Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.025 0.108 -9999.0 0.0 -0.261 68.0 68.0 epithelial cell differentiation -0.063 0.113 -9999.0 0.0 -0.296 60.0 60.0 CYFIP2 0.008 0.06 -9999.0 0.0 -0.541 6.0 6.0 ENAH 0.009 0.102 -9999.0 0.0 -0.364 1.0 1.0 EGFR -0.083 0.213 -9999.0 0.0 -0.546 89.0 89.0 EPHA2 -0.015 0.12 -9999.0 0.0 -0.496 30.0 30.0 MYO6 -0.027 0.122 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.034 -9999.0 0.0 -0.358 3.0 3.0 AQP5 -0.136 0.182 -9999.0 0.0 -0.51 75.0 75.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.027 0.121 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.129 -9999.0 0.0 -0.528 3.0 3.0 EGF -0.05 0.181 -9999.0 0.0 -0.556 58.0 58.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.076 0.126 -9999.0 0.0 -0.514 19.0 19.0 cortical microtubule organization -0.063 0.113 -9999.0 0.0 -0.296 60.0 60.0 GO:0000145 -0.025 0.115 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.064 0.114 -9999.0 0.0 -0.299 60.0 60.0 MLLT4 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 ARF6/GDP -0.057 0.095 -9999.0 0.0 -0.399 10.0 10.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.017 0.066 -9999.0 0.0 -0.402 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.028 0.124 -9999.0 0.0 -0.347 11.0 11.0 PVRL2 0.012 0.035 -9999.0 0.0 -0.541 2.0 2.0 ZYX -0.032 0.125 -9999.0 0.0 -0.516 1.0 1.0 ARF6/GTP -0.015 0.059 -9999.0 0.0 -0.528 1.0 1.0 CDH1 -0.12 0.238 -9999.0 0.0 -0.539 125.0 125.0 EGFR/EGFR/EGF/EGF -0.126 0.168 -9999.0 0.0 -0.524 47.0 47.0 RhoA/GDP -0.058 0.104 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.021 0.12 -9999.0 0.0 -0.544 1.0 1.0 IGF-1R heterotetramer 0.013 0.022 -9999.0 0.0 -0.489 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.022 -9999.0 0.0 -0.489 1.0 1.0 IGF1 -0.008 0.112 -9999.0 0.0 -0.562 20.0 20.0 DIAPH1 -0.001 0.052 -9999.0 0.0 -0.648 3.0 3.0 Wnt receptor signaling pathway 0.063 0.113 0.296 60.0 -9999.0 0.0 60.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.057 0.096 -9999.0 0.0 -0.399 10.0 10.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.122 -9999.0 0.0 -0.561 1.0 1.0 EFNA1 0.01 0.044 -9999.0 0.0 -0.489 4.0 4.0 LPP -0.042 0.137 -9999.0 0.0 -0.45 10.0 10.0 Ephrin A1/EPHA2 -0.069 0.113 -9999.0 0.0 -0.459 9.0 9.0 SEC6/SEC8 -0.05 0.092 -9999.0 0.0 -0.472 3.0 3.0 MGAT3 -0.033 0.13 -9999.0 0.0 -0.539 3.0 3.0 HGF/MET -0.164 0.179 -9999.0 0.0 -0.508 73.0 73.0 HGF -0.079 0.202 -9999.0 0.0 -0.513 91.0 91.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.025 0.109 -9999.0 0.0 -0.263 68.0 68.0 actin cable formation 0.02 0.102 -9999.0 0.0 -0.32 3.0 3.0 KIAA1543 -0.063 0.169 -9999.0 0.0 -0.546 25.0 25.0 KIFC3 -0.028 0.124 -9999.0 0.0 -0.582 1.0 1.0 NCK1 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.045 0.137 -9999.0 0.0 -0.468 8.0 8.0 NCK1/GIT1 -0.001 0.019 -9999.0 0.0 -0.429 1.0 1.0 mol:GDP -0.063 0.113 -9999.0 0.0 -0.296 60.0 60.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.027 0.122 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.027 0.122 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.004 0.079 -9999.0 0.0 -0.593 9.0 9.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.112 -9999.0 0.0 -0.369 5.0 5.0 adherens junction assembly -0.043 0.166 -9999.0 0.0 -0.517 25.0 25.0 IGF-1R heterotetramer/IGF1 -0.065 0.116 -9999.0 0.0 -0.542 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.031 -9999.0 0.0 -0.399 3.0 3.0 MET -0.146 0.251 -9999.0 0.0 -0.535 151.0 151.0 PLEKHA7 -0.037 0.135 -9999.0 0.0 -0.56 6.0 6.0 mol:GTP -0.017 0.065 -9999.0 0.0 -0.399 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.004 0.114 -9999.0 0.0 -0.447 3.0 3.0 cortical actin cytoskeleton stabilization -0.025 0.108 -9999.0 0.0 -0.261 68.0 68.0 regulation of cell-cell adhesion -0.021 0.12 -9999.0 0.0 -0.544 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.025 0.109 -9999.0 0.0 -0.263 68.0 68.0