Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.103 0.293 -9999.0 0.0 -0.717 65.0 65.0 IHH -0.014 0.086 -9999.0 0.0 -0.509 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.069 0.16 -9999.0 0.0 -0.315 143.0 143.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.148 0.313 143.0 -9999.0 0.0 143.0 SMO/beta Arrestin2 -0.036 0.174 -9999.0 0.0 -0.695 16.0 16.0 SMO -0.046 0.184 -9999.0 0.0 -0.675 20.0 20.0 AKT1 0.002 0.083 -9999.0 0.0 -0.311 6.0 6.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.062 -9999.0 0.0 -0.558 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 STIL -0.092 0.217 -9999.0 0.0 -0.524 74.0 74.0 DHH N/PTCH2 -0.058 0.144 -9999.0 0.0 -0.404 74.0 74.0 DHH N/PTCH1 -0.069 0.193 -9999.0 0.0 -0.544 37.0 37.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 DHH -0.047 0.174 -9999.0 0.0 -0.543 56.0 56.0 PTHLH -0.114 0.344 -9999.0 0.0 -0.922 63.0 63.0 determination of left/right symmetry -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.112 0.339 -9999.0 0.0 -0.907 63.0 63.0 IHH N/Hhip -0.116 0.21 -9999.0 0.0 -0.446 143.0 143.0 DHH N/Hhip -0.147 0.211 -9999.0 0.0 -0.422 180.0 180.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 pancreas development -0.14 0.251 -9999.0 0.0 -0.545 142.0 142.0 HHAT -0.006 0.108 -9999.0 0.0 -0.576 18.0 18.0 PI3K -0.001 0.019 -9999.0 0.0 -0.429 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.117 -9999.0 0.0 -0.501 28.0 28.0 somite specification -0.045 0.181 -9999.0 0.0 -0.613 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.093 0.213 -9999.0 0.0 -0.536 64.0 64.0 SHH Np/Cholesterol/PTCH2 -0.067 0.157 -9999.0 0.0 -0.31 142.0 142.0 SHH Np/Cholesterol/Megalin -0.168 0.217 -9999.0 0.0 -0.36 259.0 259.0 SHH -0.079 0.188 -9999.0 0.0 -0.406 123.0 123.0 catabolic process -0.047 0.184 -9999.0 0.0 -0.598 26.0 26.0 SMO/Vitamin D3 -0.084 0.216 -9999.0 0.0 -0.563 54.0 54.0 SHH Np/Cholesterol/Hhip -0.139 0.211 -9999.0 0.0 -0.417 137.0 137.0 LRP2 -0.191 0.273 -9999.0 0.0 -0.551 187.0 187.0 receptor-mediated endocytosis -0.179 0.219 -9999.0 0.0 -0.562 93.0 93.0 SHH Np/Cholesterol/BOC -0.057 0.152 -9999.0 0.0 -0.314 126.0 126.0 SHH Np/Cholesterol/CDO -0.075 0.168 -9999.0 0.0 -0.326 148.0 148.0 mesenchymal cell differentiation 0.152 0.198 0.414 137.0 -9999.0 0.0 137.0 mol:Vitamin D3 -0.091 0.215 -9999.0 0.0 -0.536 64.0 64.0 IHH N/PTCH2 -0.011 0.106 -9999.0 0.0 -0.446 25.0 25.0 CDON -0.025 0.144 -9999.0 0.0 -0.558 35.0 35.0 IHH N/PTCH1 -0.047 0.185 -9999.0 0.0 -0.603 26.0 26.0 Megalin/LRPAP1 -0.142 0.191 -9999.0 0.0 -0.393 187.0 187.0 PTCH2 -0.009 0.114 -9999.0 0.0 -0.558 21.0 21.0 SHH Np/Cholesterol -0.075 0.139 -9999.0 0.0 -0.315 123.0 123.0 PTCH1 -0.047 0.185 -9999.0 0.0 -0.601 26.0 26.0 HHIP -0.14 0.252 -9999.0 0.0 -0.546 142.0 142.0