 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(3), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1) 39734108 70 38 70 27 24 11 11 15 8 1 0.474 1.000 1.000 514 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), CYP4A22(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2) 37531855 68 35 68 31 16 9 7 20 16 0 0.836 1.000 1.000 515 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), DAG1(1), DGKA(3), ITPR1(4), ITPR2(13), ITPR3(13), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(2), PI3(2), PIK3C2G(1), PIK3CD(3), PSME1(3), RIPK3(1), RPS4X(2), SGCB(1) 34427863 60 35 60 27 14 5 14 15 10 2 0.836 1.000 1.000 516 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CCND1(4), CREBBP(9), EP300(5), ERCC3(2), ESR1(2), GRIP1(2), GTF2E1(3), GTF2F1(1), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), NCOR2(8), NR0B1(1), NRIP1(2), PELP1(2), POLR2A(7) 35376817 62 34 61 25 22 4 5 17 14 0 0.788 1.000 1.000 517 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(6), EHMT2(3), GCDH(1), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(1), SETD7(2), SETDB1(7), SHMT1(2), SUV39H1(2), TMLHE(2) 44501817 73 34 73 29 26 7 9 19 12 0 0.563 1.000 1.000 518 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(2), CBR3(1), CYP4F3(5), EPX(5), GGT1(2), LPO(5), LTA4H(4), MPO(2), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(2), TPO(6) 21373742 55 34 55 20 17 13 6 11 7 1 0.274 1.000 1.000 519 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(1), LIMK1(4), MYL2(2), MYLK(5), OPHN1(4), PIP5K1B(1), ROCK1(2), TLN1(5), VCL(1) 34768823 52 34 52 20 13 5 7 20 7 0 0.647 1.000 1.000 520 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), IL6ST(3), MRPL19(2), RPL10(4), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL5(3), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(2), RPS19(1), RPS2(1), RPS24(1), RPS3(3), RPS4X(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), SLC36A2(1), TBC1D10C(1), UBC(5) 40100721 72 34 72 21 15 11 8 25 13 0 0.421 1.000 1.000 521 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), DLG4(3), GNA13(2), LPA(7), MAP3K1(4), MAP3K5(3), MAPK8(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PI3(2), PIK3CB(3), PLD1(7), PLD3(1), PTK2(2), RDX(5), ROCK1(2), ROCK2(4), SERPINA4(2), SRF(2), TBXA2R(1) 37641980 68 34 68 23 18 11 12 18 8 1 0.399 1.000 1.000 522 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), CASP1(5), CASP2(1), CASP4(1), CASP8(2), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(2), FAS(1), FASLG(1), IKBKE(5), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(3), NTRK1(2), PTPN13(3), RIPK1(3), TFG(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(2), TRAF6(1) 33278537 55 33 55 21 17 9 4 14 11 0 0.567 1.000 1.000 523 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 AKT1(1), CALM3(1), CHRM1(2), CHRNA1(4), FLT1(5), FLT4(6), KDR(6), NOS3(7), PDE2A(4), PDE3A(2), PRKACG(1), PRKAR1A(2), PRKG1(1), PRKG2(1), SLC7A1(2), SYT1(2), TNNI1(1) 24323540 48 33 48 25 14 7 12 9 6 0 0.842 1.000 1.000 524 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(1), DAG1(1), ITPR1(4), ITPR2(13), ITPR3(13), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PIK3CB(3), PITX2(4), PLD1(7), PLD3(1), VN1R1(1) 34374586 64 33 64 27 21 8 12 18 3 2 0.636 1.000 1.000 525 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(1), ALAS2(1), AMT(1), ATP6V0C(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCB2(4), PLCG1(6), PLCG2(9), PSPH(2), SARDH(3), SARS(1), SHMT1(2) 32210602 52 31 51 20 16 17 3 9 7 0 0.304 1.000 1.000 526 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT1(1), FUT2(2), FUT5(3), FUT6(2), GBGT1(1), PIGA(3), PIGB(1), PIGC(1), PIGG(2), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(3), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3), UGCG(2) 37229089 65 31 65 25 24 6 5 19 11 0 0.638 1.000 1.000 527 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(4), ITPR2(13), ITPR3(13), NFAT5(4), PDE6A(2), PDE6B(3), PDE6C(7), SLC6A13(2), TF(2) 27452725 56 31 56 23 17 11 10 12 5 1 0.486 1.000 1.000 528 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), ELK1(3), FOS(1), IKBKB(1), IRAK1(1), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), PPARA(3), RELA(1), TLR10(5), TLR2(1), TLR3(5), TLR4(2), TLR6(3), TLR7(6), TLR9(3), TOLLIP(1), TRAF6(1) 27995434 50 31 49 19 16 7 8 15 4 0 0.529 1.000 1.000 529 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH4A1(2), ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(5), GOT1(2), MAOA(2), NOS1(6), NOS3(7), OAT(1), ODC1(3), P4HA1(1), RARS(2), SMS(1) 33849189 60 30 60 25 17 12 6 14 11 0 0.630 1.000 1.000 530 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(1), CD97(2), CRHR2(3), ELTD1(1), EMR1(4), EMR2(5), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GPR64(3), LPHN1(1), LPHN2(7), LPHN3(5), SCTR(1), VIPR1(1), VIPR2(1) 20442745 45 29 45 20 11 8 10 14 2 0 0.748 1.000 1.000 531 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(2), ASL(2), ASS1(3), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), EPRS(3), GLUD1(5), GLUD2(1), GOT1(2), LAP3(1), NOS1(6), NOS3(7), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4) 27487712 53 29 53 22 15 11 5 13 9 0 0.661 1.000 1.000 532 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(13), C5(6), C6(3), C7(5), ICAM1(2), IL6(1), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 19006134 45 29 45 19 14 6 7 11 7 0 0.572 1.000 1.000 533 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(1), EIF2B4(1), EIF2S2(1), FLT1(5), FLT4(6), KDR(6), NOS3(7), PLCG1(6), PRKCA(5), PTK2(2), SHC1(1) 23157931 41 28 40 22 9 6 8 11 6 1 0.931 1.000 1.000 534 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NEU1(1), NEU2(6), NEU3(2) 15619214 39 27 39 17 12 3 6 12 6 0 0.796 1.000 1.000 535 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(6), CUL3(1), FBXW7(4), FZR1(3), RBX1(1), SKP2(2), SMURF1(2), SMURF2(2), UBE2D4(2), WWP1(3), WWP2(1) 30839537 48 26 48 24 13 7 9 15 4 0 0.942 1.000 1.000 536 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(1), ANKRD6(2), APC(2), AXIN1(1), AXIN2(1), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(1), DKK2(2), DKK4(2), LRP1(20), NKD1(1), PTPRA(4), SENP2(3), SFRP1(1), WIF1(3) 30499944 52 26 52 21 14 9 5 16 8 0 0.774 1.000 1.000 537 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), C8B(4), MASP1(2) 15914567 47 25 47 22 18 6 3 14 6 0 0.799 1.000 1.000 538 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), MASP1(2), MBL2(3) 16276604 46 25 46 18 18 4 4 13 7 0 0.611 1.000 1.000 539 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(1), CREB1(1), DUSP1(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(3), IL1R1(2), MAP2K3(3), MAP3K10(1), MAP3K4(4), MAP3K5(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(1), NR2C2(2), SRF(2), TRAF6(1) 25528703 44 25 44 20 13 3 10 13 5 0 0.812 1.000 1.000 540 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA1(1), APOA4(3), APOE(2), CETP(1), CYP7A1(2), LIPC(1), LPL(2), LRP1(20), SOAT1(2) 20988506 40 25 40 18 10 8 4 14 4 0 0.803 1.000 1.000 541 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(1), CFL1(1), GNAS(4), LIMK1(4), MAPK1(2), MAPK3(1), MYL2(2), NOX1(1), PIK3C2G(1), PLCB1(3), PRKCA(5), PTK2(2), RAF1(1), ROCK2(4) 19268738 34 24 34 11 6 2 7 11 6 2 0.536 1.000 1.000 542 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(3), CXCR4(2), GNAI1(4), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(5), PTK2(2), PTK2B(2), RAF1(1), RELA(1) 18284198 31 24 30 18 7 3 7 6 6 2 0.940 1.000 1.000 543 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2) 13388883 41 23 41 17 16 3 3 13 6 0 0.712 1.000 1.000 544 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM3(1), CAMK1(1), CAMK1G(1), ELK1(3), FPR1(1), GNA15(1), MAP2K2(1), MAP2K3(3), MAP3K1(4), MAPK1(2), MAPK3(1), NCF1(2), NCF2(3), NFATC1(2), NFATC2(5), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIA(2), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(2) 29367336 53 23 53 21 15 6 7 13 11 1 0.511 1.000 1.000 545 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(2), ALAS1(1), ALAS2(1), AMT(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), PHGDH(4), PIPOX(1), PISD(1), PSAT1(2), PSPH(2), SARDH(3), SARS(1), SARS2(1), SDS(1), SHMT1(2), TARS2(1) 32685314 45 23 45 17 11 15 4 9 6 0 0.308 1.000 1.000 546 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(5), ARRB2(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(4), CNGA4(2), CNGB1(3), GNAL(1), GUCA1A(1), PDC(2), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1) 23391495 46 23 46 20 20 6 2 12 6 0 0.637 1.000 1.000 547 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 ACO2(4), DLD(1), FH(1), IDH3B(1), OGDH(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1), PDK1(2), PDK3(3), PDK4(1), PDP2(2), SDHA(4), SDHC(2), SUCLG2(1) 21159370 35 23 33 13 7 6 7 9 6 0 0.482 1.000 1.000 548 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ATP6V0C(1), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(6), EHMT2(3), GCDH(1), HADHA(2), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2) 28414456 50 23 50 21 18 7 7 10 8 0 0.500 1.000 1.000 549 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDK2(1), DIAPH2(2), GMNN(1), MCM10(4), MCM2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), NACA(5), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), PRIM1(1), RFC1(1), RFC4(3), RPA1(3), UBC(5) 38840177 57 22 57 32 7 7 7 21 15 0 0.987 1.000 1.000 550 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM7(3), GRM8(2) 16127851 35 22 35 19 14 5 2 9 5 0 0.867 1.000 1.000 551 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(3), ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(2), SOAT2(1), SRD5A1(1) 24170731 52 22 52 25 13 5 8 21 5 0 0.906 1.000 1.000 552 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), DARS2(2), EARS2(1), EPRS(3), FARS2(3), GARS(3), HARS(2), HARS2(1), IARS(1), IARS2(3), LARS(4), MARS(5), MARS2(2), MTFMT(1), NARS(2), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(4), SARS(1), SARS2(1), TARS2(1), VARS(3), VARS2(2), WARS2(2), YARS(1) 41584450 57 22 57 17 9 14 6 19 9 0 0.397 1.000 1.000 553 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(1), POLB(3), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLG(1), POLH(1), POLI(3), POLK(2), POLL(1), POLM(3), POLQ(5), PRIM1(1), PRIM2(1), REV1(3), REV3L(7) 31048185 48 22 48 20 11 7 6 15 9 0 0.873 1.000 1.000 554 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(2), CASP8(2), CFLAR(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), SPTAN1(5), TNFRSF25(1), TRADD(1), TRAF2(2) 25590668 31 21 31 11 9 7 3 8 4 0 0.481 1.000 1.000 555 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(2), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA13(2), GNAI1(4), PLCB1(3), PRKCA(5), PTK2B(2), ROCK1(2) 16926368 27 21 27 16 6 4 5 8 3 1 0.905 1.000 1.000 556 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(2), ANXA5(1), ANXA6(3), CYP11A1(4), EDNRA(1), EDNRB(1), PLA2G4A(4), PRL(1), PTGER4(1), PTGFR(6), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(2) 15836398 35 21 35 16 9 3 4 13 6 0 0.822 1.000 1.000 557 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(4), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNF(1), TRADD(1), TRAF2(2) 18491315 27 21 27 11 9 6 2 5 5 0 0.630 1.000 1.000 558 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 AGT(2), AGTR2(3), EDNRA(1), EDNRB(1), EGF(7), FOS(1), NFKB1(1), PLCG1(6), PRKCA(5), RELA(1) 13714719 28 20 27 13 8 5 3 9 2 1 0.783 1.000 1.000 559 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPNS1(1), CAPNS2(1), EGF(7), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PRKACG(1), PRKAR1A(2), PTK2(2), TLN1(5) 23034580 33 20 33 16 13 1 8 6 4 1 0.811 1.000 1.000 560 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(8), POLR2A(7), RXRA(1) 19106019 32 20 31 22 5 7 1 12 7 0 0.991 1.000 1.000 561 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(4), ATM(8), BRCA1(2), CDKN1A(1), CHEK1(3), CHEK2(3), MAPK8(2), MDM2(3), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(5), RBBP8(2), RELA(1) 22250704 39 19 39 13 9 8 6 11 5 0 0.540 1.000 1.000 562 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADM(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), MLYCD(3), SDS(1), SMS(1) 22288062 41 19 40 17 12 7 3 11 8 0 0.641 1.000 1.000 563 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(3), ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), SOAT2(1), SRD5A1(1) 17805446 36 19 36 17 10 4 5 13 4 0 0.802 1.000 1.000 564 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(3), F2R(2), FGA(6), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2) 10280444 25 19 25 10 8 3 3 7 4 0 0.632 1.000 1.000 565 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2) 15901311 27 19 27 11 13 1 5 7 1 0 0.648 1.000 1.000 566 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), FOS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), MAPK1(2), MAPK3(1), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 24842698 30 19 30 14 5 7 3 7 7 1 0.741 1.000 1.000 567 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(6), BCAR1(3), BCR(3), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), SOS1(4), TLN1(5), VCL(1) 36157811 44 19 44 17 15 6 8 9 5 1 0.535 1.000 1.000 568 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), SELE(6), SELP(2) 12224334 25 19 24 11 9 4 7 3 2 0 0.588 1.000 1.000 569 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(9), DUSP1(1), EP300(5), IKBKB(1), IL1B(2), MAP2K3(3), NFKB1(1), NFKBIA(2), NR3C1(3), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1), TNF(1) 22767082 35 19 35 14 9 6 4 11 5 0 0.673 1.000 1.000 570 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(13), C5(6), C6(3), C7(5), C8A(2) 9622069 29 18 29 14 11 2 3 8 5 0 0.812 1.000 1.000 571 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(3), FOS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 17884778 25 18 25 10 4 6 2 7 5 1 0.526 1.000 1.000 572 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1R1(2), IRAK1(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF6(1) 18660552 24 18 24 14 11 3 2 4 4 0 0.897 1.000 1.000 573 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(3), EEA1(3), GRASP(1), PFKL(5), PFKP(1), PLCG1(6), RAC1(1), RPS6KB1(2), VAV2(2) 19080196 28 18 27 16 8 7 3 5 5 0 0.859 1.000 1.000 574 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(1), TAF9(2) 26888480 39 18 39 25 10 6 4 15 4 0 0.986 1.000 1.000 575 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), CASP8(2), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(2), NFKBIA(2), NFKBIE(1), NR2C2(2), RALBP1(2), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 20859433 29 18 29 11 12 5 3 4 5 0 0.567 1.000 1.000 576 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(4), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF2(2), TRAF3(2) 17206442 25 18 25 10 12 3 1 4 5 0 0.564 1.000 1.000 577 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD7(1), IFNB1(1), IL10(1), IL12B(2), IL3(1), IL5(1), ITGAX(2), TLR2(1), TLR4(2), TLR7(6), TLR9(3) 14266044 25 17 24 15 6 2 4 10 3 0 0.949 1.000 1.000 578 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GPX6(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(2) 15628527 29 17 29 14 8 8 5 5 3 0 0.727 1.000 1.000 579 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), CA1(1), CA12(2), CA13(1), CA14(1), CA2(1), CA5A(2), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(5), GLUD2(1), GLUL(1), HAL(1) 16296819 27 17 27 14 6 6 1 9 5 0 0.880 1.000 1.000 580 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1) 18000514 31 17 31 13 8 3 5 11 4 0 0.727 1.000 1.000 581 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(9), EP300(5), FYN(1), IL7R(2), JAK1(1), JAK3(3), LCK(1), PTK2B(2), STAT5A(1), STAT5B(2) 18575251 27 17 27 11 6 3 3 11 4 0 0.751 1.000 1.000 582 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(2), CCR3(1), CCR4(2), CCR7(1), CD28(1), CD4(1), CXCR4(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(2), IL5(1), TGFB2(2), TGFB3(1) 15318056 25 17 25 16 6 3 5 9 2 0 0.947 1.000 1.000 583 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1) 12594975 23 16 23 13 6 4 5 4 4 0 0.894 1.000 1.000 584 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), CHST1(1), CHST4(1), FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 9568150 18 16 18 10 6 3 4 3 2 0 0.828 1.000 1.000 585 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(1), CA12(2), CA14(1), CA2(1), CA5A(2), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(5), GLUL(1), HAL(1) 14584452 25 16 25 10 6 5 1 8 5 0 0.672 1.000 1.000 586 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(9), EP300(5), HDAC3(1), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF6(1) 17157149 28 16 28 11 9 3 1 9 6 0 0.667 1.000 1.000 587 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(9), EP300(5), NCOA3(5), PRKACG(1), PRKAR1A(2), RXRA(1) 15875670 24 15 24 10 7 4 1 8 4 0 0.749 1.000 1.000 588 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(3), FDFT1(1), FDPS(1), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), LSS(1), MVD(3), NQO1(1), NSDHL(2), SQLE(1) 14744773 24 14 23 11 7 3 5 6 3 0 0.804 1.000 1.000 589 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR2(1), SNAP29(1), STX11(2), STX16(1), TSNARE1(3), USE1(2), VAMP4(1), VAMP5(2), VAMP8(1), VTI1A(2) 12786465 18 14 17 10 9 3 3 1 2 0 0.806 1.000 1.000 590 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), GNA13(2), MYL2(2), MYLK(5), PLCB1(3), PRKCA(5), ROCK1(2) 15823461 22 14 22 12 8 3 4 5 1 1 0.825 1.000 1.000 591 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2) 15660777 26 14 26 11 10 7 0 3 6 0 0.420 1.000 1.000 592 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), FUT1(1), FUT2(2), FUT5(3), FUT6(2), ST3GAL6(3), ST8SIA1(1) 12429865 21 13 21 12 6 2 2 6 5 0 0.933 1.000 1.000 593 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(6), PRKCA(5), PTK2B(2) 5169165 15 13 14 10 4 3 2 4 1 1 0.904 1.000 1.000 594 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(2), ALOX5(2), ALOX5AP(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGES(1), PTGS1(2), PTGS2(2), TBXAS1(2) 11525165 21 12 21 11 6 6 2 3 4 0 0.815 1.000 1.000 595 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2) 10160354 26 12 26 11 9 2 3 10 2 0 0.697 1.000 1.000 596 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK1(1), JAK2(4), JAK3(3), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), TYK2(7) 14110842 23 12 23 10 6 0 2 10 4 1 0.814 1.000 1.000 597 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 9319021 20 12 20 11 8 2 3 3 4 0 0.782 1.000 1.000 598 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), DHFR(1), HPRT1(1), IMPDH1(4), OAZ1(1), POLB(3), POLD1(2), POLG(1), PRPS2(3), RRM1(3), SRM(2) 9538000 25 12 25 11 8 5 5 4 3 0 0.603 1.000 1.000 599 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 19156495 26 11 25 10 6 5 2 12 1 0 0.722 1.000 1.000 600 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(3), ELOVL2(1), ELOVL6(1), FADS2(2), FASN(3), HADHA(2), PECR(2), SCD(1) 10969552 17 11 17 15 3 3 2 7 2 0 0.990 1.000 1.000 601 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 8255909 14 11 14 10 6 4 0 3 1 0 0.901 1.000 1.000 602 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 8661183 15 11 15 10 6 4 0 4 1 0 0.889 1.000 1.000 603 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(5) 12761359 22 10 22 13 7 4 2 8 1 0 0.924 1.000 1.000 604 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTFMT(1), MTR(2), SRM(2), TAT(1) 14490960 25 10 25 11 6 6 1 8 2 2 0.672 1.000 1.000 605 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(1), FYN(1), RELN(13), VLDLR(2) 10751396 17 9 17 11 6 6 1 3 1 0 0.871 1.000 1.000 606 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(3), PPARG(2), RXRA(1), TNF(1) 4459925 9 8 9 5 1 3 1 4 0 0 0.750 1.000 1.000 607 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(1), CNR2(2), DNMT1(3), MTNR1A(2), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(6), TBXA2R(1) 8544506 19 7 19 10 6 3 0 9 1 0 0.808 1.000 1.000 608 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(1), UBE2G2(1), UBE2L6(1), UBE2M(1), UBE3A(1) 8076040 7 7 7 10 4 0 1 1 1 0 0.998 1.000 1.000 609 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2) 4328451 10 5 10 6 1 1 1 7 0 0 0.910 1.000 1.000 610 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2), EIF2S2(1), PPP1CA(1) 8859236 6 4 6 7 1 1 2 2 0 0 0.987 1.000 1.000 611 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(2), P2RY6(2) 4580294 8 3 8 6 4 2 0 2 0 0 0.902 1.000 1.000 612 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1) 4665225 2 2 2 3 0 0 2 0 0 0 0.968 1.000 1.000 613 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 551919 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 391016 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 1174657 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 1314699 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000